Chii chinonzi Icatibant: Zvazvinoshandiswa, Mishonga, Zvazvinokonzeresa uye Zvimwe

Icatibant mushonga wakakosha wakagadzirirwa kurapa hereditary angioedema (HAE), chirwere chisingawanzoitiki chinokonzera kuzvimba kwakanyanya. Mushonga uyu unovharisa zvimwe zvinogamuchira mumuviri wako zvinokonzera zviitiko zvinotyisa zvekuzvimba, zvichipa zororo kana uchizvida zvakanyanya.

Kana iwe kana mumwe munhu waunoda akaongororwa HAE, kunzwisisa icatibant kunogona kukubatsira kuti unzwe wakagadzirira uye wakavimbika nezvekutarisira mamiriro aya. Mushonga uyu unomiririra kubudirira kukuru mukurapa HAE kurwisa, uchipa tariro uye zororo rinoshanda kune avo vanogara nechirwere ichi chinonetsa.

Chii chinonzi Icatibant?

Icatibant mushonga we synthetic unotevedzera protein yechisikigo mumuviri wako inonzi bradykinin receptor antagonist. Yakagadzirirwa kunyatsomisa kutevedzana kwezviitiko zvinotungamira kuHAE kurwisa nekudzivisa bradykinin B2 receptors.

Funga nezve bradykinin sechinhu chikuru chinovhura kuzvimba mumuviri wako. Icatibant inoshanda sekuvharisa zvakare kuti kiyi iyoyo isashande zvakare. Mushonga uyu unouya se syringe yakazadzwa kare yaunojowa pasi peganda rako, zvichiita kuti iwanikwe kuti ishandiswe nekukurumidza kumba kana munzvimbo dzekurapa.

Mushonga uyu ndewechikamu chemishonga inonzi bradykinin receptor antagonists, uye ndechimwe chezvinhu zvakanyanya kurapwa zviripo zveHAE kurwisa. Kusiyana nemishonga inopesana nekuzvimba, icatibant yakagadzirirwa kunyatsogadzirisa chikonzero cheHAE kuzvimba.

Icatibant inoshandiswa chii?

Icatibant inonyanya kushandiswa kurapa kurwisa kwakanyanya kwehereditary angioedema muvanhu vakuru nevechiri kuyaruka. HAE chirwere chisingawanzoitiki chegenetic chinokanganisa vanhu vanenge 1 kubva pa50,000 pasi rose, zvichikonzera zviitiko zvisingatarisirwi zvekuzvimba kwakanyanya.

Panguva yekurwisa kweHAE, unogona kusangana nekuzvimba kunotyisa muchiso chako, pahuro, maoko, tsoka, kana mudumbu. Zviitiko izvi zvinogona kuva zvinotyisa upenyu, kunyanya kana zvichikanganisa nzira yako yemhepo kana kukonzera kurwadziwa kwakanyanya mudumbu kunotevedzera mamwe mamiriro ekukurumidzira.

Mishonga iyi yakanyatsogadzirirwa kurwisa kweHAE uye haishandiswe kune mamwe marudzi ekugadzirisa muviri kana kuzvimba. Chiremba wako achangonyora icatibant kana uine chirwere cheHAE chakavimbiswa kuburikidza nekuyedzwa kwemajini kana nhoroondo yemhuri, pamwe chete nemiedzo yeropa inoratidza kushaikwa kana kusashanda kweC1 esterase inhibitor.

Icatibant Inoshanda Sei?

Icatibant inoshanda nekudzivisa bradykinin B2 receptors mumuviri wako wese, ndivo vanonyanya kukonzera kurwisa kweHAE. Kana ma receptors aya akashandiswa, anokonzera kupisa kwemuviri kunotungamira mukuzvimba kweHAE.

Mishonga iyi inoonekwa seyakasimba, yakatarwa kurapwa nekuti inovhiringidza zvakananga nzira chaiyo inokonzera zviratidzo zveHAE. Kusiyana neantihistamines kana corticosteroids, izvo zvinoshanda zvakanyanya pane immune system, icatibant inotarisa pane chaiyo nzira inokonzera kuzvimba kwako.

