Chii chinonzi Mercaptopurine: Zvinoshandiswa, Dosage, Side Effects uye Zvimwe

Mercaptopurine mushonga unobatsira kudzora mhando dzekenza nemamiriro ezvinhu eautoimmune nekunonotsa kukura kwemasero asina kujairika. Mushonga uyu unopiwa nemishonga ndeweboka rinonzi antimetabolites, iro rinoshanda nekupindira nemaitiro anoita masero DNA neRNA. Chiremba wako angakupa mushonga uyu sechikamu chekurapa kwako leukemia kana inflammatory bowel disease.

Chii chinonzi Mercaptopurine?

Mercaptopurine mushonga wekemotherapy wemuromo unouya muchimiro chepiritsi. Yakagadzirirwa kunangana nemasero anokurumidza kukamukana, izvo zvinosanganisira masero ekenza nemamwe masero ane hutano mumuviri wako. Mushonga unoshanda nekutevedzera chinhu chechisikigo masero ako anoda kukura nekukamura.

Mushonga uyu wakashandiswa zvakachengeteka kwemakumi emakore kurapa mamiriro akasiyana. Kunyangwe ichionekwa semushonga wekemotherapy, madosi anoshandiswa anowanzo kuve akaderera zvakanyanya pane zvaungafungidzira kubva kumishonga yechinyakare yekenza. Chiremba wako achanyatso tarisa mhinduro yako uye achigadzirisa madosi sezvinodiwa.

Chii chinonzi Mercaptopurine chinoshandiswa?

Mercaptopurine inorapa acute lymphoblastic leukemia (ALL), rudzi rwekenza yeropa inokanganisa masero machena eropa. Inopiwawo inflammatory bowel diseases senge Crohn's disease uye ulcerative colitis kana dzimwe mishonga isina kushanda zvakanaka.

Kune varwere vane leukemia, mushonga uyu unowanzo kuve chikamu chechirongwa chekurapa chakareba chinosanganisira mimwe mishonga. Chinangwa ndechekubatsira muviri wako kubvisa masero ekenza uye kuvadzivirira kuti vasadzoke. Mu inflammatory bowel disease, mercaptopurine inobatsira kudzikamisa mhinduro yakawandisa yemuviri wako inokonzera kuzvimba mudumbu rako.

Dzimwe nguva vanachiremba vanonyora mercaptopurine kune dzimwe mamiriro eautoimmune apo kurapwa kwakajairika hakupi rubatsiro rwakakwana. Mupi wako wehutano achatsanangura chaizvo kuti nei mushonga uyu wakakodzera mamiriro ako chaiwo.

Mercaptopurine Inoshanda Sei?

Mercaptopurine inoshanda nekupinzwa muDNA nemaitiro ekuvaka RNA emasero ako. Kana masero asina kujairika aedza kukura nekukamura, mushonga unokanganisa kugona kwavo kukopa zvinhu zvavo zvemajini nemazvo. Izvi zvinokonzera kuti masero aya ane matambudziko afe zvakasikwa.

Mishonga inoonekwa seyepakati nepakati, asi inowanzotsungirirwa zvakanaka kana ichishandiswa pamadosi akakodzera. Muviri wako unogadzirisa mercaptopurine kuburikidza nechiropa chako, uko inoshandurwa kuita mafomu anoshanda anoita basa chairo. Iyi nzira inotora nguva, ndosaka usingaone mhedzisiro nekukurumidza.

Nekuti mercaptopurine inokanganisa kupatsanurwa kwemasero, inogona kukanganisa ese masero asina kujairika uye mamwe masero ane hutano anokurumidza kupatsanuka. Izvi zvinosanganisira masero ari mumwongo wako, nzira yekugaya, uye immune system. Chiremba wako achatarisa nzvimbo idzi zvakanyanya panguva yekurapa.

Ndinofanira Kutora Sei Mercaptopurine?

Tora mercaptopurine sezvakanyorwa nachiremba wako, kazhinji kamwe pazuva mudumbu risina chinhu. Nguva yakanaka inowanzoita awa rimwe usati wadyisa kana maawa maviri mushure mekudya, sezvo chikafu chinogona kukanganisa kuti muviri wako unotora sei mushonga.

