Chii chinonzi Methylnaltrexone: Zvinoshandiswa, Madosi, Migumisiro Yemativi uye Zvimwe

Methylnaltrexone mushonga unopiwa nachiremba unobatsira kubvisa kuvharika kwemudumbu kunokonzerwa nemishonga yekurapa marwadzo yeopioid. Kana iwe uchitora maopioid ekurapa marwadzo uye uchinetseka nekuzvimbirwa kwakanyanya, mushonga uyu unogona kupa zororo pasina kukanganisa kutonga kwako marwadzo. Inoshanda nekudzivirira mhedzisiro yeopioid kunyanya mudumbu rako richisiya zororo remarwadzo rakachengeteka mumuviri wako wese.

Chii chinonzi Methylnaltrexone?

Methylnaltrexone mushonga wakagadzirirwa kurapa kuvharika kwemudumbu kunokonzerwa neopioid. Iyo ndeyeboka remishonga inonzi opioid antagonists, zvinoreva kuti inovharisa mamwe mhedzisiro yeopioid muzvikamu zvakasiyana zvemuviri wako. Mushonga uyu unouya sejekiseni repasi peganda, zvinoreva kuti inopiwa sejekiseni pasi peganda rako, zvakafanana nemaitiro anoita vanhu vane chirwere cheshuga kuzvipa majekiseni e insulin.

Mushonga uyu wakagadzirirwa kunyanya kushanda mudumbu rako chete uye haipindi muuropi hwako. Iyi dhizaini yakasarudzika inoreva kuti inogona kudzorera basa remudumbu rakajairika pasina kuderedza zororo remarwadzo raunowana kubva kumishonga yako yeopioid. Inobatsira zvikuru kune vanhu vanoda kurapwa kwenguva refu kweopioid asi vari kusangana nekuzvimbirwa kusingafadzi semhedzisiro yemativi.

Chii chinonzi methylnaltrexone chinoshandiswa?

Methylnaltrexone inorapa kuvharika kwemudumbu kunokonzerwa neopioid muvanhu vakuru vanotora mishonga yekurapa marwadzo yeopioid nguva dzose. Rudzi urwu rwekuvhara mudumbu rwakasiyana nekuzvimbirwa kwakajairika nekuti kunokonzerwa nemaopioid achinonotsa mudumbu rako. Vanhu vazhinji vanotora maopioid ekurwadziwa kusingaperi, marwadzo ekenza, kana mushure mekuvhiyiwa vanosangana nemhedzisiro iyi inonetsa.

Mishonga iyi inowanzo nyorerwa kana dzimwe nzira dzekurapa kuvharika kwemudumbu dzisina kushanda zvakanaka. Chiremba wako angakukurudzira kana wakaedza kuwedzera fiber, zvinonyorovesa tsvina, kana laxatives pasina rubatsiro rwakakwana. Izvi zvinokosha zvikuru kune vanhu vanofanira kuramba vachitora opioids yekurapa marwadzo asi vachida kudzosa basa remudumbu rakajairika.

Mune dzimwe nguva, vanachiremba vanonyorawo methylnaltrexone kune vanhu vane chirwere chakanyanya vari kugamuchira palliative care. Izvi zvinobatsira kuvandudza hupenyu nekugadzirisa imwe yemigumisiro isinganzwisisike yemishonga inodiwa yekurapa marwadzo.

Methylnaltrexone inoshanda sei?

Methylnaltrexone inoshanda nekudzivisa opioid receptors kunyanya mudumbu rako. Paunotora mishonga yerwadzo yeopioid, inonamatira kune receptors mumuviri wako wese, kusanganisira mumatumbu ako. Kunyange izvi zvichipa rubatsiro rwerwadzo, zvinononotsawo kufamba kwechikafu nemarara kuburikidza nemudumbu rako, zvichikonzera kuvharika kwemudumbu.

Mishonga iyi yakagadzirwa nechimiro chakakosha chinoidzivirira kuyambuka chipingamupinyi cheropa-uropi. Izvi zvinoreva kuti haigoni kusvika kune opioid receptors muuropi hwako hunodzora rubatsiro rwerwadzo. Panzvimbo pezvo, inongotarisa chete paopioid receptors mudumbu rako, ichibvumira mudumbu rako kuti rishande zvakajairika uchichengeta mishonga yako yerwadzo ichishanda.

