Chii chinonzi Maraviroc: Zvinoshandiswa, Mishonga, Migumisiro uye Zvimwe

Maraviroc mushonga unopiwa nachiremba wakagadzirirwa kurapa hutachiona hweHIV muvanhu vakuru. Iwo wekirasi yakasarudzika yemishonga yeHIV inonzi CCR5 antagonists, iyo inoshanda zvakasiyana nemimwe mishonga yeHIV nekudzivisa musuwo chaiwo uyo HIV inoshandisa kupinda mumasero ako ekudzivirira muviri.

Mushonga uyu hausi mushonga weHIV, asi unogona kuva chishandiso chine simba mumishonga yako. Kana ichishandiswa sechikamu chekurapa pamwe chete nemimwe mishonga yeHIV, maraviroc inobatsira kuchengeta hutachiona pasi pekutonga uye inotsigira kugona kwemuviri wako kudzivirira kuti urambe wakasimba.

Chii chinonzi Maraviroc?

Maraviroc mushonga weantiretroviral unonyanya kutarisana nekuti HIV inopinda sei mumasero ako eCD4. Funga nezvazvo sekukiya kwakakosha kunodzivirira HIV kubva pakushandisa imwe yenzira dzayo huru dzekupinda mumasero ako ekudzivirira muviri.

Kusiyana nemimwe mishonga yeHIV inoshanda mushure mekunge hutachiona hwapinda mumasero ako, maraviroc inoshanda pakutanga chaipo kwehutachiona. Inodzivisa iyo CCR5 receptor, iyo yakaita semusuwo uyo mhando dzeHIV dzinoshandisa kupinda mukati mumasero ako ekudzivirira muviri ane hutano.

Mushonga uyu unogara uchishandiswa pamwe chete nemimwe mishonga yeHIV, kwete wega. Chiremba wako anowanzo kuuraira sechikamu cheizvo zvinonzi combination antiretroviral therapy, kana cART, iyo inoshandisa mishonga yakawanda kurwisa HIV kubva kumativi akasiyana.

Chii chinonzi Maraviroc chinoshandiswa?

Maraviroc inonyanya kushandiswa kurapa hutachiona hweHIV-1 muvanhu vakuru vane rudzi rwakati rweHIV runonzi CCR5-tropic virus. Usati wanyora mushonga uyu, chiremba wako achada kuyedza HIV yako kuti ave nechokwadi chekuti ndiyo mhando chaiyo iyo maraviroc inogona kunyatso tarisa.

Mushonga uyu unokosha zvikuru kune vanhu vakawana kusadzivirirwa kune mamwe mishonga yeHIV. Kana kurapwa kwako kweHIV kwazvino kusingashandi sezvazvinofanira, kana wakaedza nzira dzakawanda dzisina kubudirira, maraviroc inogona kupa nzira itsva yekudzora hutachiona.

Chiremba wako angangofungawo nezve maraviroc kana uri kutanga kurapwa kweHIV kekutanga, kunyanya kana kuyedzwa kuchiratidza kuti une CCR5-tropic HIV. Zvisinei, inowanzoshandiswa muvarwere vakamborapwa vanoda dzimwe sarudzo.

Maraviroc Inoshanda Sei?

Maraviroc inoshanda semushonga weHIV wakasimba zvishoma nekudzivisa nzira chaiyo inoshandiswa neHIV kutapukisa masero ako. Inoonekwa sekurapa kwakanangana nekuti inotarisa pane imwe nzira yekutapukirwa neHIV.

Kana HIV ichiedza kupinda mumasero ako eCD4, inoda kubatana kune mamwe ma receptors pamusoro pesero. Maraviroc inonyanya kudzivisa CCR5 receptor, iyo inodzivirira CCR5-tropic HIV kubva pakupinda nekubudirira uye kutapukisa masero ako emuviri ane hutano.

Chiito ichi chekudzivisa chinoitika kunze kwemasero ako, izvo zvinoita kuti maraviroc ive yakasiyana pakati pemishonga yeHIV. Mamwe mazhinji emishonga yeHIV anoshanda mukati memasero mushure mekunge hutachiona hwaitika, asi maraviroc inomisa maitiro ekutapukirwa asati atombotanga.

Kubudirira kwemushonga kunoenderana neHIV yako iri CCR5-tropic. Vamwe vanhu vane CXCR4-tropic HIV kana dual-tropic HIV, iyo inoshandisa nzira dzakasiyana dzekupinda dzisingagoni kudzivirirwa ne maraviroc.

Ndinofanira Kutora Sei Maraviroc?

