Chii chinonzi Edaravone: Kushandiswa, Dosage, Side Effects uye Zvimwe

Edaravone mushonga unodzivirira tsinga dzehuropi unobatsira kunonotsa kufambira mberi kweALS (chirwere chaLou Gehrig). Mushonga uyu unotorwa nemuromo unoshanda nekudzivirira maseru etsinga kubva mukukuvadzwa kunokonzerwa nemamorekuru anokuvadza anonzi free radicals. Kunyange zvazvo isingagoni kurapa ALS, edaravone inogona kubatsira kuchengetedza basa remhasuru uye kunonotsa kudzikira mumabasa ezuva nezuva kune vamwe vanhu vanorarama nechirwere ichi.

Chii chinonzi Edaravone?

Edaravone mushonga unotorwa nemishonga wakagadzirirwa kurapa amyotrophic lateral sclerosis (ALS). ALS chirwere chetsinga chinofambira mberi chinokanganisa maseru etsinga ane basa rekudzora kufamba kwemhasuru kunozivikanwa. Mushonga uyu ndewechikwata chemishonga inonzi antioxidants, izvo zvinoreva kuti inobatsira kudzivirira maseru kubva mukukuvadzwa.

Pakutanga yakagadzirwa muJapan, edaravone yakatanga kubvumidzwa sechinhu chinotorwa nemutsinga. Fomu remuromo rinopa sarudzo yakasununguka kune varwere vanoda kurapwa kwenguva refu. Mushonga uyu unomiririra imwe yemishonga mishoma yeFDA-yakabvumidzwa iripo kune varwere veALS.

Mishonga inoshanda padanho rese cellular kurwisa oxidative stress, iyo inotamba basa rakakosha mukufa kweseru retsinga muALS. Nekuderedza kukuvadzwa kwecellular uku, edaravone inogona kubatsira kuchengetedza basa retsinga kwenguva yakareba.

Chii chinotorwa Edaravone?

Edaravone inonyanya kushandiswa kurapa ALS muvanhu vakuru. Mushonga uyu unonyanya kuratidzwa kune varwere vanosangana nemamwe maitiro uye vanoratidza humbowo hwekufambira mberi kwechirwere. Chiremba wako achanyatsoongorora kana kurapwa uku kwakakodzera mamiriro ako chaiwo.

Mushonga uyu hausi mushonga weALS, asi unogona kubatsira kunonotsa mwero wekudzikira mukuita kwemuviri. Zvidzidzo zvekiriniki zvakaratidza kuti vamwe varwere vanowana kufambira mberi kwemishonga zvishoma nezvishoma pavanotora edaravone vachienzaniswa nevaya vasiri kuwana kurapwa.

Parizvino, edaravone haina kubvumirwa kune dzimwe mamiriro ekuongorora, kunyangwe tsvakiridzo ichienderera mberi nekuongorora mabhenefiti ayo anogona kuve nawo mune dzimwe zvirwere zvinosanganisira oxidative stress. Murapi wako wehutano achasarudza kana iwe uri munhu akakodzera zvichibva munhoroondo yako yekurapa uye mamiriro ako azvino.

Edaravone Inoshanda Sei?

Edaravone inoshanda nekuita se antioxidant ine simba inodzivirira maseru etsinga kubva mukukuvadzwa. MuALS, mamorekuru anokuvadza anonzi free radicals anoungana uye anokonzera oxidative stress, iyo inokuvadza uye inouraya ma motor neurons. Aya ndiwo maseru etsinga anotonga kufamba kwemhasuru dzemahara.

Mushonga unotora mahara radicals aya vasati vakwanisa kukonzera kukuvadzwa kwemasero. Funga nezvazvo sechidzitiro chinodzivirira kutenderedza maseru ako etsinga, ichibatsira kuchengetedza basa ravo kwenguva yakareba sezvinobvira. Dziviriro iyi inogona kubatsira kuchengetedza simba remhasuru uye kushanda kwenguva refu kupfuura zvingaitika pasina kurapwa.

Nepo edaravone ichionekwa seimwe nzira yekurapa inoshanda zvine mwero, zvakakosha kunzwisisa kuti inoshanda zvishoma nezvishoma. Mabhenefiti angasave anocherechedzwa pakarepo, uye mushonga unofanirwa kutorwa nguva dzose kuchengetedza mhedzisiro yawo yekudzivirira.

Ndingatora Sei Edaravone?

Edaravone oral suspension inofanira kutorwa sezvakanyorwa nachiremba wako. Mushonga unouya semvura yaunoyera zvakanyatsonaka uchishandisa mudziyo wekuyera wakapihwa. Vazhinji varwere vanoi tora kaviri pazuva, asi chirongwa chako chekuyera chichavimba nezvido zvako.