Medza mahwendefa ese nemvura yakazara. Usapwanye, kutsenga, kana kuapwanya, sezvo izvi zvinogona kukanganisa mashandiro emushonga. Kana uine dambudziko rekumedza mahwendefa, taura nemupharmacy wako nezve sarudzo dzinogona kubatsira.

Edza kutora mushonga wako panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana mumuviri wako. Vanhu vazhinji vanozviwana zvichibatsira kumisa chiyeuchidzo chezuva nezuva pafoni yavo. Kana uri kutora mamwe mishonga, tarisa nachiremba wako nezve nguva yakanakisa yekudzivirira kusangana.

Dzivisa kunwa doro paunenge uchitora mercaptopurine, nekuti rinogona kuwedzera njodzi yematambudziko echiropa. Zvakare, gara kure nemagirepufuruti nemuto wemagirepufuruti, izvo zvinogona kukanganisa nzira iyo muviri wako unogadzirisa mushonga.

Ndingatora Mercaptopurine Kwenguva Yakareba Sei?

Kureba kwemushonga we mercaptopurine kunosiyana zvakanyanya zvichienderana nemamiriro ako uye kuti unopindura sei kumushonga. Kune leukemia, mushonga unowanzoenderera kwemakore maviri kusvika matatu sechikamu chechikamu chekuchengetedza mushure mekutanga kurapwa kwakanyanya.

Kana iwe uchitora mercaptopurine ye inflammatory bowel disease, unogona kuida kwemwedzi yakati wandei kusvika kumakore. Vamwe vanhu vanoda kurapwa kwenguva refu kuti vachengetedze mamiriro avo pasi pekutonga. Chiremba wako achagara achiongorora kana mushonga uchiri kudikanwa uye uchibatsira kwauri.

Usambomira kutora mercaptopurine kamwechete usina kutanga wataura nachiremba wako. Kumira kamwechete kunogona kukonzera mamiriro ako kuti abude kana kuwedzera. Kana iwe uchida kumisa mushonga, chiremba wako achagadzira chirongwa chekuita kudaro zvakachengeteka.

Ndezvipi Zvipingamupinyi zveMercaptopurine?

Semishonga yese, mercaptopurine inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese achizviwana. Mazhinji emhedzisiro anogoneka uye anowanzoita nani sezvo muviri wako uchigadzirisa kumushonga.

Heano mhedzisiro yakajairika yaungasangana nayo:

• Kusvotwa uye kurasikirwa nechido
• Kuneta uye kushaya simba
• Kuwedzera njodzi yekutapukirwa nekuda kwekuwanda kwemasero machena eropa
• Kukuvara nyore kana kubuda ropa kubva pakuwanda kwep platelet
• Maronda emuromo kana maronda
• Dhiria kana kusagadzikana mudumbu
• Kutetepa kwebvudzi (kazhinji nyoro)

Izvi zvinowanzoitika zvinowanzoita zvishoma sezvo kurapwa kwako kuchipfuurira. Chikwata chako chehutano chinogona kupa mazano ekuzvigadzirisa zvinobudirira.

Mhedzisiro yakakomba inogona kuitika, kunyangwe isingawanzoitiki. Izvi zvinoda kutariswa kwechiremba nekukasira uye zvinosanganisira:

• Zviratidzo zvematambudziko echiropa sekusvava kweganda kana maziso, weti yakasviba, kana kusvotwa kunoramba kuripo
• Zvirwere zvakakomba zvine fivha, kutonhora, kana kukosora kunoramba kuripo
• Kubuda ropa kusinganzwisisike kana kupwanyika kusingamire
• Kurwadziwa mudumbu kwakanyanya kana kurutsa kunoramba kuripo
• Maitiro ekugadzirisa muviri ane rash, kuoma kufema, kana kuzvimba

Chiremba wako achakutarisa zvakanyanya nemiedzo yeropa yenguva dzose kuti abate matambudziko ese nekukurumidza. Usazeze kubata chikwata chako chehutano kana ukaona chero zviratidzo zvinonetsa.

