Chii chinonzi Lorcaserin: Zvayakashandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Lorcaserin yaive mushonga wekurapa uremu uyo waibatsira vanhu kuderedza uremu nekuita kuti vanzwe vakaguta nekukurumidza panguva yekudya. Zvisinei, FDA yakabvisa mushonga uyu mumusika weU.S. muna Kukadzi 2020 nekuda kwekunetseka kwekuchengeteka pamusoro pekuwedzera njodzi yekenza. Kana iwe uchitora lorcaserin kana uchifunga nezve sarudzo dzekurasikirwa nehuremu, zvakakosha kunzwisisa zvakaitika uye kuongorora dzimwe nzira dzakachengeteka nachiremba wako.

Chii chinonzi Lorcaserin?

Lorcaserin yaive mushonga wekudzora chido wakagadzirirwa kubatsira vanhu vakuru kuderedza uremu kana yakabatanidzwa nekudya uye kurovedza muviri. Yakashanda nekunangana ne serotonin receptors muuropi hwako hunodzora manzwiro enzara nekuguta. Mushonga uyu waitengeswa pasi pezita rekuti Belviq uye Belviq XR.

Mishonga iyi yaive yechikamu chemishonga inonzi serotonin 2C receptor agonists. Funga nezvazvo semutumwa wemakemikari uyo akaudza uropi hwako kuti wakagutsikana nekudya zvishoma. Izvi zvakabatsira vanhu kudya zvikamu zvidiki uye kunzwa vakaguta kwenguva refu mushure mekudya.

Lorcaserin yakabvumirwa chete kune vanhu vakuru vane body mass index (BMI) ye30 kana kupfuura, kana avo vane BMI ye27 kana kupfuura avo vane mamiriro ehutano ane hukama nehuremu senge chirwere cheshuga kana BP yepamusoro.

Chii chakashandiswa Lorcaserin?

Lorcaserin yakanyorerwa zvakananga manejimendi ehuremu husingaperi muvanhu vakuru vakatambudzika nekuwanda. Haisiyo yekugadzirisa nekukurumidza kana piritsi rekudya, asi chishandiso chekutsigira kuedza kwekurasikirwa nehuremu kwenguva refu pamwe nekudya kwakanaka uye basa remuviri nguva dzose.

Vanachiremba vanowanzo nyora lorcaserin kune vanhu vakaedza nzira dzekurasikirwa nehuremu dzetsika pasina kubudirira. Mushonga uyu waifanirwa kubatsira kuparadza kutenderera kwekudya zvakanyanya nekuderedza chido uye chido chekudya. Varwere vazhinji vakawana zviri nyore kutevedzera zvinangwa zvavo zvekudya vachitora mushonga.

Mushonga uyu waishandiswawo kuvanhu vane matambudziko emuviri ane chekuita nehuremu. Izvi zvaibatanidza chirwere cheshuga che mhando 2, ropa rakakwira, cholesterol yakakwira, uye sleep apnea. Kuderedza uremu kazhinji kwaibatsira kuvandudza mamiriro aya, zvichiita kuti lorcaserin ive sarudzo yekurapa inokosha isati yabviswa.

Lorcaserin Yakashanda Sei?

Lorcaserin yakashanda nekumisa ma receptors akati wandei e serotonin muuropi hwako hwekudzora chido chekudya. Ma receptors aya, anonzi 5-HT2C receptors, anoita basa guru rekutaura muviri wako paunenge wapedza kudya. Paanenge amiswa, anotumira zviratidzo zvekuti waguta uye wazara.

Mushonga uyu waionekwa seunoshanda zvine mwero pane kuti uve mushonga wekuderedza uremu une simba. Vanhu vazhinji vakatora lorcaserin vakarasikirwa neanenge 5 kusvika ku10 muzana yehuremu hwavo mumakore. Kunyange izvi zvingasaita sezvinoshamisa, kunyange kuderedza uremu zvishoma kunogona kuvandudza zvakanyanya hutano hwevanhu vane obesity.

Kusiyana nemamwe ma appetite suppressants, lorcaserin yakagadzirirwa kuve selective mukuita kwayo. Yakanyanya kutarisisa ma receptors anobatanidzwa mukudzora chido pane kukanganisa mamwe masisitimu mumuviri wako. Kusarudzwa uku kwaive nechinangwa chekuderedza mhedzisiro yezvinhu zvichienzaniswa nemishonga yekuderedza uremu yekare.

Lorcaserin Yaifanira Kutora Sei?

