Chii chinonzi Inclisiran: Zvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Inclisiran imhando itsva yemushonga wekuderedza cholesterol unoshanda zvakasiyana nemishonga yechinyakare ye statins. Inopiwa sejojo pasi peganda rako kaviri pagore nachiremba wako, zvichiita kuti ive sarudzo iri nyore kune vanhu vanoda rubatsiro rwakawedzerwa mukugadzirisa mazinga avo e cholesterol.

Mushonga uyu ndeweboka rinonzi PCSK9 inhibitors, rinovhara protein inodzivirira chiropa chako kubvisa cholesterol yakaipa kubva muropa rako. Funga nezvazvo sekupa chiropa chako rubatsiro rwekuita basa rayo rekuchenesa cholesterol zvinobudirira.

Chii chinonzi Inclisiran?

Inclisiran mushonga unopiwa nachiremba wakagadzirirwa kuderedza LDL cholesterol, inowanzonzi

Mishonga iyi inokosha zvikuru kune vanhu vane familial hypercholesterolemia, chirwere chemagenetic chinokonzera cholesterol yakanyanya kukwira kubva pakuzvarwa. Vanhu ava vanowanzo shandisa mishonga yakawanda kuti vakwanise kudzora cholesterol yavo nemazvo.

Inclisiran inogara ichishandiswa pamwe chete nekudya kwakanaka uye kuchinja mararamiro. Haisi nzira yekutsiva kudya zvakanaka uye kuramba uchishingaira, asi chishandiso chekuwedzera chekukubatsira kuti usvike pazvinangwa zvako zvecholesterol.

Inclisiran Inoshanda Sei?

Inclisiran inoshanda nekunangana neprotein chaiyo inonzi PCSK9 mumuromo mako. Protein iyi inowanzoita kuti chiropa chako chisabvise LDL cholesterol kubva muropa rako nemazvo.

Mishonga iyi inoshandisa tekinoroji ye small interfering RNA kuti "inyararise" gene inogadzira PCSK9 protein. Kana paine PCSK9 shoma, chiropa chako chinogona kubvisa cholesterol yakawanda yakaipa kubva muropa rako, zvakafanana nekubvisa mabhureki kubva muchirongwa chechiropa chako chekuchenesa cholesterol.

Nzira iyi inoonekwa seyakasimba zvishoma zvichienzaniswa nemimwe mishonga yecholesterol. Nepo statins ichiri kurapwa kwekutanga, inclisiran inogona kuderedza LDL cholesterol neimwe 50% kana kupfuura kana yakawedzerwa kurapwa kwazvino.

Mhedzisiro yacho inogara kwemwedzi yakati wandei mushure mejekiseni rega rega nekuti mishonga inoenderera mberi ichishanda padanho remagenetic. Ichi ndicho chikonzero nei uchida majekiseni kaviri pagore panzvimbo yekutora mapiritsi ezuva nezuva.

Ndingatora Sei Inclisiran?

Inclisiran inopiwa sejekiseni pasi peganda rako nenyanzvi yehutano munzvimbo yekurapa. Hauzotore mushonga uyu kumba kana nemuromo.

Chirongwa chetsika chinotanga nejekiseni rako rekutanga, richiteverwa neimwe jekiseni mwedzi mitatu gare gare, wobva watevera mwedzi mitanhatu yega yega mushure meizvozvo. Chiremba wako achamaka mazuva aya pakarenda yako kuti usapotsa misangano.

Hamufaniri kuita chimwe chinhu chakakosha musati maenda kumusangano wenyu wejekiseni. Munogona kudya zvakajairika uye kutora mishonga yenyu imwe sezvajairika. Jekiseni racho rinotora maminitsi mashoma uye rakafanana nekuwana mushonga.

Mushure mejekiseni renyu, munogona kutangazve mabasa akajairika nekukasira. Vamwe vanhu vanonzwa kurwadziwa kudiki panzvimbo yejekiseni, zvakafanana nezvamunganzwa mushure mejekiseni ripi zvaro, asi izvi zvinowanzoenda mukati mezuva rimwe kana maviri.

Ndingatora Inclisiran Kwenguva Yakareba Sei?

Inclisiran inowanzoita kurapwa kwenguva refu yekugadzirisa cholesterol yakakwira. Vanhu vazhinji vanoenderera mberi vachiwana majekiseni kwemakore, zvakafanana nemaitiro avangatora mishonga yecholesterol yezuva nezuva.

