Chii chinonzi Fosphenytoin: Zvinoshandiswa, Mishonga, Migumisiro Yemuviri, nezvimwe

Fosphenytoin mushonga une simba wekurwisa mafivha unopiwa nejekiseni kana kudzorwa kwemafivha kwakakurumidza kuchidiwa. Iyo inonyanya kuve vhezheni yemazuva ano, yakachengeteka ye phenytoin inoshanda nekukurumidza uye inokonzera matambudziko mashoma panzvimbo yejekiseni.

Mushonga uyu unowanzo shandiswa muzvipatara uye munzvimbo dzekukurumidzira kana mumwe munhu achiita mafivha akakomba asingamire ega. Fungidzira sechishandiso chekukurumidzira chekurapa icho vanopa hutano vanoshandisa kudzikamisa nekukurumidza dutu remagetsi riri kuitika muuropi.

Chii chinonzi Fosphenytoin?

Fosphenytoin mushonga wejekiseni wekurwisa mafivha uyo wekirasi yemishonga inonzi anticonvulsants. Ndizvo zvinodaidzwa nachiremba kuti "prodrug," zvinoreva kuti inoshanduka kuita phenytoin kana yanga iri mumuviri wako.

Mushonga uyu wakagadzirirwa kunyatsogadzirisa mamwe ematambudziko aiuya nekupa phenytoin majekiseni. Kunyange phenytoin ichishandiswa kwemakumi emakore kurapa mafivha, kuipa kuburikidza neIV kunogona kukonzera kukuvadzwa kwetishu kwakakomba uye matambudziko emoyo.

Fosphenytoin inonyanya kunyorovera pamitsipa yako nemoyo, zvichiita kuti ive yakachengeteka kushandiswa nekukurumidzira. Inogona kupiwa kuburikidza nemitsara yeIV uye majekiseni emhasuru, ichipa vanachiremba kuchinjika zvakanyanya mumamiriro ekukurumidzira.

Chii chinonzi Fosphenytoin chinoshandiswa?

Fosphenytoin inonyanya kushandiswa kurapa status epilepticus, ndiko kuti mafivha anogara kwenguva refu kupfuura maminitsi mashanu kana mafivha akawanda achiitika pasina nguva yekupora pakati pavo. Iyi idambudziko guru rekurapa rinoda kurapwa nekukurumidza.

Vanachiremba vanoshandisawo mushonga uyu kudzivirira mafivha panguva yekuvhiyiwa kweuropi kana mumwe munhu asingakwanise kutora mishonga yavo yenguva dzose yemafivha nemuromo. Zvinobatsira zvikuru kana varwere vasina kuziva, pamichina yekufema, kana kuita kuvhiyiwa.

Mune dzimwe nguva, vapi vehutano vanogona kushandisa fosphenytoin sechibatsiro chenguva pfupi vachichinja varwere pakati pemishonga yakasiyana yekudzivirira kubatwa nemoyo. Izvi zvinobatsira kudzivirira kubatwa nemoyo panguva yekuchinja mishonga.

Fosphenytoin Inoshanda Sei?

Fosphenytoin inoshanda nekugadzirisa maseru etsinga akawandisa muuropi hwako. Kana kubatwa nemoyo kukaitika, zviratidzo zvemagetsi muuropi zvinopfura nekukurumidza uye zvinopararira zvisina kujairika, sekunge dutu remagetsi.

Mishonga inovhara nzira dzakatarwa mumasero etsinga dzinobvumira sodium kupfuura. Nekudzora kuyerera uku kwe sodium, fosphenytoin inobatsira kuderedza chiitiko chemagetsi chinokurumidza, chisina kujairika chinokonzera kubatwa nemoyo.

Izvi zvinoonekwa semushonga wepakati nepakati wekudzivirira kubatwa nemoyo. Haisi sarudzo yekutanga yekubatwa nemoyo kwakapfava, asi inobatsira zvakanyanya kune njodzi, inotyisa hupenyu yekubatwa nemoyo. Mhedzisiro inowanzo kutanga mukati memaminitsi gumi-20 ekubaiwa.

