Chii chinonzi Dornase Alfa: Zvayakashandiswa, Dosage, Side Effects uye Zvimwe

Dornase alfa mushonga wakakosha unobatsira vanhu vane cystic fibrosis kufema zviri nyore nekutetepa mucus gobvu, rinonamatira mumapapu avo. Mushonga uyu unofemwa unoshanda semubatsiri munyoro, uchiputsa tambo dzeDNA dzinogadzira mucus kuti ive yakaoma uye yakaoma kuchenesa. Kunyange zvichigona kurira zvakaoma, dornase alfa rave riri mushonga wakavimbika kwemakumi emakore, richipa rubatsiro rwechokwadi kune avo vanotambura nekuburitswa kwemhepo yekufema gobvu.

Chii chinonzi Dornase Alfa?

Dornase alfa ishanduro yakagadzirwa nemunhu ye enzyme inowanikwa mumuviri wako inonzi DNase. Iyi enzyme inonyanya kutariswa uye inoputsa DNA zvinhu zvinobatwa mumucus gobvu. Paunenge uine cystic fibrosis, muviri wako unogadzira mucus gobvu, rinonamatira rinova nezvizhinji zveDNA kubva kuma cell machena eropa achiedza kurwisa zvirwere.

Mushonga uyu unouya semhinduro yakajeka, isina ruvara yaunofema nemuchina we nebulizer wakakosha. Funga nezvazvo sechinhu chinotariswa chinonanga zvakananga kwachinodiwa zvakanyanya - zvakananga mumhepo yako. Iyi nzira yakananga yekutumira inobatsira mushonga kushanda zvakanyanya kupfuura kana wauitora semupiritsi.

Chii chinonzi Dornase Alfa chinoshandiswa?

Dornase alfa inonyanya kunyorerwa vanhu vane cystic fibrosis kubatsira kubata zviratidzo zvavo zvemapapu. Yakagadzirirwa kunyanya kutetepa mucus gobvu rinovaka mumhepo, zvichiita kuti zvive nyore kukosora uye kubvisa. Izvi zvinogona kubatsira kuderedza kakawanda kwezvirwere zvemapapu uye kuvandudza kufema kwese.

Chiremba wako angakurudzira dornase alfa kana uri kusangana nekukosora kunoramba kuripo, kuoma kuchenesa mucus, kana zvirwere zvekufema kakawanda. Mushonga unoshanda zvakanyanya sechikamu chechirongwa chakazara chekurapa chingave chine mamwe marapirwo senge chest physiotherapy uye maantibayoti kana zvichidikanwa.

Mune dzimwe nguva dzisingawanzoitiki, vanachiremba vangafunga nezve dornase alfa kune mamwe mamiriro ane zvakavanzika zvakakora, zvakapfuma muDNA, asi izvi hazviwanzoitiki. Vanhu vazhinji vanoshandisa mushonga uyu vane cystic fibrosis uye vanobatsirwa nezvivakwa zvaro zvinotetepa mucus.

Dornase Alfa Inoshanda Sei?

Dornase alfa inoshanda nekuparadza tambo dzeDNA dzinogadzira mucus gobvu uye rinonamatira mumapapu ako. Paunenge uine cystic fibrosis, maseru machena eropa anomhanyira kumhepo yako kurwisa zvirwere, asi anosiya DNA yawo paanofa. Iyi DNA inoita semambure, ichiita kuti mucus ive gobvu zvinoshamisa uye zvakaoma kubvisa.

Mishonga inoshanda semagetsi emamorekuru, ichicheka tambo idzi dzeDNA uye ichiita kuti mucus ive yakatetepa uye iri nyore kukosora. Izvi zvinoonekwa sekurapa kwepakati nepakati nekuti inonangana zvakananga nemudzi wezvikonzero zvezvakavanzika zvakakora, pane kungorapa zviratidzo.

Kana mucus yave yakatetepa, reflex yako yekukosora yechisikigo uye physiotherapy yechipfuva inova inoshanda zvakanyanya pakuiisa mumapapu ako. Izvi zvinobatsira kuderedza njodzi yezvirwere zvebhakitiriya uye zvinogona kuvandudza kushanda kwemapapu ako nekufamba kwenguva.

Ndingatora Sei Dornase Alfa?