Mishonga iyi inoonekwa seyakasimba zvishoma uye inowanzoita kuti mudumbu ufambe mukati memaawa mashoma kusvika pazuva mushure mejekiseni. Vanhu vazhinji vanoiwana ichishanda zvakanyanya kune chinangwa chayo, kunyange mhinduro dzemunhu mumwe nemumwe dzinogona kusiyana zvichienderana nezvinhu zvakaita sehutano hwako hwese uye kuti wanga uchitora opioids kwenguva yakareba sei.

Ndingatore sei methylnaltrexone?

Methylnaltrexone inopiwa semushonga unoiswa pasi peganda, zvinoreva kuti iwe kana munhu anokuchengeta achaiisa pasi peganda. Chiremba wako achakudzidzisa nzira yakarurama yekuiisa uye achakuratidza nzvimbo dzakanakisa dzekuiisa, kazhinji chidya chako, dumbu, kana ruoko rwepamusoro. Mushonga uyu unowanzoiswa mazuva ese, asi chiremba wako achasarudza nguva yakakodzera yezvinhu zvako.

Haufaniri kutora mushonga uyu uine chikafu, uye hapana zvirambidzo zvakakosha zvekudya. Zvisinei, zvakakosha kuti urambe uine mvura yakawanda paunenge uchishandisa chero mushonga unokanganisa basa rematumbo. Mushonga uyu unofanirwa kuiswa pakupisa kwemumba, saka unozofanira kuubvisa mufiriji maminitsi angangoita 30 usati waisa.

Nguva dzose chinjana nzvimbo dzaunoisira mushonga kuti udzivise kutsamwa kweganda kana kukuvadzwa kwematishu. Chengeta zvaunenge waisa nguva pfupi yapfuura uye sarudza imwe nzvimbo nguva imwe neimwe. Kana usinganzwe zvakanaka kuzviisa iwe pachako mishonga, nhengo yemhuri kana munhu anokuchengeta anogona kudzidza kukubatsira, kana unogona kuwana majekiseni muhofisi yachiremba wako.

Ndingatora methylnaltrexone kwenguva yakareba sei?

Kureba kwemaitiro e methylnaltrexone kunoenderana nekuti unofanirwa kutora mishonga yekurwadziwa yeopioid kwenguva yakareba sei. Sezvo mushonga uyu unorapa mhedzisiro yeopioids panzvimbo pechinhu chinokonzera, iwe unowanzoishandisa kwenguva yakareba sezvauri kusangana nekuzvimbirwa kunokonzerwa neopioid. Izvi zvinogona kuva mavhiki, mwedzi, kana kunyange kwenguva refu kune vanhu vane mamiriro ekurwadziwa kwenguva refu.

Chiremba wako achagara achiongorora kana uchiri kuda mushonga. Kana muyero wako weopioid ukaderera kana ukamira kutora opioids zvachose, iwe ungangokwanisa kumisa methylnaltrexone zvakare. Vamwe vanhu vanowana kuti kuzvimbirwa kwavo kunovandudza zvakakwana kuti vagone kubata nedzimwe nzira dzekurapa, zvichivabvumira kumisa majekiseni.

Zvakakosha kuti usamira methylnaltrexone kamwechete usina kutaura nachiremba wako. Kunyange zvazvo isingagadziri muromo, kumira kamwechete kungaita kuti kuvharika kwako mudumbu kudzoke nokukurumidza. Chiremba wako anogona kukubatsira kuona nzira yakanakisisa yezvinhu zvako.

Ndezvipi zvinoitika nemethylnaltrexone?

Vanhu vazhinji vanogashira methylnaltrexone zvakanaka, asi semishonga yose, inogona kukonzera zvinoitika. Zvinhu zvakajairika zvinowanzoita zvishoma uye zvine chokuita nekuchinja mudumbu rako sezvo richigadzirisa kumabasa akajairika.

Hezvino zvinhu zvakajairika zvaungasangana nazvo:

• Kurwadziwa mudumbu kana kukakavara, izvo zvinowanzoitika kana basa rako remudumbu richidzokera kune zvakajairika
• Nausea, kunyanya mumadosi mashoma ekutanga sezvo sisitimu yako ichigadzirisa
• Diarrhea, kunyanya kana sisitimu yako ikakanganisa kubva mukuvharika mudumbu
• Maitiro ekudzivirira nzvimbo yekujekesa senge kutsvuka, kuzvimba, kana kurwadziwa kudiki kwawakawana jekiseni
• Flatulence kana gasi sezvo sisitimu yako yekugaya ichiita basa
• Dizziness, iyo inogona kuitika kana ukashaya mvura kubva mukuwedzera basa remudumbu

Izvi zvinoitika zvakajairika zvinowanzoita zviri nani sezvo muviri wako uchigadzirisa kumushonga uye basa rako remudumbu richigadzikana.

