Chii chinonzi Guanidine: Zvayinoshandiswa, Madosi, Mativi eMuviri, nezvimwe

Guanidine mushonga unopiwa nachiremba unonyanya kushandiswa kurapa chirwere chisingawanzoitiki chekusashanda kwemhasuru chinonzi Lambert-Eaton myasthenic syndrome (LEMS). Chirwere ichi chinokanganisa hukama pakati petsinga dzako nemhasuru, zvichiita kuti mabasa ezuva nezuva sekufamba, kukwira masitepisi, kana kunyange kubata zvinhu zvive zvakaoma zvisingatarisirwi.

Nepo guanidine isiri zita remumba semamwe mishonga mazhinji, inoshanda seimwe nzira yekurapa inokosha kune vanhu vanogara nemamiriro ezvinhu akasiyana e neuromuscular. Funga nezvayo sechishandiso chakakosha chinobatsira kudzorera kumwe kutaurirana pakati petsinga dzako nemhasuru kana hukama ihwohwo husiri kushanda nemazvo.

Chii chinonzi Guanidine?

Guanidine mushonga unoshanda zvakananga pazviratidzo zvemagetsi pakati petsinga dzako nemhasuru. Iyo ndeyeboka remishonga inobatsira kuvandudza kutaurirana kwetsinga-mhasuru, kunyanya kana mamwe mamiriro e autoimmune achikanganisa maitiro aya.

Mushonga uyu wakashandiswa mumaitiro ekurapa kwemakumi emakore, kunyangwe ichionekwa seimwe nzira yekurapa pane kurapa kwekutanga. Chiremba wako anowanzo funga nezve guanidine kana mamwe marapirwo asina kupa rubatsiro rwakakwana kana kana mamiriro ako akakodzera kuita sarudzo yakakodzera.

Guanidine Inoshandiswa Kunei?

Guanidine inonyanya kunyorerwa Lambert-Eaton myasthenic syndrome (LEMS), chirwere chisingawanzoitiki che autoimmune chinokanganisa vanhu vanenge 1 pa100,000. MuLEMS, immune system yako inokanganisa nzira dze calcium mumagumo etsinga dzako, ichikanganisa zviratidzo zvinoudza mhasuru dzako kuti dzibvumirane.

Dzimwe nguva vanachiremba vanogonawo kufunga nezve guanidine kune mamwe mamiriro ane kusimba kwemhasuru, kunyange izvi zvisingawanzoitiki. Izvi zvinogona kusanganisira mamwe marudzi ekusagadzikana kwemhasuru uko hukama hwe tsinga-mhasuru hunokanganiswa, asi kushandiswa kwakadaro kunowanzo chengeterwa mamiriro chaiwo apo mamwe marapirwo asina kubudirira.

Mishonga inoshanda zvakanyanya kune vanhu vane kusimba kwemhasuru kunovandudzika zvishoma nezvishoma nekushandiswa kakawanda kwemhasuru dzakakanganiswa. Kana ukaona kuti simba rako rinovandudzika zvishoma sezvaunoramba uchifamba zuva rese, guanidine inogona kubatsira zvakanyanya mumamiriro ako ezvinhu.

Guanidine Inoshanda Sei?

Guanidine inoshanda nekuwedzera kuburitswa kwemutumwa wemakemikari anonzi acetylcholine pamusangano pakati petsinga dzako nemhasuru. Funga nezve acetylcholine sechinhu chinovhura mhasuru contraction - paunenge usina zvakakwana, mhasuru dzako hadzigone kupindura zvakanaka kune zviratidzo zve tsinga.

Mishonga iyi inobatsira zvakanyanya magumo etsinga ako kuburitsa acetylcholine yakawanda, iyo inosimbisa chiratidzo chinosvika mhasuru dzako. Zvakafanana nekukwidza vhoriyamu pachiratidzo cheredhiyo chisina simba kuitira kuti unzwe mimhanzi zvakajeka.

