Chii chinonzi Fidaxomicin: Zvayinoshandiswa, Mishonga, Matambudziko, nezvimwe zvakawanda

Fidaxomicin mushonga wemishonga unotarisa chirwere chakakomba chematumbu chinonzi C. difficile colitis. Mushonga uyu unoshanda zvakasiyana nemamwe mabhakitiriya nekuti unogara mudumbu rako, uchirwisa mabhakitiriya anokuvadza ipapo panowanikwa dambudziko racho pasina kukanganisa mabhakitiriya anobatsira mumuviri wako wese.

Chii chinonzi Fidaxomicin?

Fidaxomicin mushonga wemishonga wakagadzirirwa kurapa Clostridioides difficile (C. diff) infections mumukoloni mako. Kusiyana nemishonga yakawanda inoshanda mumuviri wako wese, fidaxomicin ndiyo inonzi nachiremba "narrow-spectrum" antibiotic inonyanya kushanda mudumbu rako.

Nzira iyi inonyanya kushanda nekuti C. diff infections inoitika kana mabhakitiriya anokuvadza akawanda mumumatumbu ako, kazhinji mushure mekunge mamwe mabhakitiriya akanganisa mabhakitiriya ako echisikigo mudumbu. Funga nezve fidaxomicin sechishandiso chechokwadi pane kuti chive chihuri kana zvasvika pakurwisa chirwere ichi.

Mushonga uyu ndewemhando yemishonga inonzi macrocyclics, iyo ine chimiro chakasiyana-siyana chakaita seringi chinovabatsira kubatana nekumisa C. diff mabhakitiriya kubva pakuzara. Iyi dhizaini yakakosha inobvumira fidaxomicin kushanda zvakanaka ichinyanya kunyoro pamabhakitiriya ako anobatsira mudumbu.

Chii chinoshandiswa Fidaxomicin?

Fidaxomicin inorapa Clostridioides difficile-associated diarrhea (CDAD) muvanhu vakuru nevana vane mwedzi 6 nekukura. Chirwere ichi chinokonzera manyoka akakomba uye kuzvimba kwematumbu kunogona kubva pakusagadzikana kusvika pakutyisa kana zvikasabatwa.

Unogona kuda fidaxomicin kana ukawana C. diff colitis mushure mekutora mamwe maantibiotics echimwe chirwere. Izvi zvinoitika nekuti maantibiotics dzimwe nguva anogona kuuraya mabhakitiriya ako anokudzivirira mudumbu, achigadzira nzvimbo iyo C. diff inogona kubudirira uye kugadzira chepfu inokuvadza colon yako.

Chiremba wako anowanzo nyora fidaxomicin kana uine chirwere cheC. diff chakavimbiswa kuburikidza nekuyedzwa kwematsutso, kunyanya kana wanga uine zvirwere zvinodzoka kana usina kupindura zvakanaka kune mamwe marapirwo. Mushonga uyu unokosha zvikuru pakudzivirira chirwere kuti chisadzoke, icho chiri dambudziko rakajairika neC. diff.

Mune zvimwe zviitiko, vanachiremba vanogona kusarudza fidaxomicin semushonga wekutanga wezvirwere zvakakomba zveC. diff kana kune varwere vari panjodzi huru yekudzoka. Izvi zvinosanganisira vanhu vakuru, vanhu vane immune systems dzakakuvadzwa, kana avo vakave nezviitiko zvakawanda zvekare.

Fidaxomicin Inoshanda Sei?

Fidaxomicin inoshanda nekudzivisa maitiro akakosha ayo mabhakitiriya eC. diff anoda kuti awande uye ararame. Inonyanya kunangana ne enzyme inonzi RNA polymerase iyo mabhakitiriya anoshandisa kugadzira mapurotini akakosha pakukura kwavo nekubereka.

