Chii chinonzi Nintedanib: Kushandiswa, Dosage, Side Effects uye Zvimwe

Nintedanib mushonga unopiwa nachiremba unobatsira kunonotsa kuvharika kwemapapu muvanhu vane zvirwere zvakakomba zvemapapu. Yakagadzirirwa zvakananga kutarisa mapuroteni anokonzera kuumbwa kwetishu yakawandisa mumapapu ako, ichipa muviri wako mukana wekufema zviri nyore nekufamba kwenguva.

Mushonga uyu unomiririra kubudirira kukuru mukurapa mamiriro aichimbova asingarapike. Kunyangwe isingakwanise kurapa kuvharika kwemapapu, inogona kunonotsa zvakanyanya kufambira mberi kwayo uye kubatsira kuchengetedza hupenyu hwako.

Chii chinonzi Nintedanib?

Nintedanib mushonga wekurapa unotarirwa uyo uri muboka remishonga inonzi tyrosine kinase inhibitors. Funga nezvayo sechishandiso chakarurama chinovhara mapuroteni chaiwo anokonzera kugadzirwa kwetishu yakawandisa mumapapu ako.

Mushonga uyu unouya muchimiro chekapsule yakapfava uye inotorwa nemuromo kaviri pazuva. Yakagadzirirwa zvakananga vanhu vane mapapu ari kukuvadzwa nekuvharika kwemaitiro asinganzwisisike anoita kuti kufema kuve kwakaoma.

Kusiyana nekurapa kwekare kwaingogadzirisa zviratidzo, nintedanib inonyatso tarisa maitiro echirwere ari pasi. Izvi zvinoita kuti ive kurapwa kunochinja chirwere panzvimbo yekungobatsira zviratidzo.

Chii chinotarisirwa Nintedanib?

Nintedanib inonyanya kushandiswa kurapa idiopathic pulmonary fibrosis (IPF), mamiriro akakomba emapapu uko tishu yemumapapu ane hutano inotsiviwa netishu yakavharika. Inotenderwawo kune mamwe marudzi echirwere chemapapu anofambira mberi.

IPF inokanganisa vanhu vanenge zviuru zana muUnited States uye inowanzoitika muvanhu vane makore anopfuura 50. Izwi rekuti "idiopathic" rinoreva kuti vanachiremba havazive chaizvo zvinokonzera, asi kuvharika kunoita kuti mapapu ako aome uye kufema kuve kwakaoma.

Chiremba wako anogonawo kukuraira nintedanib ye systemic sclerosis-associated interstitial lung disease (SSc-ILD). Izvi zvinoitika kana chirwere che autoimmune chinonzi scleroderma chikakanganisa mapapu ako, zvichikonzera matambudziko akafanana ekukuvadzwa.

Mune dzimwe nguva, vanachiremba vanogona kushandisa nintedanib kune mamwe marudzi e progressive pulmonary fibrosis kana kukuvadzwa kuchiramba kuchiwedzera kunyangwe mamwe marapirwo. Zvisinei, kushandiswa uku kunoda kuongororwa zvakanyatsonaka nenyanzvi yemapapu.

Nintedanib Inoshanda Sei?

Nintedanib inoshanda nekudzivisa matatu chaiwo ekukura factor receptors anotyaira maitiro ekukuvadzwa mumapapu ako. Aya ma receptors anowanzo kubatsira kupora, asi mu pulmonary fibrosis, anova overactive uye anogadzira nyama yakawandisa yekukuvadzwa.

Mishonga iyi inoonekwa semushonga wakasimba zvine mwero unoda kutariswa zvakanaka. Haisi mishonga yakapfava, asi inowanzo shandiswa zvakanaka kana ichishandiswa pasi pekutariswa kwakakodzera kwechiremba.

Nekudzivisa zviratidzo izvi zvakanyanyisa, nintedanib inobatsira kuderedza mwero uyo nyama yemapapu ine hutano inotsiviwa nenyama yekukuvadzwa. Izvi zvinogona kubatsira kuchengetedza basa remapapu ako uye kugona kufema kwenguva yakareba.

Mishonga iyi zvakare ine mamwe maitiro ekurwisa kuzvimba, izvo zvinogona kubatsira kuderedza kukuvadzwa kuri kuitika kunyama yako yemapapu. Zvisinei, simba rayo guru riri mukumisa maitiro ekukuvadzwa pane kudzosa kukuvadzwa kwakatoitika.

Ndinofanira Kutora Sei Nintedanib?

