Chii chinonzi Mifepristone: Zvayakashandiswa, Mishonga, Matambudziko uye Zvimwe

Mifepristone mushonga unotorwa nemurairo wechiremba unodzivisa hormone progesterone mumuviri wako. Ungazviziva zviri nani se "piritsi rekuita pamuviri" kana richishandiswa nemumwe mushonga unonzi misoprostol, asi zvakare rine mamwe mabasa akakosha ekurapa. Mushonga uyu unoshanda nekukanganisa mahomoni akakosha pakuchengetedza pamuviri, ndosaka uchishanda zvakanaka pakuita pamuviri nemamwe mamiriro ezvinhu.

Chii chinonzi Mifepristone?

Mifepristone is synthetic hormone blocker inodzivirira progesterone kubva pakushanda mumuviri wako. Progesterone ihomoni inobatsira kuchengetedza pamuviri nekuchengetedza rukoko rwemimba yako rakakora uye rinotsigira. Kana mifepristone ikadzivisa progesterone, inonyatsoudza muviri wako kuti umire kutsigira pamuviri.

Mushonga uyu wakatanga kubvumidzwa neFDA muna 2000 uye wakashandiswa zvakachengeteka nemamiriyoni evanhu pasi rese. Iyo ndeyeboka remishonga inonzi antiprogestins, zvinoreva kuti vanoshanda vachipesana nemhedzisiro yakajairika ye progesterone mumuviri wako.

Chii chinoshandiswa Mifepristone?

Mifepristone ine nzira mbiri huru dzinoshandiswa dzakabvumidzwa neFDA. Kushandiswa kwekutanga ndeyekuita pamuviri mumavhiki ekutanga ekuzvitakura, kazhinji kusvika kumavhiki gumi kubva kumwedzi wako wekupedzisira. Inoshandiswawo kudzora shuga yeropa yakakwira muvanhu vane Cushing's syndrome, chirwere chisingawanzoitiki chehomoni.

Pakuita pamuviri, mifepristone inenge ichishandiswa pamwe chete nemisoprostol, mumwe mushonga unokonzera kuti chibereko chibvumirane. Musanganiswa uyu unoshanda zvakanyanya uye unokubvumira kuti umise pamuviri pasina kuvhiyiwa muzviitiko zvakawanda.

MuCushing's syndrome, mifepristone inobatsira kudzora mazinga eshuga yeropa kana dzimwe nzira dzekurapa dzisina kushanda zvakanaka. Kushandiswa uku kunoda kunyatsoongororwa nenyanzvi dzinonzwisisa mamiriro akaoma aya.

Mifepristone inoshanda sei?

Mifepristone inoshanda nekudzivisa ma progesterone receptors mumuviri wako. Funga nezve progesterone sechinhu chakakosha uye ma receptors ayo semakiyi - mifepristone inochinja makiyi kuitira kuti chinhu chakakosha chisasashande zvakare. Izvi zvinoonekwa semaitiro akasimba uye anoshanda nekuti anokanganisa zvakananga kugona kwehomoni kushanda.

Kana progesterone isingakwanise kuita basa rayo, zvinhu zvakati wandei zvinoitika mumuviri wako. Ganda remudumbu rako rinotanga kuputsika, uye chibereko chako chinogona kutanga kupfava uye kuvhurika zvishoma. Shanduko idzi dzinogadzirira muviri wako mushonga wechipiri, misoprostol, uyo unokonzera kusangana kuti kubvise pamuviri.

Mushonga unowanzo kutanga kushanda mukati me24 kusvika kumaawa makumi mana nemasere mushure mekuutora. Zvisinei, iwe unowanzo kuda mushonga wechipiri kuti upedze maitiro acho zvinobudirira.

Ndingatora sei Mifepristone?

Mifepristone inotorwa sedosi imwe chete nemuromo, kazhinji muhofisi kana kiriniki yemupi wehutano wako. Unomedza piritsi rose nemvura - usapwanye, utaune, kana kuputsa. Mushonga unogona kutorwa uine kana usina chikafu, sezvo kudya kusinganyanyi kukanganisa mashandiro awo.

