Chii chinonzi Nadofaragene Firadenovec: Zvazvinoshandiswa, Mishonga, Mativi eMuviri uye Zvimwe

Nadofaragene firadenovec mushonga wemajini wakagadzirirwa kurapa mhando dzekenza yeguvhu. Mushonga uyu unoshanda nekutumira zvinhu zvemajini zvakananga mumasero ekenza yeguvhu kuti zibatsire masoja ako emuviri kuziva nekurwisa kenza zvakanyanya.

Kana iwe kana mumwe munhu waunoda akawanikwa aine kenza yeguvhu, kudzidza nezve sarudzo iyi yekurapa kunogona kunzwa kuremerwa. Ngatifambei nezvose zvaunoda kuziva nezve mushonga uyu nenzira inoita kuti zvinzwisisike uye zvinokubatsira kuti unzwe wakadzidziswa zvakanyanya nezvesarudzo dzako dzekutarisirwa kwehutano.

Chii chinonzi Nadofaragene Firadenovec?

Nadofaragene firadenovec mushonga wemajini unoshandisa hutachiona hwakachinjwa kutumira majini anorwisa kenza zvakananga kumasero ekenza yeguvhu. Mushonga uyu unopiwa kuburikidza ne catheter inoiswa muguvhu rako, ichibvumira mushonga kushanda chaizvo kwainodiwa zvakanyanya.

Mushonga uyu unomiririra nzira itsva yekurapa kenza inonzi immunotherapy. Panzvimbo yekushandisa mishonga yechinyakare ye chemotherapy inogona kukanganisa muviri wako wese, mushonga uyu unobatsira kudzidzisa masoja ako emuviri kuti azive zviri nani uye kurwisa masero ekenza muguvhu rako.

Mushonga uyu unozivikanwawo nezita rayo rekuti Adstiladrin. Yakagadzirirwa zvakananga vanhu vane mhando dzekenza yeguvhu dzisina kupindura zvakanaka kune dzimwe nzira dzekurapa.

Chii chinonzi Nadofaragene Firadenovec chinoshandiswa?

Mushonga uyu wemajini unoshandiswa kurapa high-grade non-muscle invasive bladder cancer ine genetic marker inonzi BCG-unresponsive carcinoma in situ. Izvi zvingaita sezvakaoma, asi chiremba wako achange aedza masero ako ekenza kuti aone kana mushonga uyu wakakukodzera.

Kurapa uku kunowanzofungwa kana dzimwe nzira dzekurapa, kunyanya BCG immunotherapy, dzisina kubudirira mukudzora kenza yako. BCG inowanzoita kurapa kwekutanga kwemhando iyi yekenza yeguvhu, uye kana ikamira kushanda zvakanaka, nadofaragene firadenovec inova sarudzo yakakosha.

Oncologist wako angakurudzira kurapa uku kana usiri munhu anokodzera kubviswa kwekuvhiya kweguvhu rako kana kana uchida kuyedza dzimwe sarudzo usati wafunga nezvekuvhiya. Chinangwa ndechekubatsira kudzora kenza uchichengetedza guvhu rako uye kuchengetedza hupenyu hwako.

Nadofaragene Firadenovec Inoshanda Sei?

Kurapa kwemajini uku kunoshanda nekushandisa adenovirus yakagadziridzwa sehurongwa hwekuendesa kuti iende nemajini ekurapa zvakananga mumaseru ako ekenza yeguvhu. Iro hutachiona hwakagadzirwa kuti huve hwakachengeteka uye hahugoni kukonzera kurwara, asi hunonyatsoita kupinda mumaseru.

Kana uri mukati memaseru ekenza, kurapa kunopa gene inogadzira protein inonzi interferon alfa-2b. Iyi protein inoita sesignal inoyambira immune system yako nezvekuvapo kwemaseru ekenza uye inobatsira kuronga mhinduro yakasimba yeimmune kwavari.

Funga nezvazvo sekupa immune system yako mirairo iri nani yekuti ingaziva sei uye kurwisa kenza. Kurapa kunoshanda munzvimbo yako yeguvhu, zvinoreva kuti inotarisa mhedzisiro yayo kwakanyatsoitika kenza panzvimbo yekukanganisa muviri wako wese.

