Chii chinonzi Dalbavancin: Zvinoshandiswa, Mishonga, Migumisiro Yakaipa uye Zvimwe

Dalbavancin mushonga une simba unopiwa nachiremba kuburikidza neIV kurapa zvirwere zvakakomba zvebhakitiriya paganda. Mushonga uyu ndeweboka rinonzi lipoglycopeptide antibiotics, iro rinoshanda nekumisa mabhakitiriya anokuvadza kubva pakuvaka madziro avo ekudzivirira masero.

Chinonyanya kuita kuti dalbavancin ive yakakosha ndeyekuti inogara mumuviri wako kwenguva refu. Izvi zvinoreva kuti iwe unowanzo shandisa dose imwe kana mbiri panzvimbo yekutora maantibiotics ezuva nezuva kwemavhiki. Yakagadzirirwa zvakananga vanhu vakuru vane matambudziko eganda uye zvirwere zvetishu zvakapfava izvo zvisina kupindura zvakanaka kune dzimwe nzira dzekurapa.

Chii chinonzi Dalbavancin chinoshandiswa?

Dalbavancin inorapa acute bacterial skin and skin structure infections (ABSSSI) muvanhu vakuru. Izvi zvirwere zvakakomba zvinopfuura pamusoro peganda rako uye zvinowanzo sanganisira zvikamu zviri pasi, kusanganisira mafuta, tsandanyama, kana tishu inobatanidza.

Chiremba wako angakupa dalbavancin kana uine zvirwere zvakaita se cellulitis, abscesses huru, kana zvirwere zvemaronda. Inonyanya kushanda pamabhakitiriya egram-positive, kusanganisira mamwe anopesana nemamwe maantibiotics. Mabhakitiriya aya anosanganisira Staphylococcus aureus (kusanganisira MRSA), Streptococcus species, uye Enterococcus faecalis.

Mushonga uyu wakachengeterwa zvirwere zvakakomba nekuti iantibiotic yakasimba. Mupi wako wehutano anowanzo sarudza dalbavancin kana mamwe maantibiotics asina kushanda kana kana chirwere chacho chakakomba zvakakwana kuti chida kupinda muchipatara.

Dalbavancin inoshanda sei?

Dalbavancin iantibiotic yakasimba kwazvo inoshanda nekurwisa madziro esero emabhakitiriya. Funga nezvemadziro esero emabhakitiriya segoko rinodzivirira rakatenderedza zai - pasina izvozvo, mabhakitiriya haagoni kurarama.

Mushonga uyu unonyanya kurwisa enzyme inonzi transglycosylase, iyo mabhakitiriya aanoda kuvaka nekuchengetedza madziro avo emasero. Kana dalbavancin ikavhara enzyme iyi, mabhakitiriya anoparara otifa. Izvi zvinoita kuti ive iyo vanachiremba vanoti "bactericidal" antibiotic, zvinoreva kuti inouraya mabhakitiriya panzvimbo yekungovadzivisa kukura.

Chinonakidza nezve dalbavancin ndiyo nguva yayo refu yehupenyu, zvinoreva kuti inoramba ichishanda mumuviri wako kwemazuva anenge 8-9 mushure meimwe dose. Kuvepo uku kwakawedzerwa kunoita kuti irambe ichirwisa hutachiona kwenguva refu mushure mekunge wagamuchira IV infusion.

Ndingatora Sei Dalbavancin?

Dalbavancin inongopihwa chete kuburikidza neIV infusion muchipatara kana kiriniki. Hauzotore mushonga uyu nemuromo kumba. Nyanzvi yehutano ichagara ichiupa kuti ive nechokwadi chekuti mushonga wakakodzera uye kukutarisa chero paine zvaunoita.

Infusion inowanzo tora maminitsi anenge 30 kuti apedze. Mukoti wako achakupa zvishoma nezvishoma kuburikidza netsinga muruoko rwako. Usati watora mushonga, haufanire kutsanya kana kudzivisa kudya zvekudya zvakakosha, kunyangwe zvichigara zvakanaka kuti urambe wakanyatsogadzirwa nemvura.

Vanhu vazhinji vanogamuchira dose imwe ye1500 mg kana maviri doses anopihwa vhiki imwe (1000 mg pakutanga, wobva wava 500 mg mazuva manomwe gare gare). Chiremba wako achasarudza kuti ndeipi purogiramu inoshanda zvakanyanya kuhutachiona hwako chaihwo uye hutano hwese.

Ndingatora Kwenguva Yakareba Sei Dalbavancin?

Runako rwe dalbavancin nderekuti iwe unowanzo shandisa dose imwe chete kana mbiri dzese. Kusiyana neanowanzo antibiotics anoda mapiritsi ezuva nezuva kwemazuva 7-14, mhedzisiro ye dalbavancin inoreba inoreva kuti kurapwa kunowanzoitwa mushure mekuenda kuchipatara kamwe kana kaviri.

