Chii chinonzi Eculizumab: Zvazvinoshandiswa, Mishonga, Mativi eMuviri uye Zvimwe

Eculizumab mushonga unokosha unopiwa kuburikidza neIV unobatsira kurapa zvirwere zvisingawanzoitiki zveropa nekudzivisa chikamu chemuviri wako wekudzivirira zvirwere. Yakagadzirirwa kudzivirira muviri wako wecomplement system (boka remapuroteni anowanzo kurwisa zvirwere) kubva pakurwisa masero ako ane hutano kana iyi sisitimu ikashanduka.

Mishonga iyi inomiririra kubudirira kwevanhu vane mamiriro akati wandei anotyisa upenyu ayo aimbove akaoma kwazvo kubata. Kunyange zvazvo ichida kutarisa zvakanaka uye kushanya kuchipatara nguva dzose, eculizumab yakashandura maonero evarwere vazhinji vane zvirwere izvi zvakaoma.

Chii chinonzi Eculizumab?

Eculizumab mushonga wemonoclonal antibody unoshanda semukiyi chaiwo wekuvhara chikamu chimwe chete chemuviri wako wekudzivirira zvirwere. Funga nezvazvo sechivhariso chinotarwa chinodzivirira yako complement system kubva pakukonzera kukuvadza masero ako matsvuku eropa, itsvo, kana zvimwe zvikamu zvemuviri.

Mishonga iyi ndeyeboka rinonzi complement inhibitors, izvo zvinoreva kuti inodzivirira mamwe mapuroteni ekudzivirira zvirwere kubva pakupedzisa basa ravo remazuva ose. Kunyange izvi zvichigona kurira zvichityisa, kune vanhu vane mamiriro eculizumab anorapa, iyi immune activity inonyanya kukuvadza pane kubatsira.

Iwe uchagamuchira mushonga uyu chete muchipatara kana kiriniki yakakosha kuburikidza neintravenous infusion. Kurapa kunoda kutariswa kwepedyo kwekurapa nekuda kwemigumisiro ine simba yemishonga uye chimiro chakakomba chezvirwere zvinorapwa.

Eculizumab Inoshandiswa Kunei?

Eculizumab inorapa mamiriro akati wandei asingawanzoitiki asi akakomba apo muviri wako wekudzivirira zvirwere unokanganisa zvikamu zvine hutano zvemuviri wako. Kushandiswa kwakajairika ndeye paroxysmal nocturnal hemoglobinuria (PNH), mamiriro apo muviri wako wekudzivirira zvirwere unoparadza masero matsvuku eropa.

Mushonga uyu unobatsirawo vanhu vane atypical hemolytic uremic syndrome (aHUS), uko immune system inokuvadza tsinga dzeropa mumatsvo. Izvi zvinogona kukonzera kutadza kwematsvo kana zvikasabatwa, zvichiita kuti eculizumab ive inoponesa hupenyu chaizvo kune varwere vazhinji.

Chiremba wako angangokurudzirawo eculizumab kune mamwe marudzi e myasthenia gravis, mamiriro anokanganisa simba remhasuru, kana generalized myasthenia gravis apo mamwe marapirwo asina kushanda zvakanaka. Mune dzimwe nguva, inoshandiswa kune neuromyelitis optica spectrum disorder, iyo inokanganisa musana uye tsinga dzeoptic.

Eculizumab Inoshanda Sei?

Eculizumab inoshanda nekudzivisa protein chaiyo inonzi C5 mune yako complement system, iyo iri chikamu chekudzivirira kwako immune. Kana iyi protein yakavharwa, haigoni kukonzera matanho ekupedzisira angajairika kuparadza masero kana kukonzera kuzvimba.

Izvi zvinoonekwa semushonga une simba uye wakatarwa nekuti unokanganisa chikamu chakakosha chemukana we immune system yako wekurwisa zvirwere. Kunyange chiito ichi chekuvhara chinomisa mhedzisiro inokuvadza pamasero ako, zvinorevawo kuti muviri wako unova wakanyanya kukanganiswa nemamwe marudzi ezvirwere zvebhakitiriya, kunyanya izvo zvinokonzerwa neNeisseria bhakitiriya.

Mushonga hauporesi mamiriro aya, asi unogona kudzora zviratidzo zvinobudirira uye kudzivirira matambudziko akakomba. Varwere vazhinji vanowana kuvandudzwa kukuru muhupenyu hwavo, kunyangwe mushonga uchifanira kuenderera mberi kwenguva refu kuti uchengetedze mabhenefiti aya.

Ndingatora Sei Eculizumab?

