Chii chinonzi Mavacamten: Zvinoshandiswa, Mishonga, Migumisiro uye Zvimwe

Mavacamten mushonga unotorwa nemishonga wakagadzirirwa kurapa hypertrophic cardiomyopathy, mamiriro apo tsandanyama yemoyo wako inova yakakora zvisingaite. Kurapa uku kwakatarwa kunoshanda nekubatsira moyo wako kupomba zvakanyanya kana madziro etsandanyama akura akakora zvakanyanya kuti ashande nemazvo.

Kana iwe kana mumwe munhu waunoda akaongororwa nehypertrophic cardiomyopathy, unogona kunzwa wakaoma nekuda kwekuoma kwemamiriro aya. Mavacamten inomiririra kubudirira kukuru mukurapa, ichipa tariro kune vanhu vakambove vaine sarudzo shoma kunze kwekuvhiyiwa.

Chii chinonzi Mavacamten?

Mavacamten ndiyo yekutanga-mukirasi cardiac myosin inhibitor iyo inonanga zvakananga chikonzero chehypertrophic cardiomyopathy. Inoshanda nekusungirira kune yakakora filaments mutsandanyama yemoyo wako, ichideredza simba rakawandisa rinokonzera kuti moyo wako ushande zvakanyanya.

Funga nezve tsandanyama yemoyo wako semushandi anofarira zvakanyanya ari kuyedza zvakanyanya. Mavacamten inonyanya kuudza iwo fiber etsandanyama kuti adzikame uye ashande zvakanyanya. Mushonga uyu wakagadzirwa zvakananga mushure memakumi emakore ekutsvaga zvikonzero zve genetic uye molecular zvehypertrophic cardiomyopathy.

Mishonga iyi inotengeswa pasi pezita rekuti Camzyos uye inomiririra kufambira mberi kukuru mukurapa mamiriro emoyo akagara nhaka. Kusiyana nekurapa kwekare kwakangoita zviratidzo, mavacamten inonyatso tarisa dambudziko riri pasi pehuwandu hwecellular.

Chii chinonzi Mavacamten chinoshandiswa?

Mavacamten inorairwa kuvanhu vakuru vane obstructive hypertrophic cardiomyopathy avo vanoramba vaine zviratidzo zvisinei nekutora mamwe mishonga yemoyo. Chiremba wako anowanzo funga nezvekurapa uku kana iwe uine kufema, kurwadziwa muchipfuva, kana kuneta kunokanganisa mabasa ako ezuva nezuva.

Mushonga uyu unonyatso ratidzwa kurapa symptomatic hypertrophic cardiomyopathy ine left ventricular outflow tract obstruction. Izvi zvinoreva kuti tsandanyama yako yemoyo yakakora iri kuvharidzira kuyerera kweropa kubva mukamuri huru yekupomba yemoyo wako, ichigadzira bottleneck inoita kuti moyo wako ushande nesimba.

Chiremba wako wemoyo angakurudzira mavacamten kana wakaedza beta-blockers, calcium channel blockers, kana mamwe marapirwo akajairika pasina zororo rakakwana rezviratidzo. Zvinonyanya kukosha kune vanhu vanoda kudzivisa kana kunonotsa kupindira kwekuvhiya senge septal myectomy kana alcohol septal ablation.

Mushonga uyu unogonawo kutariswa kune vanhu vasina kukodzera kuvhiyiwa nekuda kwezvimwe zvirwere zveutano kana zvavanofarira. Vamwe varwere vanowana kuti mavacamten inovabatsira kudzokera kumabasa avasingakwanise kunakidzwa nawo nekuda kwezviratidzo zvavo.

Mavacamten Inoshanda Sei?

Mavacamten inoshanda nekudzivisa zvakananga cardiac myosin, iyo protein inokonzera kusungirirwa kwetsandanyama yemoyo wako. Mu hypertrophic cardiomyopathy, aya mafiber etsandanyama anosungirirwa nesimba rakanyanya, achigadzira chipingamupinyi uye zviratidzo zvaunosangana nazvo.