Nzira iyi inoonekwa seyakatarisana nekurapa nekuti yakagadzirirwa kushanda zvakananga pamaseru ekenza ichisiya maseru ane hutano asina kukanganiswa zvakanyanya. Simba rekurapa uku riri mukunyatsoita kwayo uye kugona kwayo kushandisa dziviriro yako yechisikigo yeimmune.

Ndingatora Sei Nadofaragene Firadenovec?

Nadofaragene firadenovec inopiwa semushonga wakananga mudumbu rako kuburikidza necatheter, kwete semushonga kana jekiseni. Chikwata chako chekuchengetedza hutano chichabata maitiro ese ekupa, saka haufanirwe kunetseka nezvekutora mushonga uyu kumba.

Usati wapiwa mushonga wako, unozofanirwa kuderedza kunwa kwemvura kwemaawa anenge 4 kuti uve nechokwadi chekuti dumbu rako harina kuzara zvakanyanya. Chiremba wako achaisa chubhu diki, inochinjika inonzi catheter kuburikidza neurethra yako mudumbu rako, wobva wopa mushonga kuburikidza nechubhu iyi.

Mushonga wacho wapedza kupinda mudumbu rako, unozofanirwa kuuchengeta imomo kwemaawa anenge 1-2 usati watsvaga. Munguva iyi, unogona kukumbirwa kuchinja nzvimbo nguva nenguva kuti ubatsire mushonga kupfeka nzvimbo yese yemukati medumbu rako.

Mishonga inowanzo piwa kamwe chete mumwedzi mitatu. Chiremba wako achatarisa mhinduro yako kumishonga uye achasarudza chirongwa chakanakisa chemamiriro ako ega.

Ndingatora Nadofaragene Firadenovec Kwenguva Yakareba Sei?

Kureba kwemishonga ine nadofaragene firadenovec kunosiyana kubva kumunhu nemunhu uye zvinoenderana nekuti kenza yako inopindura sei kumishonga. Chiremba wako achatarisa nguva dzose kufambira mberi kwako ne cystoscopy uye mamwe maedzo kuti aone kuti mishonga inoshanda sei.

Vanhu vazhinji vanoenderera mberi nemishonga chero bedzi ichibatsira kudzora kenza yavo uye vachigamuchira zvakanaka. Vamwe varwere vanogona kugamuchira mishonga kwemwedzi yakati wandei kana kunyange makore, nepo vamwe vangangoda nzira pfupi yemishonga.

Oncologist wako achashanda newe kuti agadzire chirongwa chemishonga chinoyera zvakanakira mishonga inoenderera mberi nemhando yako yehupenyu uye hutano hwese. Kugadzwa kwekuongorora nguva dzose kuchabatsira kuona kana kuenderera mberi, kugadzirisa, kana kumisa mishonga.

Zvakakosha kuchengeta zvese zvako zvakagadzirirwa kusangana uye maedzo ekutevera, kunyangwe uchinzwa zvakanaka. Kushanya uku kunobatsira chikwata chako chekurapa kuita sarudzo dzakanakisa nezvekuchengetwa kwako kuri kuenderera mberi.

Ndezvipi Zvakaipa Zvinokonzerwa neNadofaragene Firadenovec?

Kufanana nemamwe marapirwo ekenza, nadofaragene firadenovec inogona kukonzera matambudziko, kunyangwe vanhu vazhinji vachigona kuitsungirira zvakanaka. Zvakaipa zvakajairika zvine chekuita neitsvo nemuviri wemvura, sezvo ndipo panopiwa mushonga.

Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye uzive nguva yekubata chikwata chako chehutano. Ngatitarisei zvakaipa zvaungasangana nazvo, tichitanga nezvakajairika:

Zvakaipa Zvakajairika

Izvi zvakaipa zvinoitika muvanhu vazhinji vanogamuchira kurapwa uku, asi zvinowanzo manejwa uye zvinowanzoita nani nekufamba kwenguva:

• Kusagadzikana kweitsvo kana kurwadziwa panguva yekuyera
• Kuwedzera kakawanda kwekuyera
• Kuda kukurumidza kuyera
• Ropa mumvura (hematuria)
• Kuneta kana kunzwa kuneta kupfuura zvakajairika
• Fivha yakapfava kana kutonhora
• Nausea

Izvi zviratidzo zvinowanzoitika mukati memazuva mashoma ekutanga mushure mekurapwa uye zvinowanzoenda zvega. Chiremba wako anogona kukurudzira nzira dzekugadzirisa izvi zvakaipa uye kukugadzirisa.

