Chii chinonzi Larotrectinib: Zvinoshandiswa, Mishonga, Mativi eMuviri uye Zvimwe

Larotrectinib mushonga wekenza unovharira mapuroteni akati wandei anobatsira tuma tumor tumwe kukura. Yakagadzirirwa kenza ine shanduko yakati wandei yegeni inonzi TRK fusion, iyo inokanganisa nzira iyo masero anowedzera uye kupararira mumuviri wako.

Mushonga uyu unomiririra nzira itsva yekurapa kenza, ichitarisa pagene rema tumor panzvimbo yenzvimbo yavo. Kana kenza yako iine mamakisi akakodzera e genetic, larotrectinib inogona kushanda zvakanyanya pakumisa kana kumisa kukura kwetuma tumor.

Chii chinonzi Larotrectinib chinoshandiswa?

Larotrectinib inorapa tuma tumor tumwe twakasimba twine shanduko yakati wandei yegeni inonzi TRK fusion. Shanduko iyi yegeni inogona kuitika mumhando dzakawanda dzakasiyana dzekenza, zvisinei nekuti dzakatangira kupi mumuviri wako.

Chiremba wako acharayira bvunzo dzakakosha dze genetic patishu yako yetumor kuti aone kana larotrectinib yakakunakira. Mushonga unoshanda kune vanhu vakuru nevana vane kenza yakapararira kana isingakwanise kubviswa nekuvhiyiwa.

Mhando dzakajairika dzekenza dzinogona kuva neTRK fusion dzinosanganisira mamwe tumor ehuropi, kenza yemapapu, kenza yegurokuro, uye soft tissue sarcomas. Zvisinei, shanduko iyi yegeni haina kuwanda, ichiitika mune isingasviki 1% yematumor akawanda akasimba.

Larotrectinib inoshanda sei?

Larotrectinib inodzivirira mapuroteni anonzi TRK receptors anobatsira masero ekenza kukura nekuzviparadzanisa. Kana mapuroteni aya akanyanya kushanda nekuda kweshanduko dzegeni, anotumira nguva dzose "kura" zviratidzo kumasero ekenza.

Funga nezve mapuroteni eTRK semagetsi emota akabatikana pachinzvimbo che "on". Larotrectinib inoita sekuvhurira pedal iyoyo, ichimisa zviratidzo zvekukura zvenguva dzose. Iyi nzira yakatarwa zvinoreva kuti inonyanya kukanganisa masero ekenza ichisiya masero ane hutano akawanda ega.

Mishonga iyi inofungidzirwa kuti mishonga ine simba, yekurapa kenza. Yakagadzirirwa zvakananga tumarara ane TRK fusion, zvichiita kuti ive inoshanda kana genetic match yakarurama.

Ndingatora sei Larotrectinib?

Tora larotrectinib sezvinorayirwa nachiremba wako, kazhinji kaviri pazuva uine kana pasina chikafu. Medza makapisi ese nemvura, uye usapwanye, kutsenga, kana kuavhura.

Unogona kutora mushonga uyu nezvokudya kana zvichibatsira kuderedza dumbu. Edza kutora zvikamu zvako panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana muropa rako.

Kana uri kutora fomu yemvura, shandisa mudziyo wekuyera wakapihwa ne pharmacy yako. Zvipunu zvenguva dzose zveimba hazvina kukwana pakuyera mishonga.

Ndingatora kwenguva yakareba sei Larotrectinib?

Iwe unowanzoenderera mberi uchitora larotrectinib chero ichishanda uye uchichigamuchira zvakanaka. Chiremba wako achatarisa mhinduro yako kuburikidza nekuongorora nguva dzose uye bvunzo dzeropa.

Vanhu vazhinji vanotora mushonga uyu kwemwedzi kana makore, zvichienderana nekuti kenza yavo inopindura sei. Chikwata chako chekurapa chichagara chichiongorora kana mabhenefiti achienderera mberi achikunda chero mhedzisiro yaunowana.

Usambofa wakarega kutora larotrectinib usati wataurirana nachiremba wako kutanga. Kumira kamwe kamwe kunogona kubvumira kenza yako kutanga kukura zvakare nekukurumidza.

