Chii chinonzi Natalizumab: Zvazvinoshandiswa, Madosi, Mativi eMuviri uye Zvimwe

Natalizumab mushonga wakakosha unobatsira kudzora mamwe mamiriro eautoimmune uko immune system yako inokanganisa inorwisa zvikamu zvine hutano zvemuviri wako. Inopiwa kuburikidza neIV infusion mumasvondo mana ega ega uye inoshanda nekudzivisa maseru akati wandei eimmune kubva kupinda munzvimbo dzaanogona kukonzera kukuvadza.

Mushonga uyu unomiririra kufambira mberi kukuru mukurapa mamiriro akaita se multiple sclerosis uye Crohn's disease. Kunyange zvazvo ichishanda zvakanyanya kune vanhu vazhinji, inoda kunyatsoongororwa nekuda kwemamwe njodzi dzakakomba asi dzisingawanzoitiki dzatichakurukura munyaya ino.

Chii chinonzi Natalizumab?

Natalizumab imonoclonal antibody inonangana neprotein yakati wandei inonzi alpha-4 integrin pamaseru eimmune. Funga nezvayo seimwe nzira yekurapa inonangana zvakanyanya inodzivisa maseru akati wandei eimmune kubva kufamba kuenda kunzvimbo dziri mumuviri wako dzaangakonzera kuzvimba uye kukuvadza.

Mushonga uyu ndeweboka remishonga inonzi selective adhesion molecule inhibitors. Yakagadzirirwa kuve chaiyo mukuita kwayo, ichingotarisa chete maseru eimmune anobatsira kubasa rezvirwere pane kudzora immune system yako yese.

Mishonga inogadzirwa semhinduro yakanyanya iyo inofanirwa kuderedzwa uye kupiwa kuburikidza neintravenous infusion. Iyi nzira inovimbisa kuti mushonga unosvika zvakananga muropa rako uye unogona kutanga kushanda mumuviri wako wese.

Chii chinonzi Natalizumab chinoshandiswa?

Natalizumab inonyanya kunyorerwa mamiriro maviri makuru: mafomu ekudzoka e multiple sclerosis uye moderate kusvika kune severe Crohn's disease. Kune multiple sclerosis, inobatsira kudzivirira kudzoka uye kunonotsa kufambira mberi kwekuremara.

Mu multiple sclerosis, mushonga unodzivirira masero emuviri anorwisa zvirwere kubva kuyambuka chipingamupinyi cheropa-uropi, kwavanowanzo kurwisa chifukidzo chinodzivirira chinotenderedza tsinga dzemitsipa. Izvi zvinobatsira kuderedza kuzvimba muuropi uye muspinal cord, zvichikonzera kudzoka kushoma uye kufambira mberi kwemuviri kushoma.

Pazvirwere zveCrohn, natalizumab inoshanda nekudzivirira masero emuviri anorwisa zvirwere kubva kupinda munyama yematumbu uko anokonzera kuzvimba. Inowanzo chengeterwa vanhu vasina kupindura zvakanaka kune dzimwe nzira dzekurapa kana vane chirwere chine mwero kusvika chakanyanya.

Chiremba wako angangofungawo nezvemushonga uyu kana wakaedza dzimwe nzira dzekurapa pasina kubudirira, kana kana mamiriro ako ari kushanda zvakanyanya pasinei nedzimwe nzira dzekurapa. Sarudzo yekushandisa natalizumab inosanganisira kuyera mabhenefiti ayo pamwe nenjodzi dzinogona kuitika dzakatarisana nemamiriro ako ezvinhu.

Natalizumab Inoshanda Sei?

Natalizumab inoshanda nekudzivisa protein inonzi alpha-4 integrin iyo inoita sekiyi, ichibvumira masero emuviri anorwisa zvirwere kupinda mune dzimwe nyama. Nekudzivisa protein iyi, mushonga unodzivirira masero anozvimba kubva kusvika kunzvimbo dzavanogona kukonzera kukuvadza.

Izvi zvinoonekwa semushonga une simba zvine mwero une chiito chakatarwa. Kusiyana nedzimwe nzira dzekurapa dzinodzvinyirira muviri wese unodzivirira zvirwere, natalizumab inonyanya kutarisisa kufamba kwemasero emuviri anorwisa zvirwere, izvo zvinogona kuita kuti zviwedzere kushanda zvine zvishoma zvinogona kuitika zvemukati memuviri unodzivirira zvirwere.

