Chii chinonzi Fenfluramine: Zvayakashandiswa, Madosi, Migumisiro Yakaipa nezvimwe

Fenfluramine mushonga unopiwa nachiremba unonyanya kushandiswa kurapa zvirwere zvevanhu vane Dravet syndrome, rudzi rusingawanzoitiki uye rwakakomba rweepilepsy. Mushonga uyu unoshanda nekubatsira kuderedza kuwanda uye kuoma kwezvirwere, kunyanya zvirwere zvakaoma kudzora izvo zvinoratidza mamiriro aya.

Nepo fenfluramine yakamboshandiswa kurasikirwa uremu makumi emakore apfuura, kushandiswa kwemazuva ano kwekurapa kunonyanya kufunga nezve manejimendi ezvirwere. Mushonga waungasangana nawo nhasi wakagadzirirwa zvakanyanya uye wakabvumidzwa kurapa epilepsy, kwete zvinangwa zvekudzora uremu.

Chii chinonzi Fenfluramine?

Fenfluramine mushonga unoburitsa serotonin unokanganisa makemikari ehuropi kubatsira kudzora zvirwere. Iyo ndeyeboka remishonga inoshanda nekuwedzera mazinga e serotonin munzvimbo dzakatarwa dzehuropi dzine basa rekuzununguka.

Mushonga uyu unouya semhinduro yemuromo yaunotora nemuromo. Yakagadzirirwa zvakanyanya vanhu vane Dravet syndrome, rudzi rwegenetiki rweepilepsy runowanzo kutanga muhucheche uye runogona kuve rwakaoma kwazvo kurapa nemimwe mishonga yezvirwere.

Chiremba wako achanyatso tarisa mhinduro yako kumushonga uyu, sezvo uchida nguva dzose dzekutarisa kuti uve nechokwadi chekuti iri kushanda nemazvo uye zvakachengeteka kumamiriro ako chaiwo.

Fenfluramine inoshandiswa nei?

Fenfluramine inonyanya kurairwa kuderedza kuwanda kwezvirwere muvanhu vane Dravet syndrome. Iyi mamiriro eepilepsy asingawanzoitiki e genetic anokanganisa vanhu vanenge 1 kubva pa15,000 kusvika ku20,000 uye kazhinji haipinduri zvakanaka kumishonga yakajairika yezvirwere.

Mushonga uyu unonyanya kubatsira nekuzununguka kwenguva refu, kwakanyanya kunoratidza Dravet syndrome. Zvirwere izvi zvinogona kuve zvine njodzi uye zvinokanganisa hupenyu hwezuva nezuva, zvichiita kuti kurapwa kunoshanda kuve kwakakosha kune zvese kuchengeteka uye mhando yehupenyu.

Mune dzimwe nguva, vanachiremba vanogonawo kufunga nezve fenfluramine kune dzimwe mhando dzisingawanzoitiki dzekurwara, asi izvi zvaizova kushandiswa kunze kwechinyorwa kunoda kutarisirwa kwechiremba kwakanyatsojeka uye hurukuro pamusoro pezvakanakira nenjodzi dzinogona kuitika.

Fenfluramine Inoshanda Sei?

Fenfluramine inoshanda nekuwedzera mazinga e serotonin muuropi hwako, kunyanya munzvimbo dzinodzora chiitiko chekurwara. Funga nezve serotonin semutumwa wemakemikari anobatsira maseru etsinga kuti ataure zvakanyanya uye zvakadzikama.

Mishonga iyi inoonekwa seyepakati pesimba maererano nekudzora kurwara. Haina kushanda nenzira imwechete semamwe mishonga yekurwara, ndosaka ichibatsira kana mamwe marapirwo asina kupa kutonga kwakakwana kwekurwara.

Kuwedzera kwe serotonin kunobatsira kugadzirisa chiitiko chemagetsi muuropi hwako, zvichiita kuti kurwara kusaite. Iyi nzira inotora nguva kuti ivake muhurongwa hwako, ndosaka usingaone zvizere zvinobatsira nekukasira.