Unogona kutora edaravone uine kana usina chikafu, kunyangwe kuitora nechikafu kunogona kubatsira kuderedza dumbu kana uine chero. Mushonga unofanirwa kuchengetwa mufiriji uye kuzununguswa zvakanaka usati washandiswa kuti uve nechokwadi chekusanganiswa kwakakodzera.

Zvakakosha kutora mishonga yako panguva imwe chete zuva rega rega kuti uchengetedze mazinga akaenzana mumuviri wako. Kana uine dambudziko rekumedza kana kubata fomu yemvura, taura nechikwata chako chehutano nezve nzira dzinogona kubatsira kuita kuti kushandisa kuve nyore.

Ndinofanira Kutora Edaravone Kwenguva Yakareba Sei?

Edaravone inowanzo kurairwa semushonga wenguva refu weALS. Varwere vazhinji vanoramba vachitora mushonga kwenguva yakareba sezvavanogona kuutora uye chero chiremba wavo achitenda kuti iri kupa rubatsiro. Izvi zvinogona kureva kuutora kwemwedzi kana makore.

Chiremba wako achatarisa mhinduro yako kumushonga kuburikidza nekutarisa nguva dzose uye kuongorora. Vachaongorora kana kurapwa kuri kubatsira kunonotsa kufambira mberi kwechirwere chako uye kana uri kusangana nechero mhedzisiro inokanganisa.

Sarudzo yekuramba kana kumisa edaravone inoenderana nezvinhu zvakawanda, kusanganisira kuti uri kutora sei mushonga, hutano hwako hwese, uye humbowo hwerubatsiro rwakapfuurira. Usambomira kutora edaravone usati wataurirana nazvo nemupi wako wehutano kutanga.

Ndezvipi Zvakaipa ZveEdaravone?

Semishonga yese, edaravone inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese achizviona. Zvizhinji zvemhedzisiro zvinogoneka uye zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga.

Mhedzisiro inowanzoitika yaungasangana nayo inosanganisira kurwadziwa nemusoro, dzungu, kusvotwa, uye kuneta. Zviratidzo izvi zvinowanzoita zvinyoro uye zvinowanzoita nani nekufamba kwenguva sezvo muviri wako uchijaira mushonga.

Heano mhedzisiro yakakamurwa nekuti inowanzoitika sei:

Mhedzisiro inowanzoitika (inoita kune vanopfuura 10% yevarwere):

• Kurwadziwa nemusoro
• Dzungu
• Kusvotwa kana dumbu kusagadzikana
• Kunetwa kana kuneta
• Kutadza kurara

Mhedzisiro isingawanzoitiki (inoita kune 1-10% yevarwere):

• Kurutsa
• Manyoka
• Kushaya chido chekudya
• Mavanga paganda kana kukwenya
• Kushaya simba mumhasuru
• Kutadza kufema

Mhedzisiro isingawanzoitika asi yakakomba (inoita vanhu vashoma pane 1% yevanhu vanorwara):

• Kuitika kwemuviri kwakanyanya nekuputika kwechiso, miromo, kana pahuro
• Kuitika kweganda kwakanyanya
• Matambudziko echiropa nekuita yero yeganda kana maziso
• Kuchinja kukuru mukuverenga masero eropa

Kana ukaona chero mhedzisiro yakakomba kana kuitika kwemuviri, tsvaga rubatsiro rwekurapa nekukurumidza. Mhedzisiro zhinji ndeyenguva pfupi uye inogona kubatwa nekutungamirirwa kwekurapa kwakakodzera.

Ndiani Asingafaniri Kutora Edaravone?

Edaravone haikodzeri munhu wese, uye mamiriro ezvinhu ekurapa kana mamiriro anogona kuita kuti zvisachengeteke kuti utore mushonga uyu. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wanyora edaravone.

Haufaniri kutora edaravone kana uine allergy inozivikanwa kumushonga kana chero zvikamu zvawo. Uye zvakare, vanhu vane chirwere chechiropa chakakomba kana matambudziko eitsvo vangangoda kudzivisa mushonga uyu kana kuda kuongororwa kwakakosha.

