Macitentan ne tadalafil (inorapwa nemumuromo)
Mhando dzinowanikwa
Opsynvi
Nezve mushonga uyu
Mukumbaniso waMacitentan neTadalafil unoshandiswa kurapa pulmonary arterial hypertension (PAH), iyo iri kuwedzera kweropa muropa kunoitika mumutsinga mukuru unotakura ropa kubva kurutivi rwerudyi rwemoyo (ventricular) kuenda kumapapu. Kana midziyo midiki yeropa mumapapu ikava ine simba rekudzivirira kuyerera kweropa, ventricular yekurudyi inofanira kushanda nesimba kuti ibvise ropa rakakwana kuburikidza nemapapu. Mukumbaniso waMacitentan neTadalafil unoshanda nekudzoreredza midziyo iyi yeropa uye kuwedzera kuyerera kweropa kuenda kumapapu, izvo zvinoderedza basa remwoyo. Mushonga uyu unowanikwa chete kune vakadzi pasi pechirongwa chekugovera chinonzi Macitentan-Containing Products REMS (Risk Evaluation and Mitigation Strategy) program. Varume havafanirwe kunyoresa muchirongwa cheREMS. Chigadzirwa ichi chinowanikwa mumafomu anotevera ekurapa:
Usati washandisa mushonga uyu
Pakusarudza kushandisa mushonga, ngozi dzokutorwa kwemushonga dzinofanira kuyeranidzwa nezvakanaka zvichaita. Iyi sarudzo iwe nechikamu chako muchaita. Kune mushonga uyu, zvinotevera zvinofanira kufungwa: Udza chiremba wako kana wakambonzwa chero mhinduro isingawanzoitika kana chirwere cheallergy kumushonga uyu kana mimwe mishonga. Uyewo udza nyanzvi yako yekuchengetedza utano kana uine mamwe marudzi eallergies, akadai sekudya, dyes, preservatives, kana mhuka. Kune zvigadzirwa zvisinganyorwi, verenga zvinyorwa zvepakiti kana zvinosanganiswa zvakanaka. Ongororo dzakakodzera hadzina kuitwa pane hukama hwezera kune migumisiro yemacitentan nekuwirirana kwetadalafil muvanhu vevana. Kuvimbika uye kushanda hazvina kusimbiswa. Ongororo dzakakodzera dzakaitwa kusvika pari zvino hadzina kuratidza matambudziko chaiwo echirwere chevakwegura aizoita kuti kushandiswa kwemacitentan nekuwirirana kwetadalafil kuve kwakaderera muvakuru. Hapana ongororo dzakakwana muvakadzi dzekuona ngozi yemwana pakushandisa mushonga uyu panguva yekuyamwisa. Yera mabhenefiti anogona kuitika pamwe nengozi dzinogona kuitika usati watora mushonga uyu panguva yekuyamwisa. Kunyange zvazvo mimwe mishonga isingafaniri kushandiswa pamwe chete, mune dzimwe nguva mishonga miviri yakasiyana inogona kushandiswa pamwe chete kunyange kana kuwirirana kungangoitika. Munyaya idzi, chiremba wako angada kuchinja chiyero, kana mamwe matanho angave achidiwa. Paunenge uchitora mushonga uyu, zvakakosha kuti nyanzvi yako yekuchengetedza utano izive kana uri kutora chero mishonga iri pazasi. Kuwirirana kunotevera kwakasarudzwa zvichienderana nekuwanda kwazvo uye hazvisi zvese zvinosanganisirwa. Kushandisa mushonga uyu nechero mishonga inotevera hakusi kukurudzirwa. Chiremba wako angasarudza kusakubata nemushonga uyu kana kuchinja mimwe mishonga yaunotora. Kushandisa mushonga uyu nechero mishonga inotevera kazhinji hakusi kukurudzirwa, asi kunogona kudiwa mune dzimwe nguva. Kana mishonga yose ikanyorwa pamwe chete, chiremba wako angachinja chiyero kana kuti ungashandisa imwe kana ese mishonga. Mimwe mishonga