Chii chinonzi Obinutuzumab: Zvazvinoshandiswa, Madosi, Mativi eMuviri, nezvimwe

Obinutuzumab mushonga wekenza unovavarira kubatsira masoja ako emuviri kurwisa marudzi akati wandei ekenza yeropa. Mushonga uyu ndeweboka rinonzi monoclonal antibodies, iro rinoshanda semabhomba anotungamirirwa anowana uye kurwisa masero ekenza chaiwo achisiya masero mazhinji ane hutano ari ega.

Unogona kunzwa wakaoma mwoyo uchidzidza nezve mushonga mutsva wekenza, uye izvozvo zvakajairika. Kunzwisisa kuti obinutuzumab inoshanda sei kunogona kukubatsira kuti unzwe wakagadzirira uye wakavimbika nezve chirongwa chako chekurapa.

Chii chinonzi Obinutuzumab?

Obinutuzumab ndeye antibody yakagadzirwa murabhoritari inotarisa protein chaiyo inowanikwa pamasero ekenza akati wandei. Funga nezvayo semupurisa akadzidziswa zvakanyanya anogona kuziva uye kumaka masero ekenza kuti aparadzwe nemasero ako emuviri.

Mushonga uyu unopiwa kuburikidza neIV infusion, izvo zvinoreva kuti inoyerera zvakananga muropa rako kuburikidza netsono muruoko rwako kana chiteshi. Kurapa kwakagadzirirwa kuve kwakanyatsojeka kupfuura chemotherapy yechinyakare, ichinyatso tarisa pamasero ekenza panzvimbo yekukanganisa masero ese anokurumidza kukamukana mumuviri wako.

Obinutuzumab yakatenderwa neFDA semushonga unotyora mitemo nekuti yakaratidza kuvandudzwa kukuru mukubatsira vanhu vane mamwe marudzi ekenza yeropa kurarama hupenyu hurefu, hune hutano.

Obinutuzumab inoshandiswa nei?

Obinutuzumab inorapa marudzi akati wandei ekenza yeropa, kunyanya chronic lymphocytic leukemia uye mamwe marudzi e non-Hodgkin's lymphoma. Chiremba wako angangodaro akakurudzira kurapa uku nekuti masero ako ekenza ane protein chaiyo inovaita kuti vasabatike kumushonga uyu.

Mushonga uyu unowanzo shandiswa semushonga wekutanga, zvinoreva kuti imwe yesarudzo dzekutanga iyo timu yako yezvokurapa ichaedza. Inowanzo sanganiswa nemimwe mishonga yekenza kuti igadzire nzira yakazara yekurapa.

Mune dzimwe nguva, obinutuzumab inogona kukurudzirwa kana dzimwe nzira dzekurapa dzisina kushanda sezvaitarisirwa. Chiremba wako wezve oncology achatsanangura chaizvo kuti nei kurapwa uku kuchinzwisisika mumamiriro ako chaiwo.

Obinutuzumab Inoshanda Sei?

Obinutuzumab inoshanda nekunamatira kune protein inonzi CD20 iyo inogara pamusoro pemamwe maseru ekenza. Kana yanamatira, inoratidza immune system yako kuti iparadze maseru aya akamarkwa nenzira dzakawanda.

Mishonga iyi inoonekwa seimwe nzira yekurapa ine simba uye inoshanda. Kusiyana nechemotherapy iyo inokanganisa mhando dzakawanda dzemasero, obinutuzumab inonyanya kutarisana nemasero ekenza, izvo zvinowanzoita kuti pave nemigumisiro mishoma yese.

Maitiro acho anoitika zvishoma nezvishoma pamakore akati wandei ekurapa. Muromo wako wekudzivirira muviri unova unoshanda pakuziva nekubvisa masero ekenza sezvo kurapwa kuchifambira mberi.

Ndinofanira Sei Kutora Obinutuzumab?

Obinutuzumab inogara ichipiwa seIV infusion munzvimbo yekuchengetedza hutano, kwete semushonga waunotora kumba. Chikwata chako chekuchengetedza hutano chichaisa tsono diki mutsinga muruoko rwako kana kuwana chiteshi kana uine chimwe.

Pamberi peimwe neimwe infusion, uchagamuchira pre-medications kubatsira kudzivirira allergic reactions. Izvi zvinogona kusanganisira antihistamines, acetaminophen, kana corticosteroids. Haufaniri kutsanya usati warapwa, uye kudya chikafu chakareruka pamberi pezvo kunogona kukubatsira kuti unzwe wakasununguka.

Infusion yekutanga inowanzo tora nguva yakareba kupfuura inotevera, dzimwe nguva kusvika maawa 6-8. Kurapwa kwakazotevera kunowanzo tora maawa 3-4. Uchaongororwa zvakanyanya panguva yese yekuita, uye infusion inogona kunonotswa kana kumiswa kana uine kusagadzikana.

