Chii chinonzi Iloprost: Zvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Iloprost mushonga wakakosha unobatsira kuvandudza kuyerera kweropa nekuzarura tsinga dzeropa dzakamanikana. Iyo vhezheni yekugadzira yechinhu chechisikigo chinogadzirwa nemuviri wako chinonzi prostacyclin, iyo inoita semutumwa munyoro achiudza tsinga dzako dzeropa kuti dzizorore uye dziwedzere. Mushonga uyu unowanzo kupihwa kuburikidza neIV muchipatara kana kiriniki, uko nyanzvi dzehutano dzinogona kunyatso tarisa maitiro ako ekurapa.

Chii chinonzi Iloprost?

Iloprost ndeyemhuri yemishonga inonzi prostacyclin analogs. Funga nezvayo semubatsiri anotevedzera zvinongoitwa nemuviri wako kuti ropa riyerere zvakanaka. Kana tsinga dzako dzeropa dzikava diki kana kuoma, iloprost inopinda mukati kuti ivakurudzire kuti dzivhurezve.

Mushonga uyu unoshanda padanho re cellular, achitumira zviratidzo zvinobatsira tsinga dzeropa kuzorora uye kuderedza kunamatira kwemaplatelet eropa. Mhedzisiro yacho ndiyo kutenderera kuri nani, iyo inogona kuunza zororo rinodiwa kumativi emuviri wako akanga asiri kuwana ropa rakakwana kare.

Chii chinonzi Iloprost chinoshandiswa?

Iloprost inonyanya kushandiswa kurapa pulmonary arterial hypertension (PAH), mamiriro akakomba apo BP mumapapu inova yakanyanya. Inobatsira kuvhura tsinga diki dzeropa mumapapu ako, zvichiita kuti mwoyo wako uwedzere kuburitsa ropa kuburikidza nawo.

Kunze kwePAH, vanachiremba dzimwe nguva vanoraira iloprost yeakakomba peripheral artery disease, kunyanya kana mamwe marapirwo asina kushanda zvakanaka. Muzviitiko izvi, inogona kubatsira kuvandudza kuyerera kweropa kumaoko ako nemakumbo, kuderedza kurwadziwa uye kubatsira kudzivirira kukuvadzwa kwetishu.

Mune dzimwe nguva dzakakosha, iloprost inogona kushandiswa kune critical limb ischemia, mamiriro apo kuyerera kweropa kumativi ako kunoderedzwa zvakanyanya. Inowanzo fungwawo kune mamwe marudzi eRaynaud's phenomenon kana mamiriro acho akanyanya uye mamwe marapirwo asina kupa rubatsiro rwakakwana.

Iloprost Inoshanda Sei?

Iloprost inofungidzirwa kuti ine simba revasodilator, zvinoreva kuti ine simba guru mukuvhura midzi yeropa asi inoda kuyera zvakanaka. Inoshanda nekubatanidza kune mamwe ma receptors pamadziro emidzi yeropa rako, ichikonzera chiitiko chekuti chinotungamira kuzorora uye kuwedzera.

Mishonga iyi zvakare ine anti-clotting properties, zvinoreva kuti inobatsira kudzivirira ropa rako kubva pakuve rakanyanya kunamatira kana kuumba magwamba asingadiwe. Iyi chiito kaviri chekuvhura midzi yeropa uye kuvandudza maitiro ekuyerera kweropa inoita kuti ive inoshanda zvakanyanya kune matambudziko ekutenderera.

Kusiyana nemamwe mishonga anoshanda nekukasira, mhedzisiro yeiloprost inovaka nekufamba kwenguva nekudzokorora kurapwa. Unogona kutanga kuona kuvandudzwa muzviratidzo zvako mushure mematanho akati wandei ekurapa, kunyangwe vamwe vanhu vachiwana mabhenefiti nekukurumidza.

Ndinofanira Kutora Sei Iloprost?

Iloprost inogara ichipiwa intravenously (kuburikidza neIV) munzvimbo yekurapa, kwete kumba. Chikwata chako chehutano chichaisa chubhu diki mumwe wemitsipa yako, kazhinji muruoko rwako, uye mushonga uyu uchapiwa zvishoma nezvishoma kwemaawa akati wandei.

