Chii chinonzi Galcanezumab: Zvazvinoshandiswa, Mishonga, Migumisiro Yakaipa uye Zvimwe

Galcanezumab mushonga unopiwa nachiremba wakagadzirirwa kudzivirira kurwadziwa nemusoro kwemigraine muvanhu vakuru. Iyi mishonga inoshanda nekudzivisa protein inonzi CGRP (calcitonin gene-related peptide) iyo ine basa guru mukukonzera migraine. Iyi jekiseni remwedzi inopa tariro kune vanhu vanotambudzika nekurwadziwa nemusoro kakawanda, kunovadzisa, kunovhiringidza hupenyu hwavo hwezuva nezuva.

Chii chinonzi Galcanezumab?

Galcanezumab ndeyemhando itsva yemishonga inonzi CGRP inhibitors kana monoclonal antibodies. Funga nezvayo sechivharo chakanyanya kunangana chinovharisa zviratidzo zvinogona kukonzera kurwisa kwemigraine. Kusiyana nemishonga yekare yemigraine yakatanga kugadzirwa kune mamwe mamiriro, galcanezumab yakagadzirwa chete kudzivirira migraine.

Mishonga iyi inouya sepeni yakazadzwa kana sirinji yaunojekesa pasi peganda rako kamwe chete pamwedzi. Yakagadzirirwa vanhu vanowanzova nemigraine uye vanoda kudzivirira nguva dzose, kwenguva refu pane kungorapa kurwadziwa nemusoro mushure mekutanga.

Galcanezumab Inoshandiswa Kunei?

Galcanezumab inonyanya kunyorerwa kudzivirira kurwadziwa nemusoro kwemigraine muvanhu vakuru vanovawana kakawanda. Chiremba wako angakurudzira mushonga uyu kana uine mazuva mana kana kupfuura emigraine pamwedzi uye mamwe marapirwo ekudzivirira haana kushanda zvakanaka kwauri.

Mishonga iyi inobvumidzwawo kurapa episodic cluster headaches, iyo inorwadza zvakanyanya kurwadziwa nemusoro kunoitika mumaitiro emacylical. Kurwadziwa nemusoro uku kwakasiyana nemigraine uye kunowanzoitika mumapoka kana

Galcanezumab inoshanda nekunangana neCGRP, protein inoburitswa nemuviri wako panguva yekurwisa migraine. Kana CGRP yaburitswa, inoita kuti tsinga dzeropa mumusoro mako dzivhure uye inokonzera kuzvimba uye zviratidzo zverwadzo. Mushonga uyu unoita semukiyi unokwana mukati meCGRP lock, uchidzivirira kuti isakonzere shanduko idzi dzinorwadza.

Izvi zvinoonekwa semushonga wekudzivirira une simba repakati, zvinoreva kuti unoshanda zvakanyanya asi kazhinji unochengeterwa vanhu vasina kupindura zvakanaka kurapwa kwekutanga. Kusiyana nemimwe mishonga ye migraine inokanganisa tsinga dzako dzese, galcanezumab inoshanda zvakanyanya panzira ye migraine.

Mhedzisiro inovaka nekufamba kwenguva, saka unogona kusaziva mabhenefiti akazara nekukasira. Vanhu vazhinji vanotanga kuona kuvandudzwa mukati memwedzi wekutanga, asi zvinogona kutora kusvika kumwedzi mitatu kuti uwane mhedzisiro yakazara yekudzivirira yemushonga.

Ndingatora sei Galcanezumab?

Galcanezumab inopiwa sejojo subcutaneous, zvinoreva kuti unoiisa mutishu ine mafuta pasi peganda rako. Mupi wako wehutano achakudzidzisa maitiro ekuzvipa majekiseni aya zvakachengeteka kumba. Nzvimbo dzakajairika dzekujekiseni itheyi yako, ruoko rwepamusoro, kana dumbu.