Iwe unotora dornase alfa uchishandisa muchina we nebulizer unochinja mushonga wemvura kuita mhute yakanaka yaunogona kufema. Madosi akajairika imwe 2.5 mg vial kamwe pazuva, kunyangwe chiremba wako achaziva huwandu chaihwo hwakakunakira iwe. Zvakanakisa kuzvitora panguva imwechete zuva rega rega kuti ugadzire tsika.

Haufaniri kutora mushonga uyu nechikafu, asi vanhu vazhinji vanozviwana zvichibatsira kuita physiotherapy yavo yechipfuva maminitsi makumi matatu mushure mekunyura dornase alfa. Iyi nguva inobvumira mushonga kushanda pakutetepa mucus usati waedza kuibvisa.

Ita shuwa kuti unoshandisa nebulizer system inokurudzirwa nachiremba wako chete, nekuti michina yakasiyana inogona kusashanda zvakanaka pakupa mushonga. Chenesa nebulizer yako zvinoenderana nemirairo yemugadziri kudzivirira kusvibiswa uye kuona kuti mushonga unoshanda nemazvo.

Ndinofanira Kutora Dornase Alfa Kwenguva Yakareba Sei?

Vanhu vazhinji vane cystic fibrosis vanotora dornase alfa sechinhu chinorapwa kwenguva refu, kazhinji kwemakore mazhinji kana kunyange nekusingaperi. Uyu hausi mushonga waunowanzo rega kana watanga, nekuti mamiriro ezvinhu ari pasi anokonzera mucus gobvu haaperi.

Chiremba wako achatarisa kuti mushonga uri kushanda sei kuburikidza nemiedzo yenguva dzose yebasa remapapu uye nekubvunza nezve zviratidzo zvako. Vamwe vanhu vanoona kuvandudzwa mukufema kwavo uye kugona kubvisa mucus mukati memavhiki mashoma ekutanga, nepo vamwe vachigona kutora mwedzi yakati wandei kuti vaone mabhenefiti akazara.

Usambofa wakarega kutora dornase alfa kamwechete usati wataura nachiremba wako kutanga. Kana uine mhedzisiro kana kunetseka, timu yako yekuchengetedza hutano inogona kubatsira kugadzirisa chirongwa chako chekurapa pane kumisa mushonga zvachose.

Ndezvipi Zvinokonzerwa neDornase Alfa?

Vanhu vazhinji vanotsungirira dornase alfa zvakanaka, asi semushonga chero upi zvake, unogona kukonzera mhedzisiro. Mashoko akanaka ndewekuti mhedzisiro yakakomba haisi yakajairika, uye vanhu vazhinji vanongowana zviratidzo zvishoma kana chero zvakadaro.

Heano mhedzisiro yakajairika yaungasangana nayo:

• Huro inorwadza kana hoarseness mushure mekuvhuvhuta
• Kukosora kwenguva pfupi kana kuwedzera kukosora
• Mhino inoyerera kana yakavharika
• Kusagadzikana kwepachipfuva
• Kushanduka kwezwi izvo zvinowanzo gadzirisa nekukurumidza

Zviratidzo izvi zvinowanzoitika nekuti mushonga uri kushanda kutetepa mucus yako, iyo inogona kutanga kukukosora zvakanyanya sezvo muviri wako uchibvisa zvakavhurwa zvakavanzika.

Mhedzisiro isingawanzoitiki asi yakakomba iyo inoda kutariswa kwekurapa nekukurumidza inosanganisira:

• Kunetsa kufema zvakanyanya kana kuchema
• Kurwadziwa pachipfuva kusingaperi
• Maitiro ekuita allergic senge rash, kuzvimba, kana kutsamwa kwakanyanya kwehuro
• Fivha inoramba iripo kana zviratidzo zvechirwere chemapapu

Kana ukaona chero chimwe chezviratidzo izvi zvakanyanya, taura nachiremba wako nekukasira kana kutsvaga rubatsiro rwekurapa rwechimbichimbi.

Ndiani Asingafaniri Kutora Dornase Alfa?

Dornase alfa inowanzova yakachengeteka kune vanhu vazhinji, asi pane dzimwe nguva apo ingasava sarudzo yakanaka. Hau faniri kushandisa mushonga uyu kana wakambove nekuita allergic kwakanyanya ku dornase alfa kana chero chimwe chezvinhu zvayo kare.

