Chii chinonzi Methacholine: Zvinoshandiswa, Dosages, Side Effects uye Zvimwe

Methacholine mushonga unoshandiswa zvakananga kuyedzwa kufema, kwete kurapa chero mamiriro ezvinhu. Ikomponi yekugadzira inoderedza nzira dzako dzemhepo kwenguva pfupi kubatsira vanachiremba kuongorora asthma nezvimwe zvinonetsa kufema. Funga nezvazvo sechishandiso chekuongorora chinobatsira kuratidza kuti mapapu ako anonzwa sei kune zvimwe zvinokonzeresa.

Chii chinonzi Methacholine?

Methacholine kemikari yakagadzirwa nemunhu inotevedzera chinhu chechisikigo mumuviri wako chinonzi acetylcholine. Paunoinhalera panguva yekuyedzwa kwekurapa, inokonzera kuti nzira dzako dzemhepo dzisungane zvishoma. Iyi mhinduro inodzorwa inobatsira vanachiremba kuona kuti mapapu ako anopindura sei kune zvinotsamwisa.

Mushonga uyu unouya seupfu hunosanganiswa nemhinduro yesaline uye hunoshandurwa kuita mhute yakanaka. Iwe unongosangana ne methacholine muhofisi yechiremba kana mumamiriro ezvinhu echipatara panguva yekuyedzwa kufema kunonzi methacholine challenge test. Haisati yakarairwa kushandiswa kumba kana kurapwa kuri kuenderera mberi.

Chii chinonzi Methacholine chinoshandiswa?

Methacholine inoshandiswa chete kuongorora mamiriro ekufema, kunyanya asthma. Kuyedzwa kunobatsira vanachiremba kuona kana uine airway hyperresponsiveness, zvinoreva kuti nzira dzako dzemhepo dzinopindura zvakanyanya kune zvinokonzeresa. Ruzivo urwu rwakakosha kana zviratidzo zvako zvisina kujeka kana kana bvunzo dzakajairika dzekufema dzichidzoka dzakajairika.

Chiremba wako angakurudzira bvunzo iyi kana uine zviratidzo zvakaita sekukosora kusingaperi, kufema, kana kusungirirwa pachipfuva asi mhedzisiro yebvunzo isina kujeka. Iyo methacholine challenge inogona zvakare kubatsira kusiyanisa pakati peasthma nezvimwe zvinokonzera zviratidzo zvakafanana. Dzimwe nguva inoshandiswa kuongorora kuti kurapwa kweasthma kuri kushanda sei nekufamba kwenguva.

Methacholine inoshanda sei?

Methacholine inoshanda nekubatanidza kune zvimwe zvinogamuchira mumhasuru dzemhepo yako zvinonzi muscarinic receptors. Kana ichibatanidzwa kune izvi zvinogamuchira, inokonzera mhasuru dzakatsetseka dzakatenderedza nzira dzemhepo yako kuti dzibvumirane, zvichiita kuti nzira dzemhepo dzive diki. Iyi itsika yenguva pfupi uye inodzorwa iyo inowanzo gara maminitsi mashoma.

Mushonga uyu unoonekwa semumiriri webronchial provocative ane simba repakati. Iyo ine simba rakakwana rekukonzera mhinduro inoyerwa munzira dzemhepo dzinonzwa asi yakapfava zvakakwana kuti ishandiswe zvakachengeteka mukuyedzwa kwekurapa. Mhedzisiro yacho inodzoserwa zvachose, uye nzira dzemhepo yako dzinodzokera kune zvakajairika kana mushonga wabviswa kubva muhurongwa hwako.

Ndingatora sei Methacholine?

Hautore methacholine iwe pachako - inogara ichipihwa nevashandi vehutano vakadzidziswa panguva yekuyedzwa kunotarisirwa. Mushonga unopihwa kuburikidza ne nebulizer, iyo inoshandura mhinduro yemvura kuita mhute yakanaka yaunofema nemuromo. Ucharairwa kuti utore kufema kwakadzika, kwakadzika kuti uve nechokwadi chekuti mushonga unosvika munzira dzemhepo yako nemazvo.

