Chii chinonzi Edaravone: Zvinoshandiswa, Mishonga, Migumisiro Yakaipa uye Zvimwe

Edaravone mushonga unopiwa kuburikidza neIV (intravenous) line kubatsira kunonotsa kufambira mberi kweALS, inozivikanwawo sechirwere chaLou Gehrig. Mushonga uyu unoshanda se antioxidant ine simba, zvinoreva kuti inobatsira kuchengetedza maseru ako etsinga kubva mukukuvadzwa kunokonzerwa nemamorekuru anokuvadza anonzi free radicals.

Kana iwe kana mumwe munhu waunoda akawanikwa aine ALS, kudzidza nezve edaravone kunogona kunzwa kutyisa. Mashoko akanaka ndewekuti mushonga uyu unomiririra tariro - wakagadzirirwa kubatsira kuchengetedza basa re motor neurons, maseru etsinga anotonga tsandanyama dzako.

Chii chinonzi Edaravone?

Edaravone mushonga we neuroprotective uyo uri muboka remishonga inonzi free radical scavengers. Funga nezvayo sechivharo chinobatsira kuchengetedza maseru ako etsinga kubva ku oxidative stress - rudzi rwekukuvadzwa kweseru kunoita basa guru mukufambira mberi kweALS.

Mushonga uyu pakutanga wakagadzirwa muJapan wekurapa varwere vane sitiroko. Vatsvakurudzi vakawana kuti mhedzisiro imwechete yekudzivirira yaive nayo pamasero ehuropi inogonawo kubatsira vanhu vane ALS. Iyo FDA yakabvumira edaravone yeALS kurapwa muna 2017, ichiita kuti ive mushonga wechipiri wakambobvumirwa zvakananga kune iyi mamiriro.

Uyu hausi mushonga weALS, asi unogona kubatsira kunonotsa kufambira mberi kwechirwere ichi mune vamwe varwere. Chiremba wako achasarudza kana iwe uri munhu akakodzera zvichienderana nemamiriro ako chaiwo uye kuti uri mangani muchirwere ichi.

Chii chinonzi Edaravone chinoshandiswa?

Edaravone yakanyatso bvumirwa kurapa amyotrophic lateral sclerosis (ALS), chirwere chinofambira mberi che neurodegenerative chinokanganisa maseru etsinga muuropi hwako uye musana. ALS zvishoma nezvishoma inoderedza tsandanyama mumuviri wako wese, ichikanganisa kugona kwako kufamba, kutaura, kudya, uye pakupedzisira kufema.

Mushonga uyu unoshanda zvakanaka kana wakatanga kare muchirwere. Chiremba wako anowanzo kuraira edaravone kana uine ALS yakajeka kana inogona kuitika uye uchiri mumatanho ekutanga. Zvidzidzo zvinoratidza kuti zvinogona kubatsira kuchengetedza kugona kwako kwezuva nezuva kwenguva yakareba uchienzanisa nekusina kurapwa.

Haasi munhu wese ane ALS anozobatsirwa ne edaravone. Chikwata chako chehutano chichaongorora zvinhu zvakaita sekufambira mberi kwechirwere chako, hutano hwese, uye kugona kutora kurapwa kweIV usati waraira mushonga uyu.

Edaravone Inoshanda Sei?

Edaravone inoshanda nekubata uye nekudzivirira mahara radicals - mamorekuru asina kugadzikana anogona kukuvadza maseru ako etsinga. MuALS, aya mahara radicals anoungana uye anobatsira mukufa kwema motor neurons, maseru akakosha anotonga tsandanyama dzako.

Mushonga uyu unoonekwa semumiriri we neuroprotective wepakati-kati. Haimise ALS zvachose, asi inogona kuderedza kukuvadzwa kweseru kunofambisa chirwere ichi mberi. Funga nezvazvo sekushandisa sunscreen - haidziviriri zvese zvekukuvara kwezuva, asi inozvideredza zvakanyanya.

Mishonga iyi inobatsirawo kuderedza kuzvimba muhurongwa hwako hwetsinga uye inogona kuvandudza basa re mitochondria, madiki emagetsi mukati memasero ako. Nekudzivirira zvivakwa izvi zve cellular, edaravone inobatsira ma motor neurons ako kuti arambe aine hutano kwenguva yakareba.

Ndinofanira Kutora Sei Edaravone?