Kana ukagamuchira mushonga wemadosi rimwe chete, uchagamuchira 1500 mg kamwe chete uye ndizvozvo. Nemushonga wemadosi maviri, uchagamuchira dosi rechipiri mazuva manomwe chaiwo mushure meyekutanga. Chiremba wako achasarudza nzira zvichienderana nezvinhu zvakaita sekuoma kwehutachiona hwako uye maitiro ako kumushonga.

Kunyange usiri kutora mushonga wezuva nezuva, mushonga wacho unoramba uchishanda mumuviri wako kwemavhiki mushure mejekiseni. Ichi chiitiko chakawedzerwa ndicho chinoita kuti mushonga mupfupi uyu uve unobatsira zvikuru pakurapa zvirwere zvakakomba zvepaganda.

Ndezvipi Zvakaipa ZveDalbavancin?

Semishonga yese, dalbavancin inogona kukonzera zvakaipa, kunyange vanhu vazhinji vachizvitsungirira zvakanaka. Zvakaipa zvakajairika zvinowanzoita zvishoma uye zvenguva pfupi.

Hezvino zvakaipa zvaungasangana nazvo, kutanga nezvinhu zvakajairika:

• Kusvotwa nekutsvanza
• Manyoka
• Musoro
• Dizziness
• Mavanga kana kukwenya
• Kurwadziwa, kutsvuka, kana kuzvimba panzvimbo yeIV

Zviratidzo izvi zvinowanzoita nani mukati mezuva rimwe kana maviri uye kazhinji hazvidi kuti mushonga uregwe. Zvisinei, unofanira kugara uchizivisa timu yako yehutano kana uine chero kusagadzikana.

Zvimwe zvakaipa zvakakomba hazviwanzowanikwi asi zvinogona kusanganisira maitiro akakomba ekurwara, kurova kwemoyo kusingaite, kana mamiriro ane njodzi anonzi C. diff colitis (kuzvimba kwakakomba kwematumbo). Kana uine dambudziko rekufema, kurwadziwa kwakanyanya mudumbu, kana manyoka anoramba achiyerera, tsvaga rubatsiro rwekurapa nekukurumidza.

Ndiani Asingafaniri Kutora Dalbavancin?

Dalbavancin haikodzeri munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuisa mushonga uyu. Haufaniri kugamuchira mushonga uyu kana wakambove nemaitiro ekurwara ku dalbavancin kana maantibiotics akafanana munguva yakapfuura.

Vanhu vane zvirwere zvemwoyo vanoda kungwarira nekuti dalbavancin inogona kukanganisa rhythm yemwoyo. Chiremba wako anogona kutarisa EKG usati wapiwa mushonga uyu kana uine nhoroondo yematambudziko emwoyo kana kutora mishonga inokanganisa rhythm yemwoyo wako.

Mishonga iyi haina kubvumidzwa vana vari pasi pemakore gumi nemasere, nekuti kuchengeteka uye kushanda hazvina kumiswa muvarwere vevana. Uyezve, kana iwe wakazvitakura kana kuyamwisa, chiremba wako achayerera mabhenefiti achienzanisa nenjodzi dzinogona kuitika asati akurudzira dalbavancin.

Zita reDalbavancin Brand

Dalbavancin inotengeswa pasi pezita rekuti Dalvance muUnited States. Iri ndiro zita rinowanzoonekwa mumarekodhi echipatara uye pamalebuli emishonga.

Mishonga iyi inogadzirwa neAllergan (zvino chikamu cheAbbVie) uye yave iripo kubvira 2014. Paunenge uchikurukura kurapwa kwako nevanoona nezvehutano, vanogona kureva zita rimwe chete - dalbavancin kana Dalvance.

Zvimwe Zvinogona Kushandiswa Panzvimbo peDalbavancin

Mamwe maantibiotics anogona kurapa zvirwere zvakakomba zvepaganda, kunyangwe imwe neimwe iine zvainobatsira uye zvirongwa zvekushandisa. Chiremba wako anogona kufunga nezvezvimwe zvinhu zvichibva pamabhakitiriya ako chaiwo, nhoroondo yako yezvokurapa, uye zvaunofarira pakurapa.

Zvimwe zvinowanzo shandiswa zvinosanganisira vancomycin, iyo inoda infusions yeIV yezuva nezuva kwemazuva 7-10, kana linezolid, iyo inouya mune ese ari maviri IV uye oral mafomu. Telavancin imwe sarudzo inotora nguva refu, kunyangwe ichida infusions yezuva nezuva kwemazuva 7-10 panzvimbo yeimwe kana mbiri dosi dze dalbavancin.

Zvimwe zvitsva zvinosanganisira oritavancin, iyo zvakare kurapwa kwedosi imwe chete, uye tedizolid, iyo inogona kupiwa kwemazuva matanhatu ese ari maviri IV kana nemuromo. Mupi wako wehutano achasarudza sarudzo yakanakisa zvichibva pamaitiro echirwere chako uye hutano hwako hwese.

Ko Dalbavancin iri nani pane Vancomycin?