Mishonga iyi inowanzo kutanga kushanda mukati memaminitsi makumi matatu kusvika kumaawa maviri mushure mejekiseni, nevakawanda vachiona kuvandudzwa kukuru muzviratidzo zvavo panguva iyi. Mhedzisiro inogona kugara kwemaawa akati wandei, ichipa muviri wako nguva yekugadzirisa kurwisa zvakasikwa.

Ndingatora Sei Icatibant?

Icatibant inopiwa sejekiseni repasi peganda, zvinoreva kuti inojekeswa pasi peganda pane mumhasuru kana tsinga. Madosi akajairika i30 mg, anopiwa kuburikidza nesirinji yakazadzwa kare yakagadzirirwa kushandiswa kamwe chete.

Muchinja icatibant munyama inofutisa mudumbu rako, chidya, kana ruoko rwepamusoro. Chiremba wako achakudzidzisa iwe kana nhengo yemhuri kuti ungaita sei jekiseni zvakanaka, kuitira kuti ugone kurishandisa munguva yekukurumidzira. Nzvimbo yekujekiseni inofanira kunge yakachena, uye unofanira kuchinjisa nzvimbo kana uchida madosi akawanda.

Kusiyana nemishonga yakawanda, icatibant haifaniri kutorwa nechikafu kana mvura sezvo ichijekeswa. Zvisinei, unofanira kuchengeta mushonga mufiriji yako uye woita kuti usvike tembiricha yemumba usati wajekesa. Usambofa wakazunza sirinji, sezvo izvi zvinogona kukuvadza mushonga.

Kana dose yako yekutanga isingapi rubatsiro rwakakwana mushure memaawa matanhatu, chiremba wako anogona kukurudzira jekiseni rechipiri. Vamwe vanhu vangada dose yechitatu, asi izvi zvinofanira kuitwa chete pasi pekutariswa kwechiremba.

Ndingatora Icatibant Kwenguva Yakareba Sei?

Icatibant inoshandiswa pazvinodiwa panguva yekurwisa kweHAE, panzvimbo pemushonga wezuva nezuva wekudzivirira. Kurwisa kwega kwega kunobatwa zvakasiyana, uye iwe unongoshandisa icatibant kana uri kusangana nezviratidzo zveHAE zvinoshanda.

Vanhu vazhinji vanowana kuti jekiseni rimwe rinopa rubatsiro rwekurwisa kwese, izvo zvinowanzoitika mazuva 1-5 pasina kurapwa. Neicatibant, kurwisa kwakawanda kunogadziriswa nekukurumidza, kazhinji mukati memaawa 4-8 ekujekesa.

Chiremba wako haazonyore icatibant yekushandiswa kwenguva refu zuva nezuva. Pane kudaro, vachave nechokwadi chekuti une mukana wekuwana mushonga wemamiriro ekukurumidzira uye vanogonawo kukurukura kurapwa kwekudzivirira kana iwe uchisangana nekurwisa kakawanda.

Ndezvipi Zvakaipa ZveIcatibant?

Semishonga yese, icatibant inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachizvitsungirira zvakanaka vachifunga nezvekuoma kweHAE kurwisa. Mhedzisiro yakajairika inowanzoita nyoro uye yenguva pfupi.

Heano mhedzisiro inonyanya kuziviswa yaungasangana nayo:

• Kushatirwa panzvimbo yekubaiwa jekiseni kusanganisira kutsvuka, kuzvimba, kana kurwadziwa kudiki
• Dizziness kana kunzwa musoro uchirwadza
• Nausea kana dumbu kusagadzikana
• Kutemwa nemusoro
• Fivha kana kunzwa kupisa
• Kuneta kana kunzwa kuneta

Izvi zvinowanzoitika zvinowanzoenda zvega mukati memaawa mashoma uye zvinowanzoita zvakanyanya kudzora kupfuura kurwisa kweHAE pachayo.

Zvimwe zvinokuvadza zvakanyanya hazviwanzoitiki asi zvinogona kuitika. Unofanira kutsvaga rubatsiro rwekurapa nekukasira kana ukaona:

• Zvirwere zvakanyanya zveallergy zvinosanganisira kuoma kufema kana rash yakapararira
• Kurwadziwa muchipfuva kana kurova kwemoyo kusingaite
• Dizziness yakanyanya kana kufenda
• Zviratidzo zve stroke zvakadai sekushaya simba kamwe kamwe, kuvhiringidzika, kana kuoma kutaura
• Zvirwere zvakanyanya panzvimbo yekubaiwa jekiseni nekutsvuka kana kudziya

Vanhu vazhinji vanowana kuti mabhenefiti e icatibant anopfuura njodzi dzinogona kuitika, kunyanya kana tichifunga kuti kurwisa kweHAE kusingabatwi kunogona kuva kwengozi sei.