Infusion inowanzo tora pakati pe6 kusvika ku9 maawa, uye uchafanirwa kuramba munzvimbo yekurapa panguva ino. Chikwata chako chekurapa chichatarisa ropa rako, kurova kwemoyo, uye manzwiro ako panguva yese yekuita.

Hamufaniri kutsanya musati mapiwa mushonga, asi zvinowanzoita zvakanaka kudya chikafu chakareruka pamberi sezvo maitiro acho anotora maawa akati wandei. Zvakakosha kuti muve nemvura yakakwana mumuviri, saka inwai mvura yakawanda musati mapiwa mushonga uye panguva yacho kunze kwekunge chiremba wenyu achikurudzira zvimwe.

Vamwe vanhu vanoona zvichibatsira kuuya nechinhu chokuvachengeta vakabatikana panguva refu yekuiswa mushonga, zvakadai semabhuku, mahwendefa, kana mimhanzi. Nzvimbo yekurapwa inowanzoita yakasununguka, asi muchafanira kugara makanyarara kuti musakanganisa mutsetse weIV.

Ndingatora Iloprost Kwenguva Yakareba Sei?

Kureba kwemushonga weiloprost kunosiyana zvakanyanya zvichienderana nemamiriro ako chaiwo uye kuti unopindura sei kumushonga. Kune pulmonary arterial hypertension, kutenderera kwemushonga kunowanzoita kunosanganisira infusions yezuva nezuva kwemazuva akati wandei akatevedzana, achiteverwa nenguva yekuzorora.

Vanhu vazhinji vanogamuchira kutenderera kwemushonga kunotora mazuva matatu kusvika ku5, achidzokororwa mumasvondo 6 kusvika ku12. Zvisinei, chiremba wenyu achagadzira chirongwa chakagadzirirwa iwe zvichienderana nezviratidzo zvako, mhedzisiro yebvunzo, uye hutano hwako hwese.

Kune peripheral artery disease kana critical limb ischemia, chirongwa chemushonga chingave chakasiyana, dzimwe nguva chichisanganisira kutenderera kwenguva refu kana mishonga inowanzoitika pakutanga. Chikwata chako chehutano chichagara chichiongorora kana mushonga uchibatsira uye kugadzirisa chirongwa chemushonga zvinoenderana.

Kuronga kwenguva refu kwemushonga kunoenderana nemamiriro ako ekutanga uye kana iloprost ichiramba ichipa mabhenefiti. Vamwe vanhu vanogona kuchinjira kune mamwe mishonga, nepo vamwe vachigona kuramba vaine iloprost sechikamu chekurapa kwavo kuri kuenderera mberi.

Ndezvipi Zvakaipa ZveIloprost?

Semishonga yese, iloprost inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachizvitsungirira zvakanaka kana vakatariswa zvakanaka. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye wakavimbika panguva yekurapwa.

Zvimwe zvinokonzera zvinowanzoitika zvaungasangana nazvo zvinosanganisira kurwadziwa nemusoro, flushing (kunzwa kudziya uye kutsvuka pachiso), uye kusvotwa. Izvi zvinowanzoitika panguva kana nguva pfupi mushure mekuiswa uye kazhinji zvinovandudza muviri wako sezvaunojairira mushonga.

Heano mamwe emigumisiro inowanzoitika vanhu vanosangana nayo:

• Kurwadziwa nemusoro, kunogona kubva pakureruka kusvika pakati nepakati
• Kutsvuka kwechiso uye kunzwa kudziya
• Kusvotwa kana kusagadzikana mudumbu
• Dizziness kana lightheadedness
• Kurwadziwa kwemumagumo kana kurwadziwa kwemhasuru
• Diarhea kana zvigaro zvakasununguka
• Kuneta kana kunzwa kuneta

Izvi zvinokonzera zvinowanzoitika uye kazhinji zvinoderera mukukura sezvaunogamuchira mamwe marapirwo. Chikwata chako chehutano chinogona kupa nzira dzekubatsira kuderedza kusagadzikana.