Nintedanib inofanira kutorwa sezvakanyorwa nachiremba wako, kazhinji 150 mg kaviri pazuva, maawa anenge gumi nemaviri akaparadzana. Kuitora nechikafu kwakakosha nekuti izvi zvinoderedza zvakanyanya kusagadzikana mudumbu uye zvinobatsira muviri wako kutora mishonga zvakanaka.

Medza makapisi ese nemvura yakazara. Usavhura, kupwanya, kana kutsenga makapisi, sezvo izvi zvinogona kukonzera kutsamwa mumuromo mako nehuro uye zvinogona kukanganisa mashandiro emishonga.

Kutora nintedanib pamwe chete nechikafu kana chikafu chikuru kwakakosha kuti unzwe zvakanaka. Chikafu hachifaniri kuva chikuru, asi kuva nechinhu mudumbu rako kunobatsira kudzivirira kusvotwa uye kusagadzikana kwemudumbu kunowanzoitika nemushonga uyu.

Edza kutora mishonga yako panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana mumuviri wako. Vanhu vazhinji vanoona zvichibatsira kutora mushonga mumwe chete nekudya kwemangwanani uye mumwe nekudya kwemanheru.

Kana ukaona kusagadzikana kwakanyanya mudumbu, chiremba wako angaderedza mushonga wako kwenguva pfupi kana kukukurudzira chikafu chakati kuti chinoshanda zvakanaka nemushonga. Usambofa wakachinja mushonga wako usina kutungamirirwa nachiremba.

Ndinofanira Kutora Nintedanib Kwenguva Yakareba Sei?

Nintedanib inowanzoita kurapwa kwenguva refu kwaunozofanira kuenderera mberi kwenguva isingagumi, chero zvichibatsira kunonotsa mavanga ako emapapu uye uchigamuchira zvakanaka. Vanhu vazhinji vanoitora kwemakore panzvimbo pemwedzi.

Chiremba wako achatarisa kufambira mberi kwako kuburikidza nemiedzo yenguva dzose yekushanda kwemapapu, kuongororwa kwechipfuva, uye basa reropa. Izvi zvinobatsira kuona kana mushonga uchishanda nemazvo uye kana zvakachengeteka kuti uenderere mberi.

Chinangwa ndechekunonotsa kufambira mberi kwemavanga emapapu kwenguva yakareba sezvinobvira. Kumisa mushonga kazhinji kunobvumira maitiro emavanga kuti atangazve pamwero wayo yapfuura, ndosaka kurapwa kusingapere kuchikurudzirwa.

Vamwe vanhu vangangoda kutora zororo kubva kumushonga kana vakawana mhedzisiro inoda nguva kuti igadziriswe. Chiremba wako achashanda newe kuti uwane chiyero chakakodzera pakati pekubudirira uye kugamuchirika.

Ndezvipi Zvakaipa ZveNintedanib?

Semishonga yese, nintedanib inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese achizviona. Mhedzisiro yakajairika inogoneka uye inowanzoita nani sezvo muviri wako uchigadzirisa kumushonga.

Ngatitangei nemhedzisiro yaungangosangana nayo, iyo inokanganisa vanhu vazhinji vanotora mushonga uyu:

• Manyoka (rinokanganisa vanhu vanenge 60%) - kazhinji nyoro kusvika pakati nepakati uye inogona kudzora nekuchinja kudya
• Kunzwa kusvotwa uye dumbu kusagadzikana - kutora mushonga uyu pamwe chete nechikafu kunobatsira zvakanyanya
• Kuderera kwechido chekudya uye kurasikirwa uremu - chiremba wako achazvitarisa zvakanyanya
• Kurwadziwa mudumbu kana kukramba - kazhinji kunovandudzika nekufamba kwenguva uye kudya zvakanaka
• Kurutsa - hakuzivikanwi zvakanyanya sekusvotwa asi kunogona kuitika, kunyanya mumavhiki mashoma ekutanga

Izvi zvinokonzeresa matambudziko ekugaya ndizvo zvichemo zvinowanzoitika, asi zvinowanzoita kuti zvidzorwe sezvo muviri wako uchigadzirisa kumushonga.

