Chii chinonzi Lesinurad: Zvinoshandiswa, Madosi, Migumisiro uye Zvimwe

Lesinurad mushonga unopiwa nachiremba wakagadzirirwa kubatsira vanhu vane gout kudzora mazinga avo e uric acid. Inoshanda nekudzivisa mapurotini akati wandei mumatsvo ako ayo anowanzo tora uric acid zvakare, zvichibvumira yakawanda kuti ibviswe kuburikidza neweti yako. Iyi nzira yakatarwa inobatsira kudzivirira kuunganidzwa kwemarudzi anorwadza mumajoini ayo anoratidza gout kurwisa.

Chii chinonzi Lesinurad?

Lesinurad ndeyeboka remishonga inonzi uric acid transporter inhibitors. Funga nezvayo semuchengeti wemagedhi anobatsira mumatsvo ako anokurudzira muviri wako kuti ubvise uric acid yakawandisa pane kuibata. Mushonga uyu wakagadzirirwa zvakananga vanhu vane miviri inogadzira uric acid yakawandisa kana kuwana matambudziko ekuibvisa nemazvo.

Mushonga uyu unogara uchipiwa pamwe chete nemumwe mushonga we gout unonzi xanthine oxidase inhibitor, senge allopurinol kana febuxostat. Lesinurad haishande yega nekuti inoda mushonga wekubatana kuti uve unobatsira zvakanyanya. Chiremba wako achabatana nemishonga iyi zvakanyatso kupa iwe kutonga kwakanakisa pamusoro pemazinga ako e uric acid.

Chii chinonzi Lesinurad chinoshandiswa?

Lesinurad inopiwa kurapa gout muvanhu vakuru avo mazinga e uric acid anoramba akakwira kunyangwe vachitora mimwe mishonga ye gout. Iyo yakanyatsogadzirirwa vanhu vasina kusvika pamazinga avo e uric acid akatarwa nekungoshandisa kurapwa kwakajairika. Chiremba wako angakurudzira lesinurad kana iwe wakatora mishonga yakaita se allopurinol asi mazinga ako e uric acid achiri pamusoro pehutano hwakanaka.

Mushonga uyu unobatsira zvikuru vanhu vane chirwere chinonzi nachiremba "refractory gout" - kureva gout isingapinduri zvakanaka kurapwa kwakajairika. Inoshandiswawo kana mumwe munhu achida rubatsiro rwekuwedzera kudzikisa mazinga avo e uric acid kudzivirira kurwiswa kwegout mune ramangwana. Chinangwa ndechekuita kuti uric acid yako igare iri pasi pe 6 milligrams per deciliter, izvo zvinoderera zvakanyanya njodzi yako yekurwadziwa.

Lesinurad Inoshanda Sei?

Lesinurad inoshanda nekudzivisa mapuroteni chaiwo mumatsvo ako anonzi URAT1 uye OAT4 transporters. Mapuroteni aya anowanzoita semahofisi ekudzokorodza, achidhonza uric acid kudzokera mumutsipa wako weropa panzvimbo yekuibvumira kuti ibude nemumvura yako. Nekudzivisa ma transporters aya, lesinurad inobvumira itsvo dzako kubvisa uric acid yakawanda kupfuura zvavanowanzoita.

Mushonga uyu unoonekwa seune simba zvine mwero mukuita kwayo. Inogona kuderedza mazinga e uric acid neanenge 20-30% kana ichishandiswa nemimwe mishonga yegout. Nzira yekubatanidza ine simba kupfuura kushandisa mushonga mumwe chete, ndosaka chiremba wako achizogara achiinyora pamwe chete nemumwe murapi we gout.

Mishonga inotanga kushanda mukati memaawa mashoma ekui tora, asi uchada kuitora nguva dzose kwemavhiki akati wandei kuti uone shanduko dzine musoro mumazinga ako e uric acid. Chiremba wako achatarisa kufambira mberi kwako nemiedzo yeropa yenguva dzose kuti ave nechokwadi chekuti mushonga uri kushanda zvakanaka kwauri.

