Chii chinonzi Dasatinib: Zvazvinoshandiswa, Mishonga, Mativi uye Zvimwe

Dasatinib mushonga wekenza unovharira mapuroteni akati wandei anokonzera kukura kwemasero ekenza. Inonyanya kunyorerwa marudzi akati wandei e leukemia uye inoshanda nekukanganisa zviratidzo zvinoudza masero ekenza kuti awande uye ararame.

Mishonga iyi ndeyeboka remishonga rinonzi tyrosine kinase inhibitors, iro rakagadzirirwa kuva rakarurama kupfuura chemotherapy yechinyakare. Funga nezvayo se nzira yakatarwa inotarisa nzira chaiyo masero ekenza anoshandisa kukura, pane kukanganisa masero ese anokurumidza kukamukana mumuviri wako.

Chii chinonzi Dasatinib chinoshandiswa?

Dasatinib inobvumirwa zvakananga kurapa marudzi akati wandei ekenza yeropa, kunyanya chronic myeloid leukemia (CML) uye acute lymphoblastic leukemia (ALL). Aya makenza anokanganisa masero ako anogadzira ropa mumapfupa emapfupa.

Chiremba wako anogona kunyora dasatinib kana uine CML muchikamu chechronic, accelerated, kana blast. Inoshandiswawo yePhiladelphia chromosome-positive ALL, iyo inoreva shanduko chaiyo yegeni inowanikwa mumasero ekenza. Mushonga uyu unowanzo fungwa kana dzimwe nzira dzekurapa dzakaita se imatinib dzisina kushanda zvakanaka kana dzakonzera mativi asingashiviriki.

Mune zvimwe zviitiko, dasatinib inogona kushandiswa sekurapa kwekutanga, zvinoreva kuti ndiyo yekutanga kurapa chiremba wako anokurudzira. Sarudzo inoenderana nezvinhu zvakasiyana-siyana zvinosanganisira rudzi rwako rwe leukemia, hutano hwese, uye kuti kenza yako inopindura sei kurapwa.

Dasatinib inoshanda sei?

Dasatinib inoshanda nekudzivisa mapuroteni akati wandei anonzi tyrosine kinases ayo masero ekenza anoda kukura uye kurarama. Mapuroteni aya anoita semaswitch anoudza masero ekenza kuti awande, uye dasatinib inodzima maswitch aya.

Mushonga uyu unoonekwa semushonga une simba uye unodzivisa ma kinase akawanda, zvinoreva kuti unodzivisa nzira dzakawanda dzinoshandiswa nemasero ekenza. Kusiyana nemamwe marapirwo anotariswa anongotarisa pane imwe chete protein, dasatinib inokanganisa zviratidzo zvakawanda panguva imwe chete, izvo zvinogona kuita kuti zvishande zvakanyanya pamaseru ekenza anoramba kurapwa.

Mushonga uyu unoshanda zvakanyanya kurwisa protein ye BCR-ABL, iyo iri iyo inokonzera CML uye Philadelphia chromosome-positive ALL. Nekudzivisa protein iyi, dasatinib inobatsira kuderedza kana kumisa kugadzirwa kwemasero machena eropa asina kujairika anoratidza aya marudzi ekenza.

Ndingatora sei Dasatinib?

Tora dasatinib sezvakanyorwa nachiremba wako, kazhinji kamwe pazuva panguva imwe chete zuva rega rega. Unogona kuitora uine chikafu kana usina chikafu, asi edza kuenderana nesarudzo yako kuti uchengetedze mazinga akagadzikana mumuviri wako.

Medza mahwendefa ese nemvura - usapwanye, kuputsa, kana kuitsenga. Kana uine dambudziko rekumedza mahwendefa, taura nachiremba wako nezve dzimwe sarudzo. Zvakakosha kutora dasatinib mudumbu risina chinhu kana uine chikafu chakareruka, sezvo zvimwe zvekudya zvinogona kukanganisa kuti muviri wako unotora sei mushonga.