Vamwe vanhu vanowana matambudziko asina kujairika asi achiri akakosha anoda kutariswa:

• Kuwedzera kwezvinhu zvemumuviri zvemumuviri - zvinoonekwa kuburikidza nemiedzo yeropa, kazhinji pasina zviratidzo
• Kuneta kana kunzwa kuneta - kunogona kuve kwakabatana nemushonga kana mamiriro ako epfungwa ari pasi
• Kutemwa nemusoro - kazhinji nyoro uye inopindura kune zvinorwadza zvinopfuura-the-counter
• Dizziness - inowanzoitika kana uchitanga mushonga kana kuwedzera muyero
• Kutsvuka kweganda kana kukwenya - kazhinji nyoro asi inofanira kuziviswa kuchiremba wako

Chiremba wako achatarisa kushanda kwako kwechiropa nguva dzose sezvo nintedanib inogona kukanganisa ma enzymes echiropa mune vamwe vanhu.

Zvino, ngatitaurire nezve matambudziko asingawanzoitiki asi akakomba anoda kutariswa kwekurapa nekukurumidza:

• Matambudziko akakomba echiropa - zviratidzo zvinosanganisira kuita yero yeganda kana maziso, weti yakasviba, kana kurwadziwa kwakanyanya mudumbu
• Matambudziko emoyo - kurwadziwa muchipfuva, kurova kwemoyo kusingaite, kana kufema kusingaite
• Nyaya dzeropa - kubuda ropa kusingaite kana kupwanya, kunyanya kana kwakanyanya
• Matambudziko akakomba emapapu - kukosora kutsva kana kuwedzera, fivha, kana matambudziko ekufema
• Kutsvuka kweganda kwakanyanya - kupararira kwakawanda, kuputika, kana ganda rinobvaruka

Izvi zvinokonzera matambudziko akakomba hazviwanzowanikwi, asi zvakakosha kuziva izvi uye kutsvaga rubatsiro rwekurapa nekukurumidza kana zvikaitika.

Ndiani Asingafaniri Kutora Nintedanib?

Nintedanib haikodzeri munhu wese, uye chiremba wako achanyatsoongorora kana zvakachengeteka kwauri zvichibva munhoroondo yako yezvokurapa uye mamiriro ako ehutano azvino.

Haufaniri kutora nintedanib kana uine allergic kwairi, soy, kana nzungu, sezvo makapisi ane soy lecithin. Vanhu vane hypersensitivity inozivikanwa kune chero chikamu chemushonga vanofanira kuudzivisa zvachose.

Mamiriro akati wandei ezvokurapa anoita kuti nintedanib ive nenjodzi kana kuti inoda matanho akakosha:

• Chirwere chechiropa chakakomba kana matambudziko echiropa anoshanda - mushonga unogona kuwedzera basa rechiropa
• Kurwisa kwemoyo kwemazuva ano kana chirwere chemoyo chisina kugadzikana - nintedanib inogona kukanganisa rhythm yemoyo
• Matambudziko ekubuda ropa anoshanda - mushonga unogona kuwedzera njodzi yekubuda ropa
• Chirwere cheitsvo chakakomba - itsvo dzako dzinobatsira kugadzirisa mushonga
• Kuvhiyiwa kukuru kwemazuva ano - njodzi yakawedzera yekubuda ropa panguva yekupora

Kuzvitakura nekuyamwisa zvinopesana zvachose, sezvo nintedanib inogona kukuvadza vana vari kukura uye inogona kupinda mumukaka wemazamu.

Vamwe vanhu vanoda kuongororwa kwakawedzerwa asi vanogona kutora nintedanib nekugadzirisa:

• Matambudziko echiropa akapfava kusvika pakati nepakati - inoda kugadzirisa dose uye kuongororwa kakawanda
• Nhoroondo yematambudziko emoyo - inoda kuongororwa kwemoyo uye kuenderera mberi kwekuongorora
• Kutora zvinoderedza ropa - kunoda kubatana kwakanyatsojeka nachiremba wako
• Vanhu vakuru - vanogona kuda madosi akaderera nekuda kwekuwedzera kunzwisisika
• Vanhu vane maronda mudumbu - njodzi yepamusoro yematambudziko ekugaya

Chiremba wako achayerera mabhenefiti achipesana nenjodzi dzemamiriro ako chaiwo uye anogona kukurudzira mamwe marapirwo kana nintedanib isingakodzeri iwe.

Mazita eNintedanib Brand

Nintedanib inowanikwa pasi pezita remhando yeOfev munyika zhinji, kusanganisira United States. Iri ndiro zita remhando rinozivikanwa zvakanyanya remushonga.

Mudzimba dzimwe, ungawana nintedanib pasi pemazita emhando dzakasiyana, asi Ofev inoramba iri zita guru rinoshandiswa nevakawanda vanopa hutano nemakambani emishonga.