Ndiani Asingafaniri Kutora Icatibant?

Icatibant haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana yakakukodzera. Mushonga haukurudzirwi kuvana vari pasi pemakore gumi nemasere, sezvo kuchengeteka nekushanda hazvina kumiswa muvanhu ava.

Haufaniri kushandisa icatibant kana uine allergy kumushonga kana chero zvinhu zvawo. Udza chiremba wako nezve chero zvaunoita kare kumishonga yakafanana kana uine nhoroondo yezvirwere zvakanyanya zvemadhiragi.

Vanhu vane mamwe mamiriro emoyo vangangoda kuongororwa kwakakosha pavanenge vachishandisa icatibant. Chiremba wako achanyatso chenjerera kana uine nhoroondo yezvirwere zvemtima, sitiroko, kana matambudziko ekuumbwa kweropa.

Kuzvitakura nekuyamwisa zvinoda kufunga kwakakosha. Kunyange zvazvo icatibant isina kunyatsodzidzwa muvakadzi vane pamuviri, chiremba wako achayera mabhenefiti anogona kuitika pamusoro penjodzi kana uine pamuviri uye uchiona kurwisa kwakanyanya kweHAE.

Icatibant Brand Zita

Icatibant inotengeswa pasi pezita rekuti Firazyr munyika zhinji, kusanganisira United States neEurope. Iri ndiro zita guru rauchasangana naro kana chiremba wako akanyora mushonga uyu.

Firazyr inogadzirwa neTakeda Pharmaceuticals uye inouya se syringe yakazadzwa kare ine 30 mg ye icatibant. Kurongwa kwemavara ebhuruu nechena kunoita kuti zvive nyore kuziva mumamiriro ezvinhu ekukurumidzira.

Parizvino, hapana mhando dzakajairika dze icatibant dziripo, saka Firazyr inoramba iri iyo chete sarudzo yemushonga uyu chaiwo. Inishuwarenzi yako uye mabhenefiti emakambani emishonga achasarudza mari yaunobhadhara yemushonga uyu wakakosha.

Zvimwe Zvinhu Zviri Kutsiva Icatibant

Mishonga yakati wandei inogona kurapa HAE kurwisa, kunyangwe imwe neimwe ichishanda zvakasiyana uye inogona kukodzera mamiriro akasiyana. Chiremba wako achabatsira kuona kuti ndeipi sarudzo yakanakira zvaunoda.

Ecallantide (zita rechiratidzo Kalbitor) mumwe mushonga wejekiseni unoshanda nekudzivisa kallikrein, enzyme inobatanidzwa muHAE kurwisa. Kusiyana ne icatibant, ecallantide inofanira kupihwa nachiremba nekuda kwengozi yakakwira yekuitika kwemaitiro akakomba ekugadzirisa muviri.

C1 esterase inhibitor concentrates, inowanikwa seBerinert, Cinryze, kana Ruconest, inoshanda nekutsiva protein iyo isina kukwana kana isingashande muHAE. Mishonga iyi inopihwa intravenously uye inogona kushandiswa zvese kurapa kurwisa uye kuzvidzivirira.

Plasma yakachena yechando yakashandiswa kare mishonga iyi mitsva isati yawanikwa, asi ikozvino inoonekwa seimwe sarudzo isina kunaka nekuda kwengozi yekutapukirwa nezvirwere zvinotapuriranwa neropa uye kushanda kwakasiyana.

Icatibant Zviri Nani Pane Ecallantide Here?

Icatibant ne ecallantide zvese zvinoshanda kurapa HAE kurwisa, asi imwe neimwe ine zvainobatsira zvichienderana nemamiriro ako. Sarudzo pakati pavo inowanzoenderana nekureruka, kuchengetedzwa, uye mhinduro yako pachako.

Chinhu chikuru chinobatsira icatibant ndechokuti unogona kuzvipa iwe pachako kumba, izvo zvakakosha munguva dzekukurumidzira apo kuenda kuchipatara nekukurumidza kungava kwakaoma. Iyo zvakare ine njodzi shoma yekuti muviri urambe mushonga zvakanyanya kana ichienzaniswa neecallantide.