Ndingatora Sei Fenfluramine?

Tora fenfluramine sezvinorayirwa nachiremba wako, kazhinji kaviri pazuva uine kana pasina chikafu. Mushonga uyu unouya semhinduro yemuromo yaunoyera zvakanyatso kushandisa mudziyo wekuyera wakapihwa.

Unogona kutora mushonga uyu nemvura, mukaka, kana muto kana izvo zvichiita kuti zvive nyore kumedza. Hapana zvirambidzo zvakakosha zvekudya, asi kuitora nechikafu kunogona kubatsira kuderedza chero dumbu rinogona kuitika.

Zvakakosha kutora zvikamu zvako panguva imwechete zuva rega rega kuti uchengetedze mazinga akagadzikana mumuviri wako. Gadzira zviyeuchidzo kana zvichidikanwa, sezvo nguva dzose dzichibatsira mushonga kushanda zvakanyanya.

Chiremba wako anogona kukutanga pamwero wakaderera uye zvishoma nezvishoma kuwedzera zvichienderana nekuti unopindura sei uye chero mhedzisiro yaunowana. Usambofa wakachinja chiyero chako usati wataura nemupi wehutano wako kutanga.

Ndingatora Kwenguva Yakareba Sei Fenfluramine?

Fenfluramine inowanzoitwa kurapwa kwenguva refu yekudzora kubatwa kwemwoyo muDravet syndrome. Vanhu vazhinji vanofanira kuramba vachitora kusvika rinopera kuti vachengetedze kubatwa kwemwoyo, sezvo kumira kamwe kamwe kunogona kukonzera kuwedzera kwekubatwa kwemwoyo.

Chiremba wako achagara achiongorora kuti mushonga uri kushanda zvakanaka sei kwauri, kazhinji mwedzi mishoma yega yega pakutanga, wobva wava kushoma kana kubatwa kwemwoyo kwako kwadzora. Kuongororwa uku kunobatsira kuona kana fenfluramine ichiramba iri sarudzo yakakodzera yemamiriro ako ezvinhu.

Kana iwe nachiremba wako mukasarudza kumisa fenfluramine, maitiro aya anoda kuronga zvakanaka uye kuderedzwa kwemishonga zvishoma nezvishoma. Kumisa mishonga yekubatwa kwemwoyo kamwe kamwe kunogona kuva nenjodzi uye kunogona kukonzera kubatwa kwemwoyo kakawanda kana kwakanyanya.

Ndezvipi Zvakaipa zveFenfluramine?

Semishonga yese, fenfluramine inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachizvigamuchira zvakanaka. Mhedzisiro yakajairika inowanzoita nyoro uye inowanzoita nani sezvo muviri wako uchigadzirisa kumishonga.

Heano mhedzisiro yaungangove uchiwana, uchifunga kuti vanhu vazhinji vane zvishoma kana kusava nemhedzisiro inonetsa:

• Kuderera kwechido uye kurasikirwa uremu
• Kuneta kana kunzwa kuneta kupfuura zvakajairika
• Kuzara kana kurara
• Dhayareya kana zvigaro zvakasununguka
• Kuvharika
• Fivha
• Zvirwere zvepamusoro zvekufema

Izvi zvinowanzoitika mhedzisiro zvinowanzoita zvishoma kuoneka mushure memavhiki mashoma sezvo muviri wako uchigadzirisa kumishonga. Zvisinei, zivisa chiremba wako kana vachiramba kana kuva dambudziko.

Zvimwe zvisingawanzoitiki asi zvakanyanya mhedzisiro inoda kutariswa kwekurapa nekukurumidza. Kunyange izvi zvisingawanzoitiki, zvakakosha kuziva nezvazvo:

• Matambudziko emavharuvhu emoyo kana moyo unogunun'una
• Pulmonary hypertension (kumanikidzwa kweropa rakakwira mumapapu)
• Kuchinja kwakakosha kwemanzwiro kana kuora mwoyo
• Maitiro akakomba ekugadzirisa muviri
• Glaucoma kana kuwedzera kumanikidzwa kwemaziso

Chiremba wako achakutarisa zvakanyatsonaka kuti uone mhedzisiro yakakomba idzi kuburikidza nekutarisa nguva dzose uye anogona kuraira bvunzo dzemoyo nguva nenguva kuti ave nechokwadi chekuti mushonga uyu unoramba uri wakachengeteka kwauri.