Ndingatora Sei Lesinurad?

Tora lesinurad sezvinorairwa nachiremba wako, kazhinji kamwe chete pazuva mangwanani uine chikafu. Kuitora nechikafu kunobatsira muviri wako kutora mushonga zviri nani uye kunoderedza mukana wekuti dumbu rigumbuke. Unogona kuitora nechero rudzi rwechikafu, asi kuva nechimwe chinhu mudumbu rako kwakakosha kuti utore zvakanaka.

Momedza piritsi rese nemvura yakawanda. Usapwanye, tsenga, kana kuputsa piritsi, nekuti izvi zvinogona kukanganisa nzira iyo mushonga unoburitswa mumuviri mako. Kana uine dambudziko rekumedza mapiritsi, taura nachiremba wako nezve dzimwe nzira, asi usachinje piritsi iwe pachako.

Zvakakosha kuti urambe uine mvura yakawanda paunenge uchitora lesinurad. Inwa magirazi emvura angangoita 8 zuva rese kuti ubatsire itsvo dzako kugadzirisa uric acid yakawedzerwa iri kubviswa. Kunwa mvura zvakakwana kunobatsirawo kudzivirira matombo eitsvo, izvo zvinogona kuva dambudziko nemushonga uyu.

Nguva dzose tora lesinurad nemumwe mushonga wako we gout sezvakanyorwa. Usambofa wakatora lesinurad wega, nekuti yakagadzirirwa kushanda pamwe chete nemishonga yakaita se allopurinol kana febuxostat. Chiremba wako achabatana nenguva yemishonga yese miviri kuti ive nekushanda zvakanyanya.

Ndingatora Lesinurad Kwenguva Yakareba Sei?

Lesinurad inowanzoita kurapwa kwenguva refu yekugadzirisa gout, zvakafanana nekuti vanhu vane high blood pressure kana chirwere cheshuga vanotora mishonga yavo nguva dzose. Vanhu vazhinji vanoda kuitora zvachose kuti vachengetedze mazinga e uric acid ane hutano uye kudzivirira gout attacks. Chiremba wako achasarudza nguva yakakodzera zvichienderana nekupindura kwako uye hutano hwako hwese.

Unogona kutanga kuona kuvandudzwa mumazinga ako e uric acid mukati memavhiki 2-4 ekutanga kurapwa. Zvisinei, zvinogona kutora mwedzi yakati wandei kuti uwane chinangwa chako che uric acid uye uone gout attacks shoma. Chiremba wako achatarisa kufambira mberi kwako nekuongororwa kweropa nguva dzose, kazhinji mwedzi mishoma yekutanga, wobva wazviita kazhinji kana mazinga ako agadziriswa.

Vamwe vanhu vangakwanisa kuchinja chirongwa chavo chekurapa nekufamba kwenguva. Kana mazinga ako e uric acid akaramba akagadzikana uye usina kurwadziwa ne gout, chiremba wako angangofunga kuchinja muyero wako kana nzira yekurapa. Zvisinei, kumisa mushonga zvachose kazhinji kunotungamira kumazinga e uric acid achikwira zvakare, saka vanhu vazhinji vanoramba vachiuitora kwenguva refu.

Ndezvipi Zvakaipa zveLesinurad?

Semishonga yese, lesinurad inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anoiona. Mhedzisiro yakawanda yakapfava uye inogoneka, asi zvakakosha kuziva zvekutarisa. Chiremba wako achakurukura izvi zvinogona kuitika newe uye achakutarisa zvakanyanya, kunyanya kana uchitanga kutora mushonga.

Heano mhedzisiro yakajairika yaungasangana nayo:

• Kutemwa nemusoro, kunobata vanenge 1 kubva pa10 vanhu vanotora mushonga
• Zviratidzo zvakaita sefuru, kusanganisira kunzwa kuneta kana kurwadziwa kwemuviri
• Gastroesophageal reflux (heartburn kana acid reflux)
• Kuumbwa kwematombo eitsvo, kunyanya mumwedzi mishoma yekutanga yekurapa
• Kukwidzwa kweitsvo basa bvunzo, iyo chiremba wako achatarisa kuburikidza nebasa reropa

Izvi zvakajairika mhedzisiro zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga. Kunwa mvura yakawanda uye kutora mushonga uine chikafu kunogona kubatsira kuderedza zvimwe zvezvinhu izvi.