Edaravone inopihwa chete kuburikidza neIV infusion panzvimbo yekurapa - haugone kutora mushonga uyu kumba nemuromo. Kurapa kunotevera maitiro chaiwo anochinjana pakati penguva dzekurapa nenguva dzekuzorora.

Hezvino zvinoita sechirongwa chekurapa:

• Kutenderera kwekutanga: Kudiridzwa kweIV zuva nezuva kwemazuva gumi nemana, wobva wazorora kwemazuva gumi nemana
• Kutenderera kunotevera: Kudiridzwa kweIV zuva nezuva kwemazuva gumi kubva mumazuva gumi nemana ega ega, wobva wazorora kwemazuva gumi nemana
• Kudiridzwa kwega kwega kunotora anenge maminitsi makumi matanhatu kuti apedze
• Unofanira kushanyira nzvimbo yekurapa kana nzvimbo yekudiridzwa kurapwa kwega kwega

Haufaniri kudya chero chinhu chakakosha usati wadiridzwa, asi kugara uine mvura yakawanda kunobatsira muviri wako kugadzirisa mushonga zvakanyanya. Vamwe vanhu vanoona zvichibatsira kuunza bhuku kana piritsi rekupedza nguva panguva yekudiridzwa kweawa rimwe.

Vashandi vehutano vachakutarisa panguva yekudiridzwa kwega kwega kuti vatarise chero mhedzisiro. Vachateverawo zviratidzo zvako zveALS nekufamba kwenguva kuti vaone kuti mushonga uri kushanda zvakanaka sei kwauri.

Ndingatora Edaravone kwenguva yakareba sei?

Kureba kwekurapa kweedaravone kunosiyana kubva kumunhu nemunhu uye kunoenderana nekuti unopindura sei kumushonga. Vanhu vazhinji vanoenderera mberi nekurapa chero bedzi vachibatsirwa nawo uye vachikwanisa kutsungirira mhedzisiro.

Chiremba wako achaongorora kufambira mberi kwako mwedzi mitatu yega yega achishandisa zviyero zveALS zvakajairika. Ongororo idzi dzinobatsira kuona kana mushonga uri kunonotsa kufambira mberi kwechirwere chako zvinobudirira. Kana uri kuratidza zvakanakira zvakajeka, vashandi vehutano vako vanozokurudzira kuti uenderere mberi nekurapa.

Vamwe vanhu vanotora edaravone kwemwedzi yakawanda kana kunyange makore, nepo vamwe vachigona kumira nekukurumidza nekuda kwemhedzisiro kana kufambira mberi kwechirwere. Sarudzo yekuramba kana kumisa kurapwa inofanira kugara ichiitwa pamwe chete nevashandi vako vehutano, vachifunga nezvehupenyu hwako hwese uye zvinangwa zvekurapa.

Ndezvipi Zvakaipa zveEdaravone?

Semishonga yese, edaravone inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anoiziva. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye wakavimbika nezvekurapa kwako.

Mhedzisiro yakajairika inowanzoita nyoro uye inogoneka:

• Kuvadzwa kana kuzvimba panzvimbo yeIV
• Kutemwa nemusoro
• Mavanga paganda kana kukwenya
• Nyonganyonga kana dumbu kusagadzikana
• Dizziness kana kunzwa musoro
• Kuneta mushure mekurapa

Izvi zvinowanzoitika zvinovandudzika muviri wako paunojaira mushonga. Chikwata chako chehutano chinogona kukurudzira nzira dzekuzvigadzirisa, sekushandisa aizi panzvimbo yeIV kana kutora mishonga ye nyonganyonga.

Zvimwe zvinokuvadza zvakanyanya hazviwanzoitiki asi zvinoda kutariswa kwekurapa nekukasira:

• Kusagadzikana kwakanyanya (kunetsa kufema, kuzvimba kumeso kana pahuro)
• Kuchinja kukuru mukushanda kwematsvo
• Kusagadzikana kweganda kwakanyanya kana mavanga akapararira
• Kubuda ropa kana kuvadzwa kusinganzwisisike
• Zviratidzo zvehutachiona panzvimbo yeIV (kuwedzera kutsvuka, kudziya, kana pus)

Chikwata chako chekurapa chichakutarisa zvakanyanya kuti uone izvi zvinokuvadza zvakanyanya. Vanoongorora kushanda kwematsvo ako nguva dzose kuburikidza nemiedzo yeropa uye vachatarisa chero zviratidzo zvekusagadzikana panguva yekuiswa kwako.

Ndiani Asingafaniri Kutora Edaravone?

