Chii chinonzi Daclizumab: Zvayakashandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Daclizumab yaiva mushonga wemishonga yaishandiswa kurapa multiple sclerosis (MS) nekuderedza kuzvimba muuropi uye muspinal cord. Mushonga uyu waishanda nekudzivisa zviratidzo zvakakosha zve immune system zvinobatsira kuMS attacks.

Zvisinei, daclizumab yakabviswa pachinzvimbo chemusika muna 2018 nekuda kwezvikonzero zvakakomba zvekuchengetedza. Kunyange zvazvakaratidza vimbiso mukurapa MS, matambudziko echiropa asingawanzoitiki asi akakomba akatungamira mukumisa kwayo pasi rose.

Chii chinonzi Daclizumab?

Daclizumab yaiva mushonga webiologic wakagadzirirwa kurapa mafomu ekuita multiple sclerosis. Yaiva muchikamu chemishonga inonzi monoclonal antibodies, iyo mapuroteni akagadzirwa murabhoritari anovavarira zvikamu zvakakosha zve immune system yako.

Mushonga uyu waipiwa sejojo remwedzi woga woga pasi peganda, kazhinji muzvitsitsinho zvako, dumbu, kana ruoko rwepamusoro. Yakashambadzwa pasi pezita rekuti Zinbryta uye yaionekwa sechirwere chechipiri chevarwere veMS vasina kupindura zvakanaka kune mamwe mishonga.

Kusiyana nemamwe marapirwo eMS anotsikirira zvakanyanya immune system yako, daclizumab yaishanda zvakanyanya. Yakatarisa puroteni yakakosha inonzi CD25 pamaseru eimmune, ichivavarira kuderedza autoimmune attacks inokuvadza tsinga dzemitsipa muMS.

Chii chaishandiswa Daclizumab?

Daclizumab yaive yakanyanya kunyorerwa vanhu vakuru vane mafomu ekuita multiple sclerosis. Izvi zvinosanganisira relapsing-remitting MS uye secondary progressive MS ine relapses, mamiriro apo varwere vanowana nguva yezviratidzo zvitsva zvichiteverwa nekupora zvishoma kana kwakakwana.

Chiremba wako angadai akafunga nezve daclizumab kana iwe waive uine MS relapses kazhinji kunyangwe uchishandisa mamwe marapirwo ekuchinja chirwere. Kazhinji yaichengeterwa varwere vakawana breakthrough disease activity pamarapirwo ekutanga-mutsara senge interferons kana glatiramer acetate.

Mushonga uyu wakanga usina kubvumirwa kurapa primary progressive MS, uko zviratidzo zvinowedzera kuipa pasina kudzoka kwakajeka. Izvo zvakanga zvisina kukodzerawo varwere vane mamwe mamiriro echiropa kana avo vane njodzi huru yematambudziko echiropa.

Daclizumab Inoshanda Sei?

Daclizumab yaishanda nekudzivisa receptor chaiyo inonzi CD25 paT cells dzakabatidzwa, idzo dziri maseru machena eropa anotamba basa guru mukurwisa kweautoimmune. Nekudzivisa iyi receptor, mushonga uyu wakadzivirira maseru aya anokuvadza emuviri kubva pakuwanda nekurwisa tishu yetsinga ine hutano.

Funga nezvazvo sekukiisa kiyi pamusuwo unoshandiswa nemaseru anopisa kuti apinde muuropi hwako nemuzongoza. Kana daclizumab yakadzivisa CD25 receptor, yakawedzerawo huwandu hwemasero echisikigo anouraya, ayo akabatsira kudzora mhinduro yemuviri zvakanyanya.

Nzira iyi yakatarwa yakaita kuti daclizumab ive nesimba zvishoma zvichienzaniswa nemimwe mishonga yeMS. Yakanga yakasarudzwa zvakanyanya pane immunosuppressants yakafara asi ichiri kuda kunyatso tariswa nekuda kwemigumisiro yayo pabasa remuviri.

Daclizumab Inofanira Kutora Sei?

Daclizumab yaipiwa sejojo subcutaneous kamwe chete muna vhiki ina. Madosi akajairika aive 150 mg, akapihwa kuburikidza nepre-filled syringe iyo iwe kana mupi wehutano aizojova pasi peganda rako.