Zvakaipa Zvisingawanzoitiki asi Zvakakomba

Nepo zvisingawanzoitiki, zvimwe zvakaipa zvinoda kutariswa kwekurapa nekukurumidza. Bata chikwata chako chehutano nekukurumidza kana iwe ukaona:

• Kurwadziwa kwakanyanya kweitsvo kana spasms
• Kubuda ropa kwakanyanya mumvura
• Kusagona kuyera
• Fivha yakanyanya (inopfuura 101°F)
• Zviratidzo zvakakomba zvakaita sefuruwenza
• Zviratidzo zveutachiona

Chikwata chako chekurapa chichakupa mirairo chaiyo yekuti ungavadana rini uye zviratidzo zvekutarisa. Kuva neruzivo urwu kunobatsira kuona kuti unowana kutarisirwa nekukurumidza kana zvichidikanwa.

Zvakaipa Zvisingawanzoitiki

Vamwe vanhu vanogona kusangana nezvakaipa zvisingawanzoitiki zvinokanganisa dzimwe nhengo dzemuviri. Izvi zvinogona kusanganisira:

• Kuitika kwezvirwere zvakanyanya zvemuviri
• Maitiro emuviri wega wega anokanganisa nhengo dzemuviri dzakasiyana
• Kuitika kwezvirwere zvakanyanya zvinokonzerwa nekuzvimba
• Matambudziko ane chekuita nekupinzwa kwe catheter

Kunyange zvazvo izvi zvinokonzera matambudziko zvisingawanzoitiki, chikwata chako chehutano chakadzidziswa kuzviziva nekuzvigadzirisa nekukurumidza. Kubatsirwa kwekurapa kazhinji kunokunda njodzi idzi, kunyanya kune vanhu vane sarudzo shoma dzekurapa.

Ndiani Asingafaniri Kutora Nadofaragene Firadenovec?

Nadofaragene firadenovec haina kukodzera munhu wese ane gomarara rebladder. Chiremba wako achanyatsoongorora kana kurapwa uku kwakachengeteka uye kwakakodzera mamiriro ako chaiwo.

Kurapa uku hakufaniri kushandiswa kana uine hutachiona hweurinary tract hunoshanda kana kana uri kutora mishonga inodzvinyirira immune system inogona kukanganisa mashandiro ekurapa. Immune system yako inoda kushanda zvakanaka kuti iyi gene therapy ibudirire.

Vanhu vane mamwe mamiriro eautoimmune kana avo vakambove nemaitiro akakomba kune kurapwa kwakafanana munguva yakapfuura vangave vasiri vakakodzera kurapwa uku. Chiremba wako achatarisa nhoroondo yako yezvokurapa kuti aite izvi.

Vakadzi vane pamuviri kana vanoyamwisa havafaniri kugamuchira kurapwa uku, sezvo mhedzisiro pavacheche vari kukura isingazivikanwi. Kana uri pazera rekubereka, chiremba wako achakurukura nzira dzakakodzera dzekudzivirira pamuviri panguva yekurapa.

Nadofaragene Firadenovec Zita reBrand

Zita rebrand re nadofaragene firadenovec ndiAdstiladrin. Iri ndiro zita rauchaona pachirongwa chako chekurapa uye marekodhi ekurapa.

Adstiladrin inogadzirwa neFerring Pharmaceuticals uye yakatenderwa neFDA kunyanya kurapa gomarara rebladder risingapinduri kuBCG. Paunenge uchikurukura kurapwa kwako nekambani dzeinishuwarenzi kana vamwe vanopa hutano, ungangoda kushandisa zvese zita re generic uye zita rebrand.

Zita re Nadofaragene Firadenovec

Chikwata chako chekurapa chinowanzo chitaura nezvacho nezita ripi zvaro ravanoziva zvakanyanya, asi mazita ese ari maviri anoreva mushonga mumwe chete nekurapa kumwe chete.

