Chii chinonzi Gemtuzumab: Zvazvinoshandiswa, Madosi, Mativi eMuviri, nezvimwe

Gemtuzumab mushonga wekenza unotarisa uyo unosanganisa antibody nemushonga wechemotherapy kurapa mamwe marudzi eacute myeloid leukemia (AML). Kurapa uku kwakakosha kunoshanda semutsvaki wemagariro, achitsvaga maseru ekenza chaiwo achisiya maseru mazhinji ane hutano ari ega.

Kana iwe kana mumwe munhu waunoda akanyorerwa gemtuzumab, ungangove uchinzwa wakaoma nemibvunzo. Izvozvo zvakajairika uye zvinonzwisisika. Mushonga uyu unomiririra tariro yevanhu vazhinji vanotarisana neAML, uye kunzwisisa mashandiro aunoita kunogona kukubatsira kuti unzwe wakavimbika nezvekufamba kwako kwekurapa.

Chii chinonzi Gemtuzumab?

Gemtuzumab iantibody-drug conjugate, zvinoreva kuti mishonga miviri ine simba yakasanganiswa imwe. Chikamu cheantibody chinoshanda semudziyo wekudzoka unowana maseru ekenza ane protein chaiyo inonzi CD33 pamusoro payo. Kana yangovharirwa mumasero aya, inopa mushonga wechemotherapy une simba zvakananga mukati mavo.

Funga nezvazvo seyakatarwa yekutumira system inogona kusiyanisa pakati pemasero ekenza nemasero ane hutano. Iyi nzira chaiyo inobatsira kuderedza kukuvadzwa kumatishu akajairika uchitarisa kurapwa kwainodiwa zvakanyanya. Mushonga uyu unoenda nezita rekuti Mylotarg uye ndewechikamu chemishonga inonzi monoclonal antibodies.

Kurapa uku kwakagadzirirwa zvakananga acute myeloid leukemia, rudzi rwekenza yeropa inokanganisa maseru machena eropa. Iyo CD33 protein inowanikwa pamasero mazhinji eAML, ichiita gemtuzumab sarudzo inoshanda kune varwere vazhinji vane mamiriro aya.

Gemtuzumab Inoshandiswa Kunei?

Gemtuzumab inonyanya kushandiswa kurapa acute myeloid leukemia muvanhu vakuru nevana vane makore anopfuura 2. Chiremba wako anowanzo kuraira mushonga uyu kana maseru ako ekenza akaedzwa zvakanaka kune iyo CD33 protein, iyo inoitika mune angangoita 90% yeAML kesi.

Mushonga uyu unowanzo shandiswa pamwe chete nemimwe mishonga yekemotherapy yakaita se daunorubicin uye cytarabine yeAML ichangobva kuongororwa. Nzira iyi yekubatanidza yakaratidza mhedzisiro iri nani pane kushandisa chemotherapy yoga. Chikwata chako chehutano chichasarudza chirongwa chakanakisa chekurapa zvichienderana nemamiriro ako chaiwo, zera, uye hutano hwese.

Mune dzimwe nguva, gemtuzumab inogona kushandiswa semushonga mumwe chete wevarwere vasingakwanise kutsungirira chemotherapy yakanyanya. Izvi zvinogona kushanda kuvakuru kana avo vane mamwe mamiriro ehutano anoita kuti chemotherapy yakajairika ive njodzi yakanyanya.

Gemtuzumab Inoshanda Sei?

Gemtuzumab inoshanda kuburikidza nemaitiro maviri-matanho akadzama anovavarira maseru ekenza nekunyatsojeka kunoshamisa. Kutanga, chikamu che antibody chinoziva uye chinosungirira kuCD33 mapuroteni pamusoro pemaseru eAML. Izvi zvakaita sekiyi inowana kuki yayo chaiyo.