Vanhu vane mamwe mamiriro emapapu kunze kwecystic fibrosis vanofanira kushandisa mushonga uyu nekuchenjerera. Chiremba wako achanyatsoongorora kana mabhenefiti achikunda njodzi kana uine chirwere chakanyanya chemapapu kana kufema kwakakanganiswa.

Vakadzi vane pamuviri uye vanoyamwisa vanogona kazhinji kutora dornase alfa zvakachengeteka, asi chiremba wako achada kukutarisa zvakanyanya. Mushonga uyu wakashandiswa zvakachengeteka panguva yekuzvitakura muzviitiko zvakawanda, asi mamiriro emunhu mumwe nemumwe anosiyana.

Vana vane makore mashanu zvichikwira vanogona kazhinji kushandisa dornase alfa, kunyangwe kuyera uye kuongorora kungave kwakasiyana nevakuru. Chiremba wemwana wako achasarudza nzira yakanakisisa zvichienderana nezvavanoda uye kugona kushandisa nebulizer nemazvo.

Mazita eDornase Alfa Brand

Zita rinowanzozivikanwa re dornase alfa ndeye Pulmozyme, inogadzirwa neGenentech. Iyi ndiyo yekutanga formulation yave iripo kubvira kuma1990s uye inoramba iri vhezheni inonyanya kunyorerwa.

Parizvino, Pulmozyme ndiyo mhando yekutanga inowanikwa munyika zhinji, kunyangwe dzimwe nzvimbo dzine generic versions kana mazita akasiyana emhando. Murapi wako wemishonga anogona kukubatsira kunzwisisa kuti ndeipi formulation chaiyo yaunogamuchira uye kuona kuti uri kuishandisa nemazvo.

Pasinei nezita remhando, mishonga yese ye dornase alfa ine chinhu chimwe chete chinoshanda uye inoshanda nenzira imwechete. Chinhu chakakosha kushandisa nguva dzose nehunyanzvi hwakanaka hwe nebulizer panzvimbo yekunetseka nezve mhando chaiyo yaunoshandisa.

Dzimwe nzira dze Dornase Alfa

Nepo dornase alfa ichiwanzofungidzirwa seyakajairika yegoridhe yekutetepa mucus mu cystic fibrosis, kune dzimwe nzira dzekurapa dzinogona kubatsira kubata zvakavanzika zvakakora. Hypertonic saline imwezve kurapwa kunofemwa kunobatsira kukwevera mvura mumucus, zvichiita kuti zvive nyore kubvisa.

Vamwe vanhu vanoshandisa mishonga ye mucolytic senge acetylcysteine, kunyangwe izvi zvichishanda zvakasiyana ne dornase alfa uye zvingasashanda zvakanyanya kune cystic fibrosis. Chiremba wako angakurudzira kusanganisa kurapwa panzvimbo yekutsiva dornase alfa zvachose.

Mishonga mitsva senge CFTR modulators (semuenzaniso ivacaftor kana lumacaftor) inoshanda padanho re cellular kuvandudza kukanganisa kuri pasi pe cystic fibrosis. Izvi zvinogona kushandiswa pamwe chete ne dornase alfa panzvimbo yekutsiva, zvichienderana nerudzi rwako rwe genetic rwe cystic fibrosis.

Ko Dornase Alfa Ari Nani Pane Hypertonic Saline?

Zvese dornase alfa uye hypertonic saline zvinoshanda kurapa kutetepa mucus, asi zvinoshanda nenzira dzakasiyana uye zvinogona kunge zviri nani kune vanhu vakasiyana. Dornase alfa inonyanya kutarisana neDNA mumucus, nepo hypertonic saline ichikwevera mvura mumhepo kuti itete zvakavanzika.

Vanhu vazhinji vanowana kuti dornase alfa inopa mhedzisiro inoenderana uye iri nyore kutsungirira pane hypertonic saline, iyo dzimwe nguva inogona kukonzera kukosora kana kutsamwa kwehuro. Zvisinei, vamwe vanhu vanopindura zviri nani kune hypertonic saline kana vangashandisa ese marapirwo panguva dzakasiyana dzezuva.