Chiremba wenyu achatarisa mazinga enyu echolesterol uye hutano hwese nguva dzose kuti aone kana inclisiran ichienderera mberi ichikukodzera. Ivo vanowanzoongorora mazinga enyu anenge 3-6 mwedzi mushure mekutanga kurapwa uye ipapo nguva nenguva mushure meizvozvo.

Sarudzo yekupfuurira kana kumisa inclisiran inoenderana nekuti iri kushanda sei, kana uri kusangana nemigumisiro, uye njodzi yako yese yemoyo. Vamwe vanhu vanogona kupedzisira vachichinjira kune dzimwe nzira dzekurapa kana mamiriro avo achichinja.

Zvakakosha kuchengeta majekiseni enyu akarongeka kunyangwe muchinzwa zvakanaka. Cholesterol yakakwira haigone kukonzera zviratidzo, saka mungasanzwa musiyano kunyangwe mushonga uri kushanda kuchengetedza moyo wenyu nemidziyo yeropa.

Ndezvipi Zvazvinokonzera zveInclisiran?

Vanhu vazhinji vanotsungirira inclisiran zvakanaka, asi semishonga yese, inogona kukonzera migumisiro. Mashoko akanaka ndeokuti migumisiro yakakomba haisi yakajairika.

Heano migumisiro yakajairika yaungasangana nayo:

• Kushatirwa panzvimbo yekubaiwa, sekutsveruka, kuzvimba, kana kurwadziwa
• Kurwadziwa mumajoini kana kurwadziwa kwemhasuru
• Kuneta kana kunzwa kuneta kupfuura zvakajairika
• Bronchitis kana zvirwere zvekufema zvepamusoro
• Dizziness kana lightheadedness

Izvi zvinokonzeresa zvinowanzoita zvinyoro uye zvinowanzoita nani nekufamba kwenguva sezvo muviri wako uchigadzirisa mushonga. Kushatirwa panzvimbo yekubaiwa kazhinji kunopera mumazuva mashoma.

Zvisingawanzoitiki asi zvakanyanya kukomba zvinokonzeresa zvinogona kusanganisira kusagadzikana kwakanyanya, kunyangwe izvi zvichiwanzodiwa. Zviratidzo zvekusagadzikana kwakanyanya zvinosanganisira kuoma kufema, kuzvimba kumeso kwako kana huro, kana rash yakapararira.

Vamwe vanhu vanonetsekana nezvematambudziko echiropa, asi inclisiran inoita kunge yakapfava pachiyero kupfuura mamwe mishonga ye cholesterol. Zvisinei, chiremba wako achiri kuongorora basa rechiropa chako nemiedzo yeropa nguva nenguva.

Kana iwe ukaona chero zviratidzo zvisingajairiki mushure mejekiseni rako, usazeza kubata mupi wako wehutano. Vanogona kubatsira kuona kana zvauri kusangana nazvo zvine chekuita nemushonga uye maitiro ekuzvigadzirisa.

Ndiani Asingafaniri Kutora Inclisiran?

Inclisiran haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wairaira. Mushonga haukurudzirwi kune vanhu vari pasi pemakore gumi nemasere, sezvo kuchengeteka kwayo nekushanda kwavo zvisina kugadzwa muvana.

Unofanira kudzivisa inclisiran kana wakambove nekuita kwakanyanya kune izvo kana chero zvezvinhu zvayo munguva yakapfuura. Chiremba wako achakuongorora iwe runyorwa rwakakwana rwezvinhu kana iwe uchiziva allergies.

Vakadzi vane pamuviri kana vanoyamwisa vanofanira kukurukura njodzi nemabhenefiti nachiremba wavo. Kunyange zvazvo paine mashoko mashoma pamusoro pe inclisiran kushandiswa panguva yekuzvitakura, zvinowanzokurudzirwa kuti uzvidzivise kunze kwekunge mabhenefiti achipfuura njodzi.

Vanhu vane zvirwere zvechiropa zvinogona kuda kuongororwa kwakakosha kana vangave vasiri vakakodzera inclisiran. Chiremba wako achatarisa kushanda kwechiropa chako usati watanga kurapwa uye achachiongorora nguva dzose.

Kana uine nhoroondo yechirwere chakakomba cheitsvo, chiremba wako achanyatso funga kana inclisiran yakakodzera kwauri. Mushonga hauna kunyatsodzidzwa zvakanyanya muvanhu vane matambudziko akakomba eitsvo.

Mazita eBrand eInclisiran

Inclisiran inotengeswa pasi pezita rebrand Leqvio muUnited States nedzimwe nyika zhinji. Iri ndiro zita rebrand chete rinowanikwa parizvino re inclisiran.

