Chii chinonzi Neratinib: Zvinoshandiswa, Mishonga, Zvazvinokonzera uye Zvimwe

Neratinib mushonga wekenza unovavarira uyo unoshanda nekudzivisa mapuroteni chaiwo anobatsira maseru ekenza yemazamu kuti akure nekupararira. Chikamu cheboka remishonga inonzi tyrosine kinase inhibitors, iyo inoshanda semashandisirwo emamorekuru anogona kudzima zviratidzo zvekukura kweseru rekenza.

Mushonga uyu unomiririra kufambira mberi kukuru mukurapa kenza yemazamu, uchipa tariro kuvatenda vane HER2-positive breast cancer. Unogona kunyorerwa neratinib kana wapedza kurapwa kwekutanga uye uchida kurapwa kwakawedzerwa kubatsira kudzivirira kenza kubva pakudzoka.

Neratinib Inoshandiswa Kunei?

Neratinib inonyanya kushandiswa kurapa vanhu vakuru vane early-stage HER2-positive breast cancer. Yakagadzirirwa zvakananga varwere vakambogamuchira trastuzumab (Herceptin) kurapwa uye vanoda imwe kurapwa kuderedza njodzi yekudzoka kwekenza.

Mishonga inoshanda sezvinodaidzwa nachiremba kuti "extended adjuvant therapy." Izvi zvinoreva kuti inopiwa mushure mekurapwa kwako kwekutanga kuti ipe imwe nzira yekudzivirira kenza kuti isadzoke. Oncologist wako angakurudzira neratinib kana wapedza chemotherapy yako yekutanga uye trastuzumab kurapwa mukati megore rapfuura.

Mune dzimwe nguva, neratinib inoshandiswawo kurapa advanced kana metastatic HER2-positive breast cancer, kunyanya kana ichishandiswa pamwe chete nemimwe mishonga yakaita secapecitabine. Iyi application inobatsira varwere vane kenza yakapararira kune dzimwe nhengo dzemuviri.

Neratinib Inoshanda Sei?

Neratinib inotarisa uye inovharisa mapuroteni akawanda mumhuri yeHER (human epidermal growth factor receptor), kunyanya HER2 uye EGFR. Mapuroteni aya anoshanda semashandisirwo anoudza maseru ekenza kuti akure nekukwana nekukurumidza.

Fungidzira maseru ekenza aine akawanda "on" switches ekukura. Neratinib inoshanda nekubatanidza zvachose kune aya ma switches uye kuachengeta munzvimbo ye "off". Izvi zvakasiyana nemamwe mishonga yekenza inongovharisa zviratidzo izvi kwenguva pfupi.

Seimwe nzira yekurapa yakatarwa zvine simba, neratinib ine simba kupfuura kurapa kwehomoni asi kazhinji inokonzera mashoma matambudziko akakomba kupfuura chemotherapy yechinyakare. Mushonga uyu unonyanya kutarisana nemasero ekenza uine kushoma kukanganisa kumasero ane hutano, kunyangwe iwe uchiri kuona mamwe matambudziko.

Ndingatora sei Neratinib?

Tora neratinib sezvakanyorwa nachiremba wako, kazhinji kamwe pazuva uine chikafu. Kuitora nechikafu kunobatsira muviri wako kutora mushonga zviri nani uye kunogona kuderedza dumbu.

Medza mahwendefa ese nemvura - usapwanya, kutsenga, kana kuapwanya. Kana uine dambudziko rekumedza mapiritsi, taura nechikwata chako chehutano nezve nzira dzinogona kubatsira, asi usambochinja mahwendefa iwe pachako.

Chiremba wako anogona kukurudzira kudya chikafu chakareruka kana snack usati watora neratinib. Dzivisa grapefruit uye muto wegrapefruit paunenge uri pamushonga uyu, sezvo zvinogona kukanganisa maitiro emuviri wako ekugadzirisa mushonga. Zvakakoshawo kutora neratinib panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana mumuviri wako.

Ndingatora Neratinib Kwenguva Yakareba Sei?

Vazhinji varwere vanotora neratinib kwegore rimwe (12 mwedzi) kana ichishandiswa seyakawedzerwa adjuvant therapy. Oncologist wako achasarudza nguva chaiyo zvichienderana nemamiriro ako chaiwo uye kuti unotsungirira sei mushonga.

Nguva yekurapa haina kusarudzika - tsvagiridzo inoratidza kuti gore rimwe rekurapa neratinib rinopa chiyero chakakwana pakati pekubudirira uye matambudziko anogoneka. Vamwe varwere vanogona kuda kutora zororo kana kugadzirisa chirongwa chavo chekushandisa kana vaine matambudziko akakosha.

Usambomira kutora neratinib kamwe kamwe usati wataura nachiremba wako kutanga. Kunyangwe kana uchinzwa zvakanaka, kupedzisa nzira yese yekurapa kwakakosha kuti uwane rubatsiro rwakanyanya. Chikwata chako chehutano chichakutarisa iwe mukati mekurapa uye chichaita shanduko sezvinodiwa.