Guanidine inoonekwa semushonga une simba zvine mwero maererano nemigumisiro yawo. Haina simba semamwe marapirwo ekusimba kwemhasuru, asi inogona kupa kuvandudzwa kunoreva kune vanhu vazhinji vane LEMS, kunyanya kana yakasanganiswa nemamwe marapirwo.

Ndinofanira Kutora Sei Guanidine?

Chiremba wako achakutanga padosi yakaderera ye guanidine uye zvishoma nezvishoma achiwedzera zvichienderana nekuti unopindura sei. Vanhu vazhinji vanotanga ne10-15 mg pa kilogram yezvirevo zvemuviri zuva rega rega, yakakamurwa kuita madhosi mashoma akati wandei zuva rese.

Unogona kutora guanidine uine kana usina chikafu, kunyange kutora nechikafu kunogona kubatsira kuderedza dumbu kana ukaona chero. Zvakanakisa kupatsanura madhosi ako zvakaenzana zuva rese kuti uchengetedze mazinga akagadzikana muhurongwa hwako.

Mushure meizvi, kuenderana kwakakosha nemushonga uyu. Edza kutora mishonga yako panguva imwechete zuva rega rega, uye usasvetuke mishonga kunyangwe uchinzwa zviri nani. Simba remhasuru dzako rinovimba nekuchengetedza mazinga akakodzera emushonga mumuviri wako.

Ndingatora Guanidine Kwenguva Yakareba Sei?

Kureba kwekurapa kwe guanidine kunosiyana zvakanyanya kubva kumunhu nemunhu uye kunoenderana nemamiriro ako akavanzika. Kune Lambert-Eaton myasthenic syndrome, vanhu vazhinji vanofanirwa kutora guanidine kwenguva refu kuti vachengetedze simba remhasuru dzavo uye kushanda.

Chiremba wako achatarisa mhinduro yako kumushonga kwemavhiki akati wandei kusvika kumwedzi. Vamwe vanhu vanoona kuvandudzwa mukati memazuva, nepo vamwe vachigona kuda mavhiki akati wandei kuti vawane mabhenefiti akazara.

Kugadzwa nguva dzose kunokosha nekuti chiremba wako anoda kuongorora kushanda kwemushonga uye kutarisa chero mhedzisiro inogona kuitika. Usambomira kutora guanidine kamwe kamwe usina kukurukura nachiremba wako, sezvo izvi zvinogona kutungamira mukudzoka kwemhasuru dzisina simba.

Ndezvipi Zviri Zvakaipa ZveGuanidine?

Semishonga yese, guanidine inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anoiziva. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye uzive kuti ungabatana nachiremba wako rini.

Mhedzisiro yakajairika inowanzoita nyoro uye inowanzoita nani sezvo muviri wako uchigadzirisa kumushonga:

• Nausea kana dumbu rinogumbuka
• Diarhea kana zvigaro zvakasununguka
• Dizziness kana lightheadedness
• Skin rash kana itching
• Musoro
• Kuneta kana kunzwa kuneta zvisingaite

Izvi zvinowanzoitika zvinowanzoita zvakanaka mukati memazuva mashoma kusvika kumavhiki sezvo muviri wako uchijaira mushonga. Kana vakapfuurira kana kuva dambudziko, chiremba wako anogona kugadzirisa dose yako kana nguva yekubatsira kuderedza ivo.

Mhedzisiro yakakomba haisi kazhinji asi inoda kutariswa kwechimbichimbi kwechiremba. Izvi zvinosanganisira maitiro akakomba ekurwara, shanduko dzakakosha mumoyo, kana zviratidzo zvematambudziko eitsvo zvakadai sekuchinja kwemaitiro ekuyera kana kuzvimba mumakumbo ako netsoka.

