Chii chinonzi Doxorubicin: Zvinoshandiswa, Mishonga, Migumisiro Yakaipa uye Zvimwe

Doxorubicin mushonga une simba wechemotherapy unoshandiswa kurapa marudzi akasiyana ekenza. Iyo ndeyeboka remishonga inonzi anthracyclines, iyo inoshanda nekukanganisa kugona kwemasero ekenza kukura nekukwidziridza.

Mushonga uyu wave dombo rekona rekurapa kenza kwemakumi emakore, uchibatsira varwere vasingaverengeke kurwisa chirwere chavo. Kunyange zvazvo iri mushonga une simba unoda kunyatsoongororwa, kunzwisisa mashandiro awo kunogona kukubatsira kuti unzwe wakagadzirira rwendo rwako rwekurapa.

Chii chinonzi Doxorubicin?

Doxorubicin mushonga unorwisa kenza unopiwa zvakananga muropa rako kuburikidza neIV. Inowanzozivikanwa nezita rayo rekutengesa Adriamycin, uye chikamu chemhuri yemishonga inobva kune rudzi rwebhakitiriya rinonzi Streptomyces.

Mushonga uyu unoiswa se cytotoxic drug, zvinoreva kuti yakagadzirirwa kukuvadza kana kuparadza masero. Chinangwa ndechekunangana nemasero ekenza anokurumidza kukamurana apo masero ako ane hutano ane mukana wakanaka wekupora pakati pekurapa.

Oncologist wako anowanzo kupa doxorubicin sechikamu chechirongwa chekurapa chakasanganiswa. Inoshandiswa kazhinji iri yega nekuti kuiisa pamwe chete nemimwe mishonga inowanzoita mhedzisiro iri nani pakurwisa kenza.

Chii chinonzi Doxorubicin chinoshandiswa?

Doxorubicin inorapa marudzi akawanda ekenza, zvichiita kuti ive imwe yemishonga yechemotherapy inoshanda. Chiremba wako angakupa mushonga uyu wekenza yemazamu, lymphomas, leukemias, kana tumaropa twakasiyana.

Heano mamiriro makuru uko doxorubicin inoratidza kuve inonyanya kushanda:

• Kenza yemazamu (kazhinji inosanganiswa nemimwe mishonga yekemotheraphy)
• Hodgkin's lymphoma uye non-Hodgkin's lymphoma
• Acute lymphoblastic leukemia uye acute myeloid leukemia
• Soft tissue sarcomas uye bone sarcomas
• Kenza yeovari uye kenza yeendometrial
• Kenza yeguvhu uye kenza yedumbu
• Kenza yemapapu (mamwe marudzi)
• Kenza yegurokuro mumamiriro ezvinhu akati wandei

Kazhinji, vanachiremba vanogona kushandisa doxorubicin kune kanza isingawanzoitika senge Wilms tumor muvana kana mamwe marudzi ekenza yerivate. Chiremba wako weoncologist achasarudza kana doxorubicin yakakodzera mamiriro ako chaiwo zvichienderana nerudzi rwekenza yako, nhanho, uye hutano hwese.

Doxorubicin Inoshanda Sei?

Doxorubicin inoshanda nekupinda mukati memasero ekenza uye kukuvadza DNA yavo. Funga nezve DNA semabhuku ekuraira anoudza masero kuti akure sei uye agovane - kana doxorubicin ikavhiringidza mirairo iyi, masero ekenza haakwanise kubereka zvakanaka.

Mishonga iyi inoonekwa semushonga une simba rekemotheraphy. Inovharira enzyme inonzi topoisomerase II, iyo masero ekenza anoda kukopa DNA yavo. Pasina enzyme iyi ichishanda nemazvo, masero ekenza anovhiringidzika uye pakupedzisira anofa.

Mishonga iyi inogadzirawo mamorekuru anokuvadza anonzi free radicals mukati memasero. Aya ma free radicals anokonzera kumwe kukuvadzwa kune zvivakwa zvemasero ekenza, zvichiita kuti zvive zvakaoma kuti vapone uye vazhinjise.

Nekuti doxorubicin ine simba rakanyanya, timu yako yezvokurapa ichakutarisa zvakanyanya panguva yekurapa. Simba rinoita kuti rive rinoshanda kurwisa kenza zvinorevawo kuti rinoda kubata nekuchenjerera uye kuyera kwakaringana.

Ndingatora Sei Doxorubicin?