Pamberi pebvunzo, iwe unowanzo fanirwa kudzivisa mishonga nemabasa. Chikwata chako chehutano chichakupa mirairo chaiyo yekumisa bronchodilators, kudzivisa caffeine, uye kusaita maekisesaizi pamberi. Bvunzo inowanzoitika mune yakakosha pulmonary function lab uko midziyo yekukurumidzira inowanikwa nyore nyore.

Panguva yechirongwa, iwe uchatanga nekufema zvakajairika, wobva wainhalisa kuwedzera kwe methacholine. Pakati pechiyero chega chega, nyanzvi dzichayera basa remapapu ako kuti dzione kuti nzira dzemhepo yako dzinopindura sei. Maitiro ese anowanzo tora maminitsi makumi matatu kusvika makumi mana nemashanu.

Ndingatora Methacholine kwenguva yakareba sei?

Methacholine inongoshandiswa kamwe chete panguva yekuedzwa kumwe chete - haisi mushonga waunotora kakawanda kana kwenguva yakareba. Kufumurwa chaiko ku methacholine panguva yekuedzwa kunotora maminitsi mashoma sezvo uchifema imwe neimwe concentration. Vanhu vazhinji vanopedza bvunzo yese ye methacholine challenge mukati meawa rimwe.

Mhedzisiro ye methacholine inopera nekukurumidza, kazhinji mukati memaminitsi gumi nemashanu kusvika makumi matatu mushure mekunge bvunzo yapera. Chikwata chako chekurapa chichakutarisa kusvikira kufema kwako kwadzokera kune zvakajairika uye chingakupa bronchodilator yekukurumidza kupora. Hauzodi kuenderera mberi nechero kurapwa kumba kwakabatana ne methacholine pachayo.

Ndezvipi Zvipingamupinyi zveMethacholine?

Zvakajairika zvipingamupinyi zve methacholine zvinoitika panguva kana mushure mebvunzo uye zvinowanzoita zvishoma. Izvi zviitiko zvinotarisirwa sezvikamu zvekuti bvunzo inoshanda sei. Chikwata chako chehutano chakagadzirira kubata chero zviratidzo zvinomuka.

Heano maitiro anowanzoitika aunogona kusangana nawo panguva yebvunzo ye methacholine challenge:

• Kusungirirwa muchipfuva kana kumanikidzwa
• Kufema zvishoma
• Kukosora zvishoma
• Kutsamwa kwehuro
• Kunzwa sekunge unoda kuchenesa huro yako

Izvi zviratidzo zvinowanzoenda nekukurumidza kana bvunzo yapera uye nzira dzako dzemhepo dzikazorora kudzokera kune zvakajairika.

Zvakakomba asi zvisingawanzoitiki zviitiko zvinogona kuitika, ndosaka bvunzo ichiitwa chete munzvimbo dzekurapa dzine midziyo yekukurumidzira. Izvi zvisingawanzoitiki zvinogona kusanganisira:

• Severe bronchospasm (kuderedzwa kwakakosha kwemhepo)
• Kufema kwakaoma uko kusingavandudzi nekukurumidza
• Kurwadziwa muchipfuva kupfuura kusungirirwa zvishoma
• Dizziness kana lightheadedness
• Kurova kwemoyo nekukurumidza

Chikwata chako chekurapa chinokutarisa zvakanyanya panguva yebvunzo uye chinogona nekukurumidza kushandura chero zviitiko zvakakomba nemishonga ye bronchodilator.

Ndiani Asingafaniri Kutora Methacholine?

Mapoka akati wandei evanhu anofanira kudzivisa kuyedzwa kwe methacholine nekuda kwenjodzi dzakawedzerwa. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akurudzira bvunzo iyi. Kuchengeteka nguva dzose ndiko kunonyanya kukosha kana uchifunga nezve chero nzira yekuziva chirwere.

Haufanire kuve nebvunzo yekuyedza methacholine kana uine chero imwe yemamiriro aya:

• Asthma yakakomba isingadzorwe zvakanaka
• Kurwisa kwemoyo kwemazuva ano kana mamiriro emoyo asina kugadzikana
• Basa repfungwa rakaderera kwazvo (FEV1 isingasviki 50% yeiyo yakafanotaurwa)
• Kuvhunduka kweropa kwakanyanya kusingadzorwe zvakanaka
• Sitroko yemazuva ano kana aneurysm yehuropi
• Kuzvitakura (kuchengeteka hakuna kumiswa)
• Kutapukirwa kwemweya kana kurwara

Chiremba wako achavawo akangwarira kana uri kutora mishonga yakati wandei, kunyanya iyo inogona kukanganisa mhedzisiro yebvunzo kana kuwedzera njodzi yako yematambudziko.