Uchagamuchira eculizumab se intravenous infusion muchipatara kana kiriniki yakakosha, kwete kumba. Mushonga unopihwa zvishoma nezvishoma kwemaminitsi makumi maviri nemashanu kusvika makumi mana nemashanu kuburikidza neIV line, uye uchatariswa zvakanyanya panguva uye mushure meimwe infusion.

Usati watanga kurapwa, unofanirwa kuwana mushonga we meningococcal mazuva gumi nemana usati watora mushonga wekutanga. Mushonga uyu wakakosha nekuti eculizumab inowedzera njodzi yako yekutapukirwa nezvirwere zvakakomba kubva kumabhakitiriya akati wandei. Chiremba wako achatarisawo kana uchida mamwe majekiseni akadai se pneumococcal kana Haemophilus influenzae type b majekiseni.

Chirongwa chekurapa chinowanzo tanga nekupinza mushonga kamwechete pavhiki kwemavhiki mashoma ekutanga, wobva wachiisa kamwechete pavhiki mbiri kuti uchengetedze. Chikwata chako chehutano chichasarudza nguva chaiyo zvichienderana nemamiriro ako chaiwo uye kupindura kurapwa.

Haufaniri kudya chero chinhu chakakosha usati watora mushonga, asi zvakanaka kuti urambe wakanyatsogadzirwa nemvura uye udye zvakajairika. Vamwe vanhu vanonzwa vakasununguka vaine chikafu chakareruka vasati varapwa kudzivirira chero kusagadzikana, kunyangwe izvi zvisingadiwi.

Ndingatora Eculizumab Kwenguva Yakareba Sei?

Eculizumab inowanzoita kurapwa kwenguva refu kwaunozoramba uchiita kwemakore kana pamwe chete hupenyu hwese. Mushonga unodzora mamiriro ako panzvimbo pekuarapwa, saka kumisa kurapwa kunowanzoita kuti zviratidzo zvidzokere.

Chiremba wako achagara achiongorora kuti mushonga uri kushanda sei kuburikidza nemiedzo yeropa uye nekutarisa zviratidzo zvako. Vamwe vanhu vane PNH vangangokwanisa kuderedza kuwanda kwekurapwa kwavo nekufamba kwenguva, nepo vamwe vane mamiriro akadai se aHUS vangangoda kuramba vachiisa mushonga nguva dzose.

Sarudzo pamusoro penguva yekurapa inoenderana nezvinhu zvakati wandei, kusanganisira mamiriro ako aunawo, kuti unopindura sei kurapwa, uye kana uine chero mhedzisiro yakakosha. Chikwata chako chehutano chichashanda newe kuti uwane chiyero chakakodzera pakati pekutonga mamiriro ako uye kubata chero zvinonetsa zvine chekuita nekurapa.

Ndezvipi Zvipingamupinyi zveEculizumab?

Chinhu chinonyanya kukosha ne eculizumab ndiko kuwedzera njodzi yezvirwere zvakakomba, kunyanya zvirwere zvemeningococcal zvinogona kuva njodzi kuhupenyu. Izvi zvinoitika nekuti mushonga uyu unovharira chikamu chemuviri wako wekudzivirira chirwere uyo unowanzo kurwisa mabhakitiriya aya.

Panguva yekuiswa kwemushonga, unogona kusangana nezvimwe zviitiko zvekare zvinowanzo manejwa nekutarisa kwakakodzera:

• Kutemwa nemusoro kana fivha yakapfava
• Nausea kana kunzwa usina kugadzikana
• Kurwadziwa kwemumashure kana kurwadziwa kwemhasuru
• Dizziness kana kuneta
• Kuita kweganda panzvimbo yeIV

Izvi zvinokonzerwa nekuiswa kwemushonga zvinowanzoita nani muviri wako paunojaira mushonga, uye timu yako yehutano inogona kupa mishonga yekukubatsira kuzvigadzirisa.

Vamwe vanhu vanowana matambudziko anoramba aripo anogona kuramba aripo pakati pekuiswa kwemishonga:

• Kuwedzera kutapukirwa nezvirwere zvekufema
• Kutemwa nemusoro kunoramba kuripo
• Kurwadziwa kwemajoini kana kusimba kwemhasuru
• Nyaya dzekugaya chikafu dzakadai senausea kana manyoka
• Kukanganiswa kwekurara kana shanduko dzemood

Izvi zvinoramba zvichikanganisa zvakasiyana zvakanyanya kubva kumunhu nemunhu, uye varwere vazhinji vanowana kuti mabhenefiti ekurapa anopfuura matambudziko aya anogadzirisika.