Mushonga uyu unosungirirwa kumusoro we myosin mutsandanyama yemoyo wako, uchivadzivirira kubva pakuumba mabhiriji akawanda-akawanda ane actin filaments. Izvi zvinoderedza hypercontractility iyo inoratidza hypertrophic cardiomyopathy, ichibvumira moyo wako kupomba zvakanyanya nemuedzo mudiki.

Izvi zvinoonekwa semushonga une simba zvine mwero unoda kunyatso tariswa. Chiremba wako achada kutevera kushanda kwemoyo wako zvakanyatso nekuti kuderedza contractility zvakanyanya kunogona kuderedza kugona kwemoyo wako kupomba.

Mhedzisiro yemushonga inotsamira padosi, zvinoreva kuti madosi akakwirisa anopa kumwe kudzivirirwa kwekusungirirwa kwetsandanyama. Ichi ndicho chikonzero nei chiremba wako achatanga nedosi yakaderera uye zvishoma nezvishoma achiigadzirisa zvichienderana nekuti moyo wako unoita sei uye kuti zviratidzo zvako zvinovandudza sei.

Ndingatora Sei Mavacamten?

Tora mavacamten sezvinorairwa nachiremba wako, kazhinji kamwe pazuva uine kana usina chikafu. Unogona kuitora nemvura, mukaka, kana muto, uye hapana zvirambidzo zvakakosha zvekudya zvinokanganisa mashandiro emushonga.

Haufaniri kutora mavacamten uine chikafu, asi kuitora panguva imwe chete zuva rega rega kunobatsira kuchengetedza mazinga akagadzikana mumuviri wako. Vanhu vazhinji vanoona zviri nyore kuyeuka kana vachizvitora nekudya kwemangwanani kana kwemanheru sechikamu chetsika yavo.

Mamedza kapisuru yese usina kuipwanya, kuitsenga, kana kuivhura. Mushonga wakagadzirirwa kuburitsa zvakanaka kana wamedzwa usina kukuvadzwa, uye kuchinja kapisuru kunogona kukanganisa kuti muviri wako unoiita sei.

Kana ukakanganwa dose, itore paunorangarira, kunze kwekunge yava nguva yechikamu chako chinotevera. Muchiitiko ichocho, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chetsika. Usambofa wakawedzera madhiza kuti ugadzirise imwe yakakanganwa.

Ndingatora Mavacamten Kwenguva Yakareba Sei?

Mavacamten kazhinji kurapwa kwenguva refu kwaungada kutora zvachose kuti uchengetedze zororo rezviratidzo. Chiremba wako achatarisa mhinduro yako uye anogona kugadzirisa dose yako nekufamba kwenguva, asi kumisa mushonga kazhinji zvinoreva kuti zviratidzo zvako zvichadzoka.

Vanhu vazhinji vanotanga kuona kuvandudzwa muzviratidzo zvavo mukati memavhiki mana kusvika gumi nemaviri ekutanga kurapwa. Zvisinei, mabhenefiti akazara anogona kutora mwedzi yakati wandei kuti aonekwe sezvo moyo wako uchigadzirisa kumigumisiro yemushonga.

Chiremba wako achaita nguva dzekutevera nguva dzose kuti atarise basa remoyo wako kuburikidza neechocardiograms nemamwe maedzo. Kushanya uku kunobatsira kuona kuti mushonga uri kushanda zvakanaka usingakonzere kuti basa remoyo wako rive risina simba zvakanyanya.

Vamwe vanhu vangada kumisa mavacamten kwenguva pfupi kana basa remoyo wavo richiderera zvakanyanya, asi izvi zvinowanzoitika. Chiremba wako achanyatsoenzanisa mabhenefiti ekurerutsa zviratidzo pamwe nenjodzi dzinogona kuitika pakukwanisa kwemoyo wako kupomba.

Ndezvipi Zvipingamupinyi zveMavacamten?

Kufanana nemishonga yese, mavacamten inogona kukonzera zvipingamupinyi, kunyangwe kwete munhu wese anozviwana. Chinhu chakakosha kunzwisisa ndechekuti chiremba wako achakutarisa zvakanyanya kuti abate chero mhedzisiro inonetsa pakutanga.