Kana fidaxomicin yapinda mudumbu rako, inoramba yakanyanya mudumbu rako panzvimbo yekutorwa muropa rako. Izvi zvinoreva kuti inogona kuendesa huwandu hwakawanda hwemushonga zvakananga kwainobata mabhakitiriya eC. diff, ichideredza mhedzisiro pamabhakitiriya mune dzimwe nzvimbo dzemuviri wako.

Mushonga uyu unoonekwa seune simba zvishoma uye unoshanda zvakanyanya kurwisa C. diff. Chinoita kuti chikoshe zvikuru kusarudza kwayo - inonangana nemabhakitiriya eC. diff zvine hasha zvikuru kupfuura zvaanokanganisa mabhakitiriya ako anobatsira mudumbu, achibatsira kuchengetedza chiyero chako chekugaya chikafu.

Chiito ichi chinorevawo kuti fidaxomicin ine mukana mudiki wekugadzira kuramba kwemishonga inopesana nehutachiona kana ichienzaniswa nemishonga yakakura. Mushonga uyu unoramba uchishanda kunyangwe uchinge wapedza mushonga wako, sezvo uchikwanisa kuramba uchishanda mudumbu rako kwemazuva akati wandei.

Ndingatora sei Fidaxomicin?

Tora fidaxomicin sezvinorairwa nachiremba wako, kazhinji 200 mg kaviri pazuva kwemazuva gumi. Unogona kuitora uine chikafu kana usina, asi kuitora uine chikafu chakareruka kunogona kubatsira kuderedza chero kusagadzikana mudumbu kwaungave uchiita.

Medza mahwendefa ese nemvura yakawanda - usapwanye, utaune, kana kuapwanya sezvo izvi zvinogona kukanganisa mashandiro emushonga. Edza kutora mishonga yako panguva imwe chete zuva rega rega, uchiisa nguva inenge maawa gumi nemaviri kuti uchengetedze mazinga akagadzikana mumuviri wako.

Haufaniri kudzivisa chero chikafu chakananga paunenge uchitora fidaxomicin, asi kudya chikafu chakareruka kunogona kubatsira hurongwa hwako hwekugaya chikafu kupora kubva kuC. diff infection. Zvikafu zvakaita sebhanana, mupunga, applesauce, uye toast zvinowanzo kuve nyore kushivirira panguva yekurapa.

Kana uri kutora mimwe mishonga, isa nguva inenge maawa maviri kubva ku fidaxomicin kana zvichibvira. Izvi zvinobatsira kudzivirira chero kupindirana kunogona kuitika uye inovimbisa kuti mushonga wega wega unogona kushanda nemazvo.

Ndingatora Fidaxomicin Kwenguva Yakareba Sei?

Vanhu vazhinji vanotora fidaxomicin kwemazuva gumi chete, iyo ndiyo nguva yakajairika iyo zvidzidzo zvekurapa zvakaratidza kuti zvinonyanya kushanda. Zvakakosha kupedzisa mushonga wese kunyangwe ukatanga kunzwa zviri nani mushure memazuva mashoma.

Unogona kuona kuvandudzwa kwezviratidzo zvako mukati me2-3 mazuva ekutanga kurapwa, asi mabhakitiriya anogona kuripo uye anogona kukuvadza kana ukamisa mushonga kare. Kumisa nekukurumidza kunowedzera njodzi yako yekuti hutachiona hudzoke, izvo zvinogona kuve zvakaoma kurapa.

Muzviitiko zvisingawanzoitiki, chiremba wako angachinja nguva yekurapa zvichienderana nemamiriro ako chaiwo, sekukomba kwehutachiona hwako kana hutano hwako hwese. Zvisinei, vazhinji varwere vachanamatira kuronga kwemazuva gumi kwakajairika kuti vawane mhedzisiro yakanaka.

Kusiyana nemamwe marapirwo eC. diff, fidaxomicin kazhinji haidi makosi akawedzerwa kana hurongwa hwekutapira. Zvivakwa zvemuti uyu zvakasiyana zvinoita kuti urambe uchishanda kwemazuva akati wandei mushure mekunge watora mushonga wako wekupedzisira, uchipa dziviriro inoenderera mberi kubva pakudzoka.