Vamwe vanhu vanogona kusangana nemigumisiro yakakura inoda kuongororwa zvakanyanya:

• Kuderera kweropa, izvo zvinogona kukonzera dzungu kana kufenda
• Kukurumidza kwemoyo kana palpitations
• Kutadza kufema kana kusimba pachipfuva
• Kurwadziwa kwemusoro kwakanyanya kusingavandudzike nekubatsirwa nekurapa kurwadziwa
• Zviratidzo zvekubuda ropa, zvakadai sekukuvara kusinganzwisisike kana kubuda ropa mumhino

Izvi zvinokonzera hazviwanzoitiki asi zvakakosha kuzivisa chikwata chako chehutano nekukasira kana zvikaitika.

Kazhinji, vamwe vanhu vanogona kusangana nezvinhu zvakakomba zvinoda kutariswa kwekurapa nekukasira:

• Zvirwere zvakakomba zveallergy zvine rash, kuzvimba, kana kutadza kufema
• Kuderera kukuru kweropa kunoda kupindira
• Kusiyana kwemoyo
• Pulmonary edema (mvura mumapapu)
• Zvikuru kubuda ropa

Nepo izvi zvinokonzera zvakakomba zvisingawanzoitiki, nzvimbo yekurapa uko iloprost inotungamirirwa inovimbisa kuti rubatsiro runowanikwa nekukasira kana zvichidikanwa.

Ndiani Asingafaniri Kutora Iloprost?

Iloprost haakodzwi kumunhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yezvokurapa asati akurudzira kurapwa uku. Mamiriro akati wandei kana mamiriro anoita kuti iloprost isachengeteke kana kushanda zvishoma.

Haufaniri kugamuchira iloprost kana uine chirwere chemoyo chakakomba, kunyanya mhando dzakasiyana dzekukundikana kwemoyo kana kurwisa kwemoyo kwemazuva ano. Zvinhu zvinokonzerwa nemishonga pakuwanda kweropa uye kumhanya kwemoyo zvinogona kuva nematambudziko mumamiriro ezvinhu aya.

Vanhu vane matambudziko ekubuda ropa kana avo vari kutora mishonga yekutapudza ropa havangave vakakodzera iloprost. Sezvo mushonga uyu uchikanganisa kuumbwa kweropa, unogona kuwedzera njodzi yekubuda ropa muvanhu vanotambura.

Zvimwe zvirwere zvinowanzoita kuti iloprost isashandiswe zvinosanganisira:

• Chirwere chechiropa chakakomba kana kukundikana kwechiropa
• Chirwere cheitsvo chakakomba chinoda dialysis
• Kuwanda kweropa kusingadzorwi
• Kurohwa kwemoyo kwemazuva ano kana kubuda ropa muuropi
• Chirwere che peptic ulcer chinoshanda
• Anemia yakakomba kana kuverenga kwep platelet kwakaderera

Kuzvitakura nekuyamwisa zvinoda kufunga kwakakosha, sezvo zvinhu zvinokonzerwa neiloprost pavacheche vari kukura zvisinganzwisiswi zvizere. Chiremba wako achayerera zvakanakira zvinogona kuitika pamwe nenjodzi dzinogona kuitika kana wakazvitakura kana kuronga kutakura.

Zera rega rega harisi chipingamupinyi chekurapa, asi vanhu vakuru vangada kuongororwa zvakanyanya nekuda kwekuwedzera kunzwisiswa kwezvinhu zvinokonzerwa nemishonga.

Mazita eBrand eIloprost

Iloprost inowanikwa pasi pemazita akati wandei ebrand, neVentavis ichizivikanwa zvakanyanya muUnited States. Iri brand rakagadzirirwa kurapwa kwekunhuwa, kunyangwe mafomu e intravenous aripowo pasi pemazita akasiyana.

Mamwe mazita emhando anosanganisira Ilomedin, iyo inoshandiswa munyika dzakasiyana siyana yekuiswa mumitsipa. Mhando chaiyo uye fomu rinotorwa nachiremba wako zvinoenderana nemamiriro ako uye nzira yekurapa yavanotenda kuti ichashanda zvakanaka kwauri.

Zvisinei nezita remhando, mishonga yese yeiloprost ine chinhu chimwe chete chinoshanda. Misiyano iri zvakanyanya mukukosha, nzira yekutumira, uye mitemo chaiyo yekugadzira.