Mazita eMethacholine Brand

Methacholine inowanikwa pasi pezita remhando yeProvocholine muUnited States. Iyi ndiyo fomu inonyanya kushandiswa yekuyedzwa kwe methacholine. Mushonga uyu unouya seupfu hwakachena hunosanganiswa nevashandi vehutano nemhinduro yesaline nguva pfupi vasati vaita bvunzo yako.

Zvimwe zvivakwa zvekurapa zvinogona kushandisa mamwe magadzirirwo emishonga e methacholine, asi Provocholine ndiyo yakajairika muzvipatara zvakawanda uye ma pulmonary function labs. Zvisinei nezita remhando, chinhu chinoshanda uye nzira yekuyedza zvinoramba zvakafanana.

Methacholine Alternatives

Nepo methacholine iri goridhe standard yekuyedzwa kwebronchial provocation, vanachiremba dzimwe nguva vanoshandisa mamwe maagent ekuyedza zvichienderana nemamiriro ako chaiwo. Izvi zvimwe zvinogona kupa ruzivo rwekuongorora rwakafanana asi kushanda kuburikidza nemaitiro akasiyana.

Zvimwe zviedzo zvebronchial challenge chiremba wako angangofunga zvinosanganisira:

• Muedzo wekufema mannitol (unoyera kuzvimba kwemhepo)
• Muedzo wekuedza muviri (unoshandisa basa remuviri sechikonzero)
• Kuedza mhepo inotonhora (inoshandisa shanduko dzekushisa)
• Kuedza histamine (nzira yakafanana ne methacholine)
• Kuedza adenosine (inoshandiswa mune dzimwe nzvimbo dzakakosha)

Nyanzvi yako yemapapu ichasarudza bvunzo yakakodzera zvichienderana nezviratidzo zvako, nhoroondo yako yekurapa, uye ruzivo rwakajeka rwavanoda kuti vaite kuongororwa kwakaringana.

Ko Methacholine Zviri Nani Pane Histamine Challenge?

Miedzo yese ye methacholine uye histamine challenge miedzo zvishandiso zvakanaka zvekuziva asthma, asi methacholine inowanzo kufarirwa munzvimbo zhinji dzekurapa. Methacholine inowanzo kuve yakajeka pakuona hyperresponsiveness yemhepo uye ine mashoma mativi kupfuura histamine. Mhedzisiro yacho zvakare inoenderana uye iri nyore kududzira.

Histamine inogona kukonzera mamwe mamiriro senge kurwadziwa nemusoro, flushing, uye ganda reactions nekuti inokanganisa masisitimu kupfuura kungoita mhepo yako. Methacholine inonyanya kutariswa mukuita kwayo, ichinyanya kutarisisa tsandanyama dzakatsetseka munzira dzako dzekufema. Izvi zvinoita kuti methacholine ive yakachengeteka uye yakasununguka sarudzo yevazhinji varwere.

Zvisinei, dzimwe nzvimbo dzakakosha dzichiri kushandisa histamine challenge miedzo, kunyanya munzvimbo dzekutsvagisa. Miedzo yese inopa ruzivo rwekuongorora runokosha, uye chiremba wako achasarudza zvichienderana neruzivo rwavo uye zvaunoda zvekurapa.

Mibvunzo Inowanzo Bvunzwa Nezve Methacholine

Ko Methacholine Yakachengeteka Kune Vanhu Vane Zvirwere Zvemoyo?

Methacholine kuyedzwa kunoda kungwarira kwakakosha muvanhu vane mamiriro emoyo. Mushonga unogona kukanganisa kurova kwemoyo uye kudzvinyirirwa kweropa, saka chiremba wako wemoyo uye nyanzvi yemapapu vachada kushanda pamwechete kuti vaone kana bvunzo yacho yakachengeteka kwauri. Vanhu vane chirwere chemoyo chakadzorwa zvakanaka, chakasimba vanogona kunge vachiri vakakodzera bvunzo pasi pekutariswa kwakanyatso.