Mamwe mhedzisiro isingawanzoitiki asi yakakomba inosanganisira kudzvinyirirwa kwemwongo wemapfupa, chepfu yechiropa, uye kuwedzera njodzi yemamwe marudzi ekenza nekushandiswa kwenguva refu. Chiremba wako anoyera njodzi idzi vachipesana nemabhenefiti ekurapa mamiriro ako chaiwo.

Ndiani Asingafaniri Kutora Mercaptopurine?

Mercaptopurine haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuisa. Vanhu vane mamwe ma genetic variations anokanganisa maitiro avanoita mushonga vangangoda madosi akasiyana kana mamwe marapirwo.

Haufaniri kutora mercaptopurine kana uine allergic kwairi kana mishonga yakafanana. Udza chiremba wako nezve chero maitiro ekugadzirisa muviri kune mishonga yekemotherapu kana mamwe mishonga. Pamuviri chimwe chinhu chakakosha, sezvo mercaptopurine inogona kukuvadza mwana ari kukura.

Mamwe mamiriro ekurapa anoda kungwarira kwakanyanya kana anogona kukutadzisa kutora mercaptopurine zvakachengeteka:

• Chirwere chechiropa chakakomba kana hepatitis inoshanda
• Matambudziko emwongo wemapfupa aripo
• Zvirwere zvinoshanda zvisiri pasi pekutonga
• Chirwere cheitsvo chinoda kugadziriswa kwemadosi
• Maitiro akakomba ekugadzirisa muviri kumishonga yakafanana

Kana muchida kuva nemimba kana muchiyamwisa, kurukurai izvi nachiremba wenyu. Varume nevakadzi vanofanira kushandisa nzira dzinoshanda dzekudzivirira pamuviri panguva yekurapwa uye kwenguva yakati gare gare.

Chiremba wenyu achafungawo nezvemimwe mishonga yamuri kutora, sezvo mimwe mishonga inogona kukanganisa mercaptopurine. Izvi zvinosanganisira mamwe maantibiotics, mishonga yekutadzisa ropa kuumbana, uye mimwe mishonga yekudzora immune system.

Mazita emhando dzeMercaptopurine

Mercaptopurine inowanikwa pasi pemazita akati wandei emhando, Purinethol ndiyo inonyanya kuzivikanwa. Munogonawo kuiona ichinzi 6-mercaptopurine kana 6-MP mumabhuku ezvokurapa uye hurukuro nechikwata chenyu chehutano.

Mishonga ye generic ye mercaptopurine inowanikwa zvakanyanya uye inoshanda zvakafanana nemhando dzemhando. Pharmacy yenyu inogona kutsiva fomu ye generic kunze kwekunge chiremba wenyu achikumbira zita remhando. Mafomu ese ane chinhu chimwe chete chinoshanda uye anosangana nematanho akafanana ekuchengeteka nekushanda.

Zvimwe zvingashandiswa panzvimbo peMercaptopurine

Mishonga yakati wandei inogona kufungwa kana mercaptopurine isingakukodzere kana isingashande zvakanaka. Sarudzo inoenderana nemamiriro ako chaiwo, nhoroondo yako yezvokurapa, uye maitiro ako kumishonga yapfuura.

Zvechirwere che inflammatory bowel, zvimwe zvingashandiswa zvinosanganisira azathioprine (iyo ine hukama ne mercaptopurine), methotrexate, kana mishonga mitsva yebiological senge infliximab kana adalimumab. Imwe neimwe ine mabhenefiti ayo uye maitiro emigumisiro ayo chiremba wenyu achakurukura nemi.

Mukurapa kenza, zvimwe zvingashandiswa zvinogona kusanganisira mamwe ma chemotherapy drugs, targeted therapies, kana immunotherapy options. Oncologist wenyu achafunga nezvezvinhu zvakaita serudzi rwenyu rwekenza, nhanho yechirwere, uye hutano hwese paanokurudzira zvimwe zvingashandiswa.

Sarudzo yekuchinja mishonga inofanira kugara ichiitwa mukubvunzana nechikwata chako chehutano. Vanogona kukubatsira kuyera zvakanakira nezvakaipira zvezvinhu zvakasiyana zvichibva pamamiriro ako ega.

Ko Mercaptopurine iri nani pane Azathioprine?