Nzvimbo dzekujova dzaitenderera pakati pemukati wako, dumbu, kana ruoko rwepamusoro kudzivirira kutsamwa kweganda. Unogona kutora mushonga uyu uine kana usina chikafu, sezvo kudya kusina kukanganisa maitiro emuviri wako akatora mushonga.

Usati watanga kurapwa, chiremba wako aizotora bvunzo dzeropa kuti aongorore basa rechiropa chako. Kuongorora nguva dzose kwakaenderera mberi mukati mekurapwa, nekuongororwa kweropa kazhinji kamwe chete pamwedzi kuti utarise chero zviratidzo zvematambudziko echiropa.

Mushonga uyu waifanira kuchengetwa mufiriji yako uye kuunzwa kutembiricha yemumba usati wajowa. Dose yega yega yaizouya mune imwe-inoshandiswa prefilled syringe yaizoraswa zvakachengeteka mushure mekushandisa.

Daclizumab Inofanira Kushandiswa Kwenguva Yakareba Sei?

Kureba kwenguva yekurapa ne daclizumab kwaienderana nekuti wainzwa sei kumushonga uye kana waisangana nemamwe matambudziko. Vanhu vazhinji vaibatsirwa nemushonga uyu vaienderera mberi nawo zvachose, nekuti kumisa kwaigona kukonzera kudzoka kweMS.

Chiremba wako aigara achiongorora mhinduro yako kuburikidza neMRI scans uye kuongororwa kwetsinga, kazhinji mwedzi mitanhatu kusvika gumi nemiviri. Kana waisangana nekudzoka kutsva kana kuwedzera kwekusagona kunyangwe uchirapwa, chiremba wako angangofunga kuchinja kumumwe mushonga weMS.

Zvisinei, kurapwa kwaizomiswa nekukasira kana ukawana zviratidzo zvematambudziko echiropa, sekusviba kweganda rako kana maziso, weti yakasviba, kana kusvotwa kunoramba kuripo. Mushonga uyu wakazobviswa pamusika nekuda kweizvi zvinokonzera matambudziko echiropa.

Ndezvipi Zvakaipa ZveDaclizumab?

Daclizumab yaigona kukonzera matambudziko akasiyana, kubva pakureruka kusvika pakukomba. Kunzwisisa izvi zvingaitika kwakabatsira varwere navanachiremba kuita sarudzo dzine ruzivo rwakakwana uye kuongorora zviratidzo zvinonetesa.

Matambudziko akajairika aive anowanzo manejwa uye aisanganisira:

• Kusangana kweganda panzvimbo dzekudzivirira, kusanganisira kutsvuka, kuzvimba, kana kukwenya
• Zvirwere zvekufema zvepamusoro senge dzihwa kana zvirwere zve sinus
• Rash kana kutsamwa kweganda kunze kwenzvimbo yekudzivirira
• Kuwedzera kwechiropa enzymes zvakaonekwa kuburikidza nemiedzo yeropa
• Lymph nodes akazvimba
• Zviratidzo zvakaita sefuruu mushure mejekiseni

Matambudziko akakomba aida kutariswa kwekurapa nekukasira uye aisanganisira matambudziko akakomba echiropa, ayo aigona kuva anotyisa upenyu. Nyaya idzi dzechiropa ndidzo chikonzero chikuru nei mushonga uyu wakabviswa pamusika.

Matambudziko asingawanzoitiki asi akakomba aisanganisira:

• Kuzvimba kwakanyanya kwechiropa kungaguma nekukundikana kwechiropa
• Zvirwere zvakakomba nekuda kwekudzora immune system
• Kuita kweganda kwakanyanya kunoda kupinda muchipatara
• Autoimmune encephalitis, kuzvimba kwakashata kwehuropi
• Kuita kwakanyanya kweallergy panguva kana mushure mejekiseni

Izvi zvinokonzera zvakanyanya, kunyanya matambudziko echiropa, zvakaitika mu percentage diki yevanhu asi zvaigona kuuraya. Izvi zvakaita kuti daclizumab ibviswe nekuzvidira kubva kumisika yese pasi rose.

Ndiani Asingafaniri Kutora Daclizumab?

Daclizumab yakanga isina kukodzera munhu wese aine multiple sclerosis. Mamwe mamiriro ezvinhu uye mamiriro ezvinhu akaita kuti mushonga uyu uve nenjodzi kana kusakodzera kushandiswa.