Chiremba wako achakubatsira kusarudza kurapwa kwakanakisa zvichienderana nezviratidzo zvako, bvunzo dzemabasa emapapu, uye kuti unotsungirira sei mushonga wega wega. Vamwe vanhu vanobatsirwa nekushandisa kurapwa kwese semukana wekutungamira cystic fibrosis yavo.

Mibvunzo Inowanzo Bvunzwa Nezve Dornase Alfa

Dornase Alfa Yakachengeteka Here Kune Chirwere cheShuga?

Hongu, dornase alfa inowanzova yakachengeteka kune vanhu vane chirwere cheshuga, kusanganisira avo vane cystic fibrosis-related diabetes. Sezvo mushonga uchifemwa uye uchishanda munzvimbo mumapapu, hauwanzokanganisa mazinga eshuga yeropa zvakananga.

Zvisinei, kana ukaita hutachiona hwekufema uchishandisa dornase alfa, izvi zvinogona kukanganisa kutonga kweshuga yeropa rako. Chiremba wako achada kutarisa hutano hwemapapu ako nekutungamira chirwere cheshuga zvakanyanya, kunyanya munguva dzekurwisa zvirwere.

Ndoitei kana ndikashandisa Dornase Alfa yakawandisa netsaona?

Kana netsaona ukashandisa yakawanda kupfuura chiyero chako che dornase alfa, usavhunduka. Imwe dose yakawedzerwa haigoni kukonzera kukuvadza kwakanyanya, asi unogona kuona kuwedzera kukosora kana kutsamwa kwehuro sezvo muviri wako uchigadzirisa mushonga wakawedzerwa.

Bata chiremba wako kana wezvemishonga kuti vazive zvakaitika uye kumbira gwara. Vanogona kukupa zano rekuti unoda here chero kuongorora kwakakosha kana iwe uchifanira kugadzirisa chiyero chako chinotevera. Chengeta nguva yakaitika overdose uye chero zviratidzo zvaunoona.

Ndoitei kana ndikakanganwa dose ye Dornase Alfa?

Kana ukakanganwa dose ye dornase alfa, itore paunorangarira, kunze kwekunge yava nguva yechiyero chako chinotevera. Muchiitiko ichocho, siya dose yakarasika uye uenderere mberi nehurongwa hwako hwenguva dzose.

Usambofa wakatora zvikamu zviviri panguva imwe chete kuti ugadzirise chikamu chakasiiwa, sezvo izvi zvingawedzera njodzi yako yekuwana mhedzisiro yezvinhu zvisina kufadza. Kana iwe uchikanganwa kazhinji zvikamu, funga kumisa alarm yezuva nezuva kana kushandisa chirongwa chekuyeuchidza mapiritsi kuti ikubatsire kuti urambe uri munzira.

Ndingamira Rini Kutora Dornase Alfa?

Unofanira kungomira kutora dornase alfa pasi pekutungamirirwa nachiremba wako. Sezvo cystic fibrosis iri mamiriro ehupenyu hwese, vanhu vazhinji vanoda kuramba vachitora mushonga uyu nekusingaperi kuti vachengetedze mabhenefiti emucus yakatetepa uye kufema kuri nyore.

Chiremba wako angangofunga kumisa kana kuderedza mushonga kana iwe ukawana mhedzisiro yezvinhu zvisingashiviririki, kana basa remapapu ako richichinja zvakanyanya, kana kana kurapwa kutsva kuchiwanzika kunoshanda zviri nani kune mamiriro ako. Kugara uchiongororwa kuchabatsira kuona nzira yakanakisa yenguva refu.

Ndingafamba Ne Dornase Alfa Here?

Hongu, unogona kufamba ne dornase alfa, asi uchada kuronga mberi. Mushonga unofanirwa kuchengetwa mufiriji, saka uchada firiji ine ice packs yekufamba. Uya nezvinhu zvakawanda kana paine kunonoka, uye tora tsamba kubva kuna chiremba wako ichitsanangura zvaunoda zvekurapa mushonga uye nebulizer equipment.

Paunenge uchibhururuka, paka nebulizer yako nemushonga mubhegi rako rekutakura panzvimbo yemutoro wakatariswa. Kuchengetedzwa kwendege kunobvumira zvishandiso zvekurapa nemishonga, asi kuve nemagwaro kunogona kubatsira kumhanyisa maitiro ekuongorora uye kuona kuti mushonga wako unogara patembiricha yakakodzera.