Dzivisa grapefruit uye muto wegrapefruit paunenge uchitora dasatinib, sezvo zvinogona kuwedzera huwandu hwemushonga muropa rako kusvika pamazinga anogona kuva nenjodzi. Zvakare, chenjerera nemishonga inodzivisa acid - kana ukaida, itore maawa angangoita 2 usati watora kana mushure memushonga wako we dasatinib.

Ndingatora Dasatinib Kwenguva Yakareba Sei?

Kureba kwemushonga we dasatinib kunosiyana zvakanyanya kubva kumunhu nemunhu uye zvinoenderana nekuti kenza yako inopindura sei kumushonga. Vanhu vazhinji vanotora dasatinib kwemakore, uye vamwe vangangoda kuramba vachiitora zvachose sekurapa kwenguva refu.

Chiremba wako achatarisa mhinduro yako kuburikidza nemiedzo yeropa yenguva dzose uye kuongororwa kwemuzongoza wemupfungwa. Kana kenza yako ikasvika pamatanho akati wandei emhinduro, chiremba wako angakurukura mukana wekuderedza mushonga kana, mune dzimwe nguva, kutora zororo kubva kurapwa.

Tsvakurudzo ichangoburwa yakaratidza kuti vamwe varwere vanowana mhinduro dzakadzama, dzakatsigirwa vanogona kumisa dasatinib pasi pekutariswa kwechiremba. Zvisinei, sarudzo iyi inofanira kuitwa chete nehutungamiri hweoncologist wako, sezvo kumisa nekukurumidza kunogona kutungamirira kukudzoka kwekenza.

Ndezvipi Zvipingamupinyi zveDasatinib?

Kufanana nemishonga yese yekenza, dasatinib inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anoiziva. Mhedzisiro yakajairika inowanzo manejwa nekuchengetwa kwakakodzera kwekurapa uye kuongorora.

Heano mhedzisiro yaungasangana nayo, kubva kune yakajairika kusvika kune isingawanzoitiki:

• Kuchengetwa kwemvura uye kuzvimba, kunyanya kutenderedza maziso, maoko, uye tsoka
• Kuneta uye kusava nesimba zvinogona kukanganisa mabasa ako ezuva nezuva
• Dhiria, kusvotwa, kana dzimwe nyaya dzekugaya
• Kutemwa nemusoro uye kurwadziwa kwemhasuru kana mapfupa
• Mavanga paganda kana shanduko pakuonekwa kweganda
• Kufema kwekufema kana kuoma kufema
• Kuderera kwemasero eropa, izvo zvinogona kuwedzera njodzi yekutapukirwa

Izvi zvinowanzoitika zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga, uye timu yako yehutano inogona kupa nzira dzekuzvibata zvakanaka.

Zvimwe zvisingawanzoitiki asi zvakanyanya kukomba mhedzisiro zvinoda kutariswa kwekurapa nekukurumidza. Izvi zvinosanganisira kuunganidzwa kwemvura kwakanyanya kutenderedza mapapu kana moyo, kubuda ropa kwakanyanya, zvirwere zvakakomba nekuda kwehuwandu hwehuwandu hwemasero machena eropa, kana zviratidzo zvematambudziko emoyo senge kurwadziwa kwechipfuva kana kurova kwemoyo kusina kujairika.

Mhedzisiro isingawanzoitika asi yakakomba inogona kusanganisira pulmonary arterial hypertension (kuderera kweropa mumapapu), matambudziko akakomba echiropa, kana tumor lysis syndrome (kana maseru ekenza achiputsika nekukurumidza). Kunyange izvi zvisingawanzoitiki, chiremba wako achakutarisa nguva dzose kuti abate chero shanduko dzinonetesa nekukurumidza.

Ndiani Asingafaniri Kutora Dasatinib?

Dasatinib haina kukodzera munhu wese, uye mamiriro ezvinhu kana mamiriro ezvinhu anogona kuita kuti zvisachengeteke kuti utore mushonga uyu. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuraira.

Haufaniri kutora dasatinib kana uine allergic kumushonga kana chero zvinhu zvawo. Vanhu vane chirwere chechiropa chakakomba, matambudziko ekubuda ropa, kana mamwe mamiriro emoyo vangave vasiri vakanaka vekurapa uku.