Leqvio inogadzirwa neNovartis uye inowanikwa sejekiseni rakazadzwa kare rekudzivirira. Mushonga uyu unouya mumwero we284 mg, iyo ndiyo huwandu hunopiwa mujekiseni rega rega.

Kusiyana nemimwe mishonga ine mazita akawanda ebrand kana shanduro dzakajairika, inclisiran ichiri itsva uye yakachengetedzwa patent. Izvi zvinoreva kuti Leqvio ndiyo chete vhezheni iripo parizvino.

Paunenge uchikurukura mushonga uyu nachiremba wako kana wezvemishonga, unogona kuutaura se inclisiran kana Leqvio. Vachanzwisisa kuti uri kutaura nezvemushonga mumwe chete.

Zvimwe Zvinhu Zviri Kutsiva Inclisiran

Kana inclisiran isiri yakanaka kwauri, dzimwe nzira dzakawanda dzekuderedza cholesterol dziripo. Statins dzinoramba dziri kurapwa kwemutsara wekutanga uye dzinosanganisira mishonga yakaita se atorvastatin, rosuvastatin, uye simvastatin.

Zvimwe zvinodzora PCSK9 zvinosanganisira evolocumab (Repatha) uye alirocumab (Praluent). Izvi zvinoshanda zvakafanana ne inclisiran asi zvinopiwa semajekiseni mazuva ese maviri kana pamwedzi, panzvimbo pe kaviri pagore.

Kune vanhu vasingakwanise kutsungirira statins, dzimwe nzira dzinosanganisira ezetimibe (Zetia), iyo inovhara kutora cholesterol mumukati mako, uye bile acid sequestrants senge cholestyramine.

Nzira itsva dzinosanganisira bempedoic acid (Nexletol), iyo inoshanda zvakasiyana nemastatini asi ichiri kuderedza kugadzirwa kwecholesterol muchiropa. Vamwe vanhu vanoona izvi zviri nyore kutsungirira kupfuura mastatini echinyakare.

Chiremba wako achakubatsira kusarudza sarudzo yakanakisa zvichienderana nemamiriro ako chaiwo, kusanganisira mazinga ako echolesterol, mamwe mamiriro ehutano, uye kuti unotsungirira sei mishonga yakasiyana.

Inclisiran iri nani kupfuura Evolocumab here?

Zvese inclisiran uye evolocumab (Repatha) zvinodzora PCSK9 zvinobudirira kuderedza LDL cholesterol, asi zvine zvakanakira zvakasiyana zvichienderana nezvaunofarira uye mararamiro ako.

Chinhu chikuru chinobatsira che inclisiran ndiko kuita nyore. Iwe unongoda majekiseni kaviri pagore mushure mekutanga loading phase, zvichienzaniswa neevolocumab's mazuva ese-mavhiki maviri kana majekiseni emwedzi. Izvi zvinogona kuve nyore kune vanhu vasingade majekiseni anowanzoitika kana vane hurongwa hwakabatikana.

Evolocumab yanga iripo kwenguva refu uye ine yakawanda data rekuedzwa kwekiriniki, kusanganisira zvidzidzo zvinoratidza kuti inogona kuderedza kurwisa kwemoyo uye sitiroko. Inclisiran itsva, saka nepo ichideredza cholesterol zvinobudirira, isu tine mashoma data renguva refu pamhedzisiro yemoyo.

Mishonga yese miviri inoshanda zvakafanana pakuderedza LDL cholesterol, kazhinji ichideredza mazinga ne50-60% kana yakawedzerwa kune statin therapy. Sarudzo pakati pavo inowanzoenderana nekusarudza kwejekiseni frequency uye kupindura kwemunhu.

Mutengo uye inishuwarenzi inogona zvakare kukanganisa sarudzo. Chiremba wako anogona kukubatsira kuyera izvi zvinhu uye kuona kuti ndeipi sarudzo inoita zvakanyanya pfungwa dzemamiriro ako chaiwo.

Mibvunzo Inowanzo Bvunzwa Nezve Inclisiran

Inclisiran Yakachengeteka Kune Vanhu vane Chirwere cheShuga here?

Hongu, inclisiran inoita seyakanaka kune vanhu vane chirwere cheshuga uye inogona kunge ichinyanya kubatsira kune vanhu ava. Vanhu vane chirwere cheshuga vane njodzi huru yezvirwere zvemtima, zvichiita kuti manejimendi echolesterol anoshanda ave akakosha.