Maraviroc inowanzo torwa sepiritsi kaviri pazuva, uine kana pasina chikafu. Unogona kuitora nemvura, mukaka, kana muto - chero zvinoita sekunyaradza mudumbu rako.

Kutora maraviroc nechikafu kunogona kubatsira kuderedza chero kusagadzikana mudumbu, kunyangwe zvisingadiwi. Vamwe vanhu vanowana kuti kuitora nechikafu chakareruka kana chikafu zvinoita kuti zvive nyore kuyeuka uye zvinyoro pamuviri wavo wekugaya.

Nguva yekutora mishonga yako inokosha kupfuura zvaunodya nazvo. Edza kutora mishonga yako maawa anenge gumi nemaviri ari pakati uye panguva imwechete zuva rega rega. Izvi zvinobatsira kuchengetedza mazinga akagadzikana emushonga mumuviri wako.

Kana iwe uchitora mimwe mishonga yeHIV, unozofanirwa kuronga nguva yekutora maraviroc. Dzimwe nzira dzemishonga dzinoda kutorwa pamwechete, nepo dzimwe dzichishanda zviri nani kana dzichipatsanurwa. Murapi wako wemishonga anogona kukubatsira kugadzira chirongwa chinoshanda nemimwe mishonga yako.

Ndingatora Maraviroc Kwenguva Yakareba Sei?

Maraviroc inowanzoita mushonga wenguva refu waunozotora chero bedzi uchiramba uchishanda mukudzora HIV yako. Vanhu vazhinji vanopindura zvakanaka kumaitiro ane maraviroc-containing vanoiita kwenguva isingagumi sechikamu chekurapa kwavo HIV kuri kuenderera mberi.

Chiremba wako achatarisa viral load yako nguva dzose kuti ave nechokwadi chekuti maraviroc iri kushanda nemazvo. Kana viral load yako ikaramba isingaonekwe uye CD4 count yako ichiramba yakagadzikana kana kuvandudzwa, ungangodaro ucharamba uchiitora.

Kureba kwekurapa kunoenderanawo nekuti unotsungirira sei mushonga uye kana HIV yako ichiramba ichiita CCR5-tropic. HIV yevamwe vanhu inogona kuchinja nekufamba kwenguva, zvichikwanisa kuramba maraviroc kana kuchinja kushandisa nzira dzakasiyana dzekupinda.

Usambomira kutora maraviroc usati wataurirana nachiremba wako kutanga. Kumisa mishonga yeHIV kamwe kamwe kunogona kukonzera viral rebound uye pamwe kukura kwemishonga yekuramba.

Ndezvipi Zvakaipa Zviri Kuitika zveMaraviroc?

Semishonga yese, maraviroc inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachiiita zvakanaka. Zvizhinji zvemhedzisiro zviri nyoro kusvika pakati nepakati uye zvinowanzoita nani sezvo muviri wako uchigadzirisa kumushonga.

Heano mhedzisiro yakajairika yaungangove nayo, uye zvinobatsira kuziva zvekutarisira kuti ugone kukurukura chero zvaunonetseka nazvo nechikwata chako chehutano:

• Kunyara uye kusagadzikana mudumbu
• Manyoka kana zvigaro zvakasununguka
• Kutemwa nemusoro
• Kuneta kana kunzwa kuneta
• Dizziness, kunyanya kana uchimira
• Kutadza kurara
• Kurwadziwa kwemhasuru kana marwadzo emajoini
• Kuchinja kwechido chekudya

Izvi zvinowanzoitika zvinowanzoita zvishoma zvinonetsa mukati memavhiki mashoma ekutanga ekurapa. Kana vakaenderera mberi kana kukanganisa hupenyu hwako hwezuva nezuva, chiremba wako anogona kukurudzira nzira dzekubatsira kuvadzora.

Zvimwe zvinokuvadza zvakanyanya hazviwanzoitiki asi zvinoda kutariswa kwekurapa nekukurumidza. Izvi zvinosanganisira zviratidzo zvematambudziko echiropa sekusvava kweganda rako kana maziso, kurwadziwa kwakanyanya mudumbu, kana kuneta kusinganzwisisike kusingavandudzi nekuzorora.

Vamwe vanhu vanogona kusangana nekugadzirisa kweallergy, izvo zvinogona kusanganisira rash, kukwenya, kuzvimba, kana kuoma kufema. Kana ukaona chero zviratidzo izvi, taura nemupi wako wehutano nekukurumidza.

Kune zvakare zvimwe zvisingawanzoitiki asi zvakakomba zvinokuvadza izvo chiremba wako achatarisa kuburikidza nekuongororwa kweropa nguva dzose uye kuongororwa. Izvi zvinogona kusanganisira shanduko mukushanda kwechiropa chako, matambudziko emoyo, kana zvirwere zvisinganzwisisike.