Iwe unowanzo kutanga nemutoro we240 mg (majekiseni maviri e120 mg) pazuva rako rekutanga, richiteverwa ne120 mg (jekiseni rimwe) kamwe chete pamwedzi. Tora mushonga kubva mufiriji maminitsi makumi matatu usati wajekiseni kuti uregere kusvika pakupisa kwemumba, izvo zvinoita kuti jekiseni rive nyore.

Unogona kutora galcanezumab uine kana usina chikafu sezvo ichijekiseni panzvimbo yekutorwa nemuromo. Edza kuijekiseni pazuva rimwe chete mwedzi wega wega kuti uchengetedze mazinga akagadzikana muhurongwa hwako. Kana usina kugadzikana nekuzvijekiseni, hofisi yachiremba wako inogona kuikupa iwe.

Ndingatora Galcanezumab kwenguva yakareba sei?

Vanhu vazhinji vanotora galcanezumab kwemwedzi mitatu kusvika mitanhatu kuti vaongorore zvakanaka kushanda kwayo. Chiremba wako anogona kukurudzira kuti uipe nguva yekuedza yakakodzera sezvo zvinogona kutora nguva kuti uone mabhenefiti akazara. Vamwe vanhu vanoona kuvandudzwa mukati memwedzi wekutanga, asi vamwe vangada kusvika kumwedzi mitatu.

Kana galcanezumab ichikushandira zvakanaka, chiremba wako angakurudzira kuenderera mberi nayo kwenguva refu. Vanhu vazhinji vanoi tora kwegore kana kupfuura kuti vachengetedze mhando yavo yehupenyu yakavandudzwa. Mushonga uyu unoita seunoramba uchishanda nekushandiswa kwakadzama, uye hapana humbowo hwekuti inorasikirwa nemhedzisiro yayo yekudzivirira nekufamba kwenguva.

Mupi wako wehutano achagara achiongorora newe kuti aongorore kuti mushonga uri kushanda sei uye kana uri kusangana nemhedzisiro ipi neipi. Vachakubatsira kusarudza kana uchienderera mberi, kugadzirisa nguva, kana kuongorora dzimwe sarudzo zvichibva pamhinduro yako yega.

Ndezvipi Zvipingamupinyi zveGalcanezumab?

Semishonga yese, galcanezumab inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachii shingirira zvakanaka. Mhedzisiro inowanzoitika inowanzoita nyoro uye inowanzoita nani sezvo muviri wako uchigadzirisa kumushonga.

Heano mhedzisiro inonyanya kuzivikanwa yaungasangana nayo:

• Maitiro ekudzivirira jekiseni senge kutsvuka, kuzvimba, kana kurwadziwa kudiki
• Zvirwere zvepamusoro zvekufema kana zviratidzo zvakaita sechando
• Kuvharika kana shanduko mukufamba kwematumbo
• Kuneta kana kunzwa kuneta kupfuura zvakajairika
• Dizziness kana lightheadedness
• Nausea kana kusagadzikana mudumbu

Maitiro mazhinji ekudzivirira jekiseni akapfava uye anogadzirisa mukati mezuva rimwe kana maviri. Unogona kushandisa compress inotonhora usati wajekiseni uye compress inodziya mushure meizvozvo kuti uderedze kusagadzikana.

Nepo zvisingawanzoitika, vamwe vanhu vanogona kusangana nemhedzisiro yakakomba inoda kutarisirwa kwekurapa:

• Kusagadzikana kwakanyanya kwemuviri nekuoma kufema kana kuzvimba kwechiso, miromo, kana pahuro
• Kuvharika kwakanyanya kwemudumbu kusingavanduki nemishonga yakajairika
• Kusagadzikana kunoramba kuripo kana kuwedzera panzvimbo yekubaya jekiseni
• Kuchinja kusinganzwisisike mumafungiro kana maitiro

Izvi zvinokonzeresa zvakanyanya hazviwanzoitika, asi zvakakosha kuti utaure nachiremba wako nekukasira kana uine chero zviratidzo zvinonetesa. Vanhu vazhinji vanowana kuti mabhenefiti ekuderedzwa kwemigraine anopfuura matambudziko madiki avangave nawo.