Mupi wako wehutano achakupa mirairo chaiyo yekuti utore rini mushonga wechipiri, misoprostol, kana uchishandisa mifepristone kubvisa pamuviri nemishonga. Nguva iyi yakakosha kuti kurapwa kushande nemazvo uye zvakachengeteka.

Haufaniri kudzivisa chero chikafu chakati wandei usati watora mifepristone, asi zvinobatsira kudya chimwe chinhu chakareruka kana uchinzwa kutya kana dumbu rako risina chinhu. Vamwe vanhu vanowana kuti kuva nechikafu chidiki kunobatsira kudzivirira kusvotwa.

Ndingatora Mifepristone kwenguva yakareba sei?

Pakubvisa pamuviri nemishonga, mifepristone inowanzo torwa sedosi imwe chete. Haufaniri kuitora kakawanda - dosi imwe chete inowanzoita zvese zvinodiwa nechinangwa ichi. Mhedzisiro yedosi imwe chete iyi inogona kugara kwemazuva akati wandei sezvo muviri wako uchigadzirisa mushonga.

Kana uchishandisa mifepristone yeCushing's syndrome, chiremba wako achasarudza kuti unofanira kuitora kwenguva yakareba sei zvichienderana nemamiriro ako chaiwo uye mhinduro yako kumushonga. Kushandiswa uku kunoda kuongororwa nguva dzose uye kugadziriswa.

Mupi wako wehutano achakupa mirairo yakajeka pamusoro pemisangano yekutevera kuti ave nechokwadi chekuti mushonga wakashanda sezvaitarisirwa uye kuti uri kupora zvakanaka.

Ndezvipi Zvinokonzerwa neMifepristone?

Semishonga yese, mifepristone inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese achaiwana. Mhedzisiro yakajairika ine chekuita nemhedzisiro yemushonga pane yako reproductive system uye mahomoni.

Heano mhedzisiro iwe yaunonyanya kuwana, uchifunga kuti zhinji dzeizvi zvikamu zvinotarisirwa zvemaitiro kana zvichishandiswa pakubvisa pamuviri:

• Kusvotwa uye kurutsa
• Dhiria kana kurwadziwa mudumbu
• Musoro
• Dizziness kana kunzwa lightheaded
• Kuneta kana kusava nesimba
• Kurwadziwa kwemumashure
• Kubuda ropa muvagina (kwaive kutarisirwa nekubvisa pamuviri)

Zvizhinji zvezvinhu izvi zvine mwero kusvika pakati nepakati uye zvinovandudzika mukati memazuva mashoma. Zvisinei, vamwe vanhu vanogona kuwana mhedzisiro yakakomba iyo inoda kutariswa kwekurapa nekukurumidza.

Mhedzisiro isingawanzoitiki asi yakakomba inogona kusanganisira kubuda ropa kwakanyanya kunopfuura mapads maviri akakora paawa kwemaawa maviri akatevedzana, zviratidzo zveutachiona senge fivha uye kutonhora, kana kurwadziwa kwakanyanya mudumbu kusingavandudzi nemishonga yekurwadziwa.

Muzviitiko zvisingawanzoitiki, vamwe vanhu vanogona kuwana allergic reactions, blood clots, kana matambudziko emoyo. Matambudziko akakomba aya haawanzoitiki asi anoda kutariswa kwekurapa nekukurumidza kana akaitika.

Ndiani Asingafaniri Kutora Mifepristone?

Mifepristone haisi yakachengeteka kune munhu wese, uye kune mamiriro akati wandei akakosha anoita kuti mushonga uyu usakodzere kana kuva nengozi. Chiremba wako achanyatsoongorora nhoroondo yako yezvokurapa asati akuraira.

Haufanire kutora mifepristone kana uine chero chimwe chezvinhu izvi, sezvo zvichigona kuwedzera njodzi yako yematambudziko akakomba:

• Kuzivikanwa kweallergy ku mifepristone kana misoprostol
• Kufungidzirwa ectopic pregnancy (pamuviri kunze kwechibereko)
• Kukundikana kweadrenal kwenguva refu
• Matambudziko ekubuda ropa kana kushandiswa kwazvino kwezvinoderedza ropa
• Inherited porphyria (chirwere chisingawanzoitiki cheropa)
• Matambudziko ekuwana rubatsiro rwekurapa rwekukurumidzira

Mamwe mamiriro ezvinhu anoda kungwarira kwakanyanya uye kunyatsoongorora. Izvi zvinosanganisira asthma yakakomba, chirwere chemoyo, BP yakakwira, matambudziko echiropa kana itsvo, uye chirwere chekuputika kwematumbu.

