Chii chinonzi Ezogabine: Zvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Ezogabine mushonga unorwisa kubatwa nepfari uyo waimbove uchishandiswa kurapa pfari muvanhu vakuru. Zvisinei, mushonga uyu wakamiswa uye hauchawanikwi kuti unyorerwe mishonga mitsva nekuda kwezvikonzero zvekuchengeteka. Kana uri kutsvaga nezve ezogabine, unogona kunge uchitsvaga ruzivo nezve kurapwa kwaimboveko kana kutsvaga dzimwe nzira dzekudzora kubatwa nepfari.

Kunzwisisa mishonga yakamiswa kunogona kukubatsira kuita sarudzo dzine ruzivo nezve sarudzo dzako dzazvino dzekurapa. Ngatitsvagei kuti ezogabine yaive chii, nei isingachawanikwi, uye izvi zvinorevei pakuchengetwa kwekubatwa nepfari nhasi.

Chii chinonzi Ezogabine?

Ezogabine yaive mushonga unorwisa pfari uyo waishanda zvakasiyana nemimwe mishonga yekubatwa nepfari. Yakagadzirirwa zvakananga kurapa kubatwa nepfari kunotanga munzvimbo imwe chete muvanhu vakuru kana mimwe mishonga isingapiwe kudzora kwakakwana.

Mushonga uyu waive mune kirasi yakasarudzika yemishonga inonzi potassium channel openers. Funga nezvazvo sechinhu chakakosha chinogona kuvhura nzira dzakatarwa mumasero ako ehuropi, ichibatsira kudzikamisa mabasa emagetsi anopfuura akawandisa anokonzera kubatwa nepfari.

Ezogabine yakatenderwa neFDA muna 2011 asi yakazvibvisa pachayo mumusika muna 2017. Kubviswa uku kwakaitika mushure mekunge vatsvagiri vawana migumisiro yakaipa yakakomba iyo yakapfuura mabhenefiti emushonga kune vazhinji varwere.

Ezogabine yaishandiswa chii?

Ezogabine yaive ichinyorerwa sekuwedzera kurapwa kwevanhu vakuru vane kubatwa nepfari kunotanga. Aya ndiwo kubatwa nepfari kunotangira munzvimbo imwe chete yehuropi uye inogona kana kusapararira kune dzimwe nzvimbo.

Vanachiremba vaiwanzofunga nezve ezogabine kana varwere vasiri kuwana kudzora kwakakwana kubva kumishonga yavo iripo. Haina kumbove yakagadzirirwa seyekutanga kurapwa, asi pane imwe sarudzo yevanhu vane pfari yakaoma kudzora.

Mushonga uyu wakabvumirwa zvakananga kuvakuru vane makore 18 zvichikwira. Haukabvumirwa kuvana, uye vanachiremba vaiwanzouchengetera kune nyaya idzo dzimwe nzira dzekurapa dzakaedzwa kutanga.

Ezogabine Yakashanda Sei?

Ezogabine yaishanda nekuzarura nzira dzakakosha dze potassium mumaseru ehuropi anonzi KCNQ channels. Chiito ichi chakabatsira kugadzirisa mabasa emagetsi mu neurons, zvichiita kuti zvisanyanye kupisa zvisina kujairika uye kukonzera kubatwa.

Maitiro aya aive akasiyana pakati pemishonga yekubatwa panguva iyoyo. Mamwe mazhinji emishonga inorwisa kubatwa inoshanda nekudzivisa sodium channels kana kukanganisa mamwe masisitimu e neurotransmitter, saka ezogabine yakapa imwe nzira yekudzora kubatwa.

Mushonga uyu wakaonekwa seunoshanda zvine mwero pakushandiswa kwawo. Zvisinei, mabhenefiti awo akasiyana haana kusimba zvakakwana kuti akunde njodzi dzakakomba dzakazozivikanwa mumakore awo pamusika.

Ezogabine Yaifanira Kutora Sei?

Sezvo ezogabine isisipo, ruzivo urwu runopihwa kuitira kuti ruzive nhoroondo chete. Mushonga uyu waiwanzotorwa katatu pazuva uine kana pasina chikafu.

Varwere vaiwanzotanga nedosi yakaderera iyo yaizowedzerwa zvishoma nezvishoma kwemavhiki akati wandei. Kuwedzera uku kunononoka kwakabatsira kuderedza mhedzisiro yezvinhu zvakashata uku tichitsvaga dose inoshanda zvakanyanya kumunhu mumwe nemumwe.