Edaravone haikodzeri munhu wese ane ALS. Chiremba wako achanyatsoongorora kana mushonga uyu wakakukodzera zvichibva pazvinhu zvakawanda zvakakosha.

Haufaniri kutora edaravone kana uine:

• Kuzivikanwa kwekusagadzikana ku edaravone kana chero zvezvinhu zvayo
• Chirwere chakakomba cheitsvo kana kutadza kwematsvo
• Nhoroondo yekusagadzikana kwakanyanya kumishonga yeIV
• ALS yakakwirira uko mushonga haungapi rubatsiro
• Mhando dzeALS dzisina kupindura zvakanaka ku edaravone muzvidzidzo

Chiremba wako achafungawo nezve hutano hwako hwese, kusanganisira kushanda kwemoyo wako, hutano hwechiropa, uye kugona kutsungirira kurapwa kweIV nguva dzose. Kana iwe uri nepamuviri kana kuyamwisa, njodzi nemabhenefiti zvinoda hurukuro yakanyatsoitwa nechikwata chako chehutano.

Zera chete harikukodzere kubva mukurapwa kwe edaravone, asi vanhu vakuru vangada kuongororwa zvakanyanya nekuda kwekuwedzera kunzwisiswa kumishonga uye njodzi yakakwira yemigumisiro.

Zita reBrand reEdaravone

Edaravone inotengeswa pasi pezita rebrand Radicava muUnited States. Mushonga uyu unogadzirwa naMitsubishi Tanabe Pharma uye ndiyo yaive yekutanga kurapwa kutsva kweALS yakatenderwa neFDA mumakore anopfuura makumi maviri.

Unogonawo kuona ichinzi nezita rayo re generic, edaravone, mumabhuku ekurapa kana magwaro einishuwarenzi. Mazita ese ari maviri anoreva mushonga mumwe chete une chinhu chimwe chete chinoshanda.

Zita rebrand Radicava rinobva kushoko rekuti

Ko Edaravone Ari Nani Kudarika Riluzole?

Edaravone na riluzole vanoshanda nemaitiro akasiyana, saka havagone kuenzaniswa zvakananga - funga nezvavo sematurusi akasiyana muhomwe yako yekurapa pane sarudzo dzekukwikwidzana. Vanachiremba vazhinji vanokurudzira kushandisa mishonga yese iri miviri pamwechete kana zvakakodzera.

Riluzole yanga iripo kwenguva refu uye ine ruzivo rwakawanda rwekutsvaga. Inotorwa semupfuhwira kaviri pazuva, zvichiita kuti zvive nyore kupfuura infusions ye IV ye edaravone. Zvisinei, edaravone inogona kupa mabhenefiti ayo riluzole isingapi nekuda kwemaitiro ayo akasiyana ekuita.

Zvidzidzo zvinoratidza kuti edaravone inogona kunge iri nani pakuchengetedza kugona kwezuva nezuva, nepo riluzole inogona kunge iri nani pakuwedzera nguva yekurarama. Chiremba wako achakubatsira kunzwisisa kuti ndeipi mushonga kana musanganiswa wemishonga unoita zvakanyanya kunzwisisa kune mamiriro ako chaiwo.

Sarudzo pakati pemishonga iyi inoenderana nezvinhu zvakaita sematanho ako echirwere, kugona kutora kurapwa kwe IV, inishuwarenzi, uye zvaunofarira pachako nezve nyore yekurapa vachipesana nemabhenefiti anogona kuitika.

Mibvunzo Inowanzo Bvunzwa Nezve Edaravone

Ko Edaravone Akachengeteka Kune Vanhu vane Chirwere Chemoyo?

Edaravone inogona kushandiswa zvakachengeteka muvanhu vane chirwere chemoyo, asi chiremba wako wemoyo uye neurologist vachada kushanda pamwechete kuti vakutarise zvakanyanya. Mushonga hauna zvakananga kukanganisa basa remoyo, asi infusions ye IV inowedzera mvura muhurongwa hwako.

Kana uine kukundikana kwemoyo kana mamwe mamiriro apo mvura yakawanda inogona kuve nedambudziko, timu yako yekuchengetedza hutano ichakutarisa zvakanyanya panguva ye infusions. Vanogona kugadzirisa chiyero che infusion kana kukurudzira mamwe mishonga yekubatsira muviri wako kubata mvura yakawanda.

Usati watanga edaravone, ita shuwa kuti chiremba wako anoziva nezve chero mamiriro emoyo, mishonga yekudzikisa BP, kana nhoroondo yematambudziko emoyo. Ruzivo urwu runovabatsira kupa kuchengetedzwa kwakanyanya.

