Chii chinonzi Dacarbazine: Zvayakashandiswa, Madosi, Migumisiro Yemuviri uye Zvimwe Zvinhu

Dacarbazine mushonga wechemotherapy unoshandiswa kurapa mhando dzekenza, kusanganisira melanoma uye Hodgkin's lymphoma. Mushonga uyu une simba wekurwisa kenza unoshanda nekukuvadza DNA yemasero ekenza, uchivadzivisa kukura nekuzviparadzanisa. Kunyange zvazvo ichionekwa semushonga une simba unogona kurwisa kenza zvinobudirira, inouyawo nemigumisiro yakakosha yemuviri inoda kutariswa zvakanyanya nechikwata chako chehutano.

Chii chinonzi Dacarbazine?

Dacarbazine imishonga inonzi alkylating agent, zvinoreva kuti ndeyemhando yemishonga yechemotherapy inorwisa masero ekenza zvakananga. Inopiwa chete kuburikidza neIV (intravenous) jekiseni muchipatara kana kiriniki. Mushonga uyu wanga uchishandiswa kwemakumi emakore kurapa kenza uye unoonekwa seimwe yemishonga yakajairika yeiyo melanoma yakafambira mberi uye mamwe ma lymphomas.

Mushonga uyu unogadzirwa, zvinoreva kuti unogadzirwa murabhoritari panzvimbo yekutorwa kubva kuzvinhu zvakasikwa. Oncologist wako achasarudza kana dacarbazine yakakodzera mhando yako chaiyo uye nhanho yekenza zvichienderana nezvinhu zvakasiyana-siyana zvinosanganisira hutano hwako hwese uye kuti kenza yako yakapindura sei kune dzimwe nzira dzekurapa.

Chii chinonzi Dacarbazine Chinoshandiswa Kuti?

Dacarbazine inonyanya kushandiswa kurapa melanoma yakafambira mberi uye Hodgkin's lymphoma. Kune varwere vane melanoma, inowanzoitwa kana kenza yapararira kune dzimwe nhengo dzemuviri (metastatic melanoma). Muzviitiko zveHodgkin's lymphoma, inowanzo shandiswa sechikamu chekurapa kwakabatanidzwa kunonzi ABVD.

Chiremba wako angangofungawo nezve dacarbazine kune mamwe makenza asingawanzoitiki se soft tissue sarcomas. Sarudzo yekushandisa mushonga uyu inoenderana nenhano yekenza yako, nzvimbo, uye yakapindura sei kune dzimwe nzira dzekurapa. Dzimwe nguva inoshandiswa yega, asi kazhinji inobatanidzwa nemamwe mishonga yechemotherapy kuwedzera kushanda kwayo.

Dacarbazine Inoshanda Sei?

Dacarbazine inoshanda nekukanganisa kugona kwemasero ekenza kugadzirisa nekukopa DNA yavo. Fungidzira sekukanganisa bhuku remirairo remasero ekenza, zvichiita kuti zvisakwanise kuti sero rishande nemazvo kana kugadzira masero matsva ekenza. Iyi nzira inozopedzisira yatungamira kurufu rwemasero ekenza.

Iri mushonga une simba usingasaruri pakati pemasero ekenza nemamwe masero ane hutano. Ndosaka iwe unogona kusangana nemigumisiro mune zvikamu zvemuviri wako uko masero anoparadzana nekukurumidza, senge hurongwa hwako hwekugaya, follicles yebvudzi, uye marrow yemupfupa. Mashoko akanaka ndewekuti masero ane hutano anowanzoita zviri nani pakupora kubva mukukuvadzwa uku kupfuura masero ekenza.

Ndingatora sei Dacarbazine?

Dacarbazine inogara ichipiwa kuburikidza neIV muchipatara nevanachiremba vakadzidziswa. Hauzogoni kutora mushonga uyu kumba kana nemuromo. Infusion inowanzo tora maminitsi makumi matatu kusvika awa, uye iwe uchatariswa panguva yese yekufamba.