Mishonga inotanga kushanda nekukurumidza, nevamwe vanhu vachiona kuvandudzwa mukati mekutanga infusions shoma. Zvisinei, zvinogona kutora mwedzi yakawanda kuti uone mabhenefiti akazara, uye mhedzisiro yacho inowedzera, zvinoreva kuti inovaka nekufamba kwenguva nekutarisirwa nguva dzose.

Paunomira kutora natalizumab, mhedzisiro yayo inopera zvishoma nezvishoma mumwedzi yakawanda. Ichi ndicho chikonzero nei kuchengetedza nguva yekupinza nguva dzose yakakosha pakuenderera mberi kwekushanda.

Ndingatora Sei Natalizumab?

Natalizumab inopiwa semushonga unoiswa mutsinga ropa mwedzi woga woga pavhiki ina panzvimbo yekutarisira hutano. Kuisa mushonga kunotora awa rimwe, uye uchafanira kutarisirwa kwenguva inenge awa rimwe mushure meizvozvo kuti uone kana paine zvinokurumidza kuitika.

Haufaniri kutsanya usati waiswa mushonga, uye unogona kudya zvakajairika pamazuva ekurapwa. Zvisinei, zvakanaka kuti ugare uine mvura yakawanda uye udye chikafu chakareruka usati waenda kunosangana nachiremba kuti zvikubatsire kunzwa zvakanaka panguva yekuita.

Madosi akajairika i300 mg akasanganiswa mumvura yemunyu. Chikwata chako chehutano chichaverenga huwandu chaihwo zvichienderana nehuremu hwemuviri wako uye mamiriro ako ehutano. Mushonga unoiswa zvishoma nezvishoma kuburikidza nemutsinga ropa kuti uderedze njodzi yekuitika kwemishonga.

Ronga kupedza maawa maviri kana matatu mukiriniki yekurapwa kwega kwega, kusanganisira nguva yekugadzirira uye kuongorora mushure meizvozvo. Vanhu vazhinji vanoona zvichibatsira kuuya nechinhu chekuverenga kana kuteerera panguva yekuisa mushonga.

Ndingatora Natalizumab Kwenguva Yakareba Sei?

Kureba kwekushandiswa kwe natalizumab kunosiyana zvakanyanya zvichienderana nekupindura kwako wega, mamiriro ari kurapwa, uye njodzi dzako. Vanhu vazhinji vane multiple sclerosis vanoi tora kwemakore akati wandei, nepo nguva yekurapa chirwere cheCrohn inogona kuve pfupi.

Chiremba wako achagara achiongorora kupindura kwako kurapwa uye achatarisa chero zviratidzo zvemigumisiro yakakomba. Kuongorora uku kunoenderera mberi kunobatsira kuona kana kuramba kurapwa kuchiri sarudzo yakanakisa kwauri.

Vamwe vanhu vangangoda kuzorora kubva mukurapwa kana kuchinjira kune mamwe mishonga kana zvimwe zvinokonzera njodzi zvikaitika. Sarudzo pamusoro penguva yekurapa inogara ichiitwa pamwe chete pakati pako nechikwata chako chehutano.

Kutarisa nguva dzose kunosanganisira bvunzo dzeropa uye periodic MRI scans kuti uone kufambira mberi kwemamiriro ako uye utarise chero shanduko dzinotyisa. Kutarisisa uku kunobatsira kuona kuti unowana rubatsiro rwakanyanya uchideredza njodzi.

Ndezvipi Zvakaipa ZveNatalizumab?

Semishonga yese, natalizumab inogona kukonzera zvakaipa, kunyangwe kwete munhu wese achizviwana. Zvakaipa zvakawanda zviri nyore kusvika pakati nepakati uye zvinogoneka, asi pane njodzi dzakakomba dzinoda kutariswa zvakanaka.