Heano mamiriro chaiwo apo edaravone ingasava yakakodzera:

Zvinopesana zvachose (haufaniri kutora edaravone):

• Allergy inozivikanwa kune edaravone kana zvinosanganiswa zvaro
• Chirwere chechiropa chakakomba kana kutadza kwechiropa
• Chirwere cheitsvo chekupedzisira chinoda dialysis
• Kuzvitakura kana kuyamwisa

Mamiriro anoda kungwarira kwakakosha:

• Matambudziko echiropa akapfava kusvika pakati nepakati
• Chirwere cheitsvo
• Nhoroondo yekuitika kwemuviri kwakanyanya
• Chirwere chemoyo kana kurova kwemoyo kusingaite
• Matambudziko ekufema kana chirwere chemapapu
• Matambudziko eropa

Mupi wehutano hwako achayerera mabhenefiti anogona kuwanikwa achienzanisa nenjodzi dziripo mumamiriro ako chaiwo. Vanogona kukurudzira kuongororwa kwakawanda kana mamwe marapirwo kana edaravone isiri yakakunakira.

Mazita eBrand eEdaravone

Edaravone inowanikwa pasi pemazita akawanda ebrand zvichienderana nenzvimbo yako uye chimiro chacho. Zita rebrand rinowanzo shandiswa reiyo oral form ndeye Radicava ORS (Oral Suspension), iyo ndiyo vhezheni inonyanya kurairwa muUnited States.

Iyo yekutanga intravenous form inongonzi Radicava. Zvese zviri zviviri zvinosanganisira chinhu chimwe chete chinoshanda asi zvinopihwa zvakasiyana. Chiremba wako achataura kuti ndeipi fomu uye brand yakakodzera chirongwa chako chekurapa.

Generic vhezheni dze edaravone dzinogona kuwanikwa mune ramangwana, izvo zvinogona kupa dzimwe sarudzo dzekurapa dzakachipa. Nguva dzose shandisa iyo chaiyo brand kana generic vhezheni yakarairwa nachiremba wako kuti uve nechokwadi chekuti unogamuchira chimiro chakarurama.

Zvimwe Zvingashandiswa Panzvimbo peEdaravone

Nepo edaravone iri rimwe remishonga mishoma yakatenderwa neFDA yeALS, kune mamwe mishonga nemaitiro anogona kufungwa. Riluzole imwe mishonga yakatenderwa zvakanyanya kurapa ALS inoshanda kuburikidza nemaitiro akasiyana.

Riluzole inobatsira kuderedza glutamate toxicity muuropi, iyo imwe nzira inobatanidzwa muALS kufambira mberi. Vamwe varwere vanogona kutora mishonga yese pamwe chete, nepo vamwe vachigona kushandisa imwe kana imwe zvichienderana nemhinduro yavo yega uye kushivirira.

Kunze kwemishonga, kutarisirwa kwakazara kweALS kunosanganisira physical therapy, occupational therapy, speech therapy, uye nutritional support. Aya marapirwo anotsigira anoshanda pamwe chete nemishonga kubatsira kuchengetedza hupenyu hwemhando yepamusoro uye basa kwenguva yakareba sezvinobvira.

Edaravone iri Nani Kudarika Riluzole?

Zvese edaravone ne riluzole zvinobatsira kurapa ALS, asi zvinoshanda nenzira dzakasiyana uye zvinogona kubatsira varwere vakasiyana. Pane kuti imwe ive nani kupfuura imwe, zvinowanzoonekwa sekurapa kunowedzerana kunogona kushandiswa pamwe chete.

Riluzole yanga iripo kwenguva refu uye ine data rakawanda rekuchengeteka kwenguva refu. Inoshanda nekuderedza glutamate toxicity, nepo edaravone ichitarisa kudzivirira antioxidant. Zvimwe zvidzidzo zvinoratidza kuti kusanganisa mishonga yese miviri kunogona kupa mabhenefiti akakura kupfuura kushandisa imwe chete.

Chiremba wako achafunga nezvezvinhu zvakaita sekufambira mberi kwechirwere chako, mamwe mamiriro ezvinhu ekurapa, migumisiro inogona kuitika, uye zvaunofarira iwe pachako paunenge uchisarudza kuti ndeipi kurapwa kana kusanganiswa kwekurapa kwakanakira iwe. Sarudzo inofanirwa kugara ichiitwa zvichienderana nemamiriro ako chaiwo.

Mibvunzo Inowanzo Bvunzwa Nezve Edaravone

Q1. Edaravone Yakachengeteka Here Kune Vanhu vane Chirwere Chemoyo?

Edaravone inogona kushandiswa muvanhu vane chirwere chemoyo, asi inoda kunyatsoongororwa uye kuongororwa nachiremba wako. Mushonga unogona kukanganisa rhythm yemoyo mune vamwe vanhu, saka chiremba wako achada kuongorora mamiriro ako chaiwo emoyo.

Kana uine chirwere chemoyo, chiremba wako anogona kukurudzira imwe cardiac monitoring panguva yekurapa. Izvi zvinogona kusanganisira electrocardiograms (ECGs) nguva dzose kuti utarise rhythm yemoyo wako uye uve nechokwadi chekuti mushonga hausi kukonzera chero shanduko dzinonetsa.