Kana yangobatana, sero rekenza rinokwevera molecule yese ye gemtuzumab mukati kuburikidza nemaitiro anonzi internalization. Mukati mesero, chikamu chekemotherapy (chinonzi calicheamicin) chinosunungurwa uye chinotanga kuparadza sero rekenza kubva mukati. Iyi nzira yakatarwa zvinoreva kuti mushonga une simba wekemotherapy unotumirwa zvakananga kwainodiwa.

Izvi zvinoonekwa semushonga wekenza une simba zvine mwero. Kunyangwe ichikwanisa kuuraya maseru ekenza zvinobudirira, iyo yakatarwa yekutumira system inobatsira kuderedza mhedzisiro yakapararira yaungangove nayo neyakajairika chemotherapy. Zvisinei, ichiri kurapwa kwakakomba kunoda kutariswa zvakanaka nechikwata chako chekurapa.

Ndinofanira Kutora Sei Gemtuzumab?

Gemtuzumab inopiwa se intravenous infusion zvakananga muropa rako kuburikidza netsinga. Hauzive kutora mushonga uyu nemuromo, uye unofanirwa kupihwa muchipatara kana nzvimbo yakakosha yekurapa kenza nevashandi vehutano vakadzidziswa.

Musati mumwe nemumwe wekudururwa, timu yako yezvokurapa ichakupa mishonga yekubatsira kudzivirira maitiro ekurwara. Izvi zvinowanzo sanganisira antihistamines senge diphenhydramine uye acetaminophen kuderedza fivha uye kusagadzikana. Haufaniri kudzivisa chikafu usati wapiwa mushonga, asi kugara wakanyatso hydrated nekunwa mvura yakawanda kwakakosha.

Kudururwa pachako kunowanzo tora maawa anenge 2, uye iwe uchatariswa zvakanyanya panguva uye mushure mekurapa. Chikwata chako chehutano chichatarisa chero zviratidzo zvemaitiro ekurwara kana mamwe mativi. Ronga kupedza zuva rakawanda panzvimbo yekurapa, sezvo imwe nguva yekutarisa inowanzo kuda.

Unogona kunzwa wakasununguka uchiunza bhuku, piritsi, kana kuva neshamwari kana nhengo yemhuri inogara newe panguva yekurapa. Vanhu vazhinji vanowana maitiro ekudururwa achideredza kushushikana kana vaine chimwe chinhu chekuchengeta pfungwa dzavo dzakabatikana.

Ndingatora Gemtuzumab kwenguva yakareba sei?

Kureba kwekurapa kwe gemtuzumab kunoenderana nechirongwa chako chekurapa uye kuti unopindura sei mushonga. Varwere vazhinji vanogamuchira gemtuzumab sechikamu chekurapa kwekutanga, izvo zvinowanzo sanganisira 1-2 cycles inopiwa pamavhiki akati wandei.

Kana iwe uchigamuchira kurapa kwakabatanidzwa nemimwe mishonga yekemotherapu, unogona kuwana gemtuzumab pamazuva 1, 4, uye 7 yechikamu chako chekutanga chekurapa. Kune varwere vanogamuchira gemtuzumab chete, chirongwa chinowanzoita zvakasiyana, kazhinji chichisanganisira zviyero zvakaparadzaniswa neanenge mavhiki 2.

Chiremba wako achatarisa nguva dzose kuverenga kweropa rako uye mhinduro yako yese kuti aone kana zviyero zvakawedzerwa zvichidikanwa. Vamwe varwere vanogona kugamuchira gemtuzumab panguva yekubatanidza kurapa, iyo inouya mushure mekutanga kurapa. Huwandu hwese hwezviyero kazhinji haupfuuri 3-4 kurapwa.

Zvakakosha kupedzisa nzira yakazara yekurapa sezvakatemwa, kunyangwe ukatanga kunzwa zviri nani. Kumira kare kunogona kubvumira maseru ekenza kukura zvakare uye kuoma kurapa.

Ndezvipi Zvakaipa zveGemtuzumab?