Dalbavancin ne vancomycin zvose mishonga inorapa mabhakitiriya yakanaka zvikuru yekurapa zvirwere zvakakomba zvepaganda, asi zvinoshanda nenzira dzakasiyana uye zvine zvazvinokwanisa. Chinhu chikuru chinobatsira dalbavancin ndiko kuita zvinhu zviri nyore - unongoda mushonga mumwe chete kana miviri panzvimbo pekurapwa kwezuva nezuva kweIV kwemavhiki anopfuura rimwe.

Vancomycin yanga iri yegoridhe standard kwemakumi emakore uye ine tsvakurudzo yakawanda inotsigira kushanda kwayo. Zvisinei, inoda kuongororwa kwemazuva ose kwemazinga eropa uye inogona kukonzera matambudziko eitsvo kana ikashandiswa kwenguva yakareba. Dalbavancin haidi kuongororwa kwakanyanya uku.

Panyaya yekushanda, zvidzidzo zvinoratidza kuti mishonga yose iri miviri inoshanda zvakaenzana pakurapa zvirwere zvakaoma zvepaganda. Chiremba wako achasarudza zvichienderana nezvinhu zvakaita sebasa reitsvo dzako, mabhakitiriya chaiwo anokonzera hutachiona hwako, uye kana iwe uchida kushanya kushoma kuchipatara.

Mibvunzo Inowanzo Bvunzwa Pamusoro peDalbavancin

Dalbavancin Yakachengeteka Here Kune Vanhu vane Chirwere cheItsvo?

Dalbavancin inogona kushandiswa kune vanhu vane chirwere cheitsvo, asi chiremba wako achachinja mushonga zvichienderana nekuti itsvo dzako dziri kushanda sei. Kana uine matambudziko akakomba eitsvo, unogona kupiwa mushonga mudiki kana kuve nekuongororwa kwakawanda panguva yekurapa.

Mishonga inonyanya kubviswa kuburikidza neitsvo dzako, saka basa reitsvo rakaderera rinoreva kuti mushonga unogara mumuviri wako kwenguva refu. Izvi hazvifanirwe kuva njodzi, asi zvinoda kutarisirwa kwechiremba kwakanyatsojeka kuti uve nechokwadi chekuti unowana huwandu hwakakodzera.

Ndingaita Sei Kana Ndine Allergic Reaction kuDalbavancin?

Kana iwe ukaona zviratidzo zveallergic reaction panguva kana mushure mekuiswa kwako, zivisa timu yako yehutano nekukasira. Zviratidzo zvinogona kusanganisira kuoma kufema, kuzvimba kumeso kwako kana pahuro, rash yakakomba, kana kunzwa kufenda.

Sezvo dalbavancin ichipiwa munzvimbo yekurapa, vashandi vakadzidziswa vanogona kukurumidza kupindura kune allergic reactions. Vane mishonga nemidziyo yakagadzirira kurapa mhinduro dzakakomba. Mazhinji allergic reactions ku dalbavancin akapfava, asi zvinogara zviri nani kungwarira uye kutaura kana chimwe chinhu chisinganzwike zvakanaka.

Ndingaita Sei Kana Ndikakundikana Dose yeDalbavancin?

Kana wakarongezerwa regimen ye-dose mbiri uye ukakundikana musangano wako wechipiri, taura nemupi wako wehutano nekukurumidza sezvinobvira. Dose yechipiri inofanirwa kupiwa mazuva manomwe chaiwo mushure meyekutanga, asi kazhinji pane imwe nguva yekuchinja.

Chiremba wako angangokurongera musangano unotevera uripo kana kugadzirisa chirongwa chako chekurapa zvichienderana nekuti uri kupindura sei kune dose yekutanga. Usaedze kuverenga kana kuronga zvakare wega - gara uchibatana nechikwata chako chehutano.

Ndingamira Rini Kutora Dalbavancin?

Kusiyana neantibiotics yechinyakare, haumire kutora dalbavancin nekuti kazhinji kurapwa kwe-dose imwe kana mbiri. Paunenge wagamuchira dose yako yakarairwa, kurapwa kwapera.

Mishonga inoenderera mberi ichishanda mumuviri wako kwemavhiki akati wandei mushure mekuiswa, saka haufanirwe kuita chimwe chinhu. Chiremba wako achatarisa kufambira mberi kwehutachiona hwako kuburikidza nekutevera-kumusangano uye anogona kuraira mamwe maedzo kuti ave nechokwadi chekuti kurapwa kuri kushanda nemazvo.

Ndinganwa Doro Ndiri Kurapwa neDalbavancin?

Hapana hukama chaihwo pakati pe dalbavancin nedoro, asi kazhinji kuchenjera kudzivisa kunwa uchirwisa hutachiona hwakakomba. Doro rinogona kukanganisa immune system yako uye rinogona kunonotsa kupora kwako.

Uyezve, kana uri kusangana nemigumisiro yakaita sekuona dzungu kana kurutsa kubva kumushonga, doro rinogona kuita kuti zviratidzo izvi zinyanye. Zvakanakisa kutarisa pazororo, chikafu chakakodzera, uye kugara uine mvura yakakwana apo muviri wako unorwisa hutachiona.