Ndezvipi Zvipingamupinyi zveLarotrectinib?

Vanhu vazhinji vanowana mamwe mhedzisiro ne larotrectinib, kunyangwe achiwanzogoneka nerutsigiro rwakakodzera. Nhau dzakanaka ndedzekuti mhedzisiro yakakomba haina kujairika kupfuura nemamwe marapirwo ekenza.

Heano mhedzisiro yakajairika yaungawana:

• Kuneta uye kunzwa kuneta kupfuura zvakajairika
• Dizziness, kunyanya kana uchimuka nekukurumidza
• Nausea uye dzimwe nguva kurutsa
• Kuvharika kana shanduko mumaitiro ematumbo
• Kurwadziwa kwemhasuru kana majoini
• Shanduko mukuravira kana kuderedzwa kwechido
• Mavanga emuviri akapfava kana kuoma

Izvi zvinowanzoitika zvinowanzoita nani sezvo muviri wako uchigadzirisa mushonga. Chikwata chako chehutano chinogona kupa nzira dzekubatsira kubata zviratidzo izvi zvinobudirira.

Vamwe vanhu vanogona kusangana nemigumisiro yakakomba inoda kutariswa kwekurapa nekukurumidza:

• Matambudziko akakomba echiropa, zvichikonzera kuyeruka kweganda kana maziso
• Shanduko yerhythm yemoyo kana kurova kwemoyo kusinganzwisisike
• Dizziness yakakomba kana kufenda
• Kuwedzera kukuru uremu kana kuzvimba
• Kubuda ropa kusinganzwisisike kana kupwanya
• Shanduko dzakakomba dzemafungiro kana kuvhiringidzika

Izvi zvinokanganisa zvakakomba hazviwanzoitiki asi zvakakosha kuti utarise. Bata chiremba wako nekukurumidza kana ukaona chero zviratidzo izvi.

Ndiani Asingafaniri Kutora Larotrectinib?

Larotrectinib haina kukodzera munhu wese, kunyangwe avo vane TRK fusion-positive cancer. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wanyora mushonga uyu.

Haufanire kutora larotrectinib kana uine allergic kumushonga kana chero zvikamu zvawo. Vanhu vane chirwere chechiropa chakakomba vanogona kuda kugadzirisa dose kana mamwe marapirwo.

Kufunga kwakakosha kunodiwa kana uine matambudziko emoyo, chirwere chechiropa, kana uri kutora mamwe mishonga akawanda. Chiremba wako achayerera mabhenefiti anogona kuitika pamusoro penjodzi mumamiriro ezvinhu aya.

Vakadzi vane pamuviri kana vanoyamwisa vanofanira kukurukura dzimwe nzira nechikwata chavo chehutano, sezvo larotrectinib inogona kukuvadza vana vari kukura.

Larotrectinib Mazita eBrand

Larotrectinib inotengeswa pasi pezita rekuti Vitrakvi munyika zhinji. Iri ndiro zita remhando rakabvumirwa remushonga uyu.

Chitoro chako chemishonga chingave chine vagadziri vakasiyana, asi mushonga unoshanda unogara wakafanana. Nguva dzose bvunza chiremba wako wemishonga kana uine mibvunzo pamusoro peiyo chaiyo vhezheni yaunogamuchira.

Zvimwe Zvinogona Kushandiswa Panzvimbo peLarotrectinib

Kune mhando dzekenza dzine TRK fusion-positive, entrectinib imwe nzira yekurapa inotarwa. Inoshanda zvakafanana ne larotrectinib asi inogona kusarudzwa zvichienderana nemamiriro ako chaiwo kana inishuwarenzi yako.

Kana kurapwa kunotarwa kusina kukodzera, chiremba wako angakurudzira chemotherapy yechinyakare, immunotherapy, kana radiation therapy. Nzira yakanakisa inotsamira pamhando yako yekenza, hutano hwako hwese, uye kurapwa kwakamboitwa.

Miedzo yekiriniki inogona zvakare kupa mukana wekurapa kutsva kwekuongorora. Chiremba wako weoncologist anogona kukubatsira kuti uongorore zvese zvingasarudzwa zvemamiriro ako chaiwo.