Ndiani Asingafaniri Kutora Maraviroc?

Maraviroc haakodzeri munhu wese, uye chiremba wako achanyatsoongorora kana iri sarudzo chaiyo yemamiriro ako chaiwo. Chinhu chakanyanya kukosha kuva neCCR5-tropic HIV, sezvo mushonga uyu usingashande kune mamwe marudzi eHIV.

Vanhu vane matambudziko akakomba echiropa vanofanira kushandisa maraviroc nekuchenjerera kana kuideredza zvachose. Sezvo mushonga uyu uchigadziriswa kuburikidza nechiropa chako, chirwere chiripo chechiropa chinogona kuita kuti muviri wako utadze kubata mushonga uyu zvakachengeteka.

Kana uine mamwe mamiriro emoyo, kunyanya ayo anokanganisa rhythm yemoyo wako, chiremba wako achada kuyera mabhenefiti nenjodzi nekuchenjerera. Maraviroc dzimwe nguva inogona kukanganisa basa remoyo, kunyanya muvanhu vane matambudziko emoyo aripo.

Hezvino mamiriro apo maraviroc angasava akakodzera, uye chiremba wako achakurukura izvi newe panguva yekubvunzana kwako:

• CXCR4-tropic kana dual-tropic HIV infection
• Chirwere chechiropa chakakomba kana kutadza kwechiropa
• Zvimwe zvirwere zvemoyo
• Chirwere cheitsvo chakakomba
• Kuzvitakura (data rekuchengeteka riripo)
• Kuyamwisa
• Zera riri pasi pe18 (harina kubvumirwa kushandiswa kwevana)

Chiremba wako achafungawo nezvemimwe mishonga yako, sezvo mimwe mishonga inogona kuita zvemaraviroc nenzira dzinoita kuti isashande zvakanaka kana kuwedzera mhedzisiro.

Kana uine nhoroondo yekushungurudzika kana mamwe mamiriro ehutano hwepfungwa, chiremba wako achakutarisa zvakanyanya, sezvo vamwe vanhu vanosangana nekuchinja kwemafungiro pavanotanga mishonga mitsva yeHIV.

Mazita eMaraviroc Brand

Maraviroc inowanikwa pasi pezita rekuti Selzentry muUnited States uye Celsentri mune dzimwe nyika zhinji. Zvose zvine chinhu chimwe chete chinoshanda uye zvinoshanda zvakafanana.

Mishonga inouya mumahwendefa e150mg uye 300mg, uye chiremba wako achasarudza simba rakakodzera zvichienderana nemimwe mishonga yako nezvido zvako. Dosing inogona kusiyana zvichienderana nekuti ndeapi mamwe maHIV aunotora.

Mishonga yakajairika ye maraviroc inogona kuwanikwa mune dzimwe nzvimbo, asi mhando dzemhando dzichiri dzakanyanya kunyorerwa. Murapi wako wemishonga anogona kukubatsira kunzwisisa zviri kuwanikwa munzvimbo yako.

Maraviroc Alternatives

Kana maraviroc isina kukodzera iwe, pane dzimwe sarudzo dzakawanda dzemishonga yeHIV iripo. Imwe nzira yakanakisisa inoenderana nerudzi rwako rweHIV, nhoroondo yako yekurapa, uye kuti wakapindura sei kune dzimwe mishonga.

Zvimwe zvinodzivirira kupinda zvinosanganisira enfuvirtide, kunyangwe ichipiwa nejekiseni uye isingawanzo shandiswa nhasi. Kazhinji, chiremba wako angangofunga nezve integrase strand transfer inhibitors senge dolutegravir kana raltegravir.

Zvinodzivirira protease zvakadai se darunavir kana atazanavir zvinomiririra rimwe boka remishonga yeHIV inoshanda nenzira yakasiyana. Izvi zvingave zvakanaka kana uine CXCR4-tropic HIV isingapinduri kune maraviroc.

Zvisiri-nucleoside reverse transcriptase inhibitors (NNRTIs) senge efavirenz kana rilpivirine zvinopa imwe nzira yekurapa HIV. Chiremba wako achafunga nezvezvinhu zvakaita semaitiro ako ekuramba hutachiona uye zvinogona kukonzera mhedzisiro paunenge uchisarudza dzimwe nzira.

Ko Maraviroc Ari Nani Pane Zvimwe Zvinhu Zvekushandisa HIV?