Kune zvakare zvimwe zvinoitika zvisingawanzoitiki asi zvakanyanya kukosha kuti uzive nezvazvo:

• Kurwadziwa mudumbu kwakanyanya kusingavandudzi, izvo zvingaratidza kuvharika mudumbu
• Kurutsa kusingagumi kunokutadzisa kuchengeta mvura pasi
• Zviratidzo zvekushaya mvura senge nyota yakanyanya, muromo wakaoma, kana kuderedzwa kwemvura
• Maitiro akakomba ekurwisa, kunyangwe izvi zvisingawanzoitiki
• Zviratidzo zvingaratidza kubviswa kweopioid, senge kutukwa, kushushikana, kana kurwadziwa kwemhasuru

Kana uine zviratidzo zvakakomba kana zvinonetesa, taura nachiremba wako nekukasira. Vanhu vazhinji vanowana kuti mabhenefiti ekuvandudzwa kwekuita bowel anopfuura kusagadzikana kwenguva pfupi kwemigumisiro.

Ndiani asingafaniri kutora methylnaltrexone?

Methylnaltrexone haina kuchengeteka kune munhu wese, uye kune mamiriro akati wandei akakosha apo haifaniri kushandiswa. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wanyora mushonga uyu kuti uve nechokwadi chekuti wakachengeteka kwauri.

Haufaniri kutora methylnaltrexone kana uine chero chimwe chezvinhu izvi:

• Kuzivikanwa kwekuvharika kwematumbo kana kuvharika, sezvo mushonga ungawedzera mamiriro aya ane njodzi
• Chirwere chekuputika kwematumbo chinoshanda senge chirwere cheCrohn kana ulcerative colitis panguva yekupisa
• Chirwere chakakomba cheitsvo, sezvo mushonga uchigadziriswa kuburikidza neitsvo dzako
• Allergy ku methylnaltrexone kana chero zvinhu zviri mujekiseni
• Kufungidzirwa kwekupera mumugwagwa wako wekudya

Chiremba wako achashandisawo kungwarira kwakawanda kana uine mamwe mamiriro anogona kuwedzera njodzi yako yematambudziko:

• Matambudziko eitsvo akapfava kusvika pakati nepakati, ayo anogona kuda kugadzirisa dose
• Nhoroondo yekuvhiyiwa kwemugwagwa wekudya, kunyanya maitiro achangobva kuitwa
• Diverticulitis kana mamwe mamiriro ekuputika ecolon
• Chirwere chakakomba chechiropa chinogona kukanganisa maitiro emuviri wako anogadzirisa mushonga
• Kuzvitakura kana zvirongwa zvekuva nepamuviri, sezvo data rekuchengetedza rakaganhurirwa

Nguva dzose udza mupi wako wehutano nezve mamiriro ako ese ekurapa uye mishonga iripo usati watanga methylnaltrexone. Izvi zvinobatsira kuona kuti mushonga wakachengeteka uye unoshanda kune mamiriro ako chaiwo.

Methylnaltrexone zita remhando

Methylnaltrexone inowanikwa pasi pezita rekuti Relistor. Iyi ndiyo fomu inonyanya kunyorerwa yemushonga uye inouya semajekiseni akazadzwa kare ekudzivirira jekiseni. Iyo vhezheni yezita remhando uye chero generic vhezheni zvine chinhu chimwe chete chinoshanda uye zvinoshanda nenzira imwechete.

Zvimwe zvirongwa zveinishuwarenzi zvinogona kuva nezvavanofarira zvezita remhando vachipesana nemishonga yakajairika, saka zvakakosha kutarisa nemupi wako weinishuwarenzi nezvekufukidzwa. Murapi wako wemishonga anogonawo kukubatsira kunzwisisa sarudzo dzako uye chero mutsauko wemutengo pakati pefomula dziripo.