Lorcaserin yaigara ichitorwa kaviri pazuva ine kana isina chikafu. Iyo yakajairwa yekuburitsa vhezheni yaida zvikamu zviviri zve10mg pazuva, nepo iyo yakawedzerwa-kuburitsa vhezheni (Belviq XR) yaitorwa kamwe pazuva semushonga we20mg. Chiremba wako angadai akasarudza chirongwa chakanakisa chekushandisa zvichienderana nezvido zvako.

Mushonga uyu unogona kutorwa nemvura, mukaka, kana muto. Pakanga pasina zvirambidzo zvakakosha zvekudya, kunyange zvazvo kuitora nechikafu dzimwe nguva kwaibatsira kuderedza dumbu rinovava muvanhu vanonzwa. Vazhinji vanachiremba vakakurudzira kutora mushonga panguva imwe chete zuva rega rega kuti vachengetedze mazinga akafanana mumuviri wako.

Zvaive zvakakosha kuramba uchitevera kudya kudiki-kori uye chirongwa chekurovedza muviri uchitora lorcaserin. Mushonga uyu waishanda zvakanaka kana wakabatana nekuchinja mararamiro, kwete senzira yekutsiva tsika dzakanaka. Chiremba wako angadai akapa gwara rekudya rakagadzirirwa zvinangwa zvako zvekurasikirwa nehuremu.

Lorcaserin Yaifanira Kutora Kwenguva Yakareba Sei?

Lorcaserin yakagadzirirwa kushandiswa kwenguva refu, asi vanachiremba vanowanzoongorora kushanda kwayo mushure memavhiki gumi nemaviri ekurapa. Kana usina kurasikirwa neanenge mashanu muzana ehuremu hwako hwekutanga panguva ino, chiremba wako angadai akamisa mushonga uyu sezvo usina kupa rubatsiro runokosha.

Kune avo vakapindura zvakanaka, lorcaserin inogona kuenderera mberi kwenguva yakareba pasi pekutariswa kwechiremba. Vamwe vanhu vaizvitora kwemakore akati wandei sechikamu chechirongwa chavo chekuramba vachidzora huremu. Kuongororwa nguva dzose kwaive kwakakosha kuti utarise kushanda zvakanaka uye mhedzisiro inogona kuitika.

Sarudzo yekurega kutora lorcaserin yaigara ichiitwa mukubvunzana nemupi wako wehutano. Kumira kamwe kamwe hakukonzera zviratidzo zvekubvisa, asi vanhu vazhinji vakawana chido chavo chichidzokera kumazinga apfuura nekukurumidza mushure mekumisa.

Ndezvipi Zvaive Zvakaipa ZveLorcaserin?

Semishonga yese, lorcaserin inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vaizvitsungirira zvakanaka. Mhedzisiro yakajairika yaive yakapfava uye kazhinji yaivandudzwa sezvo muviri wako waigadzirisa kumishonga. Zvisinei, kunetseka kwakakomba kwakakonzera kubviswa kwayo kwaive kuwedzera njodzi yegomarara.

Heano mhedzisiro inonyanya kuzivikanwa iyo vanhu vakawana vachitora lorcaserin:

• Kutemwa nemusoro nekutenderera
• Nausea uye dumbu rinogumbuka
• Kuneta uye kusimba
• Muromo wakaoma
• Kuzvimbirwa
• Kurwadziwa kwemuzongoza
• Kukosora uye zvirwere zvekufema zvepamusoro

Mhedzisiro iyi yaiwanzodzoreka uye yenguva pfupi. Vanhu vazhinji vakawana kuti kunwa mvura yakawanda, kudya zvokudya zvenguva dzose, uye kuwana zororo rakakwana zvakabatsira kuderedza zviratidzo izvi.

Mhedzisiro yakakomba asi isingawanzoitiki yaisanganisira serotonin syndrome, kunyanya kana yakasanganiswa nemimwe mishonga inokanganisa mazinga e serotonin. Mamiriro aya akakonzera zviratidzo zvakaita sekuvhiringika, kukurumidza kwemoyo, kuwedzera kweropa, uye kuoma kwemhasuru. Uyezve, vamwe vanhu vakawana matambudziko emavharuvhu emoyo, kunyange izvi zvisingawanzoitiki.

Chinhu chinonyanya kunetsa chaive kuwedzera kwengozi yekenza, kunyanya mapapu, pancreatic, uye colorectal cancers. Kuwanikwa uku panguva yekudzidza kwenguva refu kwakaita kuti FDA itore lorcaserin kubva kumusika muna Kukadzi 2020.

Ndivanaani Vasina Kukodzera Kutora Lorcaserin?

Mapoka akati wandei evanhu akakurudzirwa kuti asatore lorcaserin nekuda kwengozi dzakawedzera kana kushanda zvishoma. Vakadzi vane pamuviri uye vanoyamwisa vakanyatso kurambidzwa kushandisa mushonga uyu sezvo kurasikirwa uremu panguva idzi kwaigona kukuvadza vese amai nemwana.