Mushonga uyu waiuya muchimiro chepiritsi uye waifanira kumedzwa wese. Kutyora kana kupwanya mahwendefa kunogona kukanganisa nzira iyo mushonga wacho wakatambirwa uye zvinogona kukonzera mhedzisiro yezvinhu zvakashata.

Ndezvipi Zvaive Zvakaipa ZveEzogabine?

Ezogabine yakakonzera mhedzisiro yezvinhu zvakashata zvakakomba izvo zvakazopedzisira zvaita kuti ibviswe pamusika. Nyaya dzakanyanya kukomba dzaisanganisira shanduko kune retina muziso uye ruvara rweganda rwebhuruu-grey.

Heano mhedzisiro yezvinhu zvakashata zvakava zvinokonzera kunetseka panguva ye ezogabine pamusika:

• Kusanzwisisika kwemaziso kunogona kukanganisa kuona
• Ruvara rwebhuruu-grey rweganda, miromo, uye nzara
• Ruvara rwebhuruu-grey rwevachena vemaziso
• Kutenderera nemusoro nekushungurudzika
• Kuneta nekushaya simba
• Matambudziko ekubatana uye kuenzanisa
• Kutadza kuyeuka nekutarisa
• Kuchengetwa kweweti (kutadza kubvisa weti zvakakwana)

Ruvara rweganda nemaziso zvakanyanya kunetsa nekuti zvaiita sezvairamba zvichingovapo mumamiriro akawanda. Shanduko idzi hadzina kudzoka kunyangwe mushure mekumisa mushonga, izvo zvakabatsira kusarudza kubvisa ezogabine pamusika.

Ndiani Asingafanire Kunge Akatora Ezogabine?

Mapoka akati wandei evanhu akakurudzirwa kuti vasatore ezogabine nekuda kwenjodzi dzakawedzera. Chero ani zvake aine matambudziko emaziso aripo kana nhoroondo yechirwere chemaziso kazhinji haana kuonekwa semunhu akakodzera mushonga uyu.

Vanhu vane mamiriro emoyo akati wandei, matambudziko eitsvo, kana chirwere chechiropa vakatarisanawo nenjodzi dzakakwirira neezogabine. Mushonga uyu unogona kuwedzera mamiriro aya kana kubatana nemamwe marapirwo.

Vakadzi vane pamuviri nevaya vari kuronga kuva nepamuviri vakajairika kurairwa kuti vasatore ezogabine kunze kwekunge mabhenefiti achinyatso kukurira njodzi. Mushonga uyu unogona kukuvadza mwana ari kukura.

Ezogabine Mazita eBrand

Ezogabine yakatengeswa pasi pezita rebrand Potiga muUnited States. Mune dzimwe nyika, yaizivikanwa nezita rebrand Trobalt, kunyangwe yakamiswa pasi rese.

Mazita ese ebrand aireva mushonga mumwe chete une chinhu chimwe chete chinoshanda. Mazita akasiyana aingokonzerwa nemaitiro akasiyana ekushambadzira munzvimbo dzakasiyana.

Sezvo mushonga wakabviswa pasi rese, hapana zita rebrand rinowanikwa kumishonga mitsva chero kupi zvako pasi rose.

Ezogabine Zvimwe Zvingasarudzwa

Pane dzimwe nzira dzinoshanda dzekuti vanhu vaive vakakodzera ezogabine vashandise. Mishonga yemazuva ano yekudzivirira kubatwa nemusoro inopa kuchengeteka kuri nani vachichengetedza kushanda zvakanaka pakubatwa nemusoro kunotanga chikamu.

Dzimwe nzira dzinoshandiswa kazhinji dzinosanganisira:

• Lacosamide (Vimpat) - inoshanda pamakanzuru esodium iine mativi mashoma
• Perampanel (Fycompa) - inotarisa imwe sisitimu yehuropi
• Brivaracetam (Briviact) - ine hukama nelevetiracetam asi iine zvimwe zvinhu
• Eslicarbazepine (Aptiom) - imwe sodium channel blocker
• Cenobamate (Xcopri) - imwe sarudzo itsva iine nzira dzakawanda

Nyanzvi yako yetsinga dzehuropi inogona kubatsira kuona kuti ndeipi imwe nzira ingashanda zvakanyanya kune mamiriro ako chaiwo. Sarudzo inoenderana nerudzi rwekubatwa kwako nemusoro, mamwe mishonga yaunotora, uye nhoroondo yako yezvokurapa.