Heano zvipingamupinyi zvakajairika zvaungasangana nazvo:

• Dizziness kana lightheadedness, kunyanya kana uchimuka nekukurumidza
• Kuneta kana kunzwa kuneta kupfuura zvakajairika
• Kufema nekukurumidza, kunyanya panguva yekurovedza muviri
• Kurwadziwa muchipfuva kana kusagadzikana
• Kuzvimba mumakumbo ako, zvitsitsinho, kana tsoka
• Kurova kwemoyo kusingaite kana palpitations

Zviratidzo izvi zvinowanzoita nani sezvo muviri wako uchigadzirisa kumishonga, asi iwe unofanirwa kugara uchizvitaurira chiremba wako.

Zvino, ngatitaurirei nezve zvipingamupinyi zvakanyanya asi zvisingawanzoitiki zvinoda kutariswa kwekurapa nekukurumidza:

• Kufema zvakanyanya kunowedzera kana kuitika pakuzorora
• Kuzvimba kwakakosha kusingavandudzi nekukwidzwa
• Kurwadziwa muchipfuva kwakanyanya kana kwakasiyana nezviratidzo zvako zvakajairika
• Kupererwa kana zviitiko zvekupedza simba
• Kurova kwemoyo nekukurumidza kana kusingaite kunokunetsa

Mhedzisiro yakanyanya kukosha inogona kuitika kuderedzwa kukuru kwebasa remoyo wako rekupomba, ndosaka kuongorora nguva dzose kwakakosha. Chiremba wako achashandisa echocardiograms kuti atarise izvi uye achagadzirisa muyero wako kana kumisa mushonga kana zvichidikanwa.

Zvimwe zvisingawanzoitiki asi zvakakomba zvinosanganisira kusagadzikana kwakanyanya, matambudziko echiropa, kana kudonha kwakanyanya kweropa. Kunyange izvi zvisingawanzoitiki, zvakakosha kuzviziva uye kutsvaga rubatsiro rwekurapa nekukasira kana ukaona zviratidzo zvakaita serash yakanyanya, kuita yero yeganda kana maziso, kana kusvotwa uye kurutsa kunoramba kuripo.

Ndiani Asingafaniri Kutora Mavacamten?

Mavacamten haina kukodzera munhu wese ane hypertrophic cardiomyopathy. Chiremba wako achanyatsoongorora kana mushonga uyu wakachengeteka kune mamiriro ako chaiwo.

Haufaniri kutora mavacamten kana uine mamwe mamiriro emoyo anogona kuwedzerwa nekuderedza kushanda kwemoyo wako:

• Kukundikana kwemoyo kwakanyanya kana kushanda kwemoyo kwakaderedzwa zvakanyanya
• Mhando dzakasiyana dze arrhythmias dzinoda kusimba kwemoyo
• Chirwere cheitsvo chakanyanya chinokanganisa kubviswa kwemishonga
• Chirwere chechiropa chinokanganisa kugona kwemuviri wako kugadzirisa mushonga
• Kuzivikanwa kusagadzikana ku mavacamten kana chero chimwe chezvinhu zvayo

Chiremba wako achavawo akangwarira nezvekupa mavacamten kana uine mamwe mamiriro anokanganisa moyo wako.

Zvimwe zvinhu zvinoshanda kumapoka evanhu:

• Vakadzi vane pamuviri havafaniri kutora mavacamten, sezvo inogona kukuvadza mwana ari kukura
• Vakadzi vezera rekuita vana vanoda nzira yekudzivirira pamuviri yakavimbika vachitora mushonga uyu
• Vamai vanoyamwisa vanofanira kukurukura dzimwe nzira nachiremba wavo
• Vanhu vakuru vangada kugadzirisa dosi nekuda kwekuchinja kwakabatana nezera mukushanda kweitsvo kana chiropa
• Vanhu vari kutora mamwe mishonga vangave vaine kusangana kwemishonga

Chiremba wako achatarisa nhoroondo yako yezvokurapa yakazara uye mishonga iripo usati wapa mavacamten kuti ave nechokwadi chekuti yakachengeteka kwauri.

