Chii chinonzi Lanadelumab: Zvayakashandiswa, Dosages, Migumisiro Yemuviri Uye Zvimwe Zvakawanda

Lanadelumab mushonga unopiwa nachiremba wakagadzirirwa kunyanya kudzivirira kurwiswa kwehereditary angioedema (HAE), chirwere chisingawanzoitiki chegenetic chinokonzera kuzvimba kamwe kamwe muzvikamu zvakasiyana zvemuviri wako. Mushonga uyu unojekeswa unoshanda nekudzivisa protein inonzi kallikrein, iyo inokonzera zviitiko zvekuzvimba zvinogona kurwadza uye zvinogona kuva nenjodzi.

Kana iwe kana mumwe waunoda akawanikwa aine HAE, unogona kunge uchinzwa wakanyanya nekuda kwekuoma kwekugadzirisa iyi mamiriro. Mashoko akanaka ndeekuti lanadelumab inomiririra kubudirira kukuru mukurapa HAE, ichipa vanhu vazhinji mukana wekurarama nekushoma kurwiswa uye rugare rukuru rwepfungwa.

Chii chinonzi Lanadelumab?

Lanadelumab mushonga wemonoclonal antibody uyo wekirasi yemishonga inonzi kallikrein inhibitors. Funga nezvayo sechinhu chinorapwa chinotariswa chinoshanda semurindi akakosha mumuviri wako, achinyatso tarisa uye achidzivisa protein inokonzera HAE kurwisa.

Mushonga uyu unouya semvura yakajeka yaunojekesa pasi peganda rako (subcutaneously) uchishandisa syringe yakazadzwa. Mushonga uyu unozivikanwawo nezita rayo rekutengesa Takhzyro, uye inogadzirwa uchishandisa advanced biotechnology kugadzira kurapwa kwakanyanya kweHAE.

Chinonyanya kuita kuti lanadelumab ive yakasarudzika ndiyo kururama kwayo. Panzvimbo yekudzivisa zvakanyanya immune system yako semamwe mishonga, inongotarisa nzira chaiyo inokonzera HAE kurwisa, ichisiya imwe immune function yako yakakwana.

Chii chinonzi Lanadelumab chinoshandiswa?

Lanadelumab yakatenderwa neFDA kunyanya kudzivirira kurwiswa kwehereditary angioedema muvanhu vakuru nevechidiki vane makore gumi nemaviri zvichikwira. HAE imamiriro egenetic uko muviri wako usingadzore zvakanaka protein inonzi C1 esterase inhibitor, zvichikonzera zviitiko zvekuzvimba kwakanyanya.

Panguva yekurwisa kweHAE, unogona kuona kuzvimba kamwe kamwe muchiso wako, miromo, rurimi, pahuro, maoko, tsoka, kana nhengo dzako dzekubereka nadzo. Zviitiko izvi zvinogona kusazivikanwa uye zvakasiyana-siyana mukuoma. Zvimwe zvirwere zvinogona kukonzera kusagadzikana kudiki, nepo zvimwe zvinogona kuva zvinotyisa upenyu kana zvikabatanidza nzira yako yemhepo.

Mishonga yakagadzirirwa kudzivirira kwenguva refu, kwete kurapa kurwisa kuri kuitika. Kana uri kurwara neHAE yakanyanya, uchada mishonga yekukurumidzira yakasiyana iyo inoshanda nekukurumidza kumisa kuzvimba.

Chiremba wako angakurudzira lanadelumab kana uri kusangana neHAE inowanzoitika iyo inokanganisa zvakanyanya hupenyu hwako, basa, kana mabasa ezuva nezuva. Chinangwa ndeche kuderedza kakawanda uye kuoma kwezviitiko izvi.

Lanadelumab Inoshanda Sei?