Zvimwe Zvinhu Zvokutsiva Nadofaragene Firadenovec

Kana nadofaragene firadenovec isiri yakanaka kwauri kana isingashande zvakanaka, dzimwe nzira dzakawanda dzokurapa dziripo dzekenza yeguvhu. Nzira yakanakisisa yokutsiva inoenderana nerudzi rwako rwekenza uye utano hwako hwose.

Zvimwe zvirwere zveintravesical (zvakananga muguvhu) zvinosanganisira mhando dzakasiyana dzemishonga ye immunotherapy yakaita seBCG, kana usati waiedza, kana mishonga ye chemotherapy yakaita se mitomycin C kana gemcitabine. Kurapa uku kunoshanda nemaitiro akasiyana asiwo kunotumirwa zvakananga kuguvhu rako.

Kune vamwe vanhu, nzira dzekuvhiya dzinogona kufungwa, kusanganisira kubviswa kweguvhu (cystectomy) kana dzimwe nzira dzokubvisa tishu rekenza. Chiremba wako we urologist anogona kutsanangura nzira idzi uye kukubatsira kunzwisisa mabhenefiti nenjodzi dzenzira imwe neimwe.

Miedzo yekiriniki ichiongorora kurapwa kutsva kwekenza yeguvhu inowanzoitikawo. Miedzo iyi inokupa mukana wekurapa kwemazuva ano kusati kwawanikwa zvakanyanya asi kunoratidza vimbiso mukurapa rudzi rwako rwekenza.

Ko Nadofaragene Firadenovec Ari Nani Pane BCG Here?

Nadofaragene firadenovec neBCG zvinoshanda nemaitiro akasiyana, saka kuenzanisa zvakananga hakuna kunanga. BCG inowanzoita kurapwa kwekutanga kuyedzwa kwekenza yeguvhu isingapindi-muscle, nepo nadofaragene firadenovec inowanzo fungwa kana BCG yakamira kushanda.

BCG yakashandiswa kwemakumi emakore uye ine rekodhi yakasimbiswa yekushanda kune vanhu vazhinji vane kenza yeguvhu. Zvisinei, kana BCG ikatadza kudzora kenza kana kukonzera mhedzisiro isingashiviriki, nadofaragene firadenovec inopa imwe nzira inokosha.

Maitiro ekuti miviri inogamuchira mishonga iyi akasiyana. BCG inogona kukonzera zviratidzo zvakawanda zvakaita sefuruu, nepo nadofaragene firadenovec ichiita kunge inokonzera mhedzisiro yakawanda yakabatana neura. Vamwe vanhu vanotsungirira imwe zviri nani pane imwe.

Chiremba wako achakubatsira kunzwisisa kuti ndechipi chirwere chakakodzera mamiriro ako zvichienderana nemaitiro ekenza yako, nhoroondo yako yekurapa yapfuura, uye zvaunoda iwe pachako uye hutano hwako.

Mibvunzo Inowanzo Bvunzwa Nezve Nadofaragene Firadenovec

Ko Nadofaragene Firadenovec Yakachengeteka Kune Vanhu vane Chirwere Chemoyo?

Nadofaragene firadenovec inowanzoonekwa seyakachengeteka kune vanhu vane chirwere chemoyo nekuti inoshanda munzvimbo yeura panzvimbo yekukanganisa muviri wako wese. Zvisinei, chiremba wako wemoyo uye oncologist vanofanira kushanda pamwechete kuti vatarise hutano hwako hwese panguva yekurapa.

Kurapa hakuiti mhedzisiro yakabatana nemoyo, asi chero kurapwa kwekenza kunogona kuisa muviri wako kushushikana. Chikwata chako chekurapa chichaongorora mamiriro ako emoyo uye hutano hwese kuti uve nechokwadi chekuti kurapwa uku kwakakodzera kwauri.

Kana uine chirwere chemoyo, ita shuwa kuti unoudza oncologist wako nezve mishonga yako yese yemoyo, sezvo mimwe mishonga inogona kukanganisa immune system yako kana kuita pamwechete nekurapa kenza.

Ndoita Sei Kana Ndikakanganwa Dose ye Nadofaragene Firadenovec?