Usati watora mushonga wako, idya chikafu chakareruka kunze kwekunge chiremba wako achikurudzira zvimwe. Vamwe varwere vanowana kuti kuva nechinhu mudumbu ravo kunobatsira kuderedza kusvotwa. Chikwata chako chehutano chichakupa mishonga inorwisa kusvotwa usati watora mushonga kuti ibatsire kudzivirira dumbu.

Uchada kusvika pachirongwa chako wakanyatsogadzirwa nemvura, saka inwa mvura yakawanda zuva risati rasvika uye mangwanani ekurapa kwako. Dzivisa doro kwemaawa angangoita makumi maviri nemana usati watora mushonga uye mushure mekuisa, sezvo izvi zvinogona kuwedzera migumisiro uye kukanganisa maitiro emuviri wako ekugadzirisa mushonga.

Ndingatora Dacarbazine kwenguva yakareba sei?

Kureba kwekurapa kwe dacarbazine kunosiyana zvakanyanya zvichienderana nerudzi rwekenza yako uye kuti unopindura sei mushonga. Varwere vazhinji vanogamuchira kurapwa mumakore, neimwe neimwe ichigara kwemavhiki 3-4. Unogona kuda chero kubva kumakore matatu kusvika ku8, kunyangwe vamwe varwere vachida kurapwa kwenguva refu.

Chiremba wako wezve oncology achagara achiongorora kufambira mberi kwako kuburikidza nekuedzwa kweropa, scans, uye kuongororwa kwemuviri. Kana kenza yako ichipindura zvakanaka uye mhedzisiro yacho ichigoneka, kurapwa kunogona kuenderera mberi. Zvisinei, kana kenza isingapinduri kana mhedzisiro yacho ikava yakanyanya, chiremba wako achakurukura dzimwe nzira dzekurapa.

Zvakakosha kupedzisa nzira yako yese yekurapa kunyangwe ukatanga kunzwa zviri nani. Masero ekenza anogona kunge aripo kunyangwe iwe uchinzwa zvakanaka, uye kumisa kurapwa kare kungabvumira kenza kuti idzoke yakasimba kupfuura kare.

Ndezvipi Zvipingamupinyi zveDacarbazine?

Kufanana nemishonga yese yekemotherapy, dacarbazine inogona kukonzera mhedzisiro iyo inobva pakureruka kusvika kune yakakomba. Vanhu vazhinji vanowana mamwe mhedzisiro, asi yeuka kuti timu yako yehutano yakagadzirira kubatsira kuzvigadzirisa nemazvo.

Heano mhedzisiro yakajairika yaungasangana nayo:

• Kusvotwa uye kurutsa (kunokanganisa vanhu vazhinji)
• Kurasikirwa nechido
• Kuneta uye kushaya simba
• Kuderera kwemasero eropa
• Kurasikirwa nebvudzi
• Maronda emuromo
• Zviratidzo zvakaita sefuruu zvinosanganisira fivha uye kurwadziwa kwemhasuru

Izvi zvinowanzoitika mhedzisiro zvinowanzoitika zvichigoneka nekuchengetwa kunotsigira uye mishonga. Chikwata chako chehutano chichakupa mishonga inorwisa kusvotwa uye dzimwe nzira dzekurapa dzinotsigira kuti dzikubatsire kunzwa wakasununguka.

Nepo zvisingawanzoitiki, vamwe varwere vanogona kusangana nemhedzisiro yakakomba iyo inoda kutariswa kwekurapa nekukurumidza:

• Kutapukirwa kwakanyanya nekuda kwekuderera kwemasero machena eropa
• Kubuda ropa kusinganzwisisike kana kupwanya
• Matambudziko akakomba echiropa
• Allergic reactions panguva yekuiswa
• Ganda rakakomba
• Matambudziko emoyo (kashoma)

Taura nechiremba wako nekukasira kana uine fivha, kubuda ropa kusinganzwisisike, kusvotwa kwakanyanya kunokutadzisa kuchengeta mvura pasi, kana chero zviratidzo zvinokunetsa. Kupindira nekukurumidza kunogona kudzivirira matambudziko uye kukuchengeta wakasununguka.