Lanadelumab inoshanda nekudzivisa plasma kallikrein, protein inotamba basa rakakosha mukutevedzana kwezviitiko zvinotungamira kurwisa kweHAE. Kana protein iyi ichishanda, inokonzera kugadzirwa kwebradykinin, chinhu chinoita kuti midzi yeropa ive leaky uye inotungamira mukuzvimba kweHAE.

Nekudzivisa kallikrein, lanadelumab inonyatso kumisa iyi chain reaction isati yakonzera zviratidzo. Mishonga inosunga ku kallikrein uye inoidzivirira kubva pakuita basa rayo, izvo zvinoderedza zvakanyanya mukana wekurwisa kuitika.

Izvi zvinoonekwa semushonga wakasimba zvine mwero uye wakatarwa zvakanyanya. Kusiyana nemamwe marapirwo anokanganisa zvakanyanya immune system yako, lanadelumab yakagadzirirwa kuve chaiyo mukuita kwayo, izvo zvinowanzoita kuti pave nemhedzisiro shoma uye kusangana nemamwe masisitimu emuviri.

Mhedzisiro ye lanadelumab inovaka nekufamba kwenguva, ndosaka zvakakosha kuitora nguva dzose sezvakanyorwa. Vanhu vazhinji vanotanga kuona kuderedzwa kwekakawanda kwekurwisa mukati memwedzi mishoma yekutanga yekurapa.

Ndingatora Sei Lanadelumab?

Lanadelumab inopiwa semushonga unoiswa pasi peganda, zvinoreva kuti unoiisa mutishu yakakora iri pasi peganda rako. Mushonga wemwero ndeye 300 mg mumasvondo maviri ega ega, kunyangwe chiremba wako angachinje izvi zvichienderana nekuti unopindura sei kurapwa.

Unogona kuisa lanadelumab muchidya chako, ruoko rwepamusoro, kana dumbu. Zvakakosha kuchinjisa nzvimbo dzekuisa mushonga kudzivirira kutsamwa kweganda kana kukura kwemavhundi akaoma pasi peganda. Mupi wako wehutano achakudzidzisa iwe kana nhengo yemhuri kuti ungapa sei majekiseni aya zvakachengeteka kumba.

Usati waisa mushonga, bvisa mushonga mufiriji uye uregere kusvika tembiricha yemumba kwemaminitsi anenge 15-20. Mushonga unotonhora unogona kusagadzikana kuisa. Nguva dzose tarisa kuti mvura yakajeka uye isina ruvara usati waishandisa.

Unogona kutora lanadelumab uine kana pasina chikafu, sezvo ichiiswa panzvimbo pekutora nemuromo. Zvisinei, zvinobatsira kumisa tsika, senge kuisa mushonga mazuva akafanana evhiki, kukubatsira kuyeuka mishonga yako.

Ndingatora Lanadelumab Kwenguva Yakareba Sei?

Lanadelumab inowanzoitirwa kushandiswa kwenguva refu, sezvo HAE iri mamiriro echronic genetic anoda kuramba achitariswa. Vanhu vazhinji vanoramba vachitora mushonga uyu zvachose kuchengetedza dziviriro kubva pakurwiswa.

Chiremba wako achatarisa kupindura kwako kurapwa mumwedzi mishoma yekutanga uye anogona kuchinja chirongwa chemishonga zvichienderana nekuti uri kuita sei. Vamwe vanhu vane kutonga kwakanaka kwezviratidzo zvavo vangangokwanisa kupatsanura majekiseni avo kumavhiki mana ega ega panzvimbo pemavhiki maviri ega ega.

Zvakakosha kuti usamira kutora lanadelumab kamwechete usina kutanga wataura nachiremba wako. Sezvo mushonga uchishanda nekuchengetedza mazinga akagadzikana mumuviri wako, kumira kamwechete kungatungamira kudzoka kweHAE kurwiswa.

Mupi wehutano hwako achatarisa nguva dzose chirongwa chako chekurapa uye oongorora kana lanadelumab ichiramba iri sarudzo yakanakisa kwauri. Vachafunga nezvezvinhu zvakaita sekuwanda kwekurwisa, migumisiro, uye mhando yako yehupenyu.