Doxorubicin inogara ichipiwa intravenously (kuburikidza neIV) muchipatara kana nzvimbo yekurapa kenza. Hauzombotori mushonga uyu kumba kana nemuromo - inofanira kupihwa nevashandi vehutano vakadzidziswa.

Mukoti wako achaisa chubhu diki mutsinga yeruoko rwako kana kupinda muchiteshi chako kana uine chimwe. Mushonga unoyerera zvishoma nezvishoma muropa rako mumaminitsi gumi nemashanu kusvika makumi matatu, kunyangwe dzimwe nguva zvingatora nguva yakareba zvichienderana nehurongwa hwako hwekurapa.

Mberi kwekuiswa kwako, timu yako yezvokurapa ichakupa mishonga inorwisa kusvotwa kuti ibatsire kudzivirira mhedzisiro. Unogonawo kugamuchira mvura kuti ibatsire kuchengetedza itsvo dzako uye kukuchengeta uine mvura yakakwana panguva yekurapa.

Haufaniri kudya chero chinhu chakakosha usati warapwa, asi kuva nekudya kwakareruka pamberi kunogona kukubatsira kuti unzwe wakasununguka. Dzivisa doro kwemaawa makumi maviri nemana usati watanga uye mushure mekurapwa kwako, sezvo richikwanisa kukanganisa nzira iyo muviri wako unogadzirisa mishonga.

Ndingatora Doxorubicin Kwenguva Yakareba Sei?

Kureba kwekurapwa kwako kwe doxorubicin kunoenderana nerudzi rwakati rwakananga rwegomarara rako uye kuti unopindura sei kumushonga. Vanhu vazhinji vanogamuchira kurapwa mumasvondo maviri kusvika matatu ega ega kwemwedzi yakati wandei.

Oncologist wako achanyatsoverenga huwandu hwese hwe doxorubicin yaunogona kugamuchira zvakachengeteka muhupenyu hwako hwese. Izvi zvinonzi muganho wehuwandu hwehuwandu, uye zvakakosha nekuti doxorubicin inogona kukanganisa moyo wako kana yakawandisa ikazara mumuviri wako.

Kazhinji, kutenderera kwekurapa kunogara chero kubva kumwedzi mitatu kusvika mitanhatu, asi vamwe vanhu vangada nzira refu kana pfupi. Chiremba wako achatarisa nguva dzose kuverengwa kweropa rako uye basa remoyo kuti aone kana uchifanira kuenderera mberi nekurapwa.

Kana gomarara rako richipindura zvakanaka kurapwa, oncologist wako anogona kukuchinjira kumushonga wakasiyana kana kuderedza kakawanda kwekurapa. Usambomira kurapwa nekukurumidza wega - gara uchikurukura chero zvaunonetseka nazvo nechikwata chako chezvokurapa kutanga.

Ndezvipi Zvakaipa ZveDoxorubicin?

Doxorubicin inogona kukonzera mhedzisiro nekuti inokanganisa ese maseru egomarara uye mamwe maseru ane hutano mumuviri wako. Mazhinji emhedzisiro anogoneka nerutsigiro rwakakodzera uye kuongorora kubva kuchikwata chako chehutano.

Zvimwe zvinokonzeresa zvaungatarisira zvinosanganisira:

• Kutadza kudya uye kurutsa (kazhinji kunodzorwa nemishonga inorwisa kusvotwa)
• Kurasikirwa nebvudzi (kwenguva pfupi - bvudzi rako richakura zvakare mushure mekurapa)
• Maronda emuromo kana shanduko mukuravira
• Kuneta uye kusimba
• Kuwedzera njodzi yekutapukirwa nekuda kwehuwandu hwehutsvuku hweropa hwakaderera
• Kukuvadzwa nyore kana kubuda ropa nekuda kwehuwandu hweplatelet yakaderera
• Weti tsvuku kana yepingi kwemazuva 1-2 mushure mekurapa (izvi zvakajairika)

Zvimwe zvinokonzeresa zvakanyanya zvinoda kutariswa kwechiremba nekukasira. Izvi zvinosanganisira zviratidzo zveutachiona senge fivha, kukosora kunoramba kuripo, kana kuneta kusingaite nani nekuzorora.

Zvimwe zvinokonzeresa zvinonyanya kukosha kukuvadza moyo, izvo zvinogona kuitika kana iwe ukagamuchira doxorubicin yakawandisa nekufamba kwenguva. Chiremba wako achatarisa kushanda kwemoyo wako nguva dzose nemiedzo yakaita se echocardiograms kana MUGA scans.