Zita reMhando yeMavacamten

Mavacamten inotengeswa pasi pezita rekuti Camzyos, inogadzirwa neBristol Myers Squibb. Iri ndiro zita rechiratidzo chete riripo remushonga uyu muUnited States.

Camzyos inouya muchimiro chemakapsule mumasimba akasiyana: 2.5 mg, 5 mg, 10 mg, uye 15 mg. Chiremba wako achasarudza chiyero chakakodzera chekutanga zvichienderana nemamiriro ako chaiwo uye mhinduro kumushonga.

Sezvo mavacamten iri mushonga mutsva, shanduro dzakajairika hadzisati dziripo. Zita rechiratidzo Camzyos ndiro rauchaona pabhodhoro rako remushonga uye izvo chiremba wako wemishonga achagovera.

Zvimwe Zvinhu Zvokutsiva Mavacamten

Kana mavacamten isina kukukodzera kana isingapi rubatsiro rwakakwana rwezviratidzo, mishonga yakati wandei inotsiva iripo. Chiremba wako achashanda newe kuti awane nzira yakanakisa yemamiriro ako chaiwo.

Zvimwe zvinotsiva mishonga yechinyakare zvinosanganisira:

• Beta-blockers senge metoprolol kana propranolol, inoderedza kumhanya kwemoyo wako uye inoderedza simba rekukanda
• Calcium channel blockers senge verapamil, inobatsira tsandanyama dzemoyo wako kuzorora
• Disopyramide, mushonga weantiarrhythmic unogona kuderedza chipingamupinyi kune vamwe vanhu
• Diuretics kubatsira kudzora kuchengetwa kwemvura kana iwe ukavandudza zviratidzo zvekukundikana kwemoyo

Mishonga iyi yakashandiswa kwemakumi emakore uye inogona kunge ichiri kushanda kune vanhu vazhinji vane hypertrophic cardiomyopathy.

Kune vanhu vasingapinduri zvakanaka kumishonga, sarudzo dzekuvhiya dzichiripo:

• Septal myectomy, uko chiremba anobvisa chikamu chetsandanyama yemoyo yakakora
• Alcohol septal ablation, nzira isinganyanyi kupinda iyo inoparadza chikamu chetsandanyama yakakora ichishandisa doro
• Implantable cardioverter defibrillator (ICD) yevanhu vari panjodzi huru ye arrhythmias inotyisa

Chiremba wako wemoyo achakubatsira kuyera mabhenefiti nenjodzi dzesarudzo imwe neimwe zvichienderana nezera rako, hutano hwese, uye zvaunofarira.

Ko Mavacamten Zviri Nani Kudarika Metoprolol?

Mavacamten na metoprolol vanoshanda zvakasiyana uye vanoshanda mabasa akasiyana mukurapa hypertrophic cardiomyopathy. Mavacamten inonanga zvakananga dambudziko remhasuru riri pasi, nepo metoprolol iri beta-blocker inoderedza kumhanya kwemoyo uye contractility zvakanyanya.

Mavacamten inogona kunge iri nani kune vanhu vane obstruction yakakosha vasina kupindura zvakanaka kune beta-blockers senge metoprolol. Zvidzidzo zvekiriniki zvinoratidza kuti mavacamten inogona kuvandudza kugona kwekurovedza muviri uye mhando yehupenyu kupfuura mishonga yechinyakare mune varwere vazhinji.

Zvisinei, metoprolol ine rekodhi refu rekuchengeteka uye haina kudhura zvakanyanya kupfuura mavacamten. Vanachiremba vazhinji vachiri kuda kutanga ne metoprolol kana mishonga yakafanana vasati vafunga nezve mavacamten, kunyanya kune vanhu vane zviratidzo zvishoma.