Ndezvipi Zvakaipa zveNeratinib?

Chinhu chinowanzoitika cheneratinib manyoka, iyo inokanganisa vanenge vese varwere vanotora mushonga uyu. Izvi zvinowanzo kutanga mukati memazuva mashoma ekutanga ekurapa uye zvinogona kukosha pakutanga.

Heano mativi akashumwa kazhinji aunogona kusangana nawo:

• Manyoka (anowanzoita akakomba mumwedzi wekutanga)
• Nausea nekutsvuka
• Kurwadziwa mudumbu nekukotsirana
• Kuneta nekupera simba
• Kurasikirwa nechido
• Maronda mumuromo
• Mavanga paganda kana shanduko dzembambo

Chiremba wako anogona kunyora mishonga inopesana nemanyoka kuti ibatsire kubata iyi mhedzisiro. Vazhinji varwere vanowana kuti manyoka anova nyore kubata mushure memwedzi wekutanga wekurapa.

Zvisingawanzoitiki asi zvakanyanya kukomba mhedzisiro inogona kusanganisira kupera mvura mumuviri kubva kumanyoka, matambudziko echiropa, uye nyaya dzemoyo. Bata chikwata chako chehutano nekukasira kana ukaona kutsvuka kusingaperi, zviratidzo zvekupera mvura mumuviri, kuita yero yeganda kana maziso, kana kufema kusinganzwisisike.

Mamwe mativi asingawanzoitiki asi akakomba anosanganisira maitiro akakomba eganda, kuzvimba kwemapapu, uye shanduko dzakakosha mukushanda kwechiropa. Kunyangwe izvi zvisingawanzoitiki, zvakakosha kupinda mune zvese zvako zvakarongeka zvekutarisa kuti chiremba wako agone kubata chero matambudziko ekutanga.

Ndiani Asingafaniri Kutora Neratinib?

Neratinib haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wairaira. Hauzofaniri kutora neratinib kana uine allergy kwairi kana chero zvayo zvinosanganiswa.

Mamwe mamiriro ezvinhu ekurapa anogona kuita kuti neratinib isachengeteke kwauri. Chiremba wako achanyatso chenjerera kana uine:

• Kutadza kwakanyanya kwechiropa kana matambudziko ekuita basa rechiropa
• Matambudziko emoyo kana kutadza kwemoyo
• Kutadza kwakanyanya kwematsvo
• Zvirwere zvinoshanda
• Chirwere chematumbu chinopisa
• Nhoroondo yekurwadziwa kwakanyanya kwemudumbu nemimwe mishonga

Kuzvitakura nekuyamwisa zvinhu zvakakoshawo. Neratinib inogona kukuvadza mwana asati aberekwa, saka unozofanira kushandisa nzira yekudzivirira kubata pamuviri panguva yekurapwa uye kwemwedzi mumwechete mushure memushonga wako wekupedzisira.

Kana uri kuyamwisa, unozofanira kumira panguva yaunotora neratinib uye kwemwedzi mumwechete mushure memushonga wako wekupedzisira. Mushonga unogona kupinda mumukaka wemazamu uye unogona kukuvadza mwana ari kuyamwiswa.

Mazita eNeratinib Brand

Neratinib inowanikwa pasi pezita rekuti Nerlynx muUnited States nedzimwe nyika zhinji. Uyu ndiyo mhando yemushonga inonyanya kunyorerwa.

Dzimwe nyika dzinogona kunge dziine mazita akasiyana emhando kana shanduro dzakajairika dziripo. Nguva dzose tarisa nemupharmacist wako kuti uve nechokwadi chekuti uri kugamuchira mushonga wakarurama, uye usambotsiva mhando dzakasiyana pasina mvumo yachiremba wako.

Zvimwe Zvinotsiva Neratinib

Mishonga yakati wandei inogona kurapa kenza yemazamu yeHER2-positive, kunyangwe sarudzo yakanakisa inoenderana nemamiriro ako chaiwo. Zvimwe zvinotsiva zvinosanganisira trastuzumab (Herceptin), pertuzumab (Perjeta), uye T-DM1 (Kadcyla).

Kunyanya kurapwa kwe adjuvant kwakawedzerwa, chiremba wako angangofunga kuenderera mberi ne trastuzumab kwegore rimwezve panzvimbo yekuchinja kuenda ku neratinib. Vamwe varwere vanogona kunge vari vakakodzera kuyedzwa kwekiriniki kuyedza mishonga mitsva kana misanganiswa.

Sarudzo pakati pezvisarudzo izvi inoenderana nezvinhu zvakaita semaitiro ekenza yako, kurapwa kwakapfuura, hutano hwese, uye zvaunofarira. Oncologist wako achakubatsira kuyera mabhenefiti nenjodzi dzesarudzo imwe neimwe.

Neratinib Ari Nani Kupfuura Trastuzumab Here?