Kazhinji, vamwe vanhu vanogona kukudziridza gomarara rechipiri makore mushure mekurapa, kunyangwe njodzi iyi ichiwanzopfuurwa nezvakanakira kurapa gomarara rako razvino. Oncologist wako achakurukura njodzi iyi newe kana ichishanda kune yako mamiriro.

Ndiani Asingafaniri Kutora Doxorubicin?

Doxorubicin haina kuchengeteka kune vese, uye oncologist wako achanyatsoongorora nhoroondo yako yekurapa usati wairaira. Vanhu vane mamiriro emoyo akati wandei vangave vasiri vakwikwidzi vemushonga uyu.

Haufanire kugamuchira doxorubicin kana uine:

• Chirwere chemoyo chakakomba kana kutadza kwemoyo
• Kurwisa kwemoyo kwemazuva ano kana matambudziko akakomba emoyo
• Kurapa kwakapfuura nedosi yakachengeteka ye doxorubicin
• Chirwere chechiropa chakakomba chinokanganisa nzira iyo muviri wako unogadzirisa mishonga
• Kumanikidzwa kwemuzongoza wemapfupa akakomba kana huwandu hweropa hwakaderera
• Utachiona hunoshanda, husina kudzora

Chiremba wako achavawo akangwarira nezvekupa doxorubicin kana uri nepamuviri kana kuyamwisa, sezvo inogona kukuvadza vana vari kukura. Kana uri pazera rekubereka, unozofanira kushandisa nzira dzinoshanda dzekudzivirira pamuviri panguva yekurapa.

Vanhu vane makore anopfuura 65 kana avo vane matambudziko eitsvo vangada kugadzirisa mushonga kuti vagamuchire doxorubicin zvakachengeteka. Chikwata chako chekurapa chichafunga zvese izvi zvinhu pavanenge vachigadzira chirongwa chako chekurapa.

Mazita eDoxorubicin Brand

Doxorubicin inowanikwa pasi pemazita akati wandei emhando, neAdriamycin ndiyo inonyanya kuzivikanwa. Pharmacy yako kana nzvimbo yekurapa inogona kushandisa zita re generic

Chiremba wako angangofungawo nezve kurapwa nemwaranzi kana kuvhiyiwa semamwe maitiro, zvichienderana nekwaive kenza yako uye nhanho yayo. Nzira yakanakisa inotsamira zvachose pamamiriro ako ega uye zvinangwa zvekurapa.

Ko Doxorubicin iri nani pane Epirubicin?

Zvese doxorubicin uye epirubicin zvinoshanda zvinodhaka zveanthracycline chemotherapy, asi zvine zvishoma zvakasiyana. Hapana imwe yacho iri yese "iri nani" - sarudzo inotsamira pamhando yako chaiyo yekenza uye mamiriro ako ekurapa.

Doxorubicin yakashandiswa kwenguva refu uye inoonekwa seyakajairika anthracycline yemakenza mazhinji. Iine tsvagiridzo yakawanda inotsigira kushanda kwayo pamhando dzakawanda dzekenza, zvichiita kuti ive sarudzo yakavimbika kune oncologists pasi rese.

Epirubicin inogona kukonzera kukuvara kushoma kwemoyo pane doxorubicin, izvo zvinogona kukosha kana uine njodzi yemoyo. Zvisinei, inogonawo kunge isinganyanyi kushanda pamakenza mamwe, saka oncologist wako achayerera zvinhu izvi zvakanyatsonaka.

Sarudzo pakati pemishonga iyi inowanzouya pasi kune yako ega njodzi, mhando chaiyo yekenza yaunayo, uye zvimwe zvirwere zvauri kugamuchira. Oncologist wako achasarudza mushonga unopa chiyero chakanakisa chekushanda uye kuchengeteka kumamiriro ako ezvinhu.

Mibvunzo Inowanzo Bvunzwa Nezve Doxorubicin

Ko Doxorubicin Yakachengeteka Kune Vanhu Vane Chirwere Chemoyo?

Doxorubicin inoda kungwarira kwakawanda muvanhu vane chirwere chemoyo nekuti inogona kukanganisa basa remoyo. Oncologist wako achanyatsoongorora hutano hwemoyo wako usati watanga kurapwa.

Kana uine chirwere chemoyo chinyoro, unogona kuramba uchikwanisa kugamuchira doxorubicin nekutarisa pedyo. Chiremba wako anogona kuraira bvunzo dzebasa remoyo usati watanga kurapwa uye nguva dzose mukati mekutarisirwa kwako kuti ave nechokwadi chekuti moyo wako unoramba uri mune hutano.