Vamwe vanhu vanogonawo kusangana nemhedzisiro isingawanzoitika asi inokonzera kunetseka yakadai sekutinhira kwetsandanyama kwakanyanya, kuvhiringidzika, kana kuoma kufema. Kunyange zvazvo izvi zvisingawanzoitiki, zvakakosha kuziva kuti kutariswa kwechimbichimbi kwechiremba kunogona kugadzirisa nyaya idzi zvinobudirira.

Ndiani Asingafaniri Kutora Guanidine?

Vanhu vakati wandei vanofanira kudzivisa guanidine kana kuishandisa nekuchenjerera kwakanyanya. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuraira mushonga uyu kuti ave nechokwadi chekuti wakachengeteka kwauri.

Vanhu vane matambudziko akakosha eitsvo vanofanira kazhinji kudzivisa guanidine, sezvo mushonga uyu uchigadziriswa kuburikidza neitsvo. Kana uine chirwere cheitsvo, chiremba wako achada kukutarisa zvakanyanya kana kufunga nezvemimwe mishonga.

Mukuwedzera, guanidine inogona kusakodzera kana uine mamwe mamiriro emoyo, kunyanya ayo anosanganisira kusagadzikana kwemoyo. Mushonga uyu dzimwe nguva unogona kukanganisa basa remoyo, saka chiremba wako achaongorora hutano hwako hwemoyo usati watanga kurapwa.

Vakadzi vane pamuviri uye vanoyamwisa vanofanira kukurukura njodzi nemabhenefiti zvakanyatsonaka nemupi wavo wehutano, sezvo paine ruzivo rushoma nezvekuchengeteka kwe guanidine panguva yekuzvitakura nekuyamwisa.

Mazita eGuanidine Brand

Guanidine inowanikwa pasi pemazita akati wandei emhando, kunyange kuwanikwa kuchisiyana nenyika. Mune dzimwe nzvimbo, unogona kuiona ichitengeswa seGuanidine HCl kana pasi pemazita chaiwo emhando yemishonga.

Mufesi wako wemishonga anogona kukubatsira kuziva mhando chaiyo kana vhezheni yakajairika inowanikwa munzvimbo yako. Chinhu chinoshanda chinoramba chakafanana zvisinei nemugadziri, kunyange vamwe vanhu vangaona kuti vanopindura zvishoma zvakasiyana kumafomu akasiyana.

Zvimwe Zvinhu Zvitsva zveGuanidine

Kana guanidine isina kukodzera kwauri kana isingapi rubatsiro rwakakwana, pane dzimwe nzira dzekurapa dzinowanikwa dzeLambert-Eaton myasthenic syndrome nemamwe mamiriro akafanana.

3,4-diaminopyridine (3,4-DAP) inowanzoonekwa seyekutanga-mutsara wekurapa LEMS uye inogona kunge iri nyore kupfuura guanidine kune vanhu vazhinji. Mushonga uyu unoshanda zvakafanana asi unowanzoita mashoma mativi uye unotsungirirwa zviri nani.

Kurapa kunodzivirira immune system senge prednisone, azathioprine, kana mycophenolate inogona zvakare kuve sarudzo, kunyanya kana mamiriro ako aine chikamu chakasimba cheautoimmune. Mishonga iyi inoshanda nekuderedza kurwisa kwe immune system pane yako nerve-muscle connections.

Mune zvimwe zviitiko, plasma exchange kana intravenous immunoglobulin (IVIG) kurapwa zvinogona kurairwa, kunyanya panguva dzinoita kuti zviratidzo zviwedzere zvakanyanya.

Ko Guanidine iri nani kupfuura 3,4-Diaminopyridine?

3,4-diaminopyridine (3,4-DAP) inowanzoonekwa seinoshanda zvakanyanya kupfuura guanidine pakurapa Lambert-Eaton myasthenic syndrome. Mazhinji ematungamiri ekurapa anokurudzira 3,4-DAP sechisarudzo chekutanga nekuti inowanzoita kuti zviratidzo zvigadzirise zviri nani nemhedzisiro shoma.