Kana uine nhoroondo yematambudziko emoyo, ita shuwa kuti unoudza chiremba wako usati waronga kuyedzwa kwe methacholine. Vanogona kuda kuita mamwe maonero emoyo panguva yekuyedzwa kana kusarudza imwe nzira yekuongorora. Kuchengeteka kwako nguva dzose kunokosha kupfuura kuita bvunzo chaiyo.

Ndoita Sei Kana Ndakatora Methacholine Yakawandisa Netsaona?

Haugoni netsaona kutora methacholine yakawandisa nekuti inongopihwa nevashandi vehutano vakadzidziswa munzvimbo dzehutano dzine kutonga. Bvunzo inotevera mitemo yakasimba ine zviyero zvakatemerwa zvinoyerezwa zvakanyatsonaka. Kana iwe nenzira yakati wani ukagamuchira zvakawanda kupfuura zvaitarisirwa panguva yekuyedzwa, chikwata chako chekurapa chingakupa mushonga webronchodilator pakarepo kuti ubvise mhedzisiro.

Nzvimbo yekuyedzwa yakagadzirirwa ine maonero akawanda ekuchengetedza kudzivirira overdosing. Kana iwe ukaona sekuti zviratidzo zvako zviri kuwedzera kupfuura zvaitarisirwa panguva yekuyedzwa, udza nyanzvi yako pakarepo. Vanogona kumisa bvunzo uye kupa kurapwa ipapo.

Ndoita Sei Kana Ndikakanganwa Dose yeMethacholine?

Mubvunzo uyu haushande ku methacholine nekuti haisi mushonga waunotora nguva dzose kana kumba. Methacholine inongoshandiswa kamwe chete panguva yekuyedzwa kwekuongorora muchivakwa chekurapa. Kana iwe ukakanganwa kugadzwa kwako kwe methacholine challenge test, ingo rangarira zvakare kune rimwe zuva paunogona kutevera mirairo yese yekugadzirira.

Ita shuwa kuti unozivisa nzvimbo yekuyedza kana uchida kuronga zvakare, sezvo vachigadzirira mushonga zvakananga panguva yako yekugadzwa. Paunenge uchiita reschedule, unozofanirwa kutevera matungamirirwo akafanana ekugadzirira nezvekudzivisa mishonga nemabasa mamwechete pamberi.

Ndingamira Rini Kutora Methacholine?

Hapana chikonzero chekumisa kutora methacholine nekuti haisi mushonga unotorwa nguva dzose. Kujekeswa kune methacholine kunopera pakarepo kana bvunzo yako yekuziva chirwere yapera. Zvazvinoita zvinopera zvoga mukati memaminitsi gumi nemashanu kusvika makumi matatu mushure mebvunzo, uye kufema kwako kunofanira kudzokera kune zvakajairika.

Chiremba wako angangokupa mushonga webronchodilator mushure mebvunzo kuti akurumidze kupora kwako, asi ichi chingori chenjedzo. Kana bvunzo yapera, hapana methacholine yasara mumuviri wako yekunetseka nayo.

Ndingagona here Kutyaira Mushure meMethacholine Challenge Test?

Vanhu vazhinji vanogona kuzvityairira kumba mushure mebvunzo ye methacholine challenge, asi izvi zvinoenderana nekuti unonzwa sei mushure. Bvunzo pachayo haiwanzo kukonzera kurara kana kukanganisa kugona kwako kutyaira zvakachengeteka. Zvisinei, vamwe vanhu vanogona kunzwa vaneta kana kufema zvishoma kwenguva shoma mushure mebvunzo.

Chikwata chako chekurapa chichakutarisa kusvikira kufema kwako kwadzokera kune zvakajairika usati waenda. Kana iwe wakagamuchira chero mushonga webronchodilator mushure mebvunzo, unogona kunzwa uchidedera zvishoma kana kuve nekurova kwemoyo nekukurumidza kwenguva pfupi. Teerera muviri wako uye usatyaira kana uchinzwa usina kugadzikana kana kusanzwa zvakanaka mune chero nzira.