Ndiani Asingafaniri Kutora Dacarbazine?

Dacarbazine haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana zvakachengeteka kwauri. Vanhu vane immune system dzakakanganiswa zvakanyanya kana avo vakambove nekugadzirisa kwakanyanya kune dacarbazine havafaniri kugamuchira mushonga uyu.

Chiremba wako achanyatso chenjerera kana uine matambudziko echiropa, chirwere cheitsvo, kana nhoroondo yezvirwere zvemtima. Vakadzi vane pamuviri havafaniri kugamuchira dacarbazine sezvo ichigona kukuvadza mwana ari kukura. Kana iwe uchiyamwisa, uchafanirwa kumira usati watanga kurapwa.

Usati watanga dacarbazine, udza chiremba wako nezve mishonga yese yaunotora, kusanganisira zvinodhaka zvisingatengwe uye zvinowedzera. Dzimwe mishonga dzinogona kushamwaridzana ne dacarbazine uye kuwedzera mhedzisiro kana kuderedza kushanda kwayo.

Mazita eDacarbazine Brand

Dacarbazine inowanikwa pasi pezita rekuti DTIC-Dome munyika zhinji. Zvisinei, inowanzozivikanwa se dacarbazine kana DTIC munzvimbo dzekurapa. Mhando dzakajairika dzinowanikwawo uye dzinoshanda zvakafanana nemushonga wemhando.

Chipatara chako kana kiriniki ichashandisa chero vhezheni iripo, uye haufanirwe kunetseka nekukumbira mhando chaiyo. Ese mavhezheni e dacarbazine anosangana nematanho akafanana ekuchengeteka uye kushanda.

Dzimwe nzira dzeDacarbazine

Dzimwe nzira dze dacarbazine dziripo, kunyangwe sarudzo yakanakisa inoenderana nerudzi rwako rwekenza. Ye melanoma, sarudzo itsva dzinosanganisira mishonga ye immunotherapy senge pembrolizumab (Keytruda) uye nivolumab (Opdivo), iyo inobatsira immune system yako kurwisa kenza zvinobudirira.

Dzimwe nzira dzekurapa dzekemotherapu dzinosanganisira temozolomide, inotorwa nemuromo uye inoshanda zvakafanana nedacarbazine. Kune Hodgkin's lymphoma, mamwe marapirwo akasanganiswa seBEACOPP kana ICE anogona kufungwa kana ABVD (iyo ine dacarbazine) isina kukodzera.

Oncologist wako achafunga nezvezvinhu zvakaita semaitiro ekenza yako, hutano hwako hwese, uye kurapwa kwakapfuura paanenge achikurudzira dzimwe nzira. Usambomira dacarbazine kana kuchinja kurapwa usati wataurirana nechikwata chako chekuchengetedza hutano kutanga.

Ko Dacarbazine Ari Nani Kudarika Temozolomide?

Zvese dacarbazine uye temozolomide zvinoshanda zvakafanana, asi zvine zvakanakira zvakasiyana. Temozolomide inogona kutorwa semupiritsi kumba, izvo vanhu vazhinji vanowana zviri nyore kupfuura IV infusions. Zvisinei, dacarbazine yakashandiswa kwenguva refu uye ine tsvakurudzo yakawanda yakavimbika shure kwayo.

Kune brain metastases, temozolomide inogona kufarirwa nekuti inopinda muuropi nyore nyore. Kune mamwe marudzi ekenza, dacarbazine inogona kusarudzwa sechikamu chekurapa kwakasanganiswa kwakaratidzwa. Chiremba wako achafunga nezve mamiriro ako chaiwo paanenge achisarudza pakati pemishonga iyi.

Sarudzo yakanaka zvachose inoenderana nemamiriro ako ega, kusanganisira rudzi rwekenza yako, nhanho, mamwe mamiriro ehutano, uye zvaunofarira. Mishonga yese miviri yakabatsira vanhu vazhinji kurwisa kenza zvakabudirira.