Zvisingawanzoitiki asi matambudziko akakomba anogona kusanganisira maitiro akakomba ekuita allergic panguva yekuiswa kana kukura kwemuviri wemuviri kurwisa mushonga uyo unoderedza kushanda kwake. Chikwata chako chekurapa chinotarisa zviitiko izvi kuburikidza nekutarisa nguva dzose uye bvunzo dzeropa.

Ndiani Asingafaniri Kutora Eculizumab?

Eculizumab haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana yakakukodzera. Vanhu vane zvirwere zviripo, zvisina kurapwa vanofanira kumirira kusvikira chirwere chanyatsoitwa nani vasati vatanga kurapwa.

Haufaniri kugamuchira eculizumab kana usina kubaiwa jekiseni rekurwisa chirwere chemeningococcal, sezvo izvi zvichikwidza zvakanyanya njodzi yako yekutapukirwa zvirwere zvinotyisa upenyu. Kubaiwa jekiseni kunofanirwa kupedzwa angangoita mavhiki maviri usati wapiwa jekiseni rekutanga, kunze kwemamiriro ekukurumidzira apo mabhenefiti anonyatso kukunda njodzi.

Vanhu vane matambudziko emuviri ekudzivirira chirwere kana avo vari kutora mamwe mishonga inodzvinyirira immune system vangangoda kufunga kwakakosha. Chiremba wako achatarisa kana kuwedzera kudzvinyirirwa kweimmune kubva ku eculizumab kwakachengeteka mumamiriro ako chaiwo.

Kuzvitakura nekuyamwisa kunoda hurukuro yakanyatsoitwa nechikwata chako chehutano. Kunyangwe eculizumab ingave yakakosha kuchengetedza hutano hwako, mhedzisiro pamwana asati aberekwa kana mwana anoyamwisa inoda kuyerwa pamabhenefiti ekurapa.

Mazita eEculizumab Brand

Eculizumab inotengeswa pasi pezita rekuti Soliris munyika zhinji, kusanganisira United States neEurope. Iyi ndiyo yekutanga formulation inoda infusions mazuva ese mavhiki maviri mushure mekutanga loading period.

Imwe vhezheni itsva, inoshanda kwenguva refu inonzi Ultomiris (ravulizumab) inowanikwawo mune dzimwe nzvimbo. Ultomiris inoshanda zvakafanana ne eculizumab asi inogona kupihwa mazuva ese masvondo masere panzvimbo pemazuva ese mavhiki maviri, izvo vanhu vazhinji vanowana zviri nyore.

Mishonga yese iri miviri inogadzirwa nekambani imwe chete uye inoshanda nenzira imwechete, asi dosing schedule uye mamwe mashoko chaiwo anogona kusiyana. Chiremba wako achakubatsira kunzwisisa kuti ndeipi sarudzo ingave iri nani mumamiriro ako ezvinhu.

Eculizumab Alternatives

Kune mazhinji emamiriro ezvinhu eculizumab anorapa, kune zvishoma zvakananga zvinoshanda nenzira imwechete. Zvisinei, zvichienderana nemamiriro ako chaiwo, chiremba wako angangofunga dzimwe nzira dzekurapa.

Kana zvemukati mehemoglobinuria yeusiku, mamwe marapirwo angasanganisira kutarisirwa kwerutsigiro nekuwedzerwa kweropa, zvinowedzera simbi, uye mishonga yekudzivirira ropa. Kuisa pfupa remuzongoza kunogona kuporesa asi kunotakura njodzi huru uye hakuna kukodzera munhu wese.

Vanhu vane atypical hemolytic uremic syndrome vanogona kubatsirwa neplasma exchange therapy mune dzimwe nguva, kunyangwe izvi zvinowanzo shanda zvishoma pane eculizumab. Kurapa kunotsigira sekudya kunogona kuve kwakakosha kune matambudziko eitsvo.

Kune myasthenia gravis, mamwe mishonga yekudzivirira immune system senge corticosteroids, azathioprine, kana rituximab inogona kuve sarudzo, zvichienderana nekukomba kwemamiriro ako uye kuti wakanaka sei kumishonga yapfuura.

Ko Eculizumab Zviri Nani Pane Mamwe Marapirwo?

Eculizumab yakashandura kurapwa kwemamiriro ayo akatenderwa, kazhinji ichipa mabhenefiti asina kugoneka nemishonga yapfuura. Kune paroxysmal nocturnal hemoglobinuria, inogona kuderedza zvakanyanya kudiwa kwekuwedzerwa kweropa uye kuvandudza zvakanyanya hupenyu hwemhando yepamusoro.