Pane Imwe Sarudzo Yakanaka Kupfuura Ezogabine Here?

Hongu, ikozvino pane mishonga yakati wandei yekubatwa nemusoro inotariswa kuva yakachengeteka uye kazhinji inoshanda zvakanyanya kupfuura ezogabine yaive. Dzimwe nzira itsva hadzina njodzi imwechete yekushanduka kweganda zvachose kana kukuvadzwa kwemaziso.

Mishonga yakaita se lacosamide ne perampanel yakaratidza mhedzisiro yakanaka mumiedzo yekiriniki yekubatwa nemusoro kunotanga chikamu. Kazhinji vane mativi anogoneka uye haadi kuongororwa kwakanyanya kwaiitwa ezogabine.

Kubviswa kwezogabine kwakavhura mukana wezvimwe zvirongwa zvekutarisira zvirwere zviri nani. Makambani emishonga akagadzira mishonga mitsva yekudzivirira kubatwa nemusoro mumakore achangopfuura ayo anopa kuchengeteka kuri nani uye kushanda zvakanaka.

Mibvunzo Inowanzo Bvunzwa Nezve Ezogabine

Ezogabine yakachengeteka here kune vanhu vane chirwere cheshuga?

Ezogabine haichawanikwi, asi payaipihwa, vanhu vane chirwere cheshuga vaigona kuitora zvakachengeteka. Zvisinei, mamwe mativi akakomba emishonga akaita kuti ibviswe pamusika zvisinei nekuti munhu ane chirwere cheshuga here kana kwete.

Kana uine chirwere cheshuga uye pfari, chiremba wako anogona kukurudzira mishonga iripo yekudzivirira pfari yakachengeteka kune vane chirwere cheshuga uye inoshanda pakudzora pfari.

Ndoita sei kana ndakatora ezogabine yakawanda netsaona?

Sezvo ezogabine isisawanikwi, mamiriro aya haafaniri kuitika nemishonga mitsva. Kana iwe uine mukana wekuwana mapiritsi ekare eezogabine, chero overdose ingave njodzi yekurapa inoda kutarisirwa kuchipatara nekukurumidza.

Zviratidzo zveezogabine overdose zvinogona kusanganisira kuvhiringidzika kwakanyanya, kurasikirwa kwekubatana, kuoma kufema, uye kurasikirwa nekuziva. Kurapa kwekurapa kwechimbichimbi kwaizova kwakakosha.

Ndoita sei kana ndakarasikirwa nemushonga weezogabine?

Ruzivo urwu rwakare sezvo ezogabine yakamiswa. Pakutanga, varwere vaiudzwa kuti vatore mushonga wakarasika pakarepo pavairangarira, kunze kwekunge yaive pedyo nenguva yemushonga unotevera.

Mutemo wese waive wekusambowedzera mishonga kuti uzadze imwe yakarasika. Kana iwe uchitora chero mushonga wepfari, tevera mirairo chaiyo yachiremba wako yemishonga yakarasika.

Varwere vaigona kumira rini kutora ezogabine?

Varwere vaitora ezogabine payakabviswa vakashanda nachiremba vavo kuti vachinje zvishoma nezvishoma kumimwe mishonga. Kumisa chero mushonga wepfari kamwe kamwe kunogona kukonzera pfari ine njodzi.

Kuchinja kwacho kazhinji kwaibatanidza kuderedza zvishoma nezvishoma chiyero cheezogabine panguva imwe chete vachitanga mushonga wekutsiva. Iyi nzira yaigara ichitora mavhiki akati wandei kuti ipedzwe zvakachengeteka.

Nei ezogabine yakanyatsobviswa mumusika?

Ezogabine yakabviswa nekuda kwemigumisiro yakakomba, yechigarire yakazozivikanwa mushure memakore akati wandei ekushandisa. Ruvara rweganda rwebhuruu-grey uye shanduko dzeretinal dzakanga dzisingadzokeri kana vanhu vakamira kutora mushonga.

Shanduko idzi dzechigarire, pamwe chete nekuwanikwa kwemamwe mishonga akachengeteka, zvakaita kuti mugadziri azvibvise ega ezogabine. Njodzi dzakawedzera zvakanyanya kana dzichienzaniswa nemabhenefiti aipiwa nemushonga uyu.