Haufanire kunge wakatora daclizumab kana uine:

• Chirwere chechiropa chiripo kana ma enzymes echiropa akakwira zvakanyanya
• Zvirwere zviripo, kunyanya zvirwere zvakakomba zvebhakitiriya, hutachiona, kana fungal
• Nhoroondo yekuita kwakanyanya kweallergy ku daclizumab kana zvikamu zvayo
• Immune system yakakanganiswa kubva kune mamwe mamiriro kana mishonga
• Kuzvitakura kana zvirongwa zvekuva nepamuviri panguva yekurapa

Kungwarira kwakakosha kwaidiwa kune varwere vane nhoroondo yekushushikana, mamiriro eautoimmune kupfuura MS, kana avo vanotora mamwe mishonga inogona kukanganisa chiropa. Chiremba wako aizonyatsoongorora nhoroondo yako yekurapa asati anyora daclizumab.

Mushonga uyu waisakurudzirwawo kune varwere vane makore anopfuura 65, sezvo data rekuchengetedza muboka rezera iri raive shoma. Vanamai vanoyamwisa vakakurudzirwa kudzivisa mushonga uyu nekuda kwenjodzi dzinogona kuitika kuvana.

Mazita eDaclizumab Brand

Daclizumab yakatengeswa pasi pezita rekuti Zinbryta yekurapa multiple sclerosis. Iri ndiro zita rekutanga rekutengesa raishandiswa muUnited States, Europe, nedzimwe nyika dzakabvumidzwa.

Pakutanga mukufambira mberi kwayo, daclizumab yaizivikanwawo nezita rekuti Zenapax payaishandiswa kudzivirira kurambwa kwenhengo yekuisirwa. Zvisinei, iyi fomu yaive yakasiyana neiyo MS vhezheni uye yakamirawo.

Sezvo mushonga wakabviswa pamusika, Zinbryta haichawanikwi kuburikidza nechero pharmacy kana mupi wehutano. Varwere vaive vachitora mushonga uyu vakachinjirwa kune dzimwe nzira dzekurapa MS.

Daclizumab Dzimwe Nzira

Sezvo daclizumab isisawanikwi, mamwe marapirwo ekuchinja chirwere anogona kurapa zvakanaka mafomu ekudzoka e multiple sclerosis. Chiremba wako anogona kukubatsira kuwana imwe nzira yakakodzera zvichienderana nemamiriro ako chaiwo.

Dzimwe nzira dzazvino dzinosanganisira:

• Mishonga yeInterferon senge Avonex, Rebif, kana Plegridy
• Glatiramer acetate (Copaxone kana Glatopa)
• Mishonga yemuromo senge fingolimod (Gilenya) kana dimethyl fumarate (Tecfidera)
• Kurapa kwekuisa mumuviri senge natalizumab (Tysabri) kana ocrelizumab (Ocrevus)
• Zvimwe zvitsva zvinosanganisira alemtuzumab (Lemtrada) kana cladribine (Mavenclad)

Imwe neimwe nzira ine mabhenefiti ayo nenjodzi, uye chiremba wako achafunga nezvezvinhu zvakaita sebasa rechirwere chako, kurapwa kwakapfuura, uye nhoroondo yako yehutano. Chinangwa ndechekuwana mushonga unodzora MS yako zvakanaka uchideredza mhedzisiro.

Varwere vazhinji vaive vachitora daclizumab vakachinjira kubudirira kune dzimwe nzira dzekurapa nekuenderera mberi kwekutonga chirwere. Chikwata chako chehutano chichashanda pedyo newe kuti uve nechokwadi chekuchinja kwakatsetseka uye manejimendi ari kuenderera mberi eMS yako.

Daclizumab Zviri Nani Kupfuura Zvimwe Zvinhu ZveMS?

Daclizumab yakaratidza kubudirira kunovimbisa mumiedzo yekiriniki ichienzaniswa ne interferon beta-1a, ichideredza mitengo yekudzoka uye mavanga matsva muuropi muvarwere vazhinji. Zvisinei, kuchengeteka kwayo kwakanyanya kwakakunda mabhenefiti aya.

Zvidzidzo zvakaratidza kuti daclizumab yaive inoshanda zvakanyanya pane mamwe marapirwo ekutanga-mutsara mukuderedza basa rechirwere. Varwere vaiwanzova nekudzoka kushoma uye kuwedzera kwekuremara kushoma kana vachienzaniswa nevaya vaive pamishonga yeinterferon.