Zvisinei, guanidine inogona kuramba iine kukosha kune vanhu vasingapinduri zvakanaka ku3,4-DAP kana vasingakwanise kutsungirira mativi ayo. Vamwe vanhu vanogona kupindura zviri nani ku guanidine, ndosaka kuve nesarudzo dzakawanda dzekurapa zvakakosha.

Chiremba wako achafunga nezvezviratidzo zvako zvakajeka, nhoroondo yako yekurapa, uye kupindura kune dzimwe nzira dzekurapa paunenge uchisarudza pakati pemishonga iyi. Dzimwe nguva, kusanganisa kurapwa kwese kuri kuviri pamadosi akaderera kunogona kuve kunoshanda kupfuura kushandisa imwe chete.

Mibvunzo Inowanzo bvunzwa nezve Guanidine

Ko Guanidine yakachengeteka here kune vanhu vane chirwere cheshuga?

Guanidine inogona kushandiswa kune vanhu vane chirwere cheshuga, asi inoda kunyatso tariswa. Mushonga unogona kukanganisa mazinga eshuga yeropa kune vamwe vanhu, kunyangwe izvi zvisiri zvakajairika.

Chiremba wako achada kutarisa shuga yako yeropa zvakanyanya paunotanga guanidine, kunyanya kana uine chirwere cheshuga. Ita shuwa kuti uudze chiremba wako nezve chero shanduko mumaitiro ako eshuga yeropa kana mishonga yechirwere cheshuga.

Ndingaita Sei Kana Ndakatora Guanidine Yakawanda Netsaona?

Kana netsaona ukatora guanidine yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira. Kutora zvakanyanya kunogona kukonzera mhedzisiro yakakomba kusanganisira kusvotwa kwakanyanya, kurutsa, kutetereka kwemhasuru, kana matambudziko emoyo.

Usayedze kuzviita kuti urutse kunze kwekunge wairairwa zvakananga nachiremba. Chengeta bhodhoro remushonga newe paunotsvaga rubatsiro rwekurapa kuitira kuti vanachiremba vazive chaizvo zvaunotora uye zvakawanda sei.

Ndingaita Sei Kana Ndikakanganwa Dose yeGuanidine?

Kana ukakanganwa dose ye guanidine, itore paunorangarira, kunze kwekunge yava nguva yechikamu chako chinotevera. Muchiitiko ichocho, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chetsika.

Usambofa wakatora dose kaviri kuti ugadzirise imwe yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yemhedzisiro. Kana iwe uchikanganwa ma dose kazhinji, funga nezve kumisikidza zviyeuchidzo zvefoni kana kushandisa murongi wepiritsi kuti akubatsire kuti urambe uri munzira.

Ndingamira Rini Kutora Guanidine?

Unofanira kungomira kutora guanidine pasi pekutariswa kwachiremba wako. Kune vanhu vazhinji vane Lambert-Eaton myasthenic syndrome, kumisa mushonga uyu kuchaita kuti kusimba kwemhasuru kudzoke.

Chiremba wako anogona kukurudzira kuderedza zvishoma nezvishoma dose yako pane kumira kamwe kamwe. Iyi nzira inobatsira kuderedza njodzi yezviratidzo zvekubvisa uye inokutendera kuti utarise kuti muviri wako unopindura sei kune ma dose akaderera.

Ndingatyaira Here Ndichitora Guanidine?

Guanidine inogona kukonzera dzungu kana kuneta kune vamwe vanhu, izvo zvinogona kukanganisa kugona kwako kutyaira zvakachengeteka. Paunotanga kutora mushonga, zvakanaka kudzivisa kutyaira kusvikira waziva kuti zvinokukanganisa sei.

Kana wava pamushonga wakagadzikana kwenguva yakati rebei uye usina kunzwa dzungu kana zvimwe zvinokunetsa, vanhu vazhinji vanogona kutyaira zvakajairika. Zvisinei, gara uchishandisa pfungwa dzako uye usatyaira kana usina kunzwa zvakanaka kana kuneta zvisingajairiki.