Vamwe vanhu vanogona kusangana nemhedzisiro yakakomba asi isingawanzoitiki inoda kutariswa kwekurapa nekukurumidza:

• Matambudziko akakomba eitsvo, kusanganisira kukuvadzwa kweitsvo kwakanyanya
• Zviratidzo zvezvinetso zve cardiovascular, zvakadai sekurwadziwa muchipfuva kana kufema kusinganzwisisike
• Maitiro akakomba ekuita allergic, kusanganisira rash, kuzvimba, kana kuoma kufema
• Kuramba uine kusvotwa, kurutsa, kana kurwadziwa mudumbu kwakanyanya
• Kuchinja mumaitiro ekuyera weti kana ropa mumweti

Kana uine zviratidzo zvakakomba izvi, fonera chiremba wako nekukasika kana kutsvaga rubatsiro rwekurapa rwechimbichimbi. Kuchengeteka kwako ndiko kunonyanya kukosha, uye zviratidzo izvi zvinoda kuongororwa nekukurumidza.

Ndiani Asingafaniri Kutora Lesinurad?

Lesinurad haisi yakakodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuraira. Mamwe mamiriro ehutano kana mamiriro anoita kuti mushonga uyu usachengeteke kana kushanda zvishoma. Chiremba wako achafunga nezve hutano hwako hwese kuti aone kana lesinurad yakakukodzera.

Haufaniri kutora lesinurad kana uine chero mamiriro aya:

• Chirwere chakakomba cheitsvo kana kutadza kweitsvo
• Chirwere cheitsvo chekupedzisira chinoda dialysis
• Vanogamuchira transplants yeitsvo
• Tumor lysis syndrome kana mamwe mamiriro anokonzera mazinga epamusoro e uric acid
• Kuziva allergy ku lesinurad kana chero zvinosanganiswa zvayo

Chiremba wako achavawo akangwarira nezvekukuraira lesinurad kana uine matambudziko eitsvo epakati, chirwere chemoyo, kana nhoroondo yematombo eitsvo. Mamiriro aya haanyatso kukudzivisa kutora mushonga, asi anoda kuongororwa zvakanyanya uye pamwe nekugadzirisa dosing.

Vakadzi vane pamuviri kana vanoyamwisa vanofanira kukurukura njodzi nemabhenefiti nachiremba wavo, sezvo kuchengeteka kwe lesinurad panguva yekuzvitakura nekuyamwisa kusati kwanyatsoitwa. Chiremba wako anogona kukurudzira dzimwe nzira dzekurapa panguva idzi.

Mazita eLesinurad Brand

Lesinurad inowanikwa pasi pezita remhando yeZurampic munyika zhinji, kusanganisira United States. Iyi ndiyo fomu inonyanya kurairwa yemushonga. Dzimwe nzvimbo dzinogona kunge dzine mazita emhando akasiyana, saka zvakakosha kuziva zvese zita re generic (lesinurad) uye zita remhando rinoshandiswa ne pharmacy yako.

Kune zvakare mushonga wakasanganiswa unonzi Duzallo uyo une lesinurad ne allopurinol mune piritsi rimwe chete. Musanganiswa uyu unogona kuve wakasununguka kune vamwe vanhu, sezvo uchideredza huwandu hwemapiritsi aunoda kutora zuva rega rega uchivimbisa kuti unowana mishonga miviri inoshanda pamwe chete.

Nguva dzose ita shuwa kuti uri kuwana mushonga wakarurama nekutarisa mazita ese e generic uye brand nemu pharmacist wako. Kana ukafamba kunze kwenyika, zita remhando rinogona kunge rakasiyana, asi zita re generic lesinurad rinofanira kuzivikanwa nevapi vehutano pasi rese.