Ndingaita Sei Kana Ndakakanganwa Kudya Mushonga weEdaravone?

Kana ukakanganwa kudya mushonga weedaravone wakarongeka, taura nechikwata chako chekuchengetwa kwehutano nekukurumidza sezvinobvira kuti urongezve. Usaedze "kuzadza" nekugadzirisa infusions dzakawanda - izvi zvinogona kuwedzera njodzi yako yemigumisiro isina kupa zvimwe zvinobatsira.

Chikwata chako chekurapa chichakubatsira kuona nzira yakanakisisa yekudzokera munzira nechirongwa chako chekurapa. Muzviitiko zvakawanda, vachangopfuurira nemaitiro ako enguva dzose kubva kwawakasiya.

Kukanganwa imwe kana mbiri infusions dzimwe nguva hakuzokanganisi zvakanyanya kushanda kwekurapa kwako. Zvisinei, kazhinji kukanganwa kurapwa kunogona kuderedza kugona kwemushonga kunonotsa kufambira mberi kwechirwere, saka zvakakosha kuchengetedza kurapwa nguva dzose pazvinogoneka.

Ndingaita Sei Kana Ndikawana Migumisiro Panguva yeInfusion?

Kana ukaona chero zviratidzo zvisina kunaka panguva yeedaravone infusion yako, udza chikwata chako chekuchengetwa kwehutano nekukurumidza. Vakadzidziswa kuziva nekugadzirisa migumisiro ine chekuita neinfusion nekukurumidza uye zvinobudirira.

Maitiro akajairika senge kusvotwa zvishoma, kurwadziwa nemusoro, kana dzungu zvinogona kugadziriswa nekunonotsa mwero weinfusion kana kukupa mishonga yekubatsira nezviratidzo. Chikwata chako chekurapa chinogonawo kupa mvura yeIV kuti ikubatsire kunzwa zviri nani.

Kune maitiro akakomba senge kuoma kufema, rash yakakomba, kana kurwadziwa muchipfuva, chikwata chako chekuchengetwa kwehutano chichamisa infusion nekukurumidza uye chipe kurapwa kwakakodzera. Vachashandawo nachiremba wako kuti vaone kana zvakachengeteka kuenderera mberi needaravone kurapwa mune ramangwana.

Ndingamira Rini Kutora Edaravone?

Sarudzo yekumisa edaravone inofanira kugara ichiitwa pamwe chete nechikwata chako chekuchengetwa kwehutano mushure mekunyatsofunga nezvemamiriro ako ega. Hapana nguva yakatarwa yaunofanira kumisa kurapwa kana uchikwanisa kuzvitsungirira zvakanaka uye uchiratidza zvakanakira.

Ungafunga kumisa edaravone kana ukawana matambudziko asingashiviriki, kana ALS yako ikafambira mberi kusvika panguva iyo mushonga usingachapi rubatsiro runokosha, kana kana hutano hwako hwese huchichinja zvakanyanya.

Vamwe vanhu vanosarudza kumisa kurapwa nekuda kwemutoro wekushanya nguva dzose kunzvimbo dzekurapa, kunyanya kana kufamba kwavo kuchiva kwakanyanya. Chikwata chako chekuchengetwa kwehutano chinogona kukubatsira kuyera mabhenefiti ekuenderera mberi nekurapwa pamusoro pematambudziko anoshanda aanopa.

Ndingafamba Ndiri Kutora Edaravone Here?

Kufamba uchitora edaravone kunoda kuronga pachine nguva, asi kazhinji zvinogoneka nekubatana kwakakodzera. Unozofanira kuronga kurapwa panzvimbo yekupinza kana chipatara munzvimbo yaunoenda.

Chikwata chako chekuchengetwa kwehutano chinogona kukubatsira kuwana nzvimbo dzekurapa dzakakodzera mumamwe maguta uye kuronga kutarisirwa kwako. Vanogona zvakare kukupa zvinyorwa zvakakosha zvekurapa uye ruzivo rwekubata kana paine njodzi iwe uri kure.

Kwemafambiro marefu, ungangoda kugadzirisa chirongwa chako chekurapa kana kutora zororo rakarongeka kubva ku edaravone. Chiremba wako anogona kukubatsira kuona nzira yakanakisa zvichienderana nezvirongwa zvako zvekufamba uye hutano hwako hwazvino.