Vanhu vazhinji vane mamiriro emoyo vanogona kutora edaravone zvakachengeteka, asi sarudzo inoda kuyera mabhenefiti anogona kuitika eALS yako pamusoro pechero njodzi dzemoyo. Cardiologist yako uye neurologist vanofanirwa kushanda pamwe chete kuti vagadzire chirongwa chekurapa chakachengeteka kwauri.

Q2. Ndoitei kana ndikashandisa Edaravone yakawandisa netsaona?

Kana ukatora edaravone yakawanda kupfuura yakanyorerwa netsaona, fonera chiremba wako kana nzvimbo inobata chepfu nekukasira. Kutora mushonga wakawanda kunogona kuwedzera njodzi yako yezvinhu zvisingadiwi uye zvinogona kuda kuongororwa kwekurapa.

Usaedze "kugadzirisa" nekusvetuka mushonga wako unotevera. Pane kudaro, dzokera kune yako yenguva yekushandisa mushonga sezvakarairwa nachiremba wako. Chengeta zvakanaka kuti wakatora mushonga wakawanda sei uye wakautora rini.

Zviratidzo zvekutora edaravone yakawanda zvinogona kusanganisira kuwedzera kusvotwa, dzungu, kana kurwadziwa nemusoro. Kana ukaona zviratidzo zvakakomba sekufema kwakaoma, kurwadziwa muchipfuva, kana maitiro akakomba ekurwara, tsvaga rubatsiro rwekurapa nekukasira.

Q3. Ndingaita Sei Kana Ndikakanganwa Mushonga weEdaravone?

Kana ukakanganwa mushonga weedaravone, tora paunorangarira, kunze kwekunge yava nguva yekutora mushonga wako unotevera. Muchiitiko ichocho, svetuka mushonga wakakanganwa uye uenderere mberi nechirongwa chako chekushandisa mushonga.

Usambofa wakatora mishonga miviri panguva imwe chete kuti ugadzirise mushonga wakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yezvinhu zvisingadiwi. Kana iwe uchikanganwa mishonga kazhinji, funga kuseta maalarm efoni kana kushandisa chirongwa chemishonga kuti zvikubatsire kurangarira.

Kana iwe ukakanganwa mishonga yakawanda kana uine mibvunzo nezve mishonga yakakanganwa, fonera chiremba wako kuti uwane gwara. Kuenderana mukutora mushonga wako kwakakosha kuchengetedza mhedzisiro yawo yekudzivirira.

Q4. Ndingamira Rini Kutora Edaravone?

Sarudzo yekumira kutora edaravone inofanira kugara ichiitwa mukubvunzana nachiremba wako. Mushonga uyu unowanzoenderera mberi kwenguva yakareba sezvaunogona kuutambira zvakanaka uye chiremba wako anotenda kuti uri kupa rubatsiro kuALS yako.

Chiremba wako achagara achiongorora mhinduro yako kumushonga uye anogona kukurudzira kumira kana ukaona zvinhu zvisingadiwi zvisingatambiriki kana kana mamiriro ako akafambira mberi kusvika panguva iyo mushonga usisiri kubatsira.

Vamwe varwere vangada kumisa edaravone kwenguva pfupi kana vakawana mamwe mamiriro ezvinhu ekurapa kana vachida kutora mamwe mishonga inoshanda nayo. Chiremba wako achakutungamira kuburikidza nechero shanduko dzekurapa uye kukubatsira kunzwisisa chikonzero chekurudziro yavo.

Q5. Ndingatora Edaravone nemimwe mishonga yeALS here?

Edaravone inogona kutotorwa pamwe chete nemimwe mishonga yeALS yakaita seriluzole, uye varwere vazhinji vanobatsirwa nenzira iyi yekubatanidza. Chiremba wako achanyatsoongorora mishonga yako yese kuti ave nechokwadi chekuti inoshanda zvakanaka pamwe chete.

Mishonga mimwe inogona kushanda needaravone kana kukanganisa mashandiro ayo. Nguva dzose zivisa mupi wako wehutano nezve mishonga yese, zvinowedzera, uye zvinodhaka zvisingatengwe nemishonga yaunotora usati watanga edaravone.

Chiremba wako angada kugadzirisa madosi kana nguva yemimwe mishonga paunotanga edaravone. Vachakutarisa zvakanyanya kuti vaone chero kushamwaridzana uye vachaita shanduko dzinodiwa kuti vave nechokwadi chekuti unowana mubatanidzwa wekurapa wakachengeteka uye unoshanda.