Ndiani Asingafaniri Kutora Galcanezumab?

Galcanezumab haisi yemunhu wese, uye chiremba wako achanyatsoongorora kana zvakachengeteka kwauri. Vanhu vane allergy inozivikanwa ku galcanezumab kana chero zvinhu zvayo vanofanira kudzivisa mushonga uyu zvachose.

Mupi wezvehutano wako achada kukurukura nhoroondo yako yekurapa zvakadzama usati wanyora galcanezumab, kunyanya kana uine:

• Nhoroondo yekusagadzikana kwakanyanya kwemuviri kune mamwe mishonga
• Zvirwere zviripo kana immune system yakakanganiswa
• Matambudziko akakomba eitsvo kana chiropa
• Nhoroondo yezvirwere zve cardiovascular
• Zvirongwa zvekuva nepamuviri kana kuti uri kuyamwisa

Mishonga iyi haina kunyatsodzidzwa pavakadzi vane pamuviri, saka chiremba wako achayerera mabhenefiti anogona kuitika pamwe nenjodzi dzisingazivikanwi kana uri kuronga kutora mimba. Saizvozvowo, hazvizivikanwe kana galcanezumab ichipinda mumukaka wemazamu.

Vana nevechiri kuyaruka vari pasi pemakore gumi nemasere havafaniri kutora galcanezumab sezvo isina kuratidzwa kuti yakachengeteka kana kushanda mumapoka emakore madiki. Chiremba wako achafunga nezveimwe mishonga kana uri mumakore aya.

Mazita eGalcanezumab Brand

Galcanezumab inotengeswa pasi pezita rekuti Emgality muUnited States nemamwe mazhinji. Unogona kuona zita iri pane chinyorwa chako chemishonga, mapepa e inishuwarenzi, kana paunenge uchikurukura mushonga nechikwata chako chehutano.

Emgality inogadzirwa neEli Lilly and Company uye inouya mumapeni akazadzwa kare uye masirinji akazadzwa kare. Zvese zviri zviviri zvine mushonga mumwe chete uye zvinoshanda zvakaenzana, kunyangwe vamwe vanhu vachiwana imwe nzira yekupa yakasununguka kupfuura imwe.

Paunenge uchitaura nemutengesi wako wemishonga kana kambani yeinishuwarenzi, unogona kushandisa zita re generic (galcanezumab) kana zita remhando (Emgality). Vachaziva chaizvo mushonga waunoreva.

Zvimwe Zvinhu Zvokutsiva Galcanezumab

Kana galcanezumab isiri iyo yakakunakira iwe, dzimwe nzira dzakawanda dzekudzivirira migraine dziripo. Chiremba wako anogona kukubatsira kuti uongorore izvi zvimwe zvinhu zvichibva pamamiriro ako chaiwo, nhoroondo yako yezvokurapa, uye zvinangwa zvekurapa.

Zvimwe zvinodzivirira CGRP zvinoshanda zvakafanana ne galcanezumab uye zvinogona kuva zvimwe zvakanaka:

• Fremanezumab (Ajovy) - imwe nzira yekujowa yemwedzi
• Erenumab (Aimovig) - inotarisa chikamu chakasiyana cheCGRP nzira
• Eptinezumab (Vyepti) - inopiwa neIV infusion mwedzi mitatu yega yega

Mishonga yechinyakare yekudzivirira migraine inogonawo kufungwa, kunyanya kana iwe uchida mapiritsi ezuva nezuva pane majekiseni emwedzi. Izvi zvinosanganisira mamwe maantidepressants, mishonga yekurwisa-kubata, uye beta-blockers izvo zvakaratidza kushanda mukudzivirira migraines.

