Chii chinonzi Levodopa Inhalation: Zvinoshandiswa, Dosage, Side Effects uye Zvimwe

Levodopa inhalation mushonga unotyisa uyo unoendesa levodopa zvakananga kumapapu ako kuburikidza nechishandiso chekufema chakakosha. Kurapa uku kunobatsira vanhu vane chirwere cheParkinson kutarisira zviitiko zvekukasira "kudzima" apo mishonga yavo yemuromo isingapi kutonga kwakakwana kwezviratidzo.

Kusiyana nemapiritsi echinyakare e levodopa ayo anofanira kufamba nemudumbu mako, fomu rekufema rinotorwa nekukurumidza muropa rako kuburikidza nemapapu ako. Iyi nzira yekukurumidza inogona kubatsira kudzorera kufamba kwako uye kuderedza kuoma mukati memaminitsi panzvimbo yekumirira maminitsi makumi matatu kusvika makumi matanhatu kuti mishonga yemuromo itange kushanda.

Chii chinonzi Levodopa Inhalation?

Levodopa inhalation ifomu re levodopa repowder rakaoma iro raunofema uchishandisa inhaler yakakosha inonzi Inbrija device. Yakagadzirirwa zvakananga semushonga wekununura vanhu vane chirwere cheParkinson vanowana nguva dzisingatarisirwi "kudzima" zuva rese.

Mushonga uyu une chinhu chimwe chete chinoshanda semapiritsi e levodopa emuromo, asi yakagadzirirwa semaparticles madiki anogona kutora kuburikidza nemapapu ako. Paunofema poda, inokurumidza kupinda muropa rako uye inofamba kuenda kuuropi hwako, uko inoshandurwa kuita dopamine kubatsira kuvandudza zviratidzo zvako zvemotokari.

Iyi vhezheni yekufema yakatenderwa neFDA muna 2018 semushonga wekutanga uye wega wekufema weParkinson's disease off episodes. Zvinoreva kushanda pamwe chete nemishonga yako yemuromo yeParkinson, kwete kuitsiva zvachose.

Chii chinonzi Levodopa Inhalation chinoshandiswa?

Levodopa inhalation inoshandiswa zvakananga kurapa "kudzima" zviitiko muvanhu vane chirwere cheParkinson avo vatove vachitora carbidopa/levodopa mushonga. Off episodes inguva apo mushonga wako wenguva dzose unopera uye zviratidzo zvako zveParkinson zvinodzoka kana kuwedzera.

Munguva idzi dzekuzorora, unogona kusangana nekudedera kwakawedzera, kuoma kwemhasuru, kufamba zvishoma nezvishoma, kana kuoma kufamba. Zviitiko izvi zvinogona kuitika zvisingatarisirwi zuva rese, kunyangwe iwe uchitora mishonga yako yemuromo sezvakanyorwa. Levodopa inofemwa inopa rubatsiro rwekukurumidza kana zviratidzo izvi zvikaitika.

Chiremba wako achanyora mushonga uyu chete kana iwe watove wakagadzwa pane regimen yakagadzikana ye oral carbidopa/levodopa. Haina kuitirwa vanhu vachangobva kuongororwa nechirwere cheParkinson kana avo vasina kamboedza kurapwa kwelevodopa yemuromo kutanga.

Levodopa Inhalation Inoshanda Sei?

Levodopa inhalation inoshanda nekutumira mushonga zvakananga kumapapu ako, uko inokurumidza kupinzwa muropa rako. Izvi zvinopfuura zvachose hurongwa hwako hwekugaya, ndosaka ichishanda nekukurumidza kupfuura mishonga yemuromo.

Kana levodopa yasvika muuropi hwako, inoshandurwa kuita dopamine ne enzyme inonzi aromatic L-amino acid decarboxylase. Dopamine ndiyo neurotransmitter inobatsira kudzora kufamba, uye vanhu vane chirwere cheParkinson vane mazinga akaderera emakemikari akakosha muuropi hwavo.