haifaniri kushandiswa panguva yekudya kana pedyo nenguva yekudya kana kudya marudzi akati wandei ezvokudya sezvo kuwirirana kungangoitika. Kushandisa doro kana fodya nemimwe mishonga kunogona zvakare kukonzera kuwirirana kuitika. Kuwirirana kunotevera kwakasarudzwa zvichienderana nekuwanda kwazvo uye hazvisi zvese zvinosanganisirwa. Kushandisa mushonga uyu nechero zvinotevera kazhinji hakusi kukurudzirwa, asi kungasava nyore kudzivisa mune dzimwe nguva. Kana zvakashandiswa pamwe chete, chiremba wako angachinja chiyero kana kuti ungashandisa mushonga uyu, kana kukupa mirairo yakakosha pamusoro pekushandisa zvokudya, doro, kana fodya. Kushandisa mushonga uyu nechero zvinotevera kunogona kukonzera kuwedzera kengozi yemigumisiro yakati, asi kungasava nyore kudzivisa mune dzimwe nguva. Kana zvakashandiswa pamwe chete, chiremba wako angachinja chiyero kana kuti ungashandisa mushonga uyu, kana kukupa mirairo yakakosha pamusoro pekushandisa zvokudya, doro, kana fodya. Kuvapo kwemamwe matambudziko ehutano kunogona kukanganisa kushandiswa kwemushonga uyu. Ita shuwa kuti unoudza chiremba wako kana uine mamwe matambudziko ehutano, kunyanya:
Mashandisirwo aungaita mushonga uyu
Tora mushonga uyu chete sezvakarayirwa nachiremba wako. Usatore zvakawanda, usatore kazhinji, uye usatore kwenguva yakareba kupfuura zvakaodzwa nachiremba wako. Murapo wako ungada kuchinjwa kanopfuura kamwe kuti uwane chinonyanya kukushandira. Zvakakosha kwazvo kuti unzwisise zvinodiwa nechirongwa cheMacitentan-Containing Products REMS uye Bhuku reMishonga. Verenga utevedzere mirairo iyi nokungwarira. Bvunza chiremba wako kana uine mibvunzo. Bvunza mushonga wako kuti uwane bhuku re mushonga kana usina. Unogona kutora mushonga uyu nechikafu kana usina. Dya piritsi rose nemvura. Usacheke, usapwanyisa, kana kucheka. Usadye grapefruit kana kunwa muto we grapefruit paunenge uchishandisa mushonga uyu. Grapefruit nemuto we grapefruit zvinogona kuchinja huwandu hwemushonga uyu unonyura mumuviri. Murapo wemushonga uyu uchave wakasiyana kune varwere vakasiyana. Tevedzera mirairo yechiremba wako kana mirairo iri parinenge. Ruzivo runotevera runosanganisira chete avhareji yemapo emushonga uyu. Kana murapo wako wakasiyana, usauchinje kunze kwekunge chiremba wako akakuudza kudaro. Huwandu hwemushonga waunotora hunotsamira pakusimba kwemushonga. Uyewo, nhamba yemapo aunotora zuva rega rega, nguva inobvumirwa pakati pemapo, uye nguva yaunotora mushonga zvinotsamira pane dambudziko rehutano rauri kushandisa mushonga. Kana wakanganwa murapo wemushonga uyu, utora nekukurumidza sezvinobvira. Zvisinei, kana iri nguva yemurapo wako unotevera, siya murapo wakanganwa uye dzokera kune yako yakajairwa purogiramu yekupa. Usatore mapo maviri panguva imwe chete. Chengetedza mushonga mubhodhoro rakavharwa pane tembiricha yekamuri, kure nekupisa, hunyoro, uye chiedza chakananga. Chengetedza kuti urege kuoma. Chengetedza kure nevana. Usachengetere mushonga wakapfuura zuva kana mushonga usingachadiwi. Bvunza nyanzvi yako yehutano kuti ungakanda sei chero mushonga usingashandisi.