Vanhu vane mamiriro ezvinhu akati wandei vaifanira kudzivisa lorcaserin zvachose. Izvi zvaisanganisira vanhu vane chirwere chakakomba cheitsvo kana chiropa, sezvo nhengo idzi dzaive nebasa rekugadzirisa mushonga. Avo vane nhoroondo yematambudziko emavharuvhu emoyo vakakurudzirwawo kuti vasatore lorcaserin nekuda kwematambudziko emoyo anogona kuitika.

Uyezve, vanhu vachitora mimwe mishonga havana kukwanisa kushandisa lorcaserin zvakachengeteka. Izvi zvaisanganisira avo vari paMAO inhibitors, mamwe antidepressants, migraine mishonga, uye mamwe madhiragi anokanganisa mazinga e serotonin. Musanganiswa uyu unogona kutungamirira ku serotonin syndrome inotyisa.

Mazita eLorcaserin Brand

Lorcaserin yakatengeswa pasi pemazita maviri makuru emhando muUnited States. Belviq yaive vhezheni yekuburitswa nekukasira iyo yaida kutorwa kaviri pazuva, nepo Belviq XR yaive fomu rekuwedzera-kuburitswa raitorwa kamwe chete pazuva. Mhando dzese dzine chinhu chimwe chete chinoshanda asi dzakagadzirirwa nzira dzakasiyana dzekushandisa.

Mishonga iyi yakagadzirwa neArena Pharmaceuticals uye gare gare yakatengeswa neEisai Inc. Dzimwe nyika dzinogona kunge dzine mazita akasiyana emhando, asi chinhu chinoshanda chakaramba chiri lorcaserin hydrochloride zvisinei nemugadziri kana zita remhando.

Kubva pakubviswa kweFDA muna 2020, mazita emhando aya haachawanikwi muUnited States. Chero zvipi zvazviri zvakasara zvaifanira kubviswa mumakemisi uye kudzoserwa kuvagadziri.

Zvimwe Zvinhu Zviri Kutsiva Lorcaserin

Mishonga yakati wandei yekurasikirwa nehuremu yakatenderwa neFDA inowanikwa senzira yekutsiva lorcaserin. Sarudzo idzi dzinoshanda nemaitiro akasiyana uye dzinogona kukodzera zvichienderana nehutano hwako hwega uye zvinangwa zvekurasikirwa nehuremu. Chiremba wako anogona kukubatsira kuona kuti ndeipi imwe nzira ingashanda zvakanyanya kwauri.

Mishonga yemazuva ano yekurasikirwa nehuremu inosanganisira orlistat (Xenical), phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), uye liraglutide (Saxenda). Imwe neimwe ine seti yayo yezvakanakira uye zvinogona kukonzera mhedzisiro, saka kuongorora kwakanyatsoitwa nachiremba wako wehutano kwakakosha.

Zvimwe zvisiri zvekurapa zvinosanganisira zvirongwa zvakarongeka zvekurasikirwa nehuremu, zvirongwa zvekutsiva chikafu, uye kuvhiyiwa kwebariatric kune avo vanokodzera. Vanhu vazhinji vanowana kubudirira nezvirongwa zvakazara zvekuchinja mararamiro ayo anosanganisa kubvunzurudzwa kwechikafu, gwara rekurovedza muviri, uye rutsigiro rwemaitiro.

Ko Lorcaserin Yakangairi Nani Pane Dzimwe Mishonga Yekurasikirwa Nehuremu?

Kushanda zvakanaka kweLorcaserin kwakafanana nemamwe mishonga yekurasisa uremu yaivapo panguva iyoyo. Vanhu vazhinji vakarasikirwa ne5 kusvika ku10 muzana yezviremu zvavo mumakore, izvo zvakafanana nemamwe maoption akatenderwa neFDA. Chinhu chikuru chaiva chokuti chaiva nemigumisiro mishoma kana ichienzaniswa nemamwe maoption.

Zvisinei, njodzi yekenza yakawanikwa mukudzidza kwenguva refu yakapfuura chero mabhenefiti aingave akapiwa naLorcaserin. Ichi ndicho chikonzero nei FDA yakagumisa kuti njodzi dzakapfuura mabhenefiti uye yakakumbira kubviswa kwayo mumusika. Mamwe mishonga yekurasisa uremu ichiripo nekuti mabhenefiti avo-kune-njodzi profiles anoramba achifadza.

Mishonga yega yega yekurasisa uremu ine hunhu hwakasiyana hunogona kuiita kuti ive yakakodzera kana kusakodzera kune vanhu vakasiyana. Chinhu chinonyanya kukosha ndechokuwana sarudzo yakachengeteka, inoshanda iyo inoshanda nemamiriro ako ehutano uye mararamiro ako pasi pekutariswa kwakakodzera kwechiremba.