Fomu inofemwa inoonekwa semushonga wepakati nepakati unopa rubatsiro rwemunguva pfupi panzvimbo yekutarisira zviratidzo kwenguva refu. Inowanzo kutanga kushanda mukati memaminitsi gumi nemashanu uye inogona kupa kuvandudzwa kwezviratidzo kweanenge 1-2 maawa, ichikupa nguva yekuti mushonga wako unotevera wakarongeka wemuromo utange kushanda.

Ndinofanira Sei Kutora Levodopa Inhalation?

Unofanira kutora levodopa inhalation sezvinorayirwa nachiremba wako, uchishandisa chete mudziyo weInbrija inhaler unouya nemushonga wako. Madosi akajairika anowanzoita kapisuru imwe (84 mg) inofemwa kana iwe ukaona chiitiko chekuzorora, ine huwandu hwemadosi mashanu pazuva.

Usati washandisa inhaler, ita shuwa maoko ako akachena uye akaoma. Bvisa kapisuru imwe kubva mublister pack usati waishandisa, woisa mukamuri yeinhaler. Bata mudziyo wakamira, fema mweya wese panze, wobva waisa miromo yako pamuromo wekufemera wofema zvakadzama uye nekukurumidza kuti uve nechokwadi chekuti unowana dose yakazara.

Unogona kushandisa mushonga uyu uine kana usina chikafu, uye haufanirwe kunwa mvura usati kana mushure mekuita inhalation. Zvisinei, zvakakosha kusuka muromo wako nemvura mushure mekuishandisa yega yega kubvisa chero hupfu hwakasara uye kuderedza njodzi yekutsamwa kwehuro. Usadye kana kunwa chero chinhu kwemaminitsi mashanu mushure mekutora dose yako.

Nguva dzose chengeta inhaler yako nemakapisuru munzvimbo yakaoma patembiricha yekamuri. Usambofa wakashambidza mudziyo weinhaler nemvura, uye uitsive zvinoenderana nemirairo yachiremba wako, kazhinji mwedzi mishoma yega yega.

Ndingatora Levodopa Inhalation kwenguva yakareba sei?

Unofanira kuramba uchitora levodopa inhalation kwenguva yakareba sezvinokurudzirwa nachiremba wako, izvo zvinowanzoita sekureba sekuti unoramba uchiona zviitiko zvekunze nechirwere chako cheParkinson. Mushonga uyu wakagadzirirwa kushandiswa kwenguva refu sechinhu chekurapa pamwe chete nemishonga yako yemuromo yenguva dzose.

Chiremba wako achagara achiongorora kana levodopa yakafemwa ichiri kubatsira zviratidzo zvako uye inogona kugadzirisa hurongwa hwako hwese hwekurapa Parkinson nekufamba kwenguva. Vamwe vanhu vangada kuishandisa kakawanda pazuva, nepo vamwe vangangoda chete nguva nenguva kana zviitiko zvekunze zvichiitika.

Kureba kwekurapa kunoenderana nekuti chirwere chako cheParkinson chinofambira sei uye kuti mishonga yako imwe inodzora sei zviratidzo zvako. Usambofa wakarega kushandisa mushonga uyu kamwe kamwe usina kutaura nachiremba wako kutanga, sezvo izvi zvingaita kuti zviratidzo zvako zinyanye.

Ndezvipi Zvakaipa zveLevodopa Inhalation?

Sezvinongoita mishonga yese, kufema levodopa kunogona kukonzera matambudziko, kunyangwe vanhu vazhinji vachigara vachigamuchira zvakanaka. Matambudziko anowanzoitika anowanzoita akapfava uye ane chekuita nekufema pachayo.