Ndiani Asingafaniri Kutora Fenfluramine?

Fenfluramine haikodzeri munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuvimbisa. Mamwe mamiriro ehutano anoita kuti mushonga uyu usave wakachengeteka kana kushanda zvishoma.

Haufaniri kutora fenfluramine kana uine chero mamiriro aya, sezvo angawedzera njodzi yako yematambudziko akakomba:

• Chirwere chemavharuvhu emoyo kana kuchema kwemoyo
• Pulmonary hypertension
• Chirwere chakakomba chechiropa kana itsvo
• Glaucoma kana kuwedzera kumanikidzwa kwemaziso
• Kuziva allergy ku fenfluramine kana mishonga yakafanana

Uyezve, udza chiremba wako nezve mishonga yese yaunotora, sezvo fenfluramine inogona kuita nemimwe mishonga, kunyanya mamwe mishonga inokanganisa serotonin uye mamwe antidepressants.

Kuzvitakura nekuyamwisa zvinoda kufunga kwakakosha. Kunyange zvazvo kudzora kubatwa panguva yekuzvitakura kwakakosha, chiremba wako achada kuyera mabhenefiti achipesana nenjodzi dzinogona kuitika kumwana wako.

Mazita eFenfluramine Brand

Fenfluramine inowanikwa pasi pezita rekuti Fintepla muUnited States. Iyi ndiyo chaiyo formulation yakatenderwa neFDA yekurapa kubatwa kwakabatana neDravet syndrome.

Zita remhando yeFintepla rinobatsira kusiyanisa mushonga uyu wemazuva ano wekubatwa kubva kune akare fenfluramine formulations akamboshandiswa kurasikirwa uremu asi haasisipo. Nguva dzose shandisa zita remhando chaiyo uye formulation chiremba wako anoraira.

Mhando dzakajairika dze fenfluramine yekurapa kubatwa hadzisati dzichiwanzowanikwa, saka mazhinji mapepa achazadzwa nezita remhando yeFintepla.

Fenfluramine Alternatives

Mishonga mimwe yakawanda inogona kubatsira kudzora mafivha muDravet syndrome, kunyangwe sarudzo yakanakisa ichitsamira pamhinduro yako pachako uye nhoroondo yekurapa. Chiremba wako angangofunga nezveimwe nzira idzi kana fenfluramine isina kukodzera kana kushanda kwauri.

Imwe nzira dzakajairika dzinosanganisira stiripentol, clobazam, valproic acid, uye topiramate. Imwe neimwe inoshanda zvakasiyana muuropi uye inogona kushanda zvakanyanya kana zvishoma zvichienderana nemaitiro ako chaiwo emafivha uye zvimwe zvehutano.

Mishonga yakavakirwa paCannabis senge cannabidiol (CBD) inobvumidzwawo yeDravet syndrome uye inogona kufungwa seimwe nzira kana zvinowedzerwa ku fenfluramine, zvichienderana nemamiriro ako ezvinhu.

Usamboshandura mishonga usina kushanda pedyo nachiremba wako, sezvo mishonga yefivha inoda kuchinjiswa zvakanyatso kudzivirira mafivha kana kukanganisa kwekubvisa.

Ko Fenfluramine Zviri Nani Kupfuura Zvimwe Zvokurapa Zvemafivha?

Fenfluramine inopa mabhenefiti akasiyana kune vanhu vane Dravet syndrome, kunyanya nekuti inoshanda kuburikidza nemaitiro akasiyana pane mamwe akawanda emishonga yefivha. Iyi nzira yakasiyana inogona kubatsira zvakanyanya kana mamwe marapirwo asina kupa kutonga kwakakwana kwemafivha.