Ndezvipi Zvakaipa ZveFidaxomicin?

Fidaxomicin inowanzotsungirirwa zvakanaka, nevazhinji vanhu vachiwana zvishoma kana kusava nemigumisiro. Migumisiro yakajairika ndeyekureruka uye inowanzoenderana nehurongwa hwako hwekugaya sezvo huchipora kubva kuC. diff infection.

Heano migumisiro yaungawana, uchifunga kuti vanhu vazhinji vanotora fidaxomicin vasina matambudziko zvachose:

• Kunzwa kusvotwa kana kusagadzikana mudumbu
• Kurwadziwa mudumbu kana kukramba
• Kurutsa (kusingawanzoitiki)
• Kutemwa nemusoro
• Dizziness
• Kuvharika sezvo kufamba kwematumbo ako kuchinormaliza

Izvi zvinokonzeresa zvinyoro zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga uye hutachiona hwako hunopera. Vanhu vazhinji vanowana kuti kusagadzikana kupi zvako kunonyanya kudzoreka kupfuura zviratidzo zvepakutanga zveC. diff.

Migumisiro yakakomba haina kujairika asi inogona kuitika. Bata chiremba wako nekukasira kana ukaona maitiro akakomba ekuita allergic senge kuoma kufema, kuzvimba kwechiso chako kana huro, kana maitiro akakomba eganda. Tsvagawo kutariswa kwekurapa kana ukaona kurwadziwa kwakanyanya mudumbu, ropa mumatope ako, kana zviratidzo zvehutachiona hutsva.

Vamwe vanhu vanonetseka nezvekuvandudza manyoka ane chekuita nemishonga kubva ku fidaxomicin, asi izvi zvinonyanya kuitika zvichienzaniswa nemamwe maantibiotics nekuda kwechiito chayo chakatarwa. Zvisinei, kana ukaona manyoka matsva kana kuwedzera panguva yekurapa, zivisa mupi wako wehutano.

Ndiani Asingafaniri Kutora Fidaxomicin?

Fidaxomicin haina kukodzera munhu wese, kunyangwe runyoro rwevanhu vasingakwanise kuitora rwakapfupika. Kunetsekana kukuru ndekwekuti kana wakambove ne allergic reaction yakakomba ku fidaxomicin kana chero chimwe chezvinhu zvayo kare.

Chiremba wako achada kufunga fidaxomicin zvakanyatso kana uine chirwere chakakomba cheitsvo kana chiropa, sezvo izvi zvingakanganisa nzira iyo muviri wako unogadzirisa mishonga. Kunyangwe fidaxomicin isinganyanyi kupinzwa muropa rako, chiremba wako anogona kuda kukutarisa zvakanyanya.

Vanhu vane mamwe mamiriro ezvinhu emagenetic asingawanzoitika anokanganisa kugona kwavo kugadzirisa shuga dzakakosha vanofanira kukurukura izvi nachiremba wavo, sezvo mahwendefa e fidaxomicin aine huwandu hudiki hwe lactose. Zvisinei, huwandu hwacho hunowanzoita hudiki kuti huite matambudziko kune vanhu vazhinji vane lactose intolerance.

Kana uri nepamuviri kana kuyamwisa, chiremba wako achayera mabhenefiti achipesana nenjodzi dzinogona kuitika. Kunyangwe zvidzidzo zvisina kuratidza kunetsekana kukuru, C. diff infections inogona kuva yakakomba panguva yekuzvitakura, saka kurapwa kunowanzoita zvakakosha. Mupi wako wehutano achakubatsira kuita sarudzo yakanakisisa yemamiriro ako chaiwo.