Sarudzo pakati pemishonga iyi inoenderana nezviratidzo zvako zvakananga, kuti wakapindura sei kune dzimwe nzira dzekurapa, uye njodzi dzako dzega. Vamwe vanhu vanogona kutora mishonga yese iri miviri pamwechete pasi pekutariswa kwechiremba kwakanyatso.

Mibvunzo Inowanzo Bvunzwa Nezve Mavacamten

Ko Mavacamten Yakachengeteka Kune Vanhu vane Chirwere cheShuga?

Mavacamten inogona kushandiswa zvakachengeteka muvanhu vane chirwere cheshuga, asi chiremba wako achakutarisa zvakanyanya. Chirwere cheshuga chinogona kukanganisa hurongwa hwako hwemwoyo, saka musanganiswa unoda kutariswa kwakanyanya kune basa remoyo wako uye kudzora shuga yeropa.

Chiremba wako anogona kuda kubatana ne endocrinologist yako kana nyanzvi yechirwere cheshuga kuti ave nechokwadi chekuti manejimendi ako echirwere cheshuga anoramba ari akanaka paunenge uchitora mavacamten. Vamwe vanhu vane chirwere cheshuga vanogona kuve nezvimwe zvinhu zvine njodzi yemwoyo zvinokanganisa sarudzo dzekurapa.

Ndoita Sei Kana Ndikatora Mavacamten Yakawandisa Netsaona?

Kana ukatora mavacamten akawanda netsaona kupfuura akarairwa, fonera chiremba wako kana nzvimbo yekudzora muchetura nekukasira. Kutora zvakawanda zvingangodaro zvinogona kuita kuti moyo wako usakwanise kupomba ropa zvakanyanya.

Usamirira kuti uone kana uchinzwa zvakanaka. Kunyange kana usingaone zviratidzo nekukasira, overdose inogona kukanganisa basa remoyo wako nenzira dzisingaonekwe nekukasira. Chiremba wako anogona kuda kutarisa moyo wako neEKG kana echocardiogram kuti ave nechokwadi chekuti wakachengeteka.

Ndoita Sei Kana Ndakanganwa Dose yeMavacamten?

Kana ukakanganwa dose ye mavacamten, itore paunorangarira, kunze kwekunge yava nguva ye dose yako inotevera. Muchiitiko ichocho, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chemazuva ese.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa. Izvi zvinogona kukonzera kuti basa remoyo wako ridzikire zvakanyanya. Kana iwe uchikanganwa madosi kazhinji, funga kumisa alarm yezuva nezuva kana kushandisa murongi wepiritsi kuti akubatsire kurangarira.

Ndingamira Rini Kutora Mavacamten?

Haufanire kumbomira kutora mavacamten usati wataurirana nachiremba wako kutanga. Kumira kamwechete kunogona kukonzera kuti zviratidzo zvako zvidzoke, uye chiremba wako anogona kuda kutarisa basa remoyo wako sezvaunomisa mushonga.

Chiremba wako angakurudzira kumisa mavacamten kana basa remoyo wako richiderera zvakanyanya, kana ukawana mhedzisiro yakakosha, kana kana zviratidzo zvako zvanyangarika zvachose. Chero shanduko ipi zvayo kuchirongwa chako chekurapa inofanira kuitwa zvishoma nezvishoma uye pasi pekutariswa kwechiremba.

Ndingaita Maekisesaizi Ndiri Kutora Mavacamten?

Vanhu vazhinji vanotora mavacamten vanogona kuita maekisesaizi, uye vazhinji vanowana kuti mushonga uyu unovandudza kushivirira kwavo maekisesaizi nekuderedza zviratidzo zvavo. Zvisinei, chiremba wako achapa gwara rakatarwa zvichienderana nemamiriro ako ega.

Chiremba wako angakurudzira bvunzo yekushushikana yekurovedza muviri kuti aone kuti chiyero chebasa chiri kuchengeteka kwauri. Vanhu vazhinji vanowana kuti vanogona zvishoma nezvishoma kuwedzera chiyero chavo chebasa sezvo zviratidzo zvavo zvichivandudza nekurapa, asi izvi zvinofanirwa kugara zvichiitwa pasi pekutungamirirwa kwechiremba.