Ecallantide inogona kushanda nekukurumidza zvishoma mune vamwe vanhu uye inogona kushanda zvakanyanya kune mamwe marudzi eHAE kurwisa. Zvisinei, inofanira kupiwa nachiremba nekuda kwenjodzi yeanaphylaxis, iyo inodzivisa kushandiswa kwayo mumamiriro ekukurumidzira kumba.

Chiremba wako achafunga nezvezvinhu zvakaita semararamiro ako, kakawanda kaunorwara, kuwana rubatsiro rwekurapa, uye zvaunofarira iwe pachako paunenge uchikurudzira pakati pezvisarudzo izvi. Vanhu vazhinji vanoona icatibant ichishanda zvakanyanya pakukurumidzira, nepo vamwe vachigona kusarudza ecallantide kurwisa kunoitika munzvimbo dzekurapa.

Mibvunzo Inowanzo Bvunzwa Nezve Icatibant

Icatibant Yakachengeteka Here Kune Zvirwere Zvemoyo?

Vanhu vane chirwere chemoyo vanogona kushandisa icatibant, asi vanoda kuongororwa zvakanyanya kwekurapa uye kuongororwa. Mushonga uyu unogona kukanganisa ropa uye rhythm yemoyo mune vamwe vanhu, saka chiremba wako wemoyo uye nyanzvi yeHAE vachada kushanda pamwechete.

Chiremba wako achatarisa mamiriro ako chaiwo emoyo, mishonga yaunotora parizvino, uye hutano hwako hwese usati wanyora icatibant. Vanogona kukurudzira kuongororwa kwakawedzerwa kana dzimwe nzira dzekurapa kana mamiriro ako emoyo akakomba kana kusagadzikana.

Vanhu vazhinji vane chirwere chemoyo chinyoro kusvika pakati nepakati vakashandisa zvakachengeteka icatibant kurwisa HAE. Chinhu chakakosha kutaurirana pachena nechikwata chako chekurapa nezve zvese zvirwere zvako zvekurapa nemishonga.

Ndoita Sei Kana Ndikashandisa Icatibant Yakawandisa Netsaona?

Kana iwe ukabaya netsaona icatibant yakawanda kupfuura yakarairwa, taura nachiremba wako kana masevhisi ekukurumidzira nekukasira. Kunyange zvazvo overdoses dzisingawanzoitiki nekuda kwekugadzirwa kwesiringe yakazadzwa, kutora zvakanyanya kunogona kuwedzera njodzi yako yemigumisiro.

Zvizvitarise zvakanyanya nezviratidzo zvakaita sedzungu rakanyanya, kusvotwa, kana maitiro panzvimbo yekudzika jekiseni. Usaedze kupikisa overdose wega, sezvo izvi zvinogona kuomesa kurapwa kwako.

Chengeta kurongedza mushonga uuye nawo kuchipatara kuitira kuti vapi vehutano vaone chaizvo zvawakatora uye zvawakatora zvakadii. Nguva yakakosha, saka usanonoke kutsvaga rubatsiro rwekurapa kana uchinetseka nezve overdose.

Ndoita Sei Kana Ndikakanganwa Dose yeIcatibant?

Sezvo icatibant inoshandiswa chete panguva yekurwisa kweHAE panzvimbo yechirongwa, haugone chaizvo

Hongu, unogona kufamba ne icatibant, asi zvinoda kuronga nekuti mushonga unoda kutonhodzwa uye uchange wakabata zvekubaya. Ndege zhinji dzinobvumira mishonga inodiwa nemutemo mumutoro wekufambisa uine magwaro akakodzera.

Uya netsamba kubva kuna chiremba wako ichitsanangura mamiriro ako uye kudiwa kwemushonga. Paka icatibant mubhegi rine insulation rine ice packs, uye funga kuuya nezvimwe zvekushandisa kana paine kunonoka kufamba.

Tsvaga nzvimbo dzekurapa kwauri kuenda kana uchida rubatsiro rwekukurumidza kana mishonga yakawedzerwa. Nyanzvi zhinji dzeHAE dzinogona kupa gwara rekufamba zvakachengeteka nemamiriro ako nemishonga.