Hezvino zvakaipa zvakajairika zvinowanikwa nevanhu vazhinji, uye zvakakosha kuziva kuti izvi zvinowanzoitika uye zvinowanzoita nani nekufamba kwenguva:

• Kutemwa nemusoro uye kuneta, izvo zvinowanzoitika mukati mezuva rekutanga mushure mekuiswa
• Kusvotwa uye kusagadzikana mudumbu, kazhinji nyoro uye kwenguva pfupi
• Kurwadziwa mumajoini uye kurwadziwa kwemhasuru
• Kuita kwekuiswa senge flushing, dzungu, kana zviratidzo zvidiki zveallergy
• Zvirwere zvepamusoro zvekufema
• Zvirwere zvegumbo remvura

Izvi zvakaipa zvakajairika zvinowanzoita kuti zvisamire kurapwa uye zvinogona kugadziriswa nekutarisirwa kunotsigira kana kugadzirisa zvishoma kune yako kurapwa kwenguva dzose.

Zvisinei, pane zvimwe zvakaipa zvakakomba asi zvisingawanzoitiki zvinoda kutariswa kwekurapa nekukurumidza. Inonyanya kukonzera ndiyo progressive multifocal leukoencephalopathy (PML), chirwere cheuropi chisingawanzoitiki chinogona kuva chinotyisa upenyu:

• PML, iyo inokanganisa vanhu vashoma pane 1 muna 1,000 vachitora natalizumab
• Zvakanyanya allergic reactions, kusanganisira anaphylaxis
• Matambudziko echiropa, kusanganisira hepatitis
• Herpes encephalitis, chirwere cheuropi chakakomba
• Zvakanyanya ganda reactions

Chikwata chako chehutano chichakutarisa zvakanyanya kune izvi zvakaipa zvakakomba kuburikidza nekuongororwa kweropa nguva dzose, MRI scans, uye kuongororwa kwekiriniki. Njodzi yePML yakakwira muvanhu vane zvimwe zvinhu zvine njodzi, izvo chiremba wako achaziva asati atanga kurapwa.

Ndiani Asingafaniri Kutora Natalizumab?

Natalizumab haikodzerani nemunhu wese, uye pane mamiriro chaiwo apo njodzi dzinopfuura mabhenefiti. Chiremba wako achanyatsoongorora nhoroondo yako yezvokurapa uye mamiriro ako ehutano aripo usati akurudzira kurapwa uku.

Zvinhu zvakakosha zvikuru zvingakutadzisa kutora natalizumab zvinosanganisira kuva ne immune system yakakanganiswa kana hutachiona hunoshanda. Vanhu vane HIV, gomarara, kana avo vari kutora mishonga yekudzivirira immune system havafaniri kushandisa mushonga uyu.

Heano mamiriro makuru uye mamiriro apo natalizumab haikurudzirwi:

• Hutachiona hunoshanda, kunyanya hutachiona hwehutachiona hunokanganisa uropi
• Immunodeficiency disorders kana immune system kudzvinyirirwa
• Nhoroondo yapfuura yePML
• Mamwe magomarara, kunyanya magomarara eropa
• Kuzvitakura, kunze kwekunge mabhenefiti achipfuura njodzi zvakajeka
• Chirwere chakakomba chechiropa

Chiremba wako achafungawo nezve JC virus status yako, sezvo vanhu vanoedzwa vaine hutachiona hwehutachiona uhu vane njodzi yakakwira yekuvandudza PML. Izvi hazvikubvise iwe kubva mukurapwa, asi zvinoda kunyatso tarisa uye kuongorora njodzi.

Kana uine chero mamiriro aya kana zvinhu zvine njodzi, chiremba wako achakurukura dzimwe nzira dzekurapa dzinogona kukodzera mamiriro ako.

Mazita eNatalizumab Brand

Natalizumab inonyanya kuzivikanwa nezita rayo rekuti Tysabri, iro rinogadzirwa neBiogen. Iyi ndiyo yekutanga formulation yakadzidzwa zvakanyanya uye yakashandiswa zvakanyanya kubvira payakabvumidzwa.

Mune dzimwe nyika, unogona kusangana nemashandisirwo e biosimilar e natalizumab, ayo ari makopi akafanana emushonga wekutanga. Izvi zvinotsiva zvine chinhu chimwe chete chinoshanda uye zvinoshanda nenzira imwecheteyo seyemhando yekutanga.

Zvisinei nezita remhando, mhando dzese dze natalizumab dzinoda kutarisa kwakanyatsonaka uye nzira dzekuchengetedza. Chikwata chako chekuchengetedza hutano chichaziva chero mhando iripo munzvimbo yako.