Ngatitarisei matambudziko aunogona kusangana nawo, tichitanga neanowanzoitika anokanganisa hurongwa hwako hwekufema:

• Kukosora (kunokanganisa vanhu vanenge 15%)
• Kutapukirwa kwepamusoro kwemhepo
• Kutsamwa kwehuro kana kusagadzikana
• Kushanduka kwemuvara wemate (mucus yako inogona kuita yerima)
• Kukakama kana kuchinja kweinzwi

Izvi zvinokanganisa kufema zvinowanzoitika nekuti poda inogona kutsamwisa nzira dzako dzemhepo, asi kazhinji akapfava uye enguva pfupi. Kushambidza muromo wako mushure mekushandisa kwega kwega kunogona kubatsira kuderedza kutsamwa kwehuro.

Kunze kwezvinokanganisa kufema, unogonawo kusangana nematambudziko akafanana neaya kubva kumishonga yemuromo levodopa:

• Kusvotwa kana dumbu kusagadzikana
• Dizziness kana lightheadedness
• Dyskinesia (kufamba kusingadiwi)
• Hallucinations kana kuvhiringidzika
• Kuchinja kweropa

Izvi zvinokanganisa zvinowanzoitika nekuti levodopa inokanganisa muviri wako wese kana yapinda muropa rako, kwete kungoita uropi hwako chete.

Mamwe matambudziko asingawanzoitiki asi akakomba anoda kutariswa kwekurapa nekukasira. Izvi zvinosanganisira matambudziko akakomba ekufema, kurwadziwa muchipfuva, shanduko dzakakosha murhythm yemoyo, kana kutanga kamwe kamwe kwekuneta kwakanyanya. Kana iwe ukasangana nechero zviratidzo izvi, taura nachiremba wako nekukasira kana kutsvaga rubatsiro rwekurapa rwechimbichimbi.

Ndiani Asingafaniri Kutora Levodopa Inhalation?

Mapoka akati wandei evanhu haafaniri kushandisa levodopa inhalation nekuda kwezvikonzero zvekuchengetedza. Chiremba wako achanyatsoongorora kana mushonga uyu wakakodzera mamiriro ako chaiwo.

Vanhu vane mamiriro akati wandei emapapu vanofanira kudzivisa mushonga uyu nekuti kufema poda kunogona kuwedzera matambudziko avo ekufema:

• Asthma inoshanda kana nhoroondo yekurwiswa kweasthma
• Chronic obstructive pulmonary disease (COPD)
• Zvimwe zvirwere zvemapapu zvisingaperi zvinokanganisa kufema
• Zvirwere zvefemo zvichangobva kuitika kana pneumonia

Tupukanana twepoda tunogona kukonzera matambudziko ekufema kana kuwedzera kuzvimba kwemapapu mumamiriro ezvinhu aya.

Uyezve, mamwe mamiriro ezvinhu ekurapa uye kusangana kwemishonga kunoita kuti levodopa inhalation isachengeteke:

• Vanhu vari kutora monoamine oxidase inhibitors (MAOIs) mukati memazuva gumi nemana apfuura
• Avo vane narrow-angle glaucoma
• Vanhu vane zvironda zvinofungira paganda kana nhoroondo ye melanoma
• Vanhu vane chirwere chemoyo chakakomba kana kurwiswa kwemoyo kuchangobva kuitika
• Vanhu vane chirwere cheitsvo kana chiropa (vanogona kuda kugadziriswa kwemadosi)

Chiremba wako achafungawo nezve zera rako, mamwe mishonga, uye hutano hwese usati wanyora mushonga uyu.

Levodopa Inhalation Zita reBrand

Zita rebrand re levodopa inhalation ndeye Inbrija, inogadzirwa neAcorda Therapeutics. Iyi ndiyo chete FDA-yakabvumidzwa inhaled fomu ye levodopa iripo muUnited States.

Inbrija inouya seyakazara sisitimu inosanganisira ese akaoma poda makapisi uye akakosha inhaler mudziyo. Hauzive kushandisa makapisi nerimwe rudzi rwe inhaler, uye haugone kushandisa mamwe mishonga neInbrija inhaler mudziyo.