Sezvinongoita mishonga yese yekenza, gemtuzumab inogona kukonzera matambudziko, kunyange zvisiri zvese zvinowanikwa nemunhu wese. Kunzwisisa zvaungatarisira kunogona kukubatsira kugadzirira uye kuziva kuti ungabatana riini nechikwata chako chehutano.

Matambudziko anowanzoitika aunogona kusangana nawo anosanganisira kuneta, fivha, kusvotwa, uye kuwanda kwemaseru eropa. Zvinhu izvi zvinowanzoitika mumazuva mashoma ekutanga mushure mekurapwa uye zvinowanzoita nani muviri wako sezvaunojaira.

Heano matambudziko anowanzoziviswa, akarongwa kubva kune akajairika kusvika kune asingawanzoitiki:

• Kunetwa uye kushaya simba zvinogona kutora mazuva akati wandei
• Fivha nekutonhora, kunyanya mukati meawa makumi maviri nemana ekurapwa
• Kusvotwa nekurutsa, izvo zvinowanzoitwa nemishonga
• Kuwanda kwemaseru machena eropa, kuwedzera njodzi yekutapukirwa
• Kuwanda kwemaseru eplatelet, zvichikonzera kupwanya kana kubuda ropa nyore nyore
• Kutemwa nemusoro nekutadza kufema
• Maronda emuromo kana kutsamwa kwehuro
• Mavanga paganda kana kukwenya

Matambudziko aya anowanzoitika anowanzoitwa nekuchengetwa kunotsigira uye mishonga inogona kunyorerwa nachiremba wako. Vanhu vazhinji vanowana zvinhu izvi zvichivandudzika mukati mevhiki kana maviri mushure mekurapwa kwega kwega.

Kune zvakare mamwe matambudziko asingawanzoitiki asi akakomba anoda kutariswa kwekurapa nekukasira. Kunyange izvi zvisingaitike kune vazhinji varwere, zvakakosha kuziva nezvazvo kuti ugone kutsvaga rubatsiro nekukurumidza kana zvichidikanwa.

Matambudziko asingawanzoitiki asi akakomba anosanganisira:

• Matambudziko akakomba echiropa, kusanganisira mamiriro anonzi veno-occlusive disease
• Allergic reactions akakomba panguva yekuiswa
• Zvirwere zvakakomba nekuda kwehuwandu hwakaderera hwemaseru machena eropa
• Matambudziko akakomba ekubuda ropa kubva pakuwanda kwakaderera kwemaseru eplatelet
• Matambudziko emoyo kana kukuvadzwa kwemhasuru dzemoyo
• Matambudziko akakomba emapapu kana kuoma kufema

Vashandi venyu vezvehutano vachakutarisa zvakanyanya kuti uone mhedzisiro yakakomba iyi kuburikidza nemiedzo yeropa yenguva dzose uye kuongororwa kwemuviri. Kana ukaona kufema kwakaoma, kurwadziwa muchipfuva, kuita yero kweganda rako kana maziso, kana zviratidzo zveutachiona hwakakomba, taura nachiremba wako nekukurumidza.

Ndiani Asingafaniri Kutora Gemtuzumab?

Gemtuzumab haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana iri sarudzo yakanaka yemamiriro ako ezvinhu. Vanhu vane mamwe mamiriro ehutano kana mamiriro vanogona kuda dzimwe nzira dzekurapa.

Haufaniri kugamuchira gemtuzumab kana uine allergic reaction yakakomba kumushonga kana chero zvikamu zvawo. Uyezve, kana maseru ako ekenza asina protein yeCD33, kurapwa uku hakuzoshandi kwauri.

Chiremba wako anogona kukurudzira kurwisa gemtuzumab kana uine:

• Chirwere chechiropa chakakomba kana nhoroondo yematambudziko echiropa
• Zvirwere zvinoshanda, zvisingadzoreki
• Kuverenga kwemasero eropa akaderera zvakanyanya asingavandudzi nekuchengetedza
• Matambudziko emoyo akakomba kana kurwisa kwemoyo kwemazuva ano
• Kuzvitakura kana zvirongwa zvekuva nepamuviri

Kungwarira kwakakosha kunodiwa kune vakuru vakuru, sezvo vachigona kunzwa zvakanyanya kumigumisiro. Chiremba wako achayeresa mabhenefiti anogona kuitika pamusoro penjodzi zvichibva pahutano hwako hwese uye mamwe mamiriro ekurapa.