Maraviroc haisi nani kana kuipa pane mamwe mishonga yeHIV - yakasiyana uye inokosha kune mamwe mamiriro. Mishonga yeHIV yakanakisa nguva dzose ndiyo inoshanda zvakanyanya kune mamiriro ako ega ega.

Kana ichienzaniswa nemamwe mishonga mitsva yeHIV, maraviroc inoda kuyerwa kaviri pazuva, izvo vamwe vanhu vanoona zvishoma zvakakodzera pane imwe-zuva sarudzo. Zvisinei, nzira yayo yakasiyana yekuita inoita kuti isatsiviwe kune mamwe mamiriro ekurapa.

Kune vanhu vane CCR5-tropic HIV vakagadzira kuramba kune akawanda mamwe mishonga, maraviroc inogona kuva hupenyu. Inorwisa HIV kubva kune imwe kona iyo mamwe madhiragi asingaiti, izvo zvinoreva kuti inogona kushanda kunyangwe mamwe mishonga akamira kushanda.

Mishonga inowanzo shivirirwa zvakanaka nevakawanda vanhu, nemhedzisiro inowanzo manejwa. Vamwe vanhu vanonyatsoda maraviroc nekuti haikonzeri mamwe emhedzisiro yakajairika inobatanidzwa nemamwe makirasi emishonga yeHIV.

Mibvunzo Inowanzo Bvunzwa Nezve Maraviroc

Ko Maraviroc Akachengeteka Kune Vanhu Vane Chirwere Chechiropa?

Maraviroc inoda kufungwa zvakanyanya kana uine chirwere chechiropa. Vanhu vane matambudziko echiropa akapfava vanogona kutora maraviroc nekutarisa pedyo, asi avo vane chirwere chechiropa chakakomba vanogona kuda kuichinjisa zvachose.

Chiremba wako anogona kuraira bvunzo dzenguva dzose dzebasa rechiropa kuti aone kuti chiropa chako chiri kushanda sei nemishonga. Kana uine hepatitis B kana C pamwe chete neHIV, basa rechiropa chako rinova rakakosha zvikuru kuti uongorore zvakanyanya.

Zviratidzo zvematambudziko echiropa zvinosanganisira kuita yero kweganda rako kana maziso, weti yakasviba, matumbo ane ruvara rwakajeka, kana kurwadziwa mudumbu kunoramba kuripo. Kana uine chero zviratidzo izvi, taura nachiremba wako nekukurumidza.

Ndingaita Sei Kana Ndakatora Maraviroc Yakawanda Netsaona?

Kana netsaona ukatora maraviroc yakawanda kupfuura yakarairwa, usavhunduka, asi taura nachiremba wako kana nzvimbo yekudzora muchetura kuti uwane gwara. Kutora madosi akawedzerwa kunogona kuwedzera njodzi yako yemigumisiro yakaita sedzungu, kusvotwa, kana shanduko dzemoyo.

Usambofa wakaedza

Haufaniri kumbomira kutora maraviroc usati watanga kukurukura nachiremba wako. Mishonga yeHIV inoshanda zvakanyanya kana ichitorwa nguva dzose, uye kumira kamwe kamwe kunogona kukonzera viral rebound uye kugadzirwa kwekudzivirira.

Chiremba wako angangofunga kuchinja mushonga wako kana uri kusangana nemigumisiro isingashiviriki, kana HIV yako ikagadzira kuramba maraviroc, kana kana dzimwe nzira dzekurapa dziri nani dzikawanikwa mumamiriro ako ezvinhu.

Vamwe vanhu vanogona kuchinjira kune dzimwe nzira dzekurapa HIV nekufamba kwenguva, asi sarudzo iyi inofanirwa kugara ichiitwa pamwe chete nechikwata chako chehutano zvichibva pa viral load yako, CD4 count, uye hutano hwese.

Maraviroc Inogona Kudyidzana Nemimwe Mishonga Here?

Hongu, maraviroc inogona kudyidzana nemimwe mishonga, ndosaka chiremba wako achida kuziva nezvezvose zvauri kutora, kusanganisira mishonga inotengeswa pasina mushonga, zvinowedzera, uye zvigadzirwa zvemiti.

Imwe mishonga inogona kuwedzera mazinga e maraviroc muropa rako, zvichikonzera migumisiro yakawanda. Vamwe vanogona kuderedza mazinga e maraviroc, zvichiita kuti isashande zvakanyanya kurwisa HIV.

Chiremba wako angangoda kugadzirisa muyero wako we maraviroc kana uri kutora mishonga yakadai semamwe maantibiotics, mishonga yekurwisa fungal, kana mishonga yekubata zvirwere. Nguva dzose tarisa nemu pharmacist wako usati watanga chero mishonga mitsva uchitora maraviroc.