Pasinei nekushanda kwayo, kubviswa kwemushonga nekuda kwekunetseka kwekuchengeteka kwechiropa zvinoreva kuti haichazivikanwe seimwe sarudzo inoshanda. Kurapa kweMS kwazvino seocrelizumab kana natalizumab kunogona kupa kushanda kwakafanana kana kuri nani nemaprofiles ekuchengeteka anogoneka zvakanyanya.

Nzvimbo yekurapa yeMS yakachinja zvakanyanya kubva pakubviswa kwe daclizumab. Mishonga mitsva inowanzo kupa kutonga kwakanaka kwechirwere nemaprofiles emigumisiro inozivikanwa zviri nani uye inogoneka, zvichiita kuti ive sarudzo dzinofarirwa kune vazhinji varwere.

Mibvunzo Inowanzo Bvunzwa Nezve Daclizumab

Daclizumab Yakachengeteka Here Kune Vanhu Vane Matambudziko eChiropa?

Aihwa, daclizumab haina kuchengeteka kune vanhu vane matambudziko echiropa atovepo. Mushonga uyu unogona kukonzera kuzvimba kwakanyanya kwechiropa uye kukuvadzwa, ndicho chikonzero chikuru chekubviswa kwayo mumusika.

Kunyange varwere vane basa rechiropa rakajairika vaida kuongororwa kwemwedzi nemwedzi matambudziko echiropa vachitora daclizumab. Vaya vane nhoroondo yechirwere chechiropa havana kukodzera kurapwa uku nekuda kwengozi yakawedzera yematambudziko anotyisa upenyu.

Ndingaita Sei Kana Ndakashandisa Daclizumab Yakawandisa Netsaona?

Kana netsaona wakagamuchira yakawanda kupfuura chiyero chakatarwa che daclizumab, taura nachiremba wako kana masevhisi ekukurumidzira nekukasira. Overdose inogona kuwedzera njodzi yemigumisiro yakakomba, kunyanya matambudziko echiropa uye zvirwere zvakakomba.

Pakanga pasina mushonga chaiwo we daclizumab overdose, saka kurapwa kwakatarisa pakugadzirisa zviratidzo uye kuongorora matambudziko. Chiremba wako angangowedzera kakawanda kwekuongorora ropa kuti atarise matambudziko echiropa nemimwe migumisiro yakakomba.

Ndingaita Sei Kana Ndikarasikirwa neDosi yeDaclizumab?

Kana wakakundikana kuwana jekiseni rako remwedzi nemwedzi re daclizumab, taura nachiremba wako nekukurumidza sezvinobvira kuti urongezve. Kushanda kwemushonga kwaive kwakavakirwa pakuchengetedza mazinga akagadzikana mumuviri wako.

Chiremba wako aizosarudza nguva yakanakisa yekutora mushonga wako unotevera zvichienderana nekuti zvakatora nguva yakareba sei kubva pajekiseni rako rekupedzisira. Kazhinji, waizotambira mushonga wakarasika nekukurumidza sezvinobvira wobva watora mushonga wako wemwedzi nemwedzi nguva dzose.

Ndingamira Rini Kutora Daclizumab?

Sezvo daclizumab yakabviswa pamusika, varwere vese vakatomira kutora mushonga uyu. Kubviswa kwakaitwa nekuda kwekunetseka kwekuchengeteka, kunyanya matambudziko akakomba echiropa anogona kuisa hupenyu panjodzi.

Kana iwe wakambotora daclizumab, chiremba wako angadai akakubatsira kuchinjira kune imwe nzira yekurapa MS. Kumisa chero mushonga weMS kunoda kutariswa kwakanyanya kwekurapa kudzivirira kumutsiridzwa kwechirwere uye kuona dziviriro inoenderera mberi.

Ndingatora Daclizumab Panguva Yemimba Here?

Daclizumab haina kurairwa panguva yekuzvitakura nekuda kwenjodzi dzinogona kuitika kumwana ari kukura. Mushonga uyu unogona kukanganisa kukura kwemuviri wemwana uye zvinogona kukonzera matambudziko.

Vakadzi vane makore ekubereka vachitora daclizumab vakakurudzirwa kushandisa nzira dzekudzivirira pamuviri dzinoshanda panguva yekurapa uye kwemwedzi yakati wandei mushure mekumira. Kana pamuviri ukaitika uchitora mushonga, kubvunzana nekukurumidza nevanoona nezvehutano kwaive kwakakosha kuongorora njodzi nemabhenefiti.