Zita reGemtuzumab Brand

Gemtuzumab inotengeswa pasi pezita remhando yeMylotarg. Iri ndiro zita rimwe chete remhando rinowanikwa kumushonga uyu muUnited States nedzimwe nyika zhinji.

Mylotarg yakatanga kubvumidzwa neFDA muna 2000, yakabviswa mumusika muna 2010 nekuda kwekunetseka kwekuchengetedza, uye yakazobvumidzwa zvakare muna 2017 iine zvigadziriso zvekushandisa. Iyo fomu yazvino inoonekwa seyakachengeteka uye inoshanda kupfuura vhezheni yekutanga.

Paunogamuchira mushonga wenyu, bhodhoro remushonga richanyorwa kuti Mylotarg. Parizvino hapana mhando dzemishonga dze gemtuzumab dziripo, sezvo uyu uri mushonga wakanyanya kuoma uyo unoda maitiro ekuita akawanda.

Zvimwe Zvinogona Kushandiswa Panzvimbo peGemtuzumab

Kana gemtuzumab isina kukodzera mamiriro ako, kune dzimwe nzira dzekurapa acute myeloid leukemia. Chiremba wako achabatsira kuona sarudzo yakanakisa zvichienderana nerudzi rwako rweAML, zera, uye hutano hwako hwese.

Mishonga yakajairika yekurapa senge

Asi, "zvirinani" zvinoenderana nemamiriro ako emunhu. Nepo nzira yekubatanidza ingangopa kutonga kwakanaka kwekenza, inouyawo nemigumisiro yekuwedzera uye inoda kuongororwa kwakanyanya. Chiremba wako achakubatsira kuyera izvi zvinhu zvichibva pazera rako, hutano, uye zvinangwa zvekurapa.

Kune vamwe varwere, kunyanya vakuru kana avo vane mamwe mamiriro ehutano, kurapwa kwakapfava kungave kwakakodzera kunyangwe zvichigona kunge zvisina hukasha pamusoro pekenza. Kurapa kwakanakisa nguva dzose ndiko kunokupa chiyero chakanaka chekubudirira uye mhando yehupenyu.

Mibvunzo Inowanzo Bvunzwa Nezve Gemtuzumab

Gemtuzumab Yakachengeteka Kune Vanhu vane Chirwere chechiropa here?

Gemtuzumab inogona kuva nenjodzi kune vanhu vane matambudziko echiropa. Mushonga uyu unogona kukonzera mamiriro akakomba anonzi hepatic veno-occlusive disease, iyo inovhara kuyerera kweropa muchiropa uye inogona kuva inotyisa-hupenyu.

Kana uine matambudziko echiropa akapfava, chiremba wako angangofunga nezve gemtuzumab asi achakutarisa zvakanyanya nekuongororwa kweropa kakawanda. Zvisinei, kana uine chirwere chechiropa chakati wandei, chiremba wako angangokurudzira dzimwe nzira dzekurapa dzine njodzi shoma kuchiropa chako.

Usati watanga kurapwa, timu yako yehutano ichanyatsoongorora basa rechiropa chako kuburikidza nekuongororwa kweropa uye pamwe nekufungidzira zvidzidzo. Izvi zvinovabatsira kuziva kana gemtuzumab yakachengeteka kwauri uye kugadzira zviyero zvepakutanga zvekutarisa panguva yekurapa.

Ndingaita Sei Kana Ndakagamuchira Gemtuzumab yakawandisa netsaona?