Sezvo nadofaragene firadenovec ichipiwa nechikwata chako chehutano munzvimbo yekurapa, kukanganwa dose kazhinji zvinoreva kukanganwa musangano wakarongeka. Kana izvi zvikaitika, taura nehofisi yeoncologist wako nekukurumidza sezvinobvira kuti urongezve.

Chirongwa chako chekurapa chakagadzirirwa kupa immune system yako nguva yekupindura uchichengeta kudzvinyirira kunoenderana pamasero ekenza. Kunonoka kurapwa kwenguva pfupi kazhinji hakukuvadzi, asi zvakakosha kuti udzokere kumashure nekukurumidza.

Chiremba wako angada kugadzirisa chirongwa chako chekurapa kana kukutarisa zvakanyanya kana paine kunonoka kukuru. Vachashanda newe kuti vaone nzira yakanakisa yekupfuurira kurapa kwako.

Ndingaita Sei Kana Ndikawana Zvakaipa Zvikuru Zvokurapa?

Kana ukaona zvakaipa zvakanyanya zvekushandisa mishonga zvakadai sekurwadziwa kwakanyanya kweguvhu, kubuda ropa kwakanyanya, fivha yakanyanya, kana kusakwanisa kuita weti, taura nechikwata chako chehutano nekukasira kana kuenda kukamuri yekukurumidzira. Zviratidzo izvi zvinoda kutariswa kwekurapa nekukurumidza.

Kune zviratidzo zvisina kuipa asi zvinonetsa, fonera hofisi ye oncologist wako panguva dzebhizinesi. Vanogona kupa gwara rekugadzirisa zvakaipa zvekushandisa mishonga uye kuona kana uchida kuonana navo nekukurumidza kupfuura kugadzwa kwako kunotevera.

Chengeta runyorwa rwezviratidzo zvako uye nguva zvinoitika. Ruzivo urwu runobatsira chikwata chako chekurapa kunzwisisa maitiro ako ekurapa uye kuita chero shanduko dzinodiwa kuronga kwako kutarisirwa.

Ndingamira Rini Kutora Nadofaragene Firadenovec?

Sarudzo yekumisa kurapwa kwe nadofaragene firadenovec inofanira kugara ichiitwa mukubvunzana ne oncologist wako. Unogona kumisa kurapwa kana kenza yako ichipindura zvakakwana uye ichiramba ichidzorwa, kana ukaona zvakaipa zvekushandisa mishonga zvisingashiviriki, kana kana kurapwa kukamira kushanda.

Chiremba wako achashandisa bvunzo dze cystoscopy dzenguva dzose, bvunzo dze weti, uye zvidzidzo zve imaging kuti atarise maitiro ako ekurapa. Zvichienderana nemigumisiro iyi, vachakurudzira kana kuenderera mberi, kugadzirisa, kana kumisa kurapwa kwako.

Kunyangwe ukamisa kurapwa, uchada kuenderera mberi nekutarisa kuti utarise kudzoka kwekenza. Chirongwa chako chekutevera-up chichagadzirirwa mamiriro ako ega uye maitiro ekurapa.

Ndingafamba Rini Munguva yeNadofaragene Firadenovec Kurapa?

Kufamba kazhinji kunogoneka panguva ye nadofaragene firadenovec kurapa, asi nguva inokosha. Zviri nani kudzivisa kufamba kwemazuva mashoma mushure mechikamu chega chega chekurapa, sezvo iyi ndiyo nguva iyo zvakaipa zvekushandisa mishonga zvichida kuitika.

Kana muri kuronga rwendo, kurukuriranai zvirongwa zvenyu nachiremba wenyu wezvirwere zvegomarara (oncologist) kare. Vanogona kukubatsira kuronga kurapwa kwenyu zvichienderana nemazuva enyu ekufamba uye kukupa gwara rekugadzirisa chero matambudziko anogona kuitika pamunenge muri kure.

Itai shuwa kuti munotora ruzivo rwekubata nachiremba wenyu uye muve nechirongwa chekuwana rubatsiro rwekurapa kana zvichidikanwa pamunenge muchifamba. Fungai nezve inishuwarenzi yekufamba inovhara matambudziko ekurapa, kunyanya kana muri kufamba kunze kwenyika.