Mushonga haushandi zvakananga pamwero weshuga yeropa, saka haufaniri kukanganisa manejimendi ako echirwere cheshuga. Zvisinei, chiremba wako achakutarisa zvakanyatsonaka sezvo vanhu vane chirwere cheshuga vachiwanzo tora mishonga yakawanda.

Zvimwe zvidzidzo zvinoratidza kuti inclisiran inogona kuva nezvimwe zvinobatsira kunze kwekunatsa cholesterol izvo zvinogona kubatsira kudzivirira matambudziko echirwere cheshuga, kunyangwe tsvakurudzo yakawanda ichidiwa kusimbisa izvi zvinokonzeresa.

Ndoita Sei Kana Ndikakanganwa Kubaya Inclisiran?

Kana ukakanganwa kubaya inclisiran yako yakarongwa, taura nehofisi yachiremba wako nekukurumidza sezvinobvira kuti urongezve. Zvinokonzeresa mishonga zvinopera zvishoma nezvishoma nekufamba kwenguva, saka kudzokera pachirongwa kwakakosha kuchengetedza kutonga kwako cholesterol.

Usaedze "kugadzirisa" kubaya kwawakakanganwa nekuwana madosi akawedzerwa. Chiremba wako achakubatsira kuona nguva yakanakisisa yekubaya kwako kunotevera zvichienderana nekuti wakagamuchira mishonga yekupedzisira rini.

Kana wakakanganwa kubaya kwemwedzi yakati wandei, chiremba wako anogona kukurudzira kutarisa mazinga ako e cholesterol usati wakuisa dose inotevera. Izvi zvinovabatsira kunzwisisa kuti cholesterol yako yakachinja sei uye kugadzirisa chirongwa chako chekurapa kana zvichidikanwa.

Ndingamira Rini Kutora Inclisiran?

Sarudzo yekumira inclisiran inofanira kugara ichiitwa mukubvunzana nachiremba wako. Vanhu vazhinji vane cholesterol yakakwira vanoda kurapwa kwenguva refu, saka kumira kazhinji hakukurudzirwi kunze kwekunge paine zvikonzero zvakakosha zvekurapa.

Chiremba wako anogona kufunga kumisa inclisiran kana ukawana matambudziko akakosha, kana zvinangwa zvako zve cholesterol zvachinja nekuda kwezvimwe zvirinani zvehutano, kana kana kurapwa kutsva, kwakakodzera kuwanikwa.

Kana uchifunga kumira nekuti unonzwa zvakanaka, yeuka kuti cholesterol yakakwira kazhinji haina kukonzera zviratidzo. Mishonga iri kushanda kudzivirira matambudziko emoyo emunguva yemberi, kwete kurapa zviratidzo zviripo.

Ndingatora Inclisiran pamwe chete nemimwe mishonga yekuderedza cholesterol here?

Hongu, inclisiran inowanzo shandiswa pamwe chete nemimwe mishonga yekuderedza cholesterol, kunyanya statins. Muchokwadi, inowanzo wedzerwa kurapwa kwecholesterol kwakatoitika pane kuitsiva zvachose.

Kubatanidzwa kweinclisiran ne statins kunogona kushanda zvakanyanya, kazhinji kuchiwana kuderedzwa kwecholesterol iyo isina mushonga waigona kuita wega. Iyi nzira inonyanya kubatsira vanhu vane cholesterol yakanyanya kukwirira kana avo vari panjodzi huru yezvirwere zvemtima.

Chiremba wako achanyatso kuronga mishonga yako yese kuti ave nechokwadi chekuti inoshanda pamwe chete uye haikonzeri kusangana kunokuvadza. Nguva dzose zivisa vese vanopa hutano vako nezve mishonga yese yaunotora, kusanganisira inclisiran.

Inclisiran inotanga kushanda nekukurumidza sei?

Inclisiran inotanga kushanda mukati memazuva ekubaiwa kwako, asi uchaona mhedzisiro yakanyanya yekuderedza cholesterol mushure memwedzi mitatu. Ichi ndicho chikonzero chiremba wako anoronga jekiseni rako rechipiri mwedzi mitatu mushure mejekiseni rekutanga.

Chiremba wako anowanzo tarisa mazinga ako echolesterol anenge 3-6 mwedzi mushure mekutanga kurapwa kuti aone kuti mushonga uri kushanda sei. Vanhu vazhinji vanoona kuvandudzwa kukuru mumitengo yavo yecholesterol pakuongororwa kwekutanga uku.

Mhedzisiro yemushonga inovaka nekufamba kwenguva, saka unogona kuona mhedzisiro iri nani mushure mejekiseni akati wandei. Izvi zvakajairika uye zvinotarisirwa ne inclisiran kurapwa.