Kana uine intrauterine device (IUD), inofanira kubviswa usati watora mifepristone. Chiremba wako achakurukura izvi newe panguva yekugadzwa kwako.

Mazita eMifepristone Brand

MuUnited States, mifepristone inowanikwa pasi pezita remhando yeMifeprex kana ichishandiswa kubvisa pamuviri. Pakurapa Cushing's syndrome, inotengeswa pasi pezita remhando yeKorlym, kunyangwe iyi iri imwe fomula uye dosage.

Mishonga yese ine chinhu chimwe chete chinoshanda - mifepristone - asi yakagadzirwa zvakasiyana uye inoshandiswa kune zvinangwa zvakasiyana. Pharmacy yako ichapa vhezheni chaiyo iyo chiremba wako akakuraira kuti uine mamiriro ako chaiwo.

Mavhezheni eGeneric e mifepristone anowanikwawo mune dzimwe nguva, asi chiremba wako achasarudza kuti ndeipi fomula chaiyo yakakodzera zvaunoda.

Zvimwe Zvinhu Zvitsva zveMifepristone

Pane dzimwe nzira dziripo zvichienderana nechirwere chauri kurapa. Panyaya yekubvisa pamuviri munguva pfupi, kubvisa pamuviri nekuvhiyiwa ndiyo imwe nzira huru yekubvisa pamuviri nemishonga ine mifepristone. Izvi zvinosanganisira maitiro emunhu anobuda kunze kwenguva pfupi pane kutora mishonga.

Mamwe marongero ekubvisa pamuviri nemishonga aripo asi haanyanyi kushandiswa muUnited States. Mamwe acho anosanganisira mishonga yakasiyana kana nguva dzakasiyana, asi mifepristone yakasanganiswa nemisoprostol inoramba iri nzira yakanyanya kudzidzwa uye inoshandiswa zvakanyanya.

Panyaya yeCushing's syndrome, dzimwe nzira dzekurapa dzinosanganisira kuvhiyiwa kubvisa tuma, radiation therapy, kana mimwe mishonga inoshanda zvakasiyana nemifepristone kudzora mazinga e cortisol.

Mupi wako wehutano anogona kukurukura dzimwe nzira idzi newe uye kukubatsira kuona kuti ndeipi nzira ingave yakanakira mamiriro ako chaiwo uye zvaunofarira.

Ko Mifepristone Yakanaka Kupfuura Misoprostol Yoga?

Hongu, kusanganiswa kwemifepristone inoteverwa nemisoprostol kunoshanda zvakanyanya kupfuura kushandisa misoprostol yoga pakubvisa pamuviri nemishonga. Zvidzidzo zvinoratidza kuti kusanganiswa kunobudirira mune angangoita 95-98% yezviitiko, nepo misoprostol yoga ichibudirira mune angangoita 85-90% yezviitiko.

Kusanganiswa kunowanzoitawo nekukurumidza uye kunogona kukonzera kushushikana kusingaperi uye kubuda ropa zvichienzaniswa nemisoprostol yoga. Ichi ndicho chikonzero nei vazhinji vanopa hutano vachifarira nzira yemishonga miviri kana zvese zviripo.

Zvisinei, mune dzimwe nzvimbo dzepasi rose uko mifepristone isingawanikwi, misoprostol yoga ichiri kushandiswa seimwe nzira yakachengeteka uye inoshanda. Mupi wako wehutano achakurudzira nzira yakanakisa zvichienderana nezviri kuwanikwa uye zvakakodzera mamiriro ako.

Mibvunzo Inowanzo Bvunzwa Pamusoro peMifepristone

Ko Mifepristone Yakachengeteka Kune Vanhu vane Chirwere cheShuga?

Mifepristone inogona kushandiswa zvakachengeteka nevanhu vane chirwere cheshuga, asi inoda kunyatso tariswa. Mushonga uyu unogona kukanganisa mazinga eshuga yeropa, kunyanya kana uchishandisa chirwere cheCushing's syndrome. Chiremba wako achada kutarisa shuga yako yeropa zvakanyanya panguva yekurapa.