Mishonga iyi inogadzirwa neBoehringer Ingelheim, kambani yemishonga inonyanya kugadzira mishonga yekufema. Mhando dzemishonga ye nintedanib hadzisati dzichiwanzowanikwa mumisika yakawanda.

Paunenge uchitaura nezvemishonga yako nevanoona nezvehutano kana vanopa mishonga, unogona kuita seunotaura nezita rayo (nintedanib) kana zita remhando (Ofev). Mazita ese ari maviri anoreva mushonga mumwe chete.

Zvimwe Zvinogona Kushandiswa Panzvimbo peNintedanib

Kana nintedanib isiri yakakunakira kana isingashande zvakanaka, pane dzimwe nzira dzakawanda dzekurapa pulmonary fibrosis. Chiremba wako achakubatsira kusarudza nzira yakanakisa zvichienderana nemamiriro ako chaiwo uye nhoroondo yako yezvokurapa.

Pirfenidone (zita remhando Esbriet) imwe mishonga yakabvumidzwa neFDA ye idiopathic pulmonary fibrosis. Inoshanda zvakasiyana ne nintedanib nekuderedza kuzvimba uye kunonotsa kuumbwa kwenyama yemaronda nenzira dzakasiyana.

Kune vamwe vanhu, kurapwa kwechinyakare kungave kuchiri kwakakodzera:

• Corticosteroids - inobatsira kuderedza kuzvimba asi ine kushanda kushoma kweIPF
• Mishonga yekudzivirira immune system - inogona kushandiswa kune mamwe marudzi e pulmonary fibrosis
• Oxygen therapy - inobatsira nezviratidzo zvekufema asi haimisi kufambira mberi kwechirwere
• Pulmonary rehabilitation - zvirongwa zvekuita maekisesaizi nekufema kuti uchengetedze basa

Muzviitiko zvakanyanya, kutamiswa kwemapapu kunogona kufungwa nezvazvo kune varwere vanokodzera vasingapinduri kumishonga.

Vamwe vanhu vanobatsirwa nenzira dzakasiyana, senge kushandisa mishonga pamwe chete ne oxygen therapy uye pulmonary rehabilitation. Nyanzvi yako yemapapu ichagadzira chirongwa chekurapa chakakodzera zvaunoda.

Nintedanib iri nani pane Pirfenidone here?

Zvese nintedanib uye pirfenidone zvinobatsira kurapa idiopathic pulmonary fibrosis, asi zvinoshanda nenzira dzakasiyana uye zvine mhedzisiro dzakasiyana. Hapana kana imwe yakanyatso "kudai" kupfuura imwe yevese varwere.

Tsvakurudzo dzinoratidza kuti mishonga yese miviri inogona kunonotsa kudzikira kwebasa remapapu nemari yakafanana. Sarudzo pakati pavo inowanzoenderana nekuti ndedzipi mhedzisiro yaunogona kutsungirira uye mamiriro ako ehutano ega.

Nintedanib inowanzoita kuti pave nemhedzisiro yakawanda yekugaya chikafu senge manyoka uye kusvotwa, nepo pirfenidone inowanzoita kuti ganda rive sensitive kune zuva uye kusagadzikana mudumbu. Vamwe vanhu vanotsungirira imwe zviri nani pane imwe.

Chiremba wako achafunga zvinhu zvakati wandei paanenge achisarudza pakati pemishonga iyi, kusanganisira mamwe mamiriro ako ehutano, mishonga iripo, uye zvinhu zvemararamiro. Sarudzo "yakanaka" ndiyo inoshanda zvakanaka mumamiriro ako chaiwo.

Mune dzimwe nguva, vanachiremba vanogona kuyedza imwe mishonga kutanga uye vochinja kune imwe kana sarudzo yekutanga isingatsungirirwe zvakanaka kana isingaite seinoshanda zvakanaka.

Mibvunzo Inowanzo Bvunzwa Nezve Nintedanib

Q1. Nintedanib Yakachengeteka Kune Vanhu vane Chirwere Chemoyo Here?

Nintedanib inogona kushandiswa kune vanhu vane chirwere chemoyo chakagadzikana, asi inoda kunyatsoongororwa nachiremba wako. Mushonga unogona kukanganisa rhythm yemoyo uye kuwedzera njodzi yemhedzisiro ine chekuita nemoyo.