Zvimwe Zvinhu Zvokutsiva Iloprost

Mishonga yakati wandei inogona kushanda senzira yekutsiva iloprost, zvichienderana nemamiriro ako chaiwo uye zvinangwa zvekurapa. Zvimwe zvinhu izvi zvinoshanda kuburikidza nemaitiro akafanana kana akasiyana ekugadzirisa kuyerera kweropa uye kuderedza zviratidzo.

Kune pulmonary arterial hypertension, zvimwe zvinhu zvinosanganisira epoprostenol (Flolan), treprostinil (Remodulin), uye selexipag (Uptravi). Imwe neimwe ine zvainofarira uye zvainofanira kufunga nezvazvo maererano nekuyera, mhedzisiro, uye nzira dzekutonga.

Zvimwe zvingasarudzwa zvekutanga zvinogona kusanganisira endothelin receptor antagonists senge bosentan (Tracleer) kana ambrisentan (Letairis), iyo inoshanda nekudzivisa zvinhu zvinokonzera kuoma kwemidzi yeropa. Phosphodiesterase-5 inhibitors senge sildenafil (Revatio) inopa imwe nzira yekuvandudza kuyerera kweropa.

Kune peripheral artery disease, zvimwe zvinhu zvinogona kusanganisira mamwe ma vasodilators, antiplatelet mishonga, kana marapirwo matsva akagadzirirwa kusimudzira kukura kwemidzi yeropa. Chiremba wako achafunga nezvemamiriro ako chaiwo paanokurudzira zvimwe zvinhu.

Iloprost Zviri Nani Kudarika Epoprostenol Here?

Zvese iloprost uye epoprostenol analogs eprostacyclin, asi vane misiyano yakakosha inoita kuti imwe ive yakakodzera kune vamwe vanhu. Sarudzo pakati pavo inoenderana nezvido zvako zvakakosha, mararamiro, uye kuti unotsungirira sei mishonga yega yega.

Iloprost ine nguva refu yekugara mumuviri kupfuura epoprostenol, zvinoreva kuti inoramba ichishanda mumuviri mako kwenguva refu. Izvi zvinogona kuva zvakanaka nekuti zvinobvumira kushandiswa kwemishonga isingawanzoitiki uye zvinogona kupa mhedzisiro yakagadzikana zuva rese.

Epoprostenol inoda kuenderera mberi kwejekiseni kuburikidza nemutsara wepakati, zvinoreva kuti unofanirwa kutakura pombi diki newe nguva dzese. Iloprost, kune rumwe rutivi, inogona kupiwa sejekiseni rinopindirana, iro vanhu vazhinji vanowana zvakanyanya nyore muhupenyu hwavo hwezuva nezuva.

Mhedzisiro yezvinhu zvakafanana, asi vamwe vanhu vanotsungirira mushonga mumwe zviri nani pane mumwe. Chiremba wako achafunga nezve mamiriro ako ega, kusanganisira kugona kwako kubata masisitimu akasiyana ekutumira uye mhinduro yako kumishonga.

Mibvunzo Inowanzo Bvunzwa Nezve Iloprost

Iloprost Yakachengeteka Here Kune Zvirwere Zvemoyo?

Iloprost inoda kuongororwa zvakanyanya kana uine chirwere chemoyo, sezvo ichigona kukanganisa kurova kwemoyo wako uye kudzvanywa kweropa. Kune vanhu vane mamiriro emoyo akapfava kusvika pakati nepakati, zvinogona kuva zvakachengeteka pasi pekutariswa kwechiremba, asi avo vane chirwere chemoyo chakakomba kana kurwisa kwemoyo kwemazuva ano havawanzo gamuchira mushonga uyu.

Nyanzvi yako yezvinhu zvekurapa moyo uye timu inobata kurapwa kwako kwe iloprost vachashanda pamwechete kuti vaone kana zvakakodzera kune mamiriro ako emoyo chaiwo. Vachafunga nezvezvinhu zvakaita sekushanda kwemoyo wako, mishonga iripo, uye hutano hwese hwemoyo.

Kana iwe ukagamuchira iloprost uine chirwere chemoyo, ungangoda kuongororwa kakawanda panguva yekurapa, kusanganisira kurova kwemoyo uye kuongorora kudzvanywa kweropa panguva yese yekuiswa.