Mishonga inowanikwa chete nemishonga uye inowanzo vharwa nehurongwa hwakawanda hweinishuwarenzi yevanhu vane chirwere cheParkinson vanosangana nezvinhu zvakatarwa zvekushandisa kwayo.

Levodopa Inhalation Zvimwe Zvinhu

Kana levodopa inhalation isina kukodzera kwauri, dzimwe sarudzo dziripo dzekugadzirisa zviitiko zveParkinson. Chiremba wako anogona kukubatsira kuongorora idzi dzimwe nzira zvichibva pazvido zvako uye nhoroondo yekurapa.

Mamwe mishonga inokurumidza kuita yezviitiko zvinosanganisira:

• Majekiseni eApomorphine (Apokyn) - anoshanda mukati memaminitsi gumi-makumi maviri
• Mapepa eapomorphine epasi pemururimi (Kynmobi) - anonyungudika pasi perurimi rwako
• Levodopa/carbidopa yekumwa inoburitswa nekukurumidza - kunyangwe ichinonoka kupfuura mafomu anofemwa
• Kugadzirisa nguva kana muyero wemishonga yako yemuromo yenguva dzose

Zvimwe zvingasarudzwa izvi zvinoshanda kuburikidza nemaitiro akasiyana ekuendesa asi zvinovavarira kuzadzisa chinangwa chimwe chete chekukurumidza kudzorera mazinga e dopamine muuropi hwako.

Kune vamwe vanhu, kugadzirisa mishonga yavo yemuromo yenguva dzose inogona kukwana kuderedza zvikamu zvekunze. Izvi zvinogona kusanganisira kuchinja kune mafomu akawedzerwa-kuburitswa, kuwedzera mamwe mishonga yeParkinson senge dopamine agonists, kana kugadzirisa nguva yekudya kuti uvandudze kunyudzwa kwemishonga.

Ko Levodopa Inhalation Zviri Nani Kupfuura Levodopa Yemuromo Here?

Levodopa inhalation haisi nani kupfuura levodopa yemuromo, asi inoshanda chinangwa chakasiyana muhurongwa hwako hwekurapa. Fomu rinofemwa rakagadzirirwa kuzadzisa mishonga yako yemuromo yenguva dzose, kwete kuitsiva zvachose.

Mukana mukuru welevodopa inofemwa ndiko kumhanya. Nepo levodopa yemuromo inowanzo tora maminitsi makumi matatu-makumi matanhatu kuti ishande, fomu rinofemwa rinowanzo tanga kushanda mukati memaminitsi gumi-gumi nemashanu. Izvi zvinoita kuti zvive zvakakosha pakugadzirisa zvikamu zvisingatarisirwi kana iwe uchida rubatsiro rwekukurumidza.

Zvisinei, levodopa yemuromo inoramba iri hwaro hwezvirongwa zvakawanda zvekurapa Parkinson nekuti inopa kutonga kwenguva refu kwezviratidzo zuva rese. Fomu rinofemwa rinoshanda kwemaawa anenge 1-2 chete, zvichiita kuti risakodzere semushonga wako wekutanga.

Chiremba wako achakubatsira kuona musanganiswa wakanaka wemishonga zvichienderana nemaitiro ako ezviratidzo, mararamiro, uye kuti unotsungirira sei kurapwa kwakasiyana. Vanhu vazhinji vanowana kuti kushandisa mafomu ese pamwe chete kunopa manejimendi akazara ezviratidzo.

Mibvunzo Inowanzo Bvunzwa Nezve Levodopa Inhalation

Ko Levodopa Inhalation Yakachengeteka Kune Vanhu vane Chirwere Chemoyo Here?

Kufema Levodopa kunoda kufungwa zvakanyanya kana uine chirwere chemoyo. Mushonga uyu unogona kukanganisa kumhanya kwemoyo wako uye kudzvanywa kweropa, zvichikonzera matambudziko muvanhu vane matambudziko emoyo aripo.