Vakadzi vane pamuviri nevanooyamwisa havafaniri kutora dasatinib, sezvo inogona kukuvadza mwana ari kukura. Kana uri pazera rekubereka, chiremba wako achakurukura nzira dzekudzivirira kubata pamuviri dzinoshanda dzekushandisa panguva yekurapa uye kwenguva yakati rebei mushure mekumisa mushonga.

Vanhu vane mamwe mamiriro akatokura vanoda kufunga kwakakosha. Izvi zvinosanganisira avo vane matambudziko emoyo, chirwere chemapapu, matambudziko ekubuda ropa, kana nhoroondo ye pancreatitis. Chiremba wako achayera mabhenefiti achipesana nenjodzi mumamiriro ezvinhu aya.

Mazita eDasatinib Brand

Dasatinib inowanikwa pasi pezita remhando Sprycel, iro rinogadzirwa neBristol Myers Squibb. Iri ndiro zita rinonyanya kurairwa munzvimbo zhinji uko mushonga uripo.

Mhando dzakajairika dze dasatinib dzave kuwanikwa mune dzimwe nzvimbo, izvo zvinogona kuve zvakachipa uchipa mabhenefiti akafanana ekurapa. Chiremba wako kana wemishonga anogona kukubatsira kunzwisisa kuti ndeipi vhezheni yakanakira mamiriro ako uye inishuwarenzi.

Zvisinei nekuti unogamuchira zita remhando kana vhezheni yechinyakare, mushonga unoshanda uye kushanda zvinoramba zvakafanana. Chinhu chinonyanya kukosha kutora mushonga nguva dzose sezvakanyorwa nachiremba wako.

Zvimwe Zvinhu Zvokutsiva Dasatinib

Mamwe marapirwo akawanda akatarisirwa anowanikwa ekurapa marudzi akafanana e leukemia se dasatinib. Sarudzo pakati pemishonga iyi inoenderana nezvinhu zvakaita serudzi rwako rwekenza, kurapwa kwakapfuura, uye kuti unotsungirira sei mhedzisiro.

Zvimwe zvinhu zvinowanzo shandiswa zvinosanganisira imatinib (Gleevec), iyo inowanzoita yekutanga kurapwa kweCML, uye nilotinib (Tasigna), imwe tyrosine kinase inhibitor yechizvarwa chechipiri. Bosutinib (Bosulif) uye ponatinib (Iclusig) zvinowedzera sarudzo dzemamwe mamiriro.

Imwe neimwe yemishonga iyi ine yayo mhedzisiro uye maitiro ekushanda. Vamwe vanhu vanogona kuita zviri nani nemushonga mumwe pane mumwe, uye chiremba wako angangoda kuyedza dzimwe sarudzo kuti awane zvinokushandira zvakanaka. Chinangwa ndechokugara uchitsvaga kurapwa kunoshanda zvakanyanya nemhedzisiro inodzoreka zvakanyanya.

Ko Dasatinib Ari Nani Pane Imatinib?

Dasatinib uye imatinib zvese zvinoshanda kurapwa kweCML, asi zvinoshanda zvishoma zvakasiyana uye zvine zvakasiyana zvakanakira. Dasatinib inowanzoonekwa seyakasimba uye inoshanda nekukurumidza kupfuura imatinib muvarwere vazhinji.

Zvidzidzo zvekurapa zvakaratidza kuti dasatinib inogona kuwana mhinduro dzakadzama uye nekukurumidza kune vamwe vanhu, kunyanya avo vane chirwere chakanyanya kana avo vasina kupindura zvakanaka kune imatinib. Zvisinei, imatinib yanga iripo kwenguva refu uye ine rekodhi refu yekuchengeteka kwenguva refu uye kushanda.