Ndoitei Kana Ndikagamuchira Iloprost Yakawandisa Netsaona?

Sezvo iloprost ichipiwa intravenously munzvimbo yekurapa, overdoses netsaona hazviwanzoitiki nekuti nyanzvi dzehutano dzinonyatso kudzora dosing. Zvisinei, kana iwe ukaona zviratidzo zvakakomba panguva yekurapa, zvakakosha kutaura nekukurumidza.

Zviratidzo zve iloprost yakawandisa zvinogona kusanganisira kurwadziwa kwemusoro kwakanyanya, dzungu rakanyanya, kudzikira kwakanyanya kweropa, kana kuoma kufema. Chikwata chekurapa chiri kuongorora kurapwa kwako chakadzidziswa kuziva nekupindura kune izvi zviitiko nekukurumidza.

Kana mamiriro ekupfuudzwa akaitika, infusion ichamira nekukasira, uye kutarisirwa kunotsigira kuchapiwa kubatsira muviri wako kupora. Zvizhinji zvezvinhu zvinokonzerwa nekupfuudzwa zvinogona kudzoserwa kana mushonga wamiswa.

Ndingaita Sei Kana Ndikakanganwa Kurapwa kweIloprost Kwakarongeka?

Kana iwe ukakanganwa kurapwa kwe iloprost kwakarongeka, taura nemupi wezvehutano wako nekukurumidza sezvinobvira kuti urongezve. Usaedze kutsiva kurapwa kwakakanganwa nekugamuchira mushonga wakawedzerwa kana kuwedzera nguva yako inotevera ye infusion.

Zvichienderana nekuti zvakatora nguva yakareba sei kubva pakurapwa kwako kwawakakanganwa uye mamiriro ako chaiwo, chiremba wako angachinja chirongwa chako chekurapa kana kurumbidza kuongorora kwakawedzerwa paunotangazve kurapwa.

Kukanganwa kurapwa kwemumwe nemumwe kazhinji hakuna njodzi, asi kuenderana kwakakosha pakuchengetedza mabhenefiti emushonga. Shanda nechikwata chako chehutano kuti uwane chirongwa chaunogona kuchengetedza chaizvo.

Ndingamira Rini Kutora Iloprost?

Sarudzo yekumisa iloprost inofanira kugara ichiitwa mukubvunzana nemupi wako wezvehutano, kwete wega. Vamwe vanhu vanogona kumisa kurapwa kana mamiriro avo akavandudza zvakanyanya kana kana vachichinjira kune mamwe mishonga inoshanda.

Kune mamiriro akaita se pulmonary arterial hypertension, kumisa kurapwa nekukasira kunogona kuva nenjodzi uye kungatungamirira kukuwedzera nekukurumidza kwezviratidzo. Chiremba wako anowanzo deredza kazhinji yekurapwa zvishoma nezvishoma kana kumiswa kwakakodzera.

Kuongorora nguva dzose nemiedzo yakaita seechocardiograms, basa reropa, uye kuongorora zviratidzo kunobatsira chikwata chako chehutano kuona kana kurapwa kwakaitwa kuchidikanwa uye kuchibatsira kumamiriro ako chaiwo.

Ndingatyaira Here Mushure meKuwana Kurapwa kweIloprost?

Haufaniri kutyaira pakarepo mushure mekuwana kurapwa kweiloprost, sezvo mushonga uyu unogona kukonzera dzungu, musoro, uye shanduko mudzihwa remuviri zvinogona kukanganisa kugona kwako kutyaira zvakachengeteka.

Vazhinji vanopa hutano vanokurudzira kumirira angangoita maawa akati wandei mushure mekurapwa usati watyaira, uye vamwe vanokurudzira kuti mumwe munhu akutyairire kumba mushure memasesheni ako ekupinza. Nguva chaiyo yekumirira inoenderana nekuti iwe unowanzoita sei kumushonga.

Kana iwe ukaona dzungu rinoramba riripo, kuneta, kana mamwe mativi anokanganisa kugona kwako kutyaira, zviri nani kuronga imwe nzira yekufambisa kusvikira izvi zvikanganiso zvanyangarika zvachose.