Chiremba wako achada kuongorora mamiriro ako chaiwo emoyo uye mishonga yaunotora parizvino usati wanyora levodopa inofemwa. Vanogona kukurudzira kuongororwa kwemoyo kwakawedzerwa kana kugadzirisa mishonga yako yemoyo kuti uve nechokwadi chekushandisa kwakachengeteka. Mune dzimwe nguva, vanhu vane chirwere chemoyo chakakomba vangangoda kudzivisa mushonga uyu zvachose.

Ndingaita Sei Kana Ndikashandisa Levodopa Inhalation yakawandisa netsaona?

Kana ukashandisa netsaona zvakawanda kupfuura chiyero chako chakanyorwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira. Kutora levodopa yakawanda kunogona kukonzera mhedzisiro yakakomba kusanganisira kusvotwa kwakanyanya, kurutsa, kurova kwemoyo kusingaite, zviratidzo, kana kurara zvakanyanya.

Usaedze kuzviita kurutsa, sezvo izvi zvisingabatsiri kubvisa mushonga uyo watove wakatorwa nemapapu ako. Zviongorore iwe pachako zvakanyanya kune chero zviratidzo zvisingawanzoitiki uye tsvaga rubatsiro rwekurapa rwechimbichimbi kana uine kurwadziwa muchipfuva, kuoma kufema, kana kurasikirwa nekuziva.

Ndingaita Sei Kana Ndikakanganwa Dose yeLevodopa Inhalation?

Kana ukakanganwa dose panguva yechikamu chekudzima, unogona kuitora paunorangarira, chero iwe usingapfuuri 5 doses muzuva rimwe chete. Kusiyana nemishonga yakarongwa, levodopa inhalation inoshandiswa sezvinodiwa kune zviratidzo zvekutyora.

Usatore mamwe ma dose kuti ugadzirise avo vakarasika, uye nguva dzose isa ma dose ako maawa maviri akasiyana. Kana iwe uine zvikamu zvekudzima zvakawanda zvauri kukanganwa mikana yekurapa, kurukura izvi nachiremba wako sezvo iwe ungada kugadzirisa mishonga yako yemuromo yenguva dzose.

Ndingamira Rini Kutora Levodopa Inhalation?

Unogona kumira kutora levodopa inhalation kana iwe nachiremba wako maona kuti hauchadi kuti ikubatsire pakugadzirisa zviitiko zvekunze. Izvi zvinogona kuitika kana mishonga yako yemuromo yenguva dzose yakagadziriswa uye ichipa kutonga kuri nani kwezviratidzo, kana kana zviitiko zvako zvekunze zvichiwanda kana kuoma.

Nguva dzose taura nezvekumisa mushonga uyu nachiremba wako kutanga, pane kuumisa wega. Vanogona kukubatsira kuongorora kana mushonga uchiri kubatsira uye kukutungamira kuburikidza nekugadzirisa chero zvakakosha kuronga kwako kurapwa kwese.

Ndingafamba neLevodopa Inhalation here?

Hongu, unogona kufamba nelevodopa inhalation, asi uchafanirwa kutora mamwe matanho ekuwedzera. Nguva dzose takura mushonga wako mupakeji yayo yepakutanga ine chinyorwa chemishonga, uye uuye netsamba kubva kuna chiremba wako ichitsanangura zvaunoda zvekurapa zvechishandiso chekufemera.

Paunenge uchibhururuka, chengeta mushonga wako mubhegi rako rekutakura pane kutakura mune zvakatariswa kuti udzivise kupisa kwakanyanya uye kurasikirwa kunogona kuitika. Iyo TSA inobvumira inhalers zvekurapa kuburikidza nekuchengetedzwa, asi kuve nemagwaro kunogona kubatsira kumhanyisa maitiro ekuongorora. Funga kuunza makapisi ekuwedzera kana paine kunonoka kwekufamba.