Ndezvipi Zviri Zvakaipa zveLanadelumab?

Kufanana nemishonga yese, lanadelumab inogona kukonzera migumisiro, kunyangwe vanhu vazhinji vachizvitsungirira zvakanaka. Migumisiro yakajairika inowanzoita nyoro uye inoonekwa panzvimbo yekujekisisa.

Heano migumisiro inonyanya kuzivikanwa yaungangove nayo:

• Maitiro enzvimbo yekujekisisa anosanganisira kutsvuka, kuzvimba, kupwanya, kana kurwadziwa
• Zvirwere zvepamusoro zvekufema zvakaita sema colds
• Kutemwa nemusoro
• Dizziness
• Rash kana kutsamwa kweganda

Izvi zvakajairika migumisiro inowanzoita nani yega uye haidi kumisa mushonga. Maitiro akanaka ekujekisisa uye kutenderera kwenzvimbo zvinogona kubatsira kuderedza maitiro enzvimbo yekujekisisa.

Kune zvakare mamwe mashoma asi akakomba migumisiro inoda kutariswa kwekurapa nekukurumidza. Kunyangwe izvi zvichishamisa, zvakakosha kuziva nezvazvo:

• Maitiro akakomba ekuita allergic anosanganisira kuoma kufema, kuzvimba kwechiso kana huro, kana rash yakapararira
• Zviratidzo zvechirwere chakakomba zvakadai sefivha, kutonhora, kana zviratidzo zvakafanana nefuru
• Kubuda ropa kusingaite kana kupwanya
• Kutemwa nemusoro kwakanyanya kana kuramba

Vanhu vazhinji vanowana kuti chero migumisiro yavanowana inogoneka uye isingakanganisi zvakanyanya kupfuura kurwisa kweHAE kwavaive nako vasati varapwa.

Ndiani Asingafaniri Kutora Lanadelumab?

Lanadelumab haina kukodzera munhu wese, uye kune mamwe mamiriro apo chiremba wako angakurudzira imwe nzira yekurapa. Chinhu chakakosha chinopesana ndechekuti kana wakambove nemaitiro akakomba ekuita allergic ku lanadelumab kana chero zvinhu zvayo kare.

Chiremba wako achanyatsoongorora kana lanadelumab yakakukodzera kana uine chero imwe yemamiriro aya:

• Zvirwere zvakakomba zviri kushanda
• Chirwere chakakomba chechiropa kana itsvo
• Nhoroondo yezvinhu zvakakomba zvinokonzeresa allergic kune mamwe mishonga ye monoclonal antibody
• Kuzvitakura kana zvirongwa zvekuva nepamuviri
• Kuyamwisa

Kufunga kwakakosha kunodiwawo kune vanhu vane autoimmune conditions, sezvo lanadelumab inokanganisa basa re immune system. Chiremba wako achayerera mabhenefiti achipesana nenjodzi dzinogona kuitika mumamiriro ezvinhu aya.

Zera ndechimwe chinhu chakakosha. Lanadelumab inongobvumirwa chete kune vanhu vane makore 12 zvichikwira, sezvo pasina data rakakwana rekuchengeteka nekushanda kwevana vadiki.

Zita reBrand reLanadelumab

Lanadelumab inotengeswa pasi pezita rebrand Takhzyro. Iri ndiro zita rauchaona pane prescription label uye packaging paunotora mushonga wako kubva ku pharmacy.

Takhzyro inogadzirwa neTakeda Pharmaceuticals uye yakatanga kubvumidzwa neFDA muna 2018. Mushonga uyu unouya muma syringes akazadzwa kare ane 150 mg ye lanadelumab mu 1 mL yemhinduro.

Parizvino, hapana generic versions ye lanadelumab iripo, sezvo mushonga uyu uchiri pasi pekudzivirirwa kwepatent. Izvi zvinoreva kuti Takhzyro ndiyo chete brand name version yaunogona kuwana.