Zvimwe Zvingashandiswa Panzvimbo pe Lesinurad

Kana lesinurad isingakukodzere kana isingape mhedzisiro yakakwana, mishonga yakati wandei inogona kubatsira kubata gout uye kuderedza mazinga e uric acid. Chiremba wako achatarisa mamiriro ako chaiwo, kusanganisira kushanda kwematsvo ako, mamwe mamiriro ehutano, uye kuti wakanaka sei kumishonga yapfuura.

Mishonga yekuderedza uric acid inosanganisira:

• Allopurinol, iyo inoderedza kugadzirwa kwe uric acid uye inowanzoita yekutanga kurapwa
• Febuxostat, imwe mishonga inoderedza kugadzirwa kwe uric acid
• Probenecid, iyo inobatsira itsvo dzako kubvisa uric acid zvinobudirira
• Pegloticase, jekiseni rine simba remishonga yezviitiko zvakakomba

Pakubata kurwisa kwakanyanya kwe gout, chiremba wako anogona kunyora mishonga inorwisa-kuzvimba senge colchicine, NSAIDs, kana corticosteroids. Izvi zvinoshanda zvakasiyana kubva ku lesinurad asi zvinogona kuve zvikamu zvakakosha zvechirongwa chako chekugadzirisa gout.

Kugadziridzwa kwehupenyu hunogona zvakare kushanda senzira dzakakosha kana nzira dzekuwedzera. Izvi zvinosanganisira kuchengetedza uremu hune hutano, kuderedza kushandiswa kwedoro, kugara uine mvura zvakanaka, uye kudzivirira chikafu chakanyanya mu purines. Chiremba wako anogona kukubatsira kugadzira nzira yakazara inogona kuderedza kudiwa kwako kwemishonga.

Ko Lesinurad Ari Nani Pane Allopurinol Here?

Lesinurad ne allopurinol zvinoshanda nenzira dzakasiyana uye zvinowanzo shandiswa pamwe chete pane kuva dzimwe nzira dzokushandisa. Allopurinol inoderedza huwandu hwe uric acid inogadzirwa nemuviri wako, nepo lesinurad ichibatsira itsvo dzako kubvisa uric acid yakawanda. Nzira iyi yekubatanidza inowanzo shanda zvakanyanya pane kushandisa mushonga mumwe chete.

Allopurinol inowanzo kuva mushonga wekutanga vanachiremba vanonyora kurapa gout nekuti yakashandiswa zvakachengeteka kwemakumi emakore uye inoshanda zvakanaka kune vanhu vazhinji. Lesinurad inowanzo wedzerwa kana allopurinol yoga isina kukwana kusvika padanho re uric acid. Funga nezve allopurinol sechibatiso chekurapa, ne lesinurad ichipa rubatsiro rwakawedzerwa kana zvichidikanwa.

Sarudzo pakati pemishonga iyi inoenderana nemamiriro ako emunhu. Kana uine matambudziko eitsvo, chiremba wako angasarudza allopurinol nekuti inogadziriswa zvakasiyana nemuviri wako. Kana iwe wakatotora allopurinol asi uchiri kuva nekurwisa kwe gout, kuwedzera lesinurad ingave nhanho inotevera ine musoro.

Chiremba wako achafunga nezvezvinhu zvakaita sebasa reitsvo dzako, mimwe mishonga yaunotora, uye kuti wakanaka sei kumishonga yapfuura. Vanhu vazhinji vanowana kuti kubatanidzwa kwemishonga yese miviri kunopa kutonga kuri nani kwe uric acid pane imwe chete.

Mibvunzo Inowanzo Bvunzwa Nezve Lesinurad

Lesinurad Yakachengeteka Kune Vanhu vane Chirwere cheItsvo Here?

Lesinurad inoda kufungwa zvakanyanya kana uine chirwere cheitsvo, uye haina kukurudzirwa kune vanhu vane matambudziko akakomba eitsvo. Chiremba wako achaongorora basa reitsvo dzako nemiedzo yeropa usati wanyora lesinurad uye achienderera mberi nekukutarisa nguva dzose paunenge uchitora.