Kana uine chirwere cheshuga uye uchida mifepristone yekubvisa pamuviri, kushandiswa kwenguva pfupi kazhinji hakukonzere matambudziko akakosha nekudzora shuga yeropa. Zvisinei, unofanira kuzivisa chiremba wako nezvechirwere chako cheshuga kuti vakwanise kupa kutariswa kwakakodzera nekutarisirwa.

Ndoita Sei Kana Ndakatora Mifepristone Yakawandisa Netsaona?

Kana ukatora mifepristone yakawanda netsaona kupfuura yakarairwa, taura nechiremba wako kana nzvimbo yekudzora chepfu nekukasira. Kutora yakawanda kunogona kuwedzera njodzi yako yemigumisiro uye matambudziko.

Usayedze kuzviita kuti urutse kunze kwekunge wairairwa zvakananga nachiremba. Chengeta kurongwa kwemishonga newe kuti ugone kupa ruzivo rwakakodzera nezvechawakatora uye yakawanda sei.

Zviratidzo zvekuwandisa zvinogona kusanganisira kusvotwa kwakanyanya, kurutsa, manyoka, kana zviratidzo zvekushaya adrenal insufficiency senge kusava nesimba kwakanyanya uye kudzikira kweropa. Tsvaga rubatsiro rwekurapa nekukasira kana uine chero zviratidzo zvinonetsa.

Ndoita Sei Kana Ndikakanganwa Dose yeMifepristone?

Pakuita kubvisa pamuviri, mifepristone inowanzo piwa sedose imwe chete, saka kukanganwa dose kazhinji hakusi dambudziko. Zvisinei, kana uchifanira kutora mushonga wechipiri senge misoprostol uye ukakanganwa nguva iyoyo, taura nechiremba wako nekukasira kuti uwane gwara.

Kana uchitora mifepristone yeCushing's syndrome uye ukakanganwa dose, itore pakarepo paunorangarira kunze kwekunge yave nguva yekutora dose yako inotevera. Usatore madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa.

Mupi wehutano hwako achakupa mirairo chaiyo pamusoro penguva iyo yakakosha kuchengeteka kwako uye kushanda kwemushonga.

Ndingamira Rini Kutora Mifepristone?

Kuti uite kubvisa pamuviri nemishonga, unowanzo tora mifepristone kamwe chete, saka hapana kurapwa kuri kuenderera mberi kwekumisa. Zvisinei, uchada kugadzwa kwekutevera kuti uve nechokwadi chekuti kurapwa kwakabudirira uye kuti uri kupora zvakanaka.

Kana uri kutora mifepristone yeCushing's syndrome, usambomira kuitora kamwe kamwe usina kutaura nemupi wehutano hwako kutanga. Kumira kamwe kamwe kunogona kukonzera matambudziko akakomba ane chekuita nemagranzi ako eadrenal uye mazinga e cortisol.

Chiremba wako achatarisa mhinduro yako kurapwa uye achasarudza kana zvakachengeteka kuderedza muyero kana kumisa mushonga zvachose. Sarudzo iyi inoenderana nemamiriro ako ega uye kuti uri kupindura sei kurapwa.

Ndingava Nepamuviri Zvakare Mushure meKutora Mifepristone?

Hongu, mifepristone haina kukanganisa kubereka kwako kwemunguva yemberi kana kugona kuva nepamuviri. Kutenderera kwako kwemwedzi kunowanzo dzokera kune zvakajairika mukati mevhiki 4-8 mushure mekutora mifepristone yekubvisa pamuviri nemishonga.

Muchokwadi, unogona kuva nepamuviri zvakare nekukurumidza mushure mekutora mifepristone, kunyangwe usati wadzoka kumwedzi wako wekutanga. Kana usingadi kuva nepamuviri zvakare nekukurumidza, zvakakosha kutanga kushandisa nzira yekudzivirira pamuviri paunenge wagadzirira kutangazve kuita zvepabonde.

Mupi wako wehutano anogona kukurukura sarudzo dzekudzivirira pamuviri newe uye kukubatsira kusarudza nzira yakakodzera mamiriro ako uye zvaunoda.