Kune vanhu vane chirwere chemoyo chakakomba, chiremba wako wezve oncology angasarudza mishonga imwe kana kufunga nezve liposomal vhezheni ye doxorubicin, iyo inononoka pamoyo. Sarudzo inogara ichiyera mabhenefiti ekurapa kenza yako pamwe nenjodzi dzinogona kune moyo wako.

Ndingaita Sei Kana Ndikagamuchira Doro Rakawandisa reDoxorubicin?

Doxorubicin overdose haina kumbowanikwa nekuti inopiwa nevashandi vehutano vakadzidziswa munzvimbo dzakadzorwa. Kana uine hanya nekugamuchira mushonga wakawandisa, taura nemukoti wako kana chiremba nekukasira.

Zviratidzo zvekugamuchira doxorubicin yakawandisa zvinogona kusanganisira kusvotwa kwakanyanya, kurutsa, kana kunzwa kusagadzikana zvakanyanya munguva pfupi mushure mekurapa. Chikwata chako chekurapa chinokutarisa iwe panguva uye mushure mekuiswa kwega kwega kuti ubate chero matambudziko ekutanga.

Kana overdose ikaitika, chikwata chako chekurapa chaizopa rutsigiro rwekutarisira kubatsira muviri wako kugadzirisa mushonga zvakachengeteka. Izvi zvinogona kusanganisira mvura yakawanda, mishonga yekudzivirira moyo wako, uye kunyatso tarisa kuverenga kweropa rako uye basa remuviri.

Ndingaita Sei Kana Ndikakanganwa Dose yeDoxorubicin?

Kana ukakanganwa kurapwa kwe doxorubicin kwakarongwa, taura nehofisi yechiremba wako wezve oncology nekukasira kuti urongezve. Usamirira kusvika kumusangano wako unotevera - nguva yakakosha mukurapa chemotherapy.

Chikwata chako chekurapa chichasarudza nzira yakanakisa yekudzosa chirongwa chako chekurapa munzira. Dzimwe nguva vanogona kugadzirisa dose yako inotevera kana kungotangazve chirongwa chako chese, zvichienderana nekuti wanga usiri kurapwa kwenguva yakareba sei.

Kukanganwa kurapwa kumwe chete kazhinji hakukuvadzi chirongwa chako chekurapa chose, asi zvakakosha kuti utaure nechikwata chako chehutano. Vanoda kuziva nezve chero madosi akarasika kuti vave nechokwadi chekuti unogamuchira kubatsirwa kwakazara kwekurapa kwako.

Ndingamira Rini Kutora Doxorubicin?

Unofanira kungomira kurapwa nedoxorubicin kana chiremba wako wezve oncology akuudza kuti zvakachengeteka kuita kudaro. Sarudzo iyi inobva pakuti kenza yako iri kupindura sei kurapwa uye hutano hwako hwese.

Chiremba wako achatarisa kufambira mberi kwako nguva dzose kuburikidza nemiedzo yeropa, imaging scans, uye kuongororwa kwemuviri. Kana kenza yako ichipindura zvakanaka uye wapedza kutenderera kwako kwekurapa kwakarongwa, vachakuzivisa kana nguva yakwana yekumira.

Usambomira kurapwa nekukurumidza wega, kunyangwe uchinzwa zviri nani kana uchitambura nemigumisiro. Kana migumisiro iri kukutambudza, taura nechikwata chako chekurapa nezve nzira dzekuzvigadzirisa pane kumisa kurapwa zvachose.

Ndingatora Mamwe Mishonga Ndichiri paDoxorubicin?

Nguva dzose udza chiremba wako wezve oncology nezve mishonga yese yaunotora, kusanganisira mishonga yekurapa, mishonga isingatengwi nemishonga, uye zvinowedzera. Dzimwe mishonga dzinogona kuita kuti doxorubicin ishande kana kukanganisa maitiro emuviri wako ekemotheraphy.

Chikwata chako chekurapa chichaongorora mishonga yako yese uye chinogona kukukumbira kuti umise kana kugadzirisa dzimwe panguva yekurapa. Izvi zvinosanganisira mamwe mishonga yakajairika semamwe maantibiotics, mishonga yemoyo, kana zvinoderedza ropa.

Usatanga chero mishonga mitsva kana zvinowedzera usati wataurirana nechiremba wako wezve oncology. Kunyangwe zvinodhaka zvisingaite zvinoita sehazvina njodzi zvinogona kukanganisa kurapwa kwako kenza kana kuita kuti migumisiro iwedzere kuipa.