Mupi wako wehutano achafunga nezvezvinhu zvakaita semamwe mamiriro ako ezvokurapa, mishonga iripo, zvaunofarira mararamiro, uye inishuwarenzi paunenge uchikurudzira zvimwe zvinhu. Chinangwa ndechekuwana kurapwa kunoshanda zvakanyanya kunokodzera hupenyu hwako.

Ko Galcanezumab Ari Nani Pane Sumatriptan?

Galcanezumab na sumatriptan vanoshandira zvinangwa zvakasiyana mukurapa migraine, saka kuenzanisa zvakafanana nekuenzanisa maapuro nemaranjisi. Galcanezumab imishonga yekudzivirira yaunotora mwedzi wega wega kuderedza kakawanda kwemigraines, nepo sumatriptan iri kurapwa kwakanyanya kwaunotora kana migraine yatanga.

Vanhu vazhinji vanoshandisa mishonga yese miviri pamwechete sechikamu chechirongwa chakazara chekugadzirisa migraine. Unogona kutora galcanezumab mwedzi wese kudzivirira migraines uye uchengete sumatriptan paruoko remusoro unopfuura unozviratidza.

Kana iwe uchishandisa sumatriptan kazhinji (mazuva anopfuura gumi pamwedzi), chiremba wako angakurudzira kuwedzera galcanezumab kuderedza mutoro wako we migraine. Iyi nzira inogona kukubatsira kuvimba zvishoma pamishonga inokurumidza uye pamwe kudzivirira misoro inokonzerwa nekushandisa mishonga zvakanyanya.

Sarudzo

Usayedza "kurwisa" mushonga wakawedzerwa wega. Chiremba wako angada kukutarisa kuti uone kana paine mhedzisiro yakawedzerwa kana kugadzirisa mushonga wako unotevera. Chengeta mapakeji emushonga newe paunotsvaga rubatsiro rwekurapa kuitira kuti vanopa hutano vazive chaizvo zvawakatora uye zvakawanda sei.

Ndingaita Sei Kana Ndikakanganwa Dose yeGalcanezumab?

Kana ukakanganwa jekiseni rako remwedzi wega wega re galcanezumab, ritora paunorangarira, wobva watora chirongwa chako chemazuva ese chemwedzi kubva ipapo. Usawedzere madosi kana kuyedza kugadzirisa jekiseni rakapotswa nekutora mushonga wakawedzerwa.

Gadzira zviyeuchidzo zvefoni kana zviyeuchidzo zvekarenda kuti zvikubatsire kurangarira zuva rako rejekiseni remwedzi. Vamwe vanhu vanoona zvichibatsira kuronga majekiseni avo pazuva rinorangarirwa mwedzi wega wega, senge Mugovera wekutanga kana wechi15.

Ndingamira Rini Kutora Galcanezumab?

Unogona kumira kutora galcanezumab chero nguva, asi zviri nani kuti utaure nezvesarudzo iyi nemupi wako wehutano kutanga. Kusiyana nemimwe mishonga, haufanirwe kuderedza zvishoma nezvishoma dose - unogona kungomira kutora majekiseni ako emwedzi.

Migraines yako inogona kudzokera kune frequency yavo yapfuura mukati memwedzi mishoma yekumira mushonga. Chiremba wako anogona kukubatsira kuronga shanduko iyi uye kukurukura dzimwe nzira dzekurapa kana zvichidikanwa.

Ndinganwa Doro Ndiri Kutora Galcanezumab?

Hapana hukama hunozivikanwa pakati pe galcanezumab nedoro, saka kunwa zvine mwero kunowanzoonekwa sekuchengeteka. Zvisinei, doro rinowanzoita migraine trigger kune vanhu vazhinji, saka unogona kuda kutarisa kuti rinokanganisa sei misoro yako.

Kunyange zvazvo galcanezumab ichibatsira kudzivirira migraines yako, doro rinogona kukonzera misoro. Teerera kumhinduro yako pachako uye taura chero zvinokunetsa nemupi wako wehutano.