Mibvunzo Inowanzo Bvunzwa Pamusoro peLorcaserin

Lorcaserin Yakachengeteka Kune Vanhu vane Chirwere cheShuga here?

Lorcaserin pakutanga yakaonekwa seyakachengeteka kune vanhu vane chirwere cheshuga che2 uye yaigara ichirairwa kubatsira mukudzora uremu muvarwere vane chirwere cheshuga. Mushonga uyu unogona kubatsira kuvandudza kutonga kweshuga yeropa kuburikidza nekurasikirwa nehuremu. Zvisinei, njodzi yakawedzera yekenza yakatungamira mukubviswa kwayo inokanganisa munhu wese, kusanganisira avo vane chirwere cheshuga.

Kana uine chirwere cheshuga uye waishandisa lorcaserin, chiremba wako anogona kunge akakuchinjira kune imwe mishonga yekurasisa uremu kana nzira. Mamwe mishonga yechirwere cheshuga se liraglutide (Saxenda) uye semaglutide (Wegovy) zvino inopa mabhenefiti ekurasisa uremu pamwe nekutonga kweshuga yeropa.

Ndingaita Sei Kana Ndakashandisa Lorcaserin Yakawandisa Netsaona?

Kana wakatora lorcaserin yakawanda netsaona, unofanira kunge wakabata chiremba wako kana nzvimbo yekudzora muchetura nekukasira. Zviratidzo zvekuwandisa zvinogona kusanganisira kusvotwa, kurutsa, dzungu, kurara, uye zvinogona kukanganisa zvakanyanya pamoyo wako uye kudzvinyirirwa kweropa.

Sezvo lorcaserin isisipo, kuwandisa hakusisiri dambudziko. Zvisinei, kana uine mishonga yekare yasara, inofanira kuraswa zvakanaka kuburikidza nechirongwa chekudzosa mishonga yemapharumacy kana kutevera matungamirirwo eFDA ekuraswa kwemishonga zvakachengeteka.

Ndingadai ndakaita sei kana ndakakanganwa dose yeLorcaserin?

Kana wakakanganwa dose ye lorcaserin, zano rakajairika raive rekutora nekukasira sezvaunorangarira, kunze kwekunge yave nguva yechikamu chako chinotevera. Muchiitiko ichocho, waizosiya dose yakakanganwa uye uenderere mberi nechirongwa chako chekushandisa mishonga. Kutora zvikamu zviviri panguva imwe chete hakuna kumbokurudzirwa.

Kune vhezheni yakawedzerwa-kusunungurwa (Belviq XR), nguva yaive yakakosha zvakanyanya sezvo yakagadzirirwa kugara maawa makumi maviri nemana. Kukanganwa zvikamu zvinogona kukanganisa kushanda kwemushonga mukudzora chido mukati mezuva.

Ndingamira rini kutora Lorcaserin?

Waigona kumira kutora lorcaserin chero nguva pasina kuona zviratidzo zvekubviswa, asi sarudzo yaifanira kugara ichiitwa nekuraira kwechiremba wako. Vazhinji vanachiremba vakakurudzira kumira kana usina kurasikirwa neanenge mashanu muzana e uremu hwako mushure memavhiki gumi nemaviri ekurapa.

Kubva pakubviswa kweFDA muna 2020, munhu wese aitora lorcaserin akakurudzirwa kumira nekukasira uye kubvunza mupi wavo wehutano nezve nzira dzimwe dzekudzora uremu. Kuchinja kumira kwaive kwakatsetseka, kunyangwe mazinga echido anowanzo dzokera kumazinga ekutanga-kurapa nekukurumidza.

Pane chero matambudziko ehutano enguva refu kubva pakutora Lorcaserin?

Kunetseka kukuru kwenguva refu kubva pakutora lorcaserin ndiko kuwedzera kwengozi yekenza iyo yakatungamira mukubviswa kwayo. Kana iwe wakambotora lorcaserin, zvakakosha kuti ukurukure nhoroondo iyi nachiremba wako uye urambe uchiziva nezve bvunzo dzekenza dzakakurudzirwa. Zvisinei, kutora mushonga hakuvimbisi kuti uchawana kenza.

Mupi wako wehutano anogona kukubatsira kunzwisisa njodzi dzako dzega uye kugadzira chirongwa chakakodzera chekutarisa. Vanhu vazhinji vakatora lorcaserin yekurasikirwa uremu vakabudirira kuchinjira kune dzimwe nzira dzekutarisira uremu vasina kusangana nematambudziko enguva refu.