Kana uine chirwere cheitsvo chakareruka kusvika pakati nepakati, chiremba wako angaramba achikupa lesinurad asi anogona kutanga nemwero wakaderera uye achakutarisa zvakanyanya. Mushonga uyu unogona kuisa kushushikana kwakawanda pamatsvo ako nekuti unowedzera huwandu hwe uric acid hwavanoita kuti vagadzirise, ndosaka kugara uine mvura yakawanda kwakakosha.

Ndingaita Sei Kana Ndakatora Lesinurad Yakawandisa Netsaona?

Kana netsaona ukatora lesinurad yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira, kunyangwe usina kunzwa kurwara. Kutora yakawanda kunogona kuwedzera njodzi yako yematambudziko eitsvo uye mamwe matambudziko akakomba. Usamirira kuti uone kana zviratidzo zvichioneka, sezvo kutariswa kwekutanga kwekurapa kwakakosha.

Paunenge uchitsvaga zano rekurapa, inwa mvura yakawanda kuti ibatsire itsvo dzako kugadzirisa mushonga wakawandisa. Dzivisa kutora mamwe madosi kusvikira wataura nemupi wehutano. Chengeta bhodhoro remushonga newe kuitira kuti nyanzvi dzekurapa dzikwanise kuona chaizvo zvawakatora uye zvakawanda sei.

Ndingaita Sei Kana Ndikakanganwa Dose yeLesinurad?

Kana ukakanganwa dose ye lesinurad, itore paunorangarira, chero zvichiri zuva rimwe chetero. Kana usingarangariri kusvika zuva rinotevera, siya dose yakakanganwa uye tora dose yako inotevera yakarongwa panguva yakajairika. Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa.

Edza kutora lesinurad panguva imwe chete zuva rega rega kuti ikubatsire kurangarira. Vanhu vazhinji vanozviwana zvichibatsira kuzvitora nekudya kwemangwanani kana kumisa chiyeuchidzo chezuva nezuva pafoni yavo. Kana uchikanganwa madosi kazhinji, taura nachiremba wako nezve nzira dzekukubatsira kuchengetedza kutevedzera mushonga nguva dzose.

Ndingamira Rini Kutora Lesinurad?

Unofanirwa kungomira kutora lesinurad pasi pekutariswa nachiremba wako. Vanhu vazhinji vanoda kuramba vachizvitora kwenguva refu kuti vachengetedze mazinga e uric acid ane hutano uye kudzivirira kurwisa kwe gout. Kumisa mushonga kazhinji kunokonzera mazinga e uric acid kukwira zvakare mukati memavhiki mashoma.

Chiremba wako angatarisa kugadzirisa kurapwa kwako kana wachengeta mazinga e uric acid akagadzikana kwenguva yakareba uye wakaita shanduko huru muhupenyu hwako. Zvisinei, chero shanduko kune yako mishonga regimen inofanira kuva zvishoma nezvishoma uye inofanira kucherechedzwa zvakanyanya. Usambomira kutora lesinurad kamwechete usina kutanga wataurirana nachiremba wako.

Ndinganwe Doro Ndiri Kutora Lesinurad?

Zvakanaka kuderedza kunwa doro uchitora lesinurad, nekuti doro rinogona kukanganisa kugona kwemuviri wako kubvisa uric acid uye rinogona kukonzera kurwisa kwe gout. Doro nemimwe mweya zvinonyanya kuoma nekuti zvinogona kuwedzera kugadzirwa kwe uric acid uye kuderedza basa reitsvo.

Kana ukasarudza kunwa doro dzimwe nguva, ita izvozvo zvine mwero uye ita shuwa kunwa mvura yakawanda kuti urambe uine mvura yakakwana mumuviri. Kurukura kunwa kwako doro nachiremba wako, sezvo vachigona kupa gwara rakagadzirirwa iwe zvichienderana nehutano hwako hwese uye zvinangwa zvekutarisira gout. Vamwe vanhu vanowana kuti kudzivisa doro zvachose kunovabatsira kuwana kutonga kuri nani kwe uric acid.