Ndingashandisa Sei Fosphenytoin?

Fosphenytoin inongopiwa nevapi vehutano munzvimbo dzekurapa dzakadai sezvipatara kana makamuri ekuvhiya. Hauzotore mushonga uyu kumba kana kuzvipa iwe pachako.

Mishonga inogona kupiwa kuburikidza nemutsara weIV muruoko rwako kana sekubaiwa mumhasuru hombe. IV administration inowanzoitika kune emergency nekuti inoshanda nekukurumidza, nepo majekiseni emhasuru angashandiswa kana kuwana IV kwakaoma.

Vashandi vehutano vachakutarisa zvakanyanya panguva uye mushure mejekiseni. Vanozoongorora rhythm yemoyo wako, BP, uye kufema nekuti mushonga unogona kukanganisa mabasa aya akakosha. Haufaniri kunetseka nezve nguva yekudya sezvo uyu usiri mushonga wemuromo.

Ndingashandisa Fosphenytoin Kwenguva Yakareba Sei?

Fosphenytoin inowanzo shandiswa kurapa kwenguva pfupi panguva yekukurumidza kwekurapa. Vanhu vazhinji vanoiwana kwemadosi mashoma chete kwemaawa kana mazuva vachiri muchipatara.

Kureba kwenguva kunoenderana nekuti nei uri kuipiwa. Kana uri kurwara ne status epilepticus, unogona kupiwa mushonga mumwe kana miviri kuti kumisa zvirwere. Kuti udzivise zvirwere panguva yekuvhiwa, unogona kuupiwa usati wavhiwa, panguva yekuvhiwa, uye nguva pfupi mushure mekuvhiwa.

Chiremba wako anowanzo kukuchinjira kumishonga yekurapa zvirwere inotorwa nemuromo kana wava kugadzikana uye uchikwanisa kumedza zvakanaka. Mushonga uyu hauna kugadzirirwa kushandiswa kwenguva refu kumba.

Ndezvipi Zvakaipa Zvinokonzerwa neFosphenytoin?

Semishonga yese, fosphenytoin inogona kukonzera zvakaipa, kunyangwe zvakakomba zvisingawanzoitiki kana ichipiwa zvakanaka munzvimbo dzekurapa. Zvizhinji zvezvakaipa zvinongova zvenguva pfupi uye zvinopera kana mushonga wapera.

Zvakaipa zvinowanzoitika zvaungasangana nazvo zvinosanganisira dzungu, kurara, uye kunzwa kusagadzikana. Vamwe vanhu vanoonawo kusvotwa, kurwadziwa nemusoro, kana kuvhiringidzika zvishoma sezvo muviri wavo uchigadzirisa mushonga.

Zvimwe zvakaipa zvinokanganisa zvinogona kusanganisira shanduko mumoyo, kudzikira kweropa, kana kuoma kufema. Ichi ndicho chikonzero nei uchizotariswa zvakanyanya panguva yekurapwa. Chikwata chako chekurapa chakadzidziswa kuti chitarise izvi zvinokonzerwa uye kupindura nekukurumidza kana zvikaitika.

Vamwe vanhu vanonzwa kunzwa kunzwa, kupisa, kana kukwenya, kunyanya munzvimbo yavo yegroin. Izvi zvinonzi "purple glove syndrome" uye hazviwanzoitiki ne fosphenytoin kana ichienzaniswa neyakajairika phenytoin.

Zvakaipa zvisingawanzoitiki asi zvakakomba zvinogona kusanganisira maitiro akakomba ekugadzirisa, matambudziko eropa, kana matambudziko echiropa. Zvisinei, izvi hazviwanzoitiki nekushandiswa kwenguva pfupi, uye chikwata chako chekurapa chichatarisa zviratidzo zveizvi zvinetso.

Ndiani Asingafaniri Kutora Fosphenytoin?