Ko Larotrectinib Zviri Nani Pane Zvimwe Zvinhu Zvinorapa Kenza Here?

Larotrectinib inogona kushanda zvakanyanya kupfuura kurapwa kwechinyakare kune mhando dzekenza dzine TRK fusion-positive. Zvidzidzo zvinoratidza mitengo yekupindura yeanenge 75-80% muvanhu vane mamaki akakodzera emagenetic.

Kana ichienzaniswa ne chemotherapy, larotrectinib inowanzoita mashoma mativi akaipa uye inogona kushanda kwenguva refu. Zvisinei, inoshanda chete kune mhando dzekenza dzine TRK fusion, izvo zvinodzora kushandiswa kwayo kune chikamu chidiki chevarwere vane kenza.

Kune vanhu vane tumor vane TRK fusion, larotrectinib inowanzoonekwa seyakasarudzwa yekutanga-mutsara wekurapa. Chinhu chakakosha kuva nekukodzera kwemajini pakati petumor yako nemushonga.

Mibvunzo Inowanzo Bvunzwa Pamusoro peLarotrectinib

Larotrectinib Yakachengeteka Kune Vanhu vane Chirwere chechiropa Here?

Larotrectinib inogona kushandiswa nekuchenjerera muvanhu vane matambudziko echiropa akapfava kusvika pakati nepakati, asi chiremba wako anogona kuderedza muyero wako. Mushonga unogadziriswa kuburikidza nechiropa chako, saka kushanda kwechiropa kwakakanganiswa kunogona kukanganisa kuti muviri wako unozvigadzirisa sei.

Kana uine chirwere chakakomba chechiropa, chiremba wako angakurudzira mamwe marapirwo kana kunyatsoongorora. Kuongororwa kweropa nguva dzose kuchatevera kushanda kwechiropa chako mukati mekurapwa.

Ndoitei Kana Ndakatora Larotrectinib Yakawandisa Netsaona?

Taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira kana wakatora yakawanda kupfuura mushonga wawakanyorerwa. Kunyange zvazvo pasina mushonga chaiwo wekuwandisa kwe larotrectinib, nyanzvi dzezvekurapa dzinogona kupa rubatsiro.

Zviratidzo zvekutora zvakawanda zvinogona kusanganisira dzungu rakanyanya, kusvotwa, kana kuneta kusinganzwisisike. Usaedze kurapa zviratidzo izvi iwe pachako - tsvaga rubatsiro rwekurapa nekukasira.

Ndoitei Kana Ndikakanganwa Dose yeLarotrectinib?

Tora dose yako yakakanganwa nekukasira paunoyeuka, kunze kwekunge yava nguva yechikamu chako chinotevera. Muchiitiko ichocho, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chetsika.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa. Izvi zvinogona kuwedzera njodzi yako yemigumisiro isingadiwi pasina kuvandudza kushanda kwemushonga.

Ndingamira Rini Kutora Larotrectinib?

Unofanira kuenderera mberi nekutora larotrectinib chero ichidzora kenza yako uye uchichigamuchira zvakanaka. Chiremba wako achagara achiongorora mhinduro yako kuburikidza nekuongorora uye kuongororwa kweropa.

Kana kenza yako ikamira kupindura kana migumisiro isingadiwi ikava yakaoma kwazvo kubata nayo, chiremba wako achakurukura dzimwe nzira dzekurapa. Sarudzo yekumira inogara ichiitwa pamwe chete nechikwata chako chehutano.

Ndingatora Mamwe Mishonga NeLarotrectinib Here?

Mamwe mishonga anogona kushamwaridzana ne larotrectinib, achikanganisa mashandiro ayo kana kuwedzera migumisiro isingadiwi. Nguva dzose udza chiremba wako nezve mishonga yese, zvinowedzera, uye zvigadzirwa zvemiti zvauri kutora.

Mishonga yakati wandei inokanganisa ma enzymes echiropa inogona kuda kugadziriswa kwemadosi kana yakabatanidzwa ne larotrectinib. Murapi wako wemishonga anogonawo kubatsira kuziva kushamwaridzana kunogona kuitika paanenge achizadza mapepa ekurapa.