Mibvunzo Inowanzo Bvunzwa Nezve Dacarbazine

Ko Dacarbazine Akachengeteka Kuvanhu Vane Chirwere Chechiropa?

Dacarbazine inoda kungwarira zvakanyanya muvanhu vane matambudziko echiropa nekuti chiropa chinogadzirisa mushonga uyu. Chiremba wako anogona kuraira bvunzo dzekushanda kwechiropa usati watanga kurapwa uye achavaongorora nguva dzose mukati mekurapa kwako.

Kana uine matambudziko emuviri akapfava, chiremba wako angachinja mushonga wako kana kukutarisa zvakanyanya. Zvisinei, vanhu vane chirwere chakakomba chechiropa vangave vasina kukodzera dacarbazine. Iva akatendeseka nechikwata chako chehutano nezve nhoroondo yechero matambudziko echiropa, kusanganisira hepatitis kana kushandisa doro zvakanyanya.

Ndingaita Sei Kana Ndikagamuchira Dacarbazine Yakawandisa Netsaona?

Sezvo dacarbazine inopiwa chete nevashandi vehutano vakadzidziswa muzvipatara, overdoses netsaona hazviwanzoitiki. Chikwata chako chehutano chinonyatsoverenga mushonga wako zvichienderana nehukuru hwemuviri wako uye chinotarisa infusion zvakanyanya.

Kana uine hanya nemushonga wako kana uine mhedzisiro yakakomba mushure mekurapa, taura nemupi wako wehutano nekukurumidza. Vanogona kupa rutsigiro rwekutarisira uye kukutarisa chero matambudziko. Usambofa wakaedza kurapa zviratidzo zvekuwandisa wega.

Ndingaita Sei Kana Ndikarasikirwa Nemushonga weDacarbazine?

Kana ukapotsa musangano wakarongeka we dacarbazine, taura nehofisi yechiremba wako weoncologist nekukurumidza sezvinobvira kuti urongezve. Usaedza kugadzirisa mishonga yakapotswa kana kuwedzera kurapwa. Chikwata chako chehutano chichagadzirisa chirongwa chako chekurapa zvakachengeteka.

Kupotsa mushonga mumwe chete hakuzokanganisi kurapwa kwako, asi kuenderana kwakakosha kuti uwane mhedzisiro yakanaka. Kana uine matambudziko ekuchengeta misangano nekuda kwemhedzisiro kana dzimwe nyaya, kurukura izvi nechikwata chako chehutano. Vanogona kukubatsira kudzora mhedzisiro kana kugadzirisa chirongwa chako kana zvichidikanwa.

Ndingamira Rini Kutora Dacarbazine?

Unofanirwa kungomira dacarbazine kana chiremba wako weoncologist achiona zvakakodzera. Sarudzo iyi inobva pakuti kenza yako iri kupindura sei kurapwa, kuti mhedzisiro yako yakakomba sei, uye hutano hwako hwese.

Vamwe varwere vanopedzisa kurapwa kwavo kwakarongwa zvakanaka, asi vamwe vangada kumira kare nekuda kwemigumisiro kana kusapindura. Chiremba wako achashandisa ma scans enguva dzose uye bvunzo dzeropa kuti aongorore kufambira mberi kwako uye aite sarudzo iyi newe.

Ndingatyaira Mushure meDacarbazine Kurapa?

Varwere vazhinji vanonzwa vaneta kana kusanzwa zvakanaka mushure me dacarbazine infusions, saka zviri nani kuronga kuti mumwe munhu akutyairire kumba mushure mekurapa. Kuneta, kusvotwa, uye zviratidzo zvakaita sefuruwenza zvinogona kukanganisa kugona kwako kutyaira zvakachengeteka.

Ronga kuzorora kwezuva rose mushure mekurapa kwako. Varwere vazhinji vanonzwa zviri nani mukati mezuva kana maviri, asi teerera muviri wako uye usatyaira kana uchinzwa usina kunaka kana dzungu. Kuchengeteka kwako nekuchengeteka kwevamwe vari mumugwagwa ndizvo zvakanyanya kukosha.