Mazita eBrand eFidaxomicin

Fidaxomicin inowanikwa kazhinji pasi pezita rebrand Dificid muUnited States. Iri ndiro zita rekutanga rebrand iro vanachiremba vazhinji nemafamasi vachaziva pavanonyora kana kupa mushonga.

Mune dzimwe nyika, unogona kuwana fidaxomicin ichitengeswa pasi pemazita akasiyana ebrand, senge Dificlir mune mamwe misika yeEurope. Zvisinei, chinhu chinoshanda uye kushanda zvinoramba zvakafanana zvisinei nezita rebrand pane pasuru.

Mhando dzegeneric dze fidaxomicin dziri kuwedzera kuwanikwa mune mamwe misika, izvo zvinogona kubatsira kuderedza mutengo wekurapa. Mupharmacy yako anogona kukuudza kana vhezheni yegeneric iripo munzvimbo yako uye kana ichizokodzera chiremba wako.

Pasinei nezita remhando, ita shuwa kuti uri kuwana fidaxomicin zvakananga kurapwa kweC. diff, nekuti yakasiyana zvakanyanya kubva kune mamwe maantibayoti uye haigone kuchinjiswa nemamwe mishonga.

Zvimwe Zvingashandiswa Panzvimbo peFidaxomicin

Mamwe maantibayoti anogona kurapa zvirwere zveC. diff, kunyangwe fidaxomicin kazhinji iine zvakanakira maererano nekudzivirira kudzoka. Vancomycin ndiyo imwe nzira inowanzo shandiswa uye yanga iri iyo yakajairika kurapwa kwemakore mazhinji.

Metronidazole yakamboshandiswa kazhinji kune zvirwere zvakapfava zveC. diff, asi nhungamiro dzazvino dzemishonga dzinowanzo kurumbidza vancomycin kana fidaxomicin sezviri nani zvekutanga. Chiremba wako angangodaro achiri kufunga nezve metronidazole mumamiriro ezvinhu chaiwo, kunyanya kana mutengo uri kunetsa zvakanyanya.

Kune zviitiko zvakakomba kana zvakaoma, chiremba wako angangokurudzira kurapwa kwakasiyana kana kurapwa kutsva senge bezlotoxumab, iyo inorapwa nemuviri inobatsira kudzivirira kudzoka. Muzviitiko zvakanyanya, kupindira kwekuvhiya kungave kwakakosha, kunyangwe izvi zvisingawanzoitiki.

Sarudzo pakati pezvimwe zvingashandiswa zvinoenderana nezvinhu zvakaita sekukomba kwehutachiona hwako, nhoroondo yako yekurapa, zviitiko zvakapfuura zveC. diff, uye hutano hwako hwese. Chiremba wako achafunga zvese izvi zvikonzero paanenge achisarudza nzira yakanakisa yekurapa mamiriro ako chaiwo.

Ko Fidaxomicin iri nani pane Vancomycin?

Fidaxomicin yakaratidza zvimwe zvakanakira pamusoro pevancomycin, kunyanya mukudzivirira zvirwere zveC. diff kubva pakudzoka. Zvidzidzo zvekurapa zvakawana kuti vanhu vanorapwa nefidaxomicin havangave vaine zvirwere zvinodzoka zvichienzaniswa nevaya vanorapwa nevancomycin.

Mishonga yese iri miviri inoshanda zvakanyanya pakuchenesa hutachiona hwekutanga hweC. diff, iine mitengo yekubudirira yakafanana. Zvisinei, kugona kwefidaxomicin kuchengetedza mabhakitiriya ako anobatsira emudumbu uchirwisa C. diff kunoratidzika kupa dziviriro iri nani kwenguva refu.

Chinhu chikuru chinofungwa nevakawanda vane chirwere ichi ndiyo mari, nekuti fidaxomicin inowanzoita mari yakawanda kupfuura vancomycin. Zvisinei, kana ukaverenga njodzi shoma yekudzoka kwechirwere uye mukana wekuda mamwe marapirwo, fidaxomicin inogona kuva nemari shoma kana ukaiona munguva refu.