Zvimwe zvingasarudzwa zveMethylnaltrexone

Kana methylnaltrexone isiri yakanaka kwauri, pane dzimwe nzira dzekurapa dzekuvharika kwemudumbu kunokonzerwa neopioid. Chiremba wako angakurudzira kuyedza idzi dzimwe nzira zvichibva pamamiriro ako chaiwo uye nhoroondo yekurapa.

Zvimwe zvinorayirwa mishonga yekuvharika kwemudumbu kunokonzerwa neopioid zvinosanganisira:

• Naloxegol (Movantik), iyo inotorwa semupiritsi wezuva nezuva pane jekiseni
• Naldemedine (Symproic), imwe mishonga yemuromo inoshanda zvakafanana
• Lubiprostone (Amitiza), iyo inoshanda zvakasiyana nekukwidza mvura mumudumbu mako

Nzira dzisiri dzekurayirwa dzinogona kuratidzwa nachiremba wako dzinosanganisira:

• Osmotic laxatives senge polyethylene glycol (Miralax)
• Stimulant laxatives senge senna kana bisacodyl
• Stool softeners senge docusate
• Kuwedzera fiber yezvokudya uye kunwa mvura
• Kushanda muviri nguva dzose sezvinoshivirirwa

Nzira yakanakisa inowanzo sanganisira kusanganisa nzira dzakasiyana. Mupi wako wehutano anogona kukubatsira kugadzira chirongwa chakazara chinogadzirisa kuvharika kwemudumbu kwako uchichengeta kutonga kurwadziwa kunoshanda.

Ko methylnaltrexone iri nani pane naloxegol?

Zvese methylnaltrexone uye naloxegol zvinoshanda pakurapa kuvharika kwemudumbu kunokonzerwa neopioid, asi zvine zvakanakira zvakasiyana zvichienderana nemamiriro ako. Sarudzo pakati pavo inowanzouya pasi pezvido zvako, mararamiro, uye kuti muviri wako unopindura sei kumushonga wega wega.

Methylnaltrexone inogona kunge iri nani kana iwe uchida kushandisa zvishoma kazhinji, sezvo inowanzo kupiwa mazuva ese pane zuva nezuva. Vamwe vanhu vanowanawo kuti jekiseni rinoshanda nekukurumidza uye zvakavimbika kupfuura mishonga yemuromo. Inogona kunge iri sarudzo yakanaka kana iwe uine dambudziko rekuyeuka kutora mishonga yezuva nezuva kana kana uine nyaya dzekugaya dzinokanganisa kunyudzwa kwemapiritsi.

Naloxegol inogona kunge iri nani kana iwe usinganzwe zvakanaka nejekiseni kana uchida nyore nyore kutora piritsi. Inotorwa kamwe chete pazuva nemuromo uye haidi zvinhu zvejekiseni kana matekiniki. Vamwe vanhu vanowana mishonga yemuromo iri nyore kuisa mukati mezuva ravo.

Mishonga yese iri miviri inoshanda nemaitiro akafanana uye ine kushanda kwakafanana kune vanhu vazhinji. Chiremba wako anogona kukubatsira kuyera zvakanakira nezvayakaipira zveimwe neimwe sarudzo zvichibva pazvido zvako, zvaunofarira, uye nhoroondo yako yekurapa.

Mibvunzo inowanzo bvunzwa nezve methylnaltrexone

Methylnaltrexone yakachengeteka here kune chirwere cheitsvo?

Methylnaltrexone inoda kufunga zvakanyanya kana uine chirwere cheitsvo. Sezvo itsvo dzako dzichibatsira kugadzirisa nekubvisa mushonga uyu kubva mumuviri wako, matambudziko eitsvo anogona kukanganisa mashandiro emushonga uye zvinogona kuwedzera njodzi yako yemigumisiro.

Kana uine chirwere cheitsvo chinyoro kusvika pakati nepakati, chiremba wako anogona kunyora mushonga wakaderera kana kukutarisa zvakanyanya paunenge uchitora mushonga. Kune vanhu vane chirwere cheitsvo chakanyanya, methylnaltrexone kazhinji haina kukurudzirwa nekuti inogona kuvaka mumuviri wako uye kukonzera matambudziko.

Gara uchizivisa chiremba wako nezvematambudziko ese aunawo nematsvo, kunyangwe akaita sediki. Vanogona kuda kutarisa kushanda kwematsvo ako nemiedzo yeropa vasati vatanga mushonga uye nguva nenguva paunenge uchitora.