Zvimwe zvingashandiswa panzvimbo peLanadelumab

Nepo lanadelumab ichishanda zvakanyanya kune vanhu vazhinji vane HAE, haisi iyo chete sarudzo yekurapa iripo. Chiremba wako angangofunga nezvezvimwe zvingashandiswa kana lanadelumab isingashande zvakanaka kwauri kana ukawana mhedzisiro isingashiviririke.

Mamwe mishonga yekudzivirira yeHAE anosanganisira:

• Berotralstat (Orladeyo) - mushonga wemuromo unotorwa zuva nezuva
• C1 esterase inhibitor concentrates inopiwa neIV infusion
• Danazol - mushonga wemuromo wanga uchishandiswa kwemakumi emakore
• Tranexamic acid - mushonga wemuromo unogona kubatsira vamwe vanhu

Imwe neimwe yesarudzo idzi ine mabhenefiti akasiyana uye zvipingamupinyi. Semuenzaniso, berotralstat inopa nyore nyore yekutora mushonga wemuromo zuva rega rega, nepo C1 esterase inhibitor concentrates inotsiva protein iyo isina kukwana muHAE.

Chiremba wako achakubatsira kuyera zvinhu zvakaita sekushanda, mhedzisiro, nyore, uye mutengo pakusarudza kurapwa kwakanakisa kwemamiriro ako chaiwo.

Ko Lanadelumab Ari Nani Pane Berotralstat?

Ose ari maviri lanadelumab uye berotralstat ndiyo kurapwa kwemazuva ano kunoshanda kweHAE kudzivirira, asi anoshanda nenzira dzakasiyana uye ane zvakanakira zvakasiyana. Sarudzo yakanakisa inoenderana nezvido zvako, zvaunofarira, uye mamiriro ako ekurapa.

Lanadelumab inopiwa sejojo mazuva ese maviri, nepo berotralstat ichitorwa sekapsule yemuromo zuva rega rega. Vamwe vanhu vanosarudza nyore nyore yekusafanira kuyeuka mushonga wezuva nezuva, nepo vamwe vachisarudza kudzivirira majojo.

Panyaya yekushanda, mishonga yese iri miviri inoderedza zvakanyanya HAE kurwisa mitengo kune vanhu vazhinji. Zvidzidzo zvekiriniki zvinoratidza kuti lanadelumab inoderedza kurwisa mitengo neavhareji ye87%, nepo berotralstat ichideredza ne44%. Zvisinei, mhinduro dzemunhu dzinogona kusiyana zvakanyanya.

Maprofile emhedzisiro anopesanawo pakati pemishonga miviri. Mhedzisiro huru yeLanadelumab ndiyo nzvimbo yekujekesa maitiro, nepo berotralstat inogona kukonzera zviratidzo zvemudumbu zvakaita senausea uye kurwadziwa mudumbu kune vamwe vanhu.

Chiremba wako achafunga nezvekuwanda kwekurwisa kwako, mararamiro, mamwe mishonga yaunotora, uye zvaunofarira iwe pachako pakukubatsira kusarudza pakati pezvisarudzo izvi.

Mibvunzo Inowanzo Bvunzwa Nezve Lanadelumab

Q1. Lanadelumab Yakachengeteka Kune Vanhu vane Chirwere Chemoyo Here?

Lanadelumab inowanzoonekwa seyakachengeteka kune vanhu vane chirwere chemoyo, sezvo isingakanganisi basa remoyo. Zvisinei, chiremba wako achada kukutarisa zvakanyatsonaka kana uine matambudziko makuru emoyo.

Mushonga uyu haumbonyanyi kukonzera shanduko muropa kana rhythm yemoyo. Sezvo uchijekeswa pasi peganda panzvimbo yekutorwa nemuromo, haushandiwo nemishonga yakawanda yemoyo sezvingaita mishonga inotorwa nemuromo.