Kupfuura chiyero chegemtuzumab hakuiti nekuti inotungamirirwa nenyanzvi dzehutano dzakadzidziswa munzvimbo dzakadzorwa. Zvisinei, kana uchifungidzira kuti kukanganisa kwakaitika kana uchiona zviratidzo zvakakomba panguva kana mushure mekurapa, zivisa timu yako yekurapa nekukasira.

Zviratidzo zvekuwedzera mushonga zvinogona kusanganisira kusvotwa kwakanyanya, kurutsa, kuneta kwakanyanya, kana zviratidzo zvisingawanzoitiki zvinoita sezvakaipa kupfuura zvaitarisirwa. Chikwata chako chekuchengetedza hutano chichakutarisa zvakanyanya uye chichapa rutsigiro rwekuchengeta matambudziko ese.

Hapana mushonga chaiwo we gemtuzumab, saka kurapwa kunotarisa pakugadzirisa zviratidzo uye kutsigira kupora kwemuviri wako. Izvi zvinogona kusanganisira mishonga yekudzora kusvotwa, mvura yeIV kudzivirira kupera mvura mumuviri, uye kunyatso tarisa kuverenga kweropa rako.

Ndoita Sei Kana Ndakarasikirwa NeDosisi yeGemtuzumab?

Sezvo gemtuzumab ichipiwa muchipatara kana nzvimbo yekurapa zvinoenderana nehurongwa chaihwo, kupotsa dosi kazhinji hachisi chinhu chinoitika netsaona. Chikwata chako chekuchengetedza hutano chinonyatso rongera chikamu chega chega chekurapa sechikamu chechirongwa chako chekurapa.

Kana uchida kunonotsa dosi yakarongwa nekuda kwekurwara, kuverenga ropa kwakaderera, kana dzimwe nyaya dzehutano, chiremba wako achasarudza nzira yakanakisa. Dzimwe nguva kurapwa kunogona kunonotswa nemazuva mashoma kana mavhiki kusvika muviri wako wagadzirira kubata mushonga zvakachengeteka.

Usambofa wakaedza kutsiva dosi yakarasika nekuwedzera inotevera. Chiremba wako achagadzirisa hurongwa hwako hwekurapa sezvinodiwa uchichengetedza kuchengeteka uye kushanda kwekurapa kwako. Kukurukurirana nechikwata chako chekuchengetedza hutano ndicho chakakosha pakugadzirisa chero shanduko dzekuronga.

Ndingamira Rini Kutora Gemtuzumab?

Iwe hauwanzoti

Mune dzimwe nguva, kurapwa kungamira nekukurumidza kana ukaona matambudziko akakomba kana kana kenza yako isingapinduri sezvaitarisirwa. Chikwata chako chekuchengetedza hutano chichagara chichikoshesa kuchengeteka kwako uye kugara zvakanaka pakuita zvisarudzo izvi.

Ndingagona Kubata Pamuviri Ndichitora Gemtuzumab?

Gemtuzumab inogona kukonzera kukuvadza kwakakomba kumwana asati aberekwa, saka pamuviri unofanirwa kudziviswa panguva yekurapwa uye kwemwedzi yakati wandei mushure meizvozvo. Varume nevakadzi vanofanira kushandisa nzira dzekudzivirira pamuviri dzinoshanda pavanenge vachitora mushonga uyu.

Kana uri mukadzi wezera rekubereka, chiremba wako anogona kukumbira bvunzo yekuzvitakura usati watanga kurapwa. Unofanira kuramba uchishandisa nzira dzekudzivirira pamuviri dzakavimbika kwemwedzi inenge 7 mushure meiyo dose yako yekupedzisira ye gemtuzumab.

Varume vanofanirawo kushandisa nzira dzekudzivirira pamuviri panguva yekurapwa uye kwemwedzi inenge 4 mushure meiyo dose yavo yekupedzisira, sezvo mushonga unogona kukanganisa sperm uye zvinogona kukuvadza mwana ari kukura. Kana uri kuronga kuva nevana mune ramangwana, kurukura sarudzo dzekuchengetedza kubereka ne chiremba wako usati watanga kurapwa.