Zvimwe Zvinhu Zviri Mutsiva Natalizumab

Mishonga yakati wandei inogona kurapa multiple sclerosis uye chirwere cheCrohn, kunyangwe imwe neimwe iine zvainobatsira uye njodzi dzayo. Kusarudzwa kweimwe nzira kunoenderana nemamiriro ako chaiwo, kurapwa kwakapfuura, uye zvinhu zvengozi zvemunhu.

Kune multiple sclerosis, dzimwe nzira dzinosanganisira mamwe marapirwo anochinja chirwere senge ocrelizumab, fingolimod, kana dimethyl fumarate. Imwe neimwe yeiyi inoshanda zvakasiyana uye inogona kunge yakakodzera zvichienderana nemaitiro ako echirwere uye zvaunofarira.

Kune chirwere cheCrohn, dzimwe nzira dzinogona kusanganisira mamwe mishonga yebhayoloji senge adalimumab, infliximab, kana vedolizumab. Mishonga iyi inotarisa zvikamu zvakasiyana zve immune system uye inogona kukodzera kana natalizumab isina kukodzera iwe.

Chiremba wako achakubatsira kuyera zvakanakira nezvakaipira zvezvinhu zvakasiyana zvekutsvaga kurapwa zvichibva munhoroondo yako yekurapa, zviratidzo zvazvino, uye zvinangwa zvekutsvaga kurapwa. Dzimwe nguva kuyedza mushonga wakasiyana kunotungamira kumigumisiro iri nani ine mashoma mativi.

Natalizumab Yakanyanya Here Pane Mamwe Mishonga Yakafanana?

Natalizumab inoshanda zvakanyanya kune vanhu vazhinji, asi kana iri "iri nani" pane mamwe mishonga zvinoenderana nemamiriro ako ega. Inoonekwa seimwe yeanonyanya kushanda marapirwo anowanikwa e multiple sclerosis, aine humbowo hwakasimba hwekuderedza kudzoka uye kunonotsa kufambira mberi kwechirwere.

Ichienzaniswa nemamwe marapirwo, natalizumab inowanzo ratidza kushanda kwakanyanya mumiedzo yekiriniki, kunyanya kune vanhu vane chirwere chinoshanda. Zvisinei, kushanda kwakanyanya uku kunouya nezvinodiwa zvakawedzerwa zvekutarisa uye njodzi dzakakosha dzisina mamwe mishonga.

Sarudzo yekuti mushonga upi wakanakisa inosanganisira kuenzanisa kushanda zvakanaka, kuchengeteka, nyore, uye zvaunofarira iwe pachako. Vamwe vanhu vanosarudza chirongwa chejekiseni remwedzi, nepo vamwe vachisarudza mishonga yemuromo yezuva nezuva kana majekiseni asingawanzoitiki.

Chikwata chako chehutano chichakubatsira kunzwisisa kuti natalizumab inoenzaniswa sei nedzimwe sarudzo zvichibva pakutsvagurudza kwazvino uye zvaunoda zvekurapa. Zvinoshanda zvakanakisa kune mumwe munhu zvingasava zvakanaka kune mumwe.

Mibvunzo Inowanzo Bvunzwa Nezve Natalizumab

Q1. Natalizumab Yakachengeteka Here Kune Vanhu Vane Zvimwe Zvirwere Zvekuzvitakura?

Natalizumab inogona kushandiswa kune vanhu vane zvimwe zvirwere zvekuzvitakura, asi izvi zvinoda kuongororwa zvakanyatsoitwa nechikwata chako chehutano. Kuva nezvirwere zvakawanda zvekuzvitakura hakukudzivisi otomatiki kushandisa natalizumab, asi zvinogona kukanganisa chirongwa chako chekurapa uye chirongwa chekutarisa.

Chiremba wako achada kufunga kuti natalizumab ingaite sei pamwe chete nemishonga yezvimwe zvirwere zvako. Dzimwe mishonga inoshandiswa kuzvirwere zvekuzvitakura inogona kuwedzera njodzi yekutapukirwa kana ikasanganiswa ne natalizumab.

Chinhu chakakosha kutaurirana pachena nevapi vako vese vehutano kuti uve nechokwadi chekuti vanonzwisisa mufananidzo wako wekurapa wakazara. Izvi zvinovabatsira kuita sarudzo dzakachengeteka uye dzinoshanda dzekurapa hutano hwako hwese.