Ndoita sei kana ndikashandisa methylnaltrexone yakawandisa netsaona?

Kana ukabaya methylnaltrexone yakawandisa netsaona, taura nechiremba wako kana nzvimbo yekudzora muchetura nekukasira. Kunyange zvazvo kuwandisa kusiri kwakajairika nemushonga uyu, kutora yakawandisa kungakonzera kurwadziwa kwakanyanya mudumbu, manyoka, kusvotwa, kana kurutsa.

Usaedze kuzvirapa iwe pachako kana kumirira kuti uone kana zviratidzo zvichioneka. Kunyangwe ukaita zvakanaka pakutanga, zvakakosha kuwana zano rekurapa nekukurumidza. Mhedzisiro yemushonga wakawandisa ingasazviratidza pakarepo asi inogona kuva yakakomba.

Chengeta kurongedzerwa kwemushonga newe paunotsvaga rubatsiro, sezvo ruzivo urwu runogona kukosha kune vanachiremba. Munguva yemberi, tarisa kaviri muyero wako uye nzira yekubaya kudzivirira kuwandisa netsaona.

Ndoita sei kana ndikakanganwa dose ye methylnaltrexone?

Kana ukakanganwa dose ye methylnaltrexone, itore pakarepo paunorangarira, kunze kwekunge yava nguva yechikamu chako chinotevera. Muchiitiko ichocho, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chekushandisa. Usatore zvikamu zviviri panguva imwe chete kuti ugadzirise dose yakakanganwa.

Kukanganwa dose dzimwe nguva hakuna njodzi, asi unogona kuona kuti kuvharika kwako kunodzoka kana kuwedzera kwenguva pfupi. Kana iwe uchikanganwa dose kazhinji, funga kumisikidza zviyeuchidzo zvefoni kana kushandisa app yekutevera mishonga kuti ikubatsire kuti urambe uri pachirongwa.

Kana iwe uchikanganwa dose nguva dzose, taura nechiremba wako nezve nzira dzekuvandudza kutevedzera kana kuti chirongwa chemushonga chakasiyana chingashanda zviri nani kumaitiro ako ehupenyu.

Ndingamira rini kutora methylnaltrexone?

Unogona kumira kutora methylnaltrexone kana usisachidi nekuda kwekuvharika kwemudumbu kunokonzerwa neopioid. Izvi zvinowanzoitika kana ukaderedza dose yako yeopioid zvakanyanya, kumira kutora maopioid zvachose, kana kuona kuti kuvharika kwemudumbu kwako kwavandudzika zvakakwana kuti ugone kurapa nezvimwe zvirongwa.

Nguva dzose kurukura kumisa mushonga nachiremba wako pane kuzvisarudzira wega. Vanogona kukubatsira kuona nguva yakanakisa uye kana uchida kuderedza dose zvishoma nezvishoma kana kumira kamwechete.

Vamwe vanhu vanoona kuti basa remudumbu ravo rinoramba ravandudzwa kunyangwe vakamisa methylnaltrexone, kunyanya kana vakaitawo shanduko dzekudya kana mararamiro. Vamwe vangangoda kutangazve mushonga kana kuvharika kwemudumbu kukadzoka pavanomisa.

Ndingatora methylnaltrexone nemamwe ma laxatives here?

Unogona kazhinji kutora methylnaltrexone nemamwe ma laxatives, asi izvi zvinofanirwa kuitwa pasi pekutariswa kwechiremba. Chiremba wako angakurudzira kusanganisa kurapwa kana uchida rubatsiro rwekuwedzera nekuvharika kwemudumbu, asi vachada kukutarisa zvakanyanya kudzivirira chiitiko chakawandisa chemudumbu.

Kana iwe wakatotora mamwe ma laxatives paunotanga methylnaltrexone, chiremba wako angagadzirisa iwo ma doses kudzivirira manyoka kana cramping. Kusanganiswa kwekurapwa kunogona kushanda zvakanyanya, asi kunoda kubatana kwakanyanya kudzivirira overcorrection.

Nguva dzose udza chiremba wako nezve zvese zvirongwa zvekuvharika kwemudumbu zvauri kushandisa, kusanganisira mishonga isingatengwe, zvinowedzera, uye mishonga yemumba. Izvi zvinovabatsira kugadzira chirongwa chekurapa chakachengeteka uye chinoshanda kwauri.