Kana uine nhoroondo yematambudziko emoyo, chiremba wako anogona kuda kuita bvunzo dzebasa remoyo usati watanga nintedanib uye kukutarisa zvakanyanya panguva yekurapa. Vanhu vane kurwisa kwemoyo kwemazuva ano kana mamiriro emoyo asina kugadzikana vangangoda kudzivisa mushonga uyu.

Nyanzvi yako yezvemoyo uye nyanzvi yemapapu vachashanda pamwechete kuti vaone kana nintedanib yakachengeteka kwauri uye kuti kuongorora kunodiwa kuti uishandise zvakachengeteka.

Q2. Ndoita Sei Kana Ndikatora Nintedanib Yakawandisa Netsaona?

Kana ukatora nintedanib yakawanda kupfuura yakarairwa netsaona, fonera chiremba wako kana nzvimbo inobata chepfu nekukasira. Usamirira kuti uone kana zviratidzo zvichioneka, sezvo kuita nekukurumidza kwakakosha kuchengeteka kwako.

Kutora nintedanib yakawanda kunogona kuwedzera njodzi yako yezvinetso zvakakomba, kunyanya matambudziko echiropa uye matambudziko ekubuda ropa. Kunyangwe ukanzwa zvakanaka, kuongororwa kwekurapa kunodiwa kuti uve nechokwadi chekuti hapana kukuvadzwa kwakaitika.

Uya nebhodhoro remushonga newe kuimba yekukurumidzira kana uive naro paunofona kuti uwane rubatsiro. Ruzivo urwu runobatsira nyanzvi dzekurapa kuti dzizive nzira yakanakisa yekutora.

Q3. Ndingaita Sei Kana Ndikakanganwa Dose yeNintedanib?

Kana ukakanganwa dose ye nintedanib, itore paunorangarira, chero zvichiri mukati memaawa mashoma enguva yako yakarongwa. Zvisinei, kana yava nguva yechikamu chako chinotevera, siya dose yakakanganwa uye uenderere mberi nechirongwa chako chetsika.

Usambofa wakatora zvikamu zviviri panguva imwe chete kuti ugadzirise dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yezvinetso. Zviri nani kusvetuka dose imwe pane kuwedzera.

Kana iwe uchikanganwa zvikamu kazhinji, funga kushandisa murongi wepiritsi kana kumisa zviyeuchidzo zvefoni. Kudzora nguva dzose kunobatsira kuchengetedza mazinga akagadzikana emushonga mumuviri wako kuti uwane kushanda zvakanaka.

Q4. Ndingamira Rini Kutora Nintedanib?

Unofanira kungomira kutora nintedanib pasi pekutungamirirwa nachiremba wako. Iyi inowanzoita kurapwa kwenguva refu, uye kuimisa kazhinji kunobvumira maitiro ekukwenenzvera mapapu kuti atangezve kumhanya kwayo yapfuura.

Chiremba wako angakurudzira kumisa nintedanib kana iwe ukagadzira zvinetso zvakakomba zvisingavandudzi nekugadzirisa dose, kana basa remapapu ako richiramba richiderera pasinei nekurapa, kana iwe usingachakwanisi kutsungirira mushonga.

Dzimwe nguva, kuzorora kwenguva pfupi kubva kumushonga kunodiwa kuti utarise mhedzisiro, asi vanhu vazhinji vanotangazve kurapwa kana nyaya dzagadziriswa. Nguva dzose kurukura zvaunonetseka nazvo nechikwata chako chehutano usati wachinja chero chinhu kuronga kwako kurapwa.

Q5. Ndingatora Nintedanib nemimwe mishonga here?

Nintedanib inogona kuita kuti pave nekudyidzana nemimwe mishonga, saka zvakakosha kuti uudze chiremba wako nezve mishonga yese yakanyorwa, mishonga isingatengwi, uye zvinowedzera zvauri kutora. Dzimwe nzira dzekubatanidza dzinogona kuva nenjodzi kana kuderedza kushanda kwemishonga yako.

Mishonga inotetesa ropa yakaita se warfarin inoda kutariswa zvakanyanya nekuti nintedanib inogona kuwedzera njodzi yekubuda ropa. Chiremba wako achada kutarisa kuumbwa kweropa rako zvakanyanya kana iwe uchitora mishonga yese iri miviri.

Mamwe maantibayoti, mishonga yekurwisa fungal, uye mishonga yekurwisa kubatwa nemoyo inogona kukanganisa maitiro emuviri wako nintedanib. Chiremba wako angangoda kugadzirisa zviyero kana kusarudza dzimwe mishonga kudzivirira kudyidzana kunokuvadza.