Chiremba wako achafunga nezve njodzi dzako wega dzekudzoka kwechirwere, kuoma kwechirwere chako, uye hutano hwako hwese paachasarudza pakati pezvisarudzo izvi. Zvese zviri zvinodhaka zvakanaka, uye sarudzo yakanaka zvinoenderana nemamiriro ako chaiwo panzvimbo yekuti chimwe chive chakanaka zvakanyanya.

Mibvunzo Inowanzo Bvunzwa Nezve Fidaxomicin

Fidaxomicin Yakachengeteka Here Kune Vanhu vane Chirwere cheShuga?

Hongu, fidaxomicin inowanzova yakachengeteka kune vanhu vane chirwere cheshuga. Mushonga hauna zvakawanda zvaunoita pamwero weshuga yeropa nekuti unogara zvakanyanya mudumbu rako panzvimbo yekutorwa muropa rako.

Zvisinei, C. diff infections dzimwe nguva dzinogona kukanganisa chido chako uye maitiro ekudya, izvo zvingakanganisa kutonga kweshuga yeropa rako. Tarisa mwero wako weshuga yeropa sezvaunowanzoita uye taura nachiremba wako kana ukaona chero shanduko dzisinganzwisisike panguva yekurapa.

Ndoitei Kana Ndikatora Fidaxomicin Yakawandisa Netsaona?

Kana netsaona ukatora mushonga wefidaxomicin wakawanda, usavhunduka. Nekuti mushonga hautorwi zvakanyanya muropa rako, zviratidzo zvekuwandisa hazviite zvakanyanya.

Taura nachiremba wako kana muzvinamutsa mishonga kuti uwane gwara, kunyanya kana wakatora yakawanda kupfuura yakarairwa. Vanogona kukupa zano rekuti unoda kutariswa kwekurapa uye maitiro ekugadzirisa chirongwa chako chekushandisa mushonga mberi.

Ndoitei Kana Ndikakanganwa Kutora Mushonga weFidaxomicin?

Kana ukakanganwa kutora mushonga, tora nekukasira paunorangarira, kunze kwekunge yava nguva yekutora mushonga wako unotevera. Muchiitiko ichocho, rega mushonga wakakanganwa uye uenderere mberi nechikwereti chako chemazuva ese - usawedzere mishonga.

Edza kutevedzera nguva ye maawa gumi nemaviri pakati pemishonga kana zvichibvira. Kana uchikanganwa mishonga kazhinji, funga kuisa zviyeuchidzo pafoni yako kana kushandisa chirongwa chemishonga kuti zvikubatsire kutevedzera kurapwa kwako.

Ndingamira rini kutora Fidaxomicin?

Mira kutora fidaxomicin chete kana wapedza mazuva gumi akazara akanyorwa nachiremba wako, kunyangwe ukanzwa zvakanaka zvachose. Kumira kutora mishonga nguva isati yakwana kunowedzera njodzi yekuti hutachiona hudzoke.

Kana ukaona matambudziko akakomba kana kuita allergic reaction, taura nachiremba wako nekukasira kuti uwane mazano. Vanogona kuda kugadzirisa kurapwa kwako, asi usamira mishonga wega usina kutariswa nachiremba.

Ndingatora Probiotics here ne Fidaxomicin?

Vazhinji vanachiremba vanokurudzira kumirira kusvika wapedza fidaxomicin usati watanga probiotics. Izvi zvinobvumira mushonga weantibiotic kuti ushande zvakanaka usingavhiringidzwi nemabhakitiriya akawedzerwa, kunyangwe akanaka.

Mushure mekupera fidaxomicin, probiotics inogona kubatsira kudzorera chiyero chebhakitiriya mumatumbo ako, asi taura izvi nemupi wako wehutano kutanga. Vanogona kukurudzira nguva yakakodzera uye mhando dzeprobiotics zvichienderana nezvido zvako zvekupora.