Fosphenytoin haina kukodzera munhu wese, uye chikwata chako chekurapa chichanyatso funga nezve nhoroondo yako yehutano usati wakuipa. Vanhu vane mamwe mamiriro emoyo vangangoda kuongororwa kwakawedzerwa kana mamwe marapirwo.

Kana muchiziva kuti mune allergy ye phenytoin kana fosphenytoin, hamufaniri kupihwa mushonga uyu. Vanachiremba venyu vachavawo vakangwarira kana mune matambudziko akakomba emoyo, mamwe marudzi e heart block, kana blood pressure yakaderera zvikuru.

Vanhu vane chirwere chechiropa chakakomba vangada kugadzirisa muyero wemushonga sezvo chiropa chichigadzirisa mushonga uyu. Chikwata chenyu chekurapa chichafungawo nezvemimwe mishonga yamuri kutora, sezvo mimwe mishonga inogona kuita interaction ne fosphenytoin.

Vakadzi vane pamuviri vanoda kufungwa zvakakosha, sezvo fosphenytoin inogona kukanganisa mwana ari kukura. Zvisinei, mumamiriro ezvinhu anotyisidzira hupenyu e seizure emergencies, mabhenefiti anowanzo kukunda njodzi.

Mazita eBrand eFosphenytoin

Zita rinowanzozivikanwa re fosphenytoin ndi Cerebyx, iyo inogadzirwa ne Pfizer. Iri ndiro zita rekutanga rakatenderwa ne FDA.

Mhando dze generic dze fosphenytoin dziripowo uye dzinobata zvakanyatsonaka semhando yezita. Chipatara chenyu kana nzvimbo yekurapa inowanzo chengeta chero vhezheni yavanofarira zvichienderana nemutengo uye kuwanikwa.

Zvimwe Zvinotsiva Fosphenytoin

Mishonga yakati wandei inogona kushandiswa kurapa seizures akakomba kana fosphenytoin isina kukodzera. Lorazepam (Ativan) inowanzo shandiswa seyekutanga-mutsara kurapa status epilepticus nekuti inoshanda nekukurumidza.

Levetiracetam (Keppra) imwe imwe nzira inogona kupihwa intravenously uye ine mashoma drug interactions. Valproic acid (Depacon) inoshandiswawo kune seizure emergencies, kunyanya mune mamwe marudzi eepilepsy.

Kuti uenderere mberi nekugadzirisa seizure, mishonga yemuromo yakaita se phenytoin, carbamazepine, kana mishonga mitsva yakaita se lamotrigine inogona kushandiswa. Chiremba wenyu achasarudza imwe nzira yakanakisa zvichienderana nemamiriro enyu chaiwo uye nhoroondo yekurapa.

Ko Fosphenytoin iri nani pane Phenytoin?

Fosphenytoin inopa zvakanakira zvakawanda kupfuura phenytoin yechinyakare kana ichipiwa nejekiseni. Yakachengeteka zvikuru kumitsipa yako nemoyo, uye inogona kupiwa nekukurumidza pasina kukonzera kukuvadzwa kwematishu kunowanzoitika phenytoin.

Chakanakira chikuru ndechekuti fosphenytoin inogona kupiwa nemitsipa midiki yeIV uye kunyange mumhasuru, nepo phenytoin ichida tsinga hombe uye kupa zvishoma nezvishoma. Izvi zvinoita kuti fosphenytoin ive inoshanda zvikuru mumamiriro ezvinhu ekukurumidzira.

Zvisinei, mishonga yese iri miviri inoshanda zvakafanana kana yanga iri mumuviri wako, sezvo fosphenytoin ichichinja kuita phenytoin. Sarudzo pakati pavo inowanzobva pakuti kurapwa kunodiwa nekukurumidza sei uye rudzi rwei rweIV ruripo.