Sarudzo pakati pemishonga iyi inowanzouya pasi pezvinhu zvemunhu mumwe nemumwe. Vamwe vanhu vanotsungirira imatinib zviri nani, nepo vamwe vaine mativi mashoma ane dasatinib. Chiremba wako achafunga nezve mamiriro ako chaiwo, kusanganisira hunhu hwekenza yako, hutano hwese, uye zvaunofarira iwe pachako paunenge uchiita sarudzo iyi.

Mibvunzo Inowanzo Bvunzwa Pamusoro peDasatinib

Dasatinib Yakachengeteka Kune Vanhu vane Chirwere Chemoyo Here?

Dasatinib inoda kunyatsoongororwa muvanhu vane mamiriro emoyo aripo. Mushonga unogona dzimwe nguva kukonzera kuchengetwa kwemvura yakatenderedza moyo kana kukanganisa rhythm yemoyo, saka chiremba wako achada kuongorora hutano hwemoyo wako usati watanga kurapwa.

Kana uine chirwere chemoyo, chiremba wako anogona kuraira bvunzo dzemoyo dzekutanga uye kukutarisa zvakanyanya panguva yekurapa. Vanhu vazhinji vane mamiriro emoyo vanogona kutora dasatinib zvakachengeteka, asi zvinoda kutariswa zvakanyanya uye pamwe kugadzirisa dose.

Ndoitei Kana Ndikatora Dasatinib Yakawanda Netsaona?

Kana netsaona ukatora dasatinib yakawanda kupfuura yakarairwa, taura nachiremba wako kana masevhisi ekukurumidzira nekukasira. Usamirira kuti uone kana ukaona zviratidzo, sezvo overdose inogona kukonzera matambudziko akakomba.

Paunenge uchimirira rubatsiro rwekurapa, usaedze kuzviita kurutsa kana kutora mimwe mishonga kunze kwekunge wakanzi zvakananga nachiremba wezvehutano. Chengeta bhodhoro remishonga newe kuitira kuti nyanzvi dzekurapa dzikwanise kuona chaizvo zvawakatora uye zvakawanda sei.

Ndoitei Kana Ndikarasikirwa neDose yeDasatinib?

Kana ukakanganwa dose ye dasatinib, itore paunorangarira, kunze kwekunge yava nguva yechikamu chako chinotevera. Muchiitiko ichocho, skip the missed dose uye uenderere mberi nechirongwa chako chetsika - usatore zvikamu zviviri panguva imwe chete.

Kana uchikanganwa madosi kakawanda, funga kuisa zviyeuchidzo pafoni yako kana kushandisa chirongwa chemapiritsi. Kushandisa mushonga zuva nezuva nguva dzose kwakakosha kuchengetedza mazinga emushonga mumuviri wako achishanda.

Ndingamira rini kutora Dasatinib?

Sarudzo yekumira dasatinib inofanirwa kuitwa chete nekutungamirirwa nachiremba wako weoncologist, kunyangwe uchinzwa zvakanaka. Vamwe varwere vanowana mhinduro dzakadzama, dzakatsigirwa vanogona kunge vari vakakodzera remission isina kurapwa, asi izvi zvinoda kutarisa zvakanyanya.

Chiremba wako achaongorora zvinhu zvakaita sekuti wava nenguva yakareba sei mu remission, kudzama kwemhinduro yako, uye njodzi dzako dzega. Kana ukamira, unozoda kutarisa kakawanda kuti uone kuti kenza haina kudzoka.

Ndingatora mimwe mishonga ndichiri kutora Dasatinib here?

Mishonga yakawanda inogona kushamwaridzana ne dasatinib, saka zvakakosha kuti uudze chiremba wako nezve mishonga yese yakanyorwa, mishonga isingatengeswe, uye zvinowedzerwa zvaunotora. Dzimwe kushamwaridzana kunogona kuita kuti dasatinib isashande zvakanaka kana kuwedzera njodzi yemigumisiro.

Kushamwaridzana kwakajairika kunosanganisira mamwe maantacids, zvinoderedza ropa, uye mishonga inokanganisa acid yemudumbu. Chiremba wako nemupharmacist vanogona kukubatsira kubata izvi kushamwaridzana zvakachengeteka, kazhinji nekugadzirisa nguva kana madosi emishonga yako.