Kana ichienzaniswa nemishonga yekare senge immunosuppressive drugs kana plasma exchange, eculizumab inopa chiito chakanyanya chinangwa chine zvishoma zvinogona kuve nemigumisiro yakapararira. Zvisinei, inouya nenjodzi dzayo dzakakosha, kunyanya njodzi yakawedzera yekutapukirwa.

Sarudzo

Eculizumab inogona kushandiswa zvakachengeteka muvanhu vane chirwere cheitsvo, uye kune avo vane atypical hemolytic uremic syndrome, inogona kubatsira kuchengetedza kushanda kweitsvo. Chiremba wako achanyatso tarisa kushanda kweitsvo yako kuburikidza nemiedzo yeropa yenguva dzose.

Mushonga hauwanzokonzera matambudziko eitsvo, asi nekuti inokanganisa immune system yako, iwe uchada kuwedzera kutariswa kwezvirwere zvinogona kukanganisa itsvo dzako. Chikwata chako chehutano chichagadzirisa zvirongwa zvekutarisa zvichibva pakushanda kweitsvo yako uye hutano hwese.

Ndingaita Sei Kana Ndakanganwa Kamwechete Dose yeEculizumab?

Kana iwe ukakanganwa infusion yakarongwa, taura nemupi wako wehutano nekukurumidza kuti urongezve nekukurumidza sezvinobvira. Usamirira kusvika kumusangano wako unotevera wakarongeka, sezvo kusavapo mukurapa kunogona kubvumira mamiriro ako kuti avepo zvakare.

Chiremba wako angakurudzira kutariswa kwepedyo kana mamwe bvunzo dzeropa mushure me dose yakarasika kuti ave nechokwadi chekuti mamiriro ako anoramba akagadzikana. Mune dzimwe nguva, unogona kuda kudzokera kune yakawanda dosing schedule kwenguva pfupi kuti uwanezve kutonga kwakanaka kwemamiriro ako.

Ndingaita Sei Kana Ndine Zviratidzo zveZvirwere Ndichitora Eculizumab?

Tsvaga rubatsiro rwekurapa nekukurumidza kana iwe ukaita fivhiri, kurwadziwa kwemusoro kwakanyanya, kuoma kwemutsipa, kusvotwa nekutsvomoka, kunzwa chiedza, kana rash isingapere kana yakatsikirirwa. Izvi zvinogona kunge zviri zviratidzo zvechirwere chakakomba chinoda kurapwa nekukurumidza.

Kunyangwe zvirwere zvinoita sezvidiki zvakaita sema colds kana urinary tract infections zvinofanirwa kuongororwa nekukurumidza nemupi wako wehutano. Nekuti eculizumab inokanganisa immune system yako, zvirwere zvinogona kuve zvakanyanya kukurumidza kupfuura zvazvingadai zvakaita.

Ndingamira Rini Kutora Eculizumab?

Sarudzo yekumisa eculizumab inofanira kugara ichiitwa mukukurukura nechikwata chako chehutano, sezvo kumisa kurapwa kunowanzoita kuti mamiriro ako ezvinhu adzoke. Vamwe vanhu vanogona kukwanisa kuderedza kakawanda kwavo kurapwa nekufamba kwenguva, asi kumisa zvachose hakukurudzirwi kazhinji.

Kana uri kufunga kumisa kurapwa nekuda kwemigumisiro kana dzimwe nyaya, kurukura dzimwe nzira nachiremba wako kutanga. Vanogona kukwanisa kugadzirisa chirongwa chako chekurapa, kupa mamwe mishonga yekugadzirisa migumisiro, kana kuratidza dzimwe nzira dzekuita kuti kurapwa kuve nyore.

Ndingafamba here ndichitora Eculizumab?

Unogona kufamba uchitora eculizumab, asi zvinoda kuronga zvakanaka uye kubatana nechikwata chako chehutano. Unozofanira kuronga infusions yako pazvipatara zvakakodzera pamunhu waunoenda kana kuronga rwendo rwako zvichienderana nechirongwa chako chekurapa.

Tora tsamba kubva kuna chiremba wako ichitsanangura mamiriro ako uye kurapwa, pamwe neruzivo rwekukurumidzira rwekubata chikwata chako chehutano. Funga nezve inishuwarenzi yekufamba inovhara zviitiko zvekukurumidzira zvekurapa, uye tsvaga zvipatara pamunhu waunoenda zvinogona kupa hanya kana zvichidikanwa.