Zvidzidzo zvekiriniki zvinoratidza kuti fenfluramine inogona kuderedza zvakanyanya kuwanda kwemafivha muvanhu vazhinji vane Dravet syndrome, kazhinji ichipa kutonga kuri nani pane mamwe mishonga yechinyakare yefivha yega. Zvisinei,

Ko Fenfluramine Yakachengeteka Kushandisa Kwenguva Refu?

Hongu, fenfluramine yakagadzirirwa kushandiswa kwenguva refu muvanhu vane Dravet syndrome, uye zvidzidzo zvinotsigira kuchengeteka kwayo kana ichishandiswa pasi pekutariswa kwechiremba. Chiremba wako achakutarisa nguva dzose nekutarisa uye bvunzo dzenguva nenguva kuti ave nechokwadi chekuchengeteka kwakakwana.

Kiyi yekushandisa kwenguva refu zvakachengeteka ndeyekutarisa nguva dzose, kunyanya bvunzo dzemoyo, sezvo fenfluramine dzimwe nguva inogona kukanganisa mavharuvhu emoyo. Aya ma check-ups anobatsira kubata chero nyaya dzinogona kuitika pakutanga kana dzichigona kubatwa zvakanyanya.

Ndoitei Kana Ndikatora Fenfluramine Yakawandisa Netsaona?

Kana iwe netsaona ukatora fenfluramine yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira, kunyangwe ukaita zvakanaka. Kutora zvakanyanya kunogona kukanganisa moyo wako, BP yako, uye basa rehuropi.

Usamirira kuti zviratidzo zviite vasati vatsvaga rubatsiro, sezvo mamwe mhedzisiro yekupfuudzwa inogona kusazivikanwa nekukasira. Chengeta bhodhoro remushonga newe paunotsvaga kutariswa kwekurapa kuitira kuti vanopa hutano vazive chaizvo zvawakatora uye zvakawanda sei.

Ndoitei Kana Ndikakanganwa Dose yeFenfluramine?

Kana iwe ukakanganwa dose, itore nekukasira paunorangarira, kunze kwekunge yava nguva yechikamu chako chinotevera. Muchiitiko ichocho, skip the missed dose uye uenderere mberi nechirongwa chako chekushandisa.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yemhedzisiro. Kana iwe uchikanganwa madosi kazhinji, funga kuseta zviyeuchidzo zvefoni kana kushandisa murongi wepiritsi kuti ubatsire kuchengetedza kuenderana.

Ndingamira Rini Kutora Fenfluramine?

Unofanirwa kungomira kutora fenfluramine pasi pekutungamirirwa nechiremba wako nekutariswa. Kumira kamwe kamwe kunogona kutungamira mukuwedzera kwekuita kwekubata, izvo zvinogona kuva njodzi kuvanhu vane Dravet syndrome.

Kana iwe nachiremba wako mukasarudza kumisa fenfluramine, maitiro acho anowanzo sanganisira kuderedza zvishoma nezvishoma mushonga wako kwemavhiki akati wandei kana mwedzi. Iyi nzira yekungwarira inobatsira kuderedza njodzi yekubviswa kwemakakatanwa uchitarisa maitiro ako ekuchinja.

Ndingatyaira Here Ndichitora Fenfluramine?

Kutyaira uchitora fenfluramine zvinoenderana nekuti makakatanwa ako anodzora sei uye kuti mushonga unokukanganisa sei iwe pachako. Mushonga uyu unogona kukonzera kurara kana kuneta kune vamwe vanhu, izvo zvinogona kukanganisa kugona kutyaira.

Kurukurai kuchengeteka kwekutyaira nachiremba wako, sezvo vachigona kukubatsira kunzwisisa zvese zvinodzora kutyaira zvine chekuita nemakakatanwa munzvimbo yako uye kana mhedzisiro ye fenfluramine ingakanganisa kugona kwako kutyaira zvakachengeteka. Vanhu vazhinji vane makakatanwa anodzorwa zvakanaka vanogona kutyaira, asi izvi zvinoda kuongororwa kwemishonga kwemunhu mumwe nemumwe.