Neratinib na trastuzumab anoshanda zvakasiyana uye anowanzo shandiswa panguva dzakasiyana dzekurapa, saka kuenzanisa zvakananga hakuna kunanga. Trastuzumab inowanzo shandiswa sechikamu chekurapa kwekutanga, nepo neratinib inowanzo kupiwa mushure meizvozvo sekurapa kwakawedzerwa.

Tsvagiridzo inoratidza kuti kuwedzera neratinib mushure mekupedza kurapwa kwe trastuzumab kunogona kuwedzera kuderedza njodzi yekudzoka kwekenza zvichienzaniswa ne trastuzumab chete. Zvisinei, neratinib inowanzoita zvimwe zvinokonzera, kunyanya manyoka.

Sarudzo ye "zvirinani" inoenderana nemamiriro ako ega, kusanganisira maitiro ako ekenza, maitiro ako akashandisa kurapwa kwapfuura, uye hutano hwako hwese. Chiremba wako wekenza achakubatsira kunzwisisa kuti ndeipi nzira inoita zvakanyanya kunzwisisika kune mamiriro ako chaiwo.

Mibvunzo Inowanzo Bvunzwa Pamusoro peNeratinib

Neratinib Yakachengeteka Kune Vanhu vane Chirwere cheShuga?

Neratinib inogona kushandiswa zvakachengeteka muvanhu vane chirwere cheshuga, asi mazinga ako eshuga yeropa anogona kuda kuongororwa zvakanyanya. Mushonga hauna zvakananga kukanganisa glucose yeropa, asi mhedzisiro yakaita semanyoka, kusvotwa, uye shanduko muvimbiso inogona kuita kuti manejimendi echirwere cheshuga ave nematambudziko.

Chikwata chako chehutano chichashanda newe kugadzirisa mishonga yako yechirwere cheshuga kana zvichidikanwa uye kukubatsira kuchengetedza kutonga kwakanaka kweshuga yeropa mukati mekurapa. Zvakakosha zvikuru kuti ugare uine mvura yakakwana uye uchengetedze chikafu chakanaka pasinei nemhedzisiro inogona kuitika.

Ndingaita Sei Kana Ndikatora Neratinib Yakawandisa Netsaona?

Kana netsaona ukatora neratinib yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira. Usamirira kuti uone kana zviratidzo zvichikura - kuwana zano rekurapa nekukurumidza kwakakosha.

Kupfuura muyero unogona kukonzera shanduro dzakakomba dzemhedzisiro yakajairika, kunyanya manyoka, kusvotwa, uye kurutsa. Chikwata chako chehutano chinogona kukurudzira kurapwa kwakakosha kubatsira kubata izvi zviratidzo uye kukutarisa iwe kuti utarise matambudziko.

Ndingaita Sei Kana Ndakanganwa Kudya Mushonga weNeratinib?

Kana ukakanganwa kudya mushonga we neratinib, udye paunorangarira musi iwoyo. Asi, kana yava nguva yekudya mushonga unotevera, siya mushonga wakakanganwa uenderere mberi nechirongwa chako chekudya mishonga.

Usambofa wakadya mishonga miviri panguva imwe chete kuti ugadzirise mishonga yakakanganwa. Izvi zvinogona kuwedzera njodzi yako yekuwana matambudziko akakomba. Kana uchikanganwa kudya mishonga kakawanda, funga nezvekugadza zviyeuchidzo pafoni yako kana kushandisa chirongwa chemishonga kuti zvikubatsire kuti urambe uchidya mishonga yako.

Ndingamira Rini Kudya Neratinib?

Unofanira kungomira kudya neratinib kana chiremba wako akakuudza, kazhinji mushure mekupedza gore rose rekurapwa. Kumira nekukurumidza kunogona kuderedza kushanda kwemushonga mukudzivirira kudzoka kwekenza.

Kana uri kusangana nematambudziko akakomba, taura nachiremba wako nezvekugadzirisa mushonga wako kana kutora zororo kwenguva pfupi pane kumira zvachose. Chikwata chako chehutano chinogona kukubatsira kuwana nzira dzekugadzirisa matambudziko uchiri kuwana zvizere zvekubatsirwa nekurapwa.

Ndinganwa Doro Here Ndichidya Neratinib?

Kunyange hazvo pasina hukama hwakananga pakati pe neratinib nedoro, zviri nani kudzora kana kudzivisa doro panguva yekurapwa. Doro rinogona kuwedzera mamwe matambudziko akadai sekunzwa kusvotwa uye dumbu, uye rinogona kukanganisa kugona kwemuviri wako kugadzirisa mushonga.

Uyezve, doro rinogona kuita kuti muviri uome, izvo zvinonyanya kukosha sezvo manyoka ari matambudziko anowanzoitika e neratinib. Kana ukasarudza kunwa dzimwe nguva, ita izvi zvine mwero uye ita shuwa kuti unogara uine mvura yakakwana mumuviri.