Mercaptopurine uye azathioprine mishonga ine hukama hwepedyo inoshanda nenzira dzakafanana, asi haisi iyo chaiyo imwechete. Azathioprine inoshandurwa kuita mercaptopurine mumuviri wako, saka mercaptopurine ndiyo fomu inoshanda inoita basa chairo.

Hapana mushonga wakanyatso

Kushandisa kwenguva refu kunounza njodzi dzakawedzerwa, kusanganisira mukana mudiki wekuvandudza zvirwere zvakasiyana kana, kazhinji, mamwe marudzi ekenza. Zvisinei, kune vanhu vazhinji, mabhenefiti ekudzora mamiriro avo epasi anopfuura njodzi idzi. Chiremba wako achakurukura izvi newe uye achagadzirisa chirongwa chako chekurapa sezvinodiwa.

Q2. Ndingaita Sei Kana Ndakatora Mercaptopurine Yakawandisa Netsaona?

Kana netsaona ukatora mercaptopurine yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira, kunyangwe ukanzwa zvakanaka. Kutora yakawanda kunogona kuwedzera njodzi yemigumisiro yakakomba, kunyanya kukanganisa kuverengwa kweropa rako uye basa rechiropa.

Usamirira kuti zviratidzo zviite usati watsvaga rubatsiro. Nyora pasi chaizvo zvawakatora uye rini, sezvo ruzivo urwu ruchabatsira vanopa hutano kuti vaone nzira yakanakisisa yekutora. Mune zvimwe zviitiko, unogona kuda mamwe bvunzo dzeropa kana kuongororwa kuti uve nechokwadi chekuti wakachengeteka.

Q3. Ndingaita Sei Kana Ndikakanganwa Dose yeMercaptopurine?

Kana ukakanganwa dose uye iri mukati memaawa mashoma enguva yako yenguva dzose, itore paunorangarira. Zvisinei, kana yava nguva yechikamu chako chinotevera, skip the missed dose uye uenderere mberi nechirongwa chako chetsika. Usambofa wakatora zvikamu zviviri panguva imwe chete kuti ugadzirise dose yakakanganwa.

Kana iwe uchikanganwa zvikamu kazhinji, taura nachiremba wako nezve nzira dzekukubatsira kurangarira. Kudzora nguva dzose kwakakosha kuti mushonga ushande nemazvo. Funga nezvekuseta maalarm efoni, kushandisa murongi wemapiritsi, kana kubatanidza mushonga wako kune tsika yezuva nezuva.

Q4. Ndingamira Rini Kutora Mercaptopurine?

Sarudzo yekumisa mercaptopurine inofanira kugara ichiitwa nehutungamiri hwechiremba wako. Kuti urape kenza, kazhinji pane chirongwa chekurapa chakagadzirirwa chinotaura kuti uchada mushonga kwenguva yakareba sei. Kuti urape chirwere chematumbo chinopisa, nguva yacho inoenderana nekuti mamiriro ako akadzorwa sei uye kana mamwe marapirwo angave akakodzera.

Chiremba wako achafunga nezvezvinhu zvakaita semhinduro yako kumishonga, matambudziko auri kusangana nawo, uye njodzi yekuti chirwere chako chidzokezve. Vanogona kuderedza zvishoma nezvishoma mushonga wako pane kumisa kamwechete kudzivirira njodzi yekuti chirwere chako chidzokezve.

Q5. Ndingawana Majekiseni Ndiri Kutora Mercaptopurine Here?

Majekiseni mazhinji anowanzoitwa akachengeteka uchiita mercaptopurine, asi unofanira kudzivisa majekiseni mhenyu akaita sejekiseni remhino reflu, jekiseni rechickenpox, kana jekiseni reMMR. Immune system yako inogona kunge yakadzvanywa zvishoma, saka majekiseni mhenyu anogona kukonzera matambudziko.

Majekiseni asina simba akaita sejekiseni reflu, jekiseni renyumonia, uye majekiseni eCOVID-19 anowanzo kurudzirwa uye akachengeteka. Zvisinei, anogona kusashanda zvakanaka sezvinowanzoitwa nekuti immune response yako inogona kuderedzwa. Nguva dzose taura nechikwata chako chehutano usati watora majekiseni kuti uve nechokwadi chekuti akakodzera mamiriro ako.