Kuti utarisire kutambudzika kwenguva refu, phenytoin yemumuromo ichiri kushandiswa kazhinji uye haina kudhura zvakanyanya kupfuura majekiseni e fosphenytoin. Fomu rejekiseni rakagadzirirwa kushandiswa mumamiriro ezvinhu ekukurumidzira uye muchipatara.

Mibvunzo Inowanzo Bvunzwa Nezve Fosphenytoin

Q1. Fosphenytoin Yakachengeteka Here Kune Varwere Vane Moyo?

Fosphenytoin inowanzova yakachengeteka kune varwere vane moyo kupfuura majekiseni e phenytoin akajairika, asi ichiri kuda kutarisa zvakanaka. Mushonga unogona kukanganisa rhythm yemoyo uye kudzvanywa kweropa, saka timu yako yezvokurapa ichatarisa moyo wako zvakanyanya panguva yekurapa.

Kana uine mamiriro emoyo akakomba senge heart block yakakomba kana rhythm yemoyo inononoka zvikuru, vanachiremba vako vangasarudza mamwe mishonga. Zvisinei, mumamiriro ezvinhu ekukurumidzira ekutambudzika kunotyisa upenyu, zvakanakira zvinowanzokunda njodzi dzemoyo.

Q2. Ndingaita Sei Kana Ndikagamuchira Fosphenytoin Yakawandisa Netsaona?

Sezvo fosphenytoin ichipiwa chete nenyanzvi dzehutano munzvimbo dzekurapa, overdoses netsaona hazviwanzowaniki. Kana yakawanda ikapiwa, iwe ungangodaro uchizowana mhedzisiro yakanyanya senge kurara zvakanyanya, kuvhiringidzika, kana shanduko yerhythm yemoyo.

Vashandi venyu vezvokurapa vakadzidziswa kuziva nekubata zviratidzo zvekuwandisa mushonga nekukasira. Vangakupa mishonga yekutsigira kufema kwenyu nebasa remoyo apo fosphenytoin inobviswa mumuviri wenyu.

Mubvunzo 3. Chii chinoitika kana ndikakanganwa mushonga weFosphenytoin?

Kukanganwa mushonga hachisi chinhu chaunofanira kunetseka nacho sezvo nyanzvi dzezveutano dzichidzora zvese zvekupa mishonga. Kana iwe uchifanira kupiwa mishonga yakawanda uye imwe yakonzerwa kunonoka, chikwata chako chekurapa chichachinja nguva zvichienderana nekudzora kwako kubatwa uye mazinga eropa.

Vanachiremba vako vachatarisa mhinduro yako uye vanogona kutarisa mazinga eropa kuti vaone kuti uri kuwana huwandu hwakakodzera hwemushonga wemamiriro ako ezvinhu.

Mubvunzo 4. Ndingamira rini kutora Fosphenytoin?

Hauzvisarudzi iwe pachako kuti ungamira rini fosphenytoin sezvo ichipiwa munzvimbo dzekurapa kuti ishandiswe kwenguva pfupi. Vanachiremba vako vachaimisa kana kubatwa kwako kwadzorwa uye iwe unogona kutora mishonga yemuromo zvakachengeteka.

Kuchinja kunowanzoitika mukati memazuva mashoma, zvichienderana nekupora kwako uye kugona kumedza mishonga. Chikwata chako chekurapa chichava nechokwadi chekuti une dziviriro yakakwana yekubatwa panguva yekuchinja uku.

Mubvunzo 5. Fosphenytoin inogona kupiwa kumba here?

Kwete, fosphenytoin haimbopiwi kumba. Inoda kutariswa kwehunyanzvi hwekurapa nekuda kwemigumisiro inogona kukonzera inokanganisa moyo wako, kufema, uye kudzvanywa kweropa.

Kana iwe uchida kudzora kubatwa kwenguva refu kumba, chiremba wako achanyora mishonga yemuromo. Mishonga yekukurumidzira yekubatwa kumba yakasiyana uye inosanganisira sarudzo dzakaita semaspira emumhino kana magel erectal ayo nhengo dzemhuri dzinogona kupa zvakachengeteka.