Q2. Ndingaita Sei Kana Ndikakanganwa Dose yeNatalizumab?

Kana iwe ukakanganwa jekiseni rako re natalizumab rakarongeka, taura nechikwata chako chehutano nekukurumidza sezvinobvira kuti urongezve. Kazhinji, kana iwe wakareba svondo rimwe chete, unogona kungotangazve chirongwa chako chakajairika nejekiseni rinotevera.

Zvisinei, kana iwe wakakanganwa dose yako kwemavhiki anopfuura rimwe kana maviri, chiremba wako angangoda kuongorora kana zvakachengeteka kuenderera mberi kana kana iwe uchida kumwe kutariswa usati watangazve kurapwa. Kuzorora kwenguva refu kubva ku natalizumab dzimwe nguva kunogona kutungamira mukumutsiridzwa kwechirwere.

Usayedze kuwedzera mishonga kana kuchinja purogiramu yako pasina gwara rechiremba. Chikwata chako chekuchengetwa kwehutano chichakubatsira kuti udzokere munzira apo vachivimbisa kuchengeteka kwako uye kushanda zvakanaka kwemishonga.

Q3. Ndingaita Sei Kana Ndine Reaction yeInfusion?

Kana ukaona zviratidzo panguva kana nguva pfupi mushure mekuiswa kwako natalizumab, zivisa chikwata chako chekuchengetwa kwehutano nekukasira. Zviratidzo zvakajairika zvekuiswa zvinosanganisira flushing, dzungu, kusvotwa, kana kuita kweganda, uye zvakawanda zvinogona kutariswa zvakanaka.

Chikwata chako chekurapa chakadzidziswa kubata nekuita kwekuiswa uye chichava nemishonga iripo yekuvabata. Vanogona kuderedza kumhanya kwekuiswa, kukupa mishonga yekuderedza kuita, kana kumisa kwechinguvana kuisa kana zvichidikanwa.

Maitiro mazhinji ekuiswa akapfava uye haakudzivise kuti uenderere mberi nekurapa. Zvisinei, kana uine reaction yakakomba, chiremba wako achada kuongorora kana natalizumab ichiramba yakachengeteka kwauri kana kana uchida kuchinja kune imwe kurapwa.

Q4. Ndingamira Rini Kutora Natalizumab?

Sarudzo yekumisa natalizumab inofanira kugara ichiitwa mukubvunzana nechikwata chako chekuchengetwa kwehutano. Vamwe vanhu vangada kumira nekuda kwemigumisiro, kushaya kushanda, kana shanduko mukuisa kwavo njodzi, nepo vamwe vachigona kuenderera mberi kwemakore mazhinji.

Chiremba wako achatarisa nguva dzose mhinduro yako kurapwa uye chero zvinhu zvitsva zvengozi zvingaitika. Iyi ongororo inoenderera mberi inobatsira kuona nguva yakakodzera yekufunga kumisa kana kuchinja kurapwa.

Kana iwe ukamisa natalizumab, chiremba wako anogona kukurudzira kutanga imwe kurapwa kudzivirira chirwere chekudzokazve. Nguva yekuchinja uku yakakosha uye inoda kuronga zvakanaka kuchengetedza kutonga kwechirwere.

Q5. Ndingawana Majekiseni Ndiri Kutora Natalizumab Here?

Unogona kuwana majekiseni mazhinji uchitora natalizumab, asi zvakakosha kuti utaure izvi nechikwata chako chehutano kutanga. Majekiseni mhenyu kazhinji haakurudzirwi, asi majekiseni asina basa anowanzo chengeteka uye anokurudzirwa.

Chiremba wako anogona kukurudzira mamwe majekiseni, kunyanya jekiseni regore negore reflu, kuti akubatsire kukudzivirira kubva kuzvirwere apo immune system yako iri kuchinjwa nemushonga. Nguva yekujekeswa maererano ne infusions yako inogona kukosha kuti ive yakanyanya kushanda.

Chengeta rekodhi rejekiseni rako uye ugovane ruzivo urwu nevapi vako vese vehutano. Izvi zvinobatsira kuona kuti unogara uchiziva nezvekudzivirirwa kunokurudzirwa uchichengetedza kuchengeteka kwako pa natalizumab.