Kana uine chirwere chemoyo, ita shuwa kuti unoudza chiremba wako nezve mishonga yako yese yemoyo usati watanga lanadelumab. Vanogona kuda kuita mamwe bvunzo ekutanga uye kukutarisa zvakanyanya pakutanga.

Q2. Ndingaita Sei Kana Ndikashandisa Zvakawandisa Lanadelumab Netsaona?

Kana netsaona ukajekesa lanadelumab yakawanda kupfuura yakarairwa, usavhunduka. Bata chiremba wako kana mupi wehutano nekukasira kuti uvaudze zvaitika uye uwane gwara rakatarwa remamiriro ako ezvinhu.

Muzviitiko zvakawanda, overdose imwe ye lanadelumab haina kukonzera matambudziko akakomba nekukasira, asi unofanirwa kutsvaga mazano ekurapa. Chiremba wako angada kukutarisa zvakanyanya kana kugadzirisa mushonga wako unotevera.

Chengeta kurongwa kwemishonga uye chero masirinji asara kuti ugone kuudza mupi wako wehutano kuti wakatora mishonga yakawanda sei. Ruzivo urwu ruchavabatsira kukupa zano rakanaka.

Q3. Ndingaita Sei Kana Ndikakanganwa Dose yeLanadelumab?

Kana ukakanganwa dose ye lanadelumab, itore paunorangarira, wobva wenderera mberi nehurongwa hwako hwekurapa. Usatore dose kaviri kuti ugadzirise iyo yakakanganwa.

Kana yava nguva yechikamu chako chinotevera, siya dose yakakanganwa uye uenderere mberi nehurongwa hwako hwenguva dzose. Kutora mishonga iri pedyo zvikuru kunogona kuwedzera njodzi yako yemigumisiro isingapi mibairo yekuwedzera.

Kukanganwa dose imwe chete dzimwe nguva kazhinji hakuzokonzera matambudziko nekukasira, asi edza kuchengetedza hurongwa hwako hwenguva dzose sezvinobvira kuti uwane dziviriro yakanaka pakurwisa HAE.

Q4. Ndingamira Rini Kutora Lanadelumab?

Unofanira kungomira kutora lanadelumab pasi pekutungamirirwa nachiremba wako. Sezvo HAE iri mamiriro ehupenyu hwese ehupenyu, vanhu vazhinji vanoda kuramba vachitora mushonga wekudzivirira kusvika pakusingaperi kuti vachengetedzwe kubva pakurwiswa.

Chiremba wako angangofunga kumisa kana kupatsanura zvikamu kana wanga uine kutonga kwakanaka kwezviratidzo zvako kwenguva yakareba. Zvisinei, sarudzo iyi inofanira kuitwa nekuchenjerera nekutarisa pedyo.

Kana uchida kumisa kurapwa nechikonzero chipi nechipi, taura izvi nemupi wako wehutano kutanga. Vanogona kukubatsira kuyera njodzi nemabhenefiti uye pamwe vanokurudzira mamwe marapirwo kana zvichidikanwa.

Q5. Ndingafamba neLanadelumab here?

Hongu, unogona kufamba ne lanadelumab, asi zvinoda kuronga nekuti mushonga unofanira kuchengetwa mufiriji. Nguva dzose takura mushonga wako mumutoro wako wekufamba kana uchibhururuka, kwete mumutoro wakaongororwa.

Tora tsamba kubva kuchiremba wako ichitsanangura kuti unofanira kutakura mushonga unojekeswa wehutano. Izvi zvinogona kubatsira nekuchengetedzwa kwendege netsika kana uchifamba kunze kwenyika.

Shandisa firiji diki ine ice packs kuchengetedza mushonga pakupisa kwakakodzera panguva yekufamba. Mushonga unogona kuva pakupisa kwemumba kwenguva pfupi, asi haufaniri kuisa kupisa kwakanyanya kana tembiricha inotonhora.