Ndinofanira Kutora Obinutuzumab Kwenguva Yakareba Sei?

Kureba kwekurapwa kwako kweobinutuzumab kunoenderana nerudzi rwako rwekenza uye kuti unopindura sei kumushonga. Zvirongwa zvakawanda zvekutarisira zvinosanganisira makore akawanda pamwedzi yakati wandei.

Hurongwa hwekurapa hunowanzoita mazuva makumi maviri nemasere, hunogona kusanganisira matanhatu, uye mukati mekutanga, unogona kupihwa mushonga kakawanda, wobva wapiwa zvishoma mumatanhatu anotevera.

Chiremba wako achatarisa kufambira mberi kwako nguva dzose kuburikidza nemiedzo yeropa uye zvidzidzo zvekuongorora. Zvichienderana nekuti kenza yako inopindura sei uye kuti unotsungirira sei kurapwa, timu yako yezvokurapa inogona kuchinja nguva kana kakawanda kwekuiswa kwako.

Ndezvipi Zvakaipa ZveObinutuzumab?

Kufanana nemamwe marapirwo ekenza, obinutuzumab inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachizvitsungirira zviri nani kupfuura chemotherapy yechinyakare. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye uzive nguva yekubata timu yako yehutano.

Mhedzisiro zhinji inogoneka, uye timu yako yezvokurapa ine ruzivo rwekubatsira varwere kuburikidza nematambudziko ese anomuka. Ngatitarisei mhedzisiro yakajairika yaungasangana nayo.

Mhedzisiro Yakajairika

Mhedzisiro inowanzoitika nekuti immune system yako iri kushanda nesimba uye muviri wako uri kugadzirisa mushonga. Mhedzisiro iyi inowanzoitika kwenguva pfupi uye inovandudzika pakati pematanhatu ekurapa.

• Kuneta uye kunzwa kuneta kupfuura zvakajairika
• Kusvotwa kana dumbu diki rinogumbuka
• Kutemwa nemusoro
• Kurwadziwa kwemhasuru kana majoini
• Fivha kana kutonhora
• Kukosora kana zviratidzo zvekufema zvishoma
• Meno kana kuita ganda
• Dhiria kana kuvharika

Zviratidzo izvi zvinowanzoita nani sezvo muviri wako uchigadzirisa kurapwa. Timu yako yehutano inogona kupa mishonga uye nzira dzekubatsira kubata chero kusagadzikana kwaunosangana nako.

Infusion-Related Reactions

Vamwe vanhu vanosangana nekupindura panguva kana nguva pfupi mushure mekuwana infusion. Timu yako yezvokurapa inokutarisa zvakanyanya kuti uwane izvi zvinopindura, ndosaka uchizowana pre-medications uye kugara pasi pekuongorora.

• Fiva kana kutonhora panguva yekurapa
• Kufema kwemhepo kana kuoma kufema
• Kusungirirwa pachipfuva kana kurwadziwa
• Kurova kwemoyo nekukurumidza
• Dizziness kana lightheadedness
• Kutsva kweganda kana kutsvuka
• Kuzvimba kwechiso, miromo, kana huro

Kana chero chimwe chezvinhu izvi chikaitika, mukoti wako anogona kuderedza kana kumisa zvishoma nezvishoma infusion. Mazhinji emhinduro akapfava uye anogadziriswa nekukurumidza nekutarisirwa kwakakodzera.

Mhedzisiro Yakakomba

Nepo isingawanzoitiki, dzimwe mhedzisiro inoda kutariswa kwekurapa nekukurumidza. Chikwata chako chehutano chichakudzidzisa chaizvo zviratidzo zvekuchenjerera zvekutarisa uye kuti ungavadana rini.

• Zviratidzo zvehutachiona senge fivha inoramba iripo, kuneta kwakanyanya, kana zviratidzo zvisina kujairika
• Matambudziko ekufema akakomba kana kurwadziwa pachipfuva
• Kubuda ropa kusingajairiki kana kupwanya
• Kurwadziwa kwakanyanya mudumbu
• Kuvhiringidzika kana shanduko mumamiriro epfungwa
• Mhinduro dzeganda dzakakomba kana rash yakapararira
• Kusviba kweganda kana maziso

Izvi zvinokanganisa zvakakomba hazviwanzoitiki, asi kuzviziva kare kunovimbisa kuti unowana kurapwa nekukurumidza kana zvichidikanwa.

Mhedzisiro Isingawanzoitiki asi Yakakosha

Dzimwe mhedzisiro isingawanzoitiki inogona kuitika vhiki kana mwedzi mushure mekurapa. Nepo izvi zvisingawanzoitiki, kuziva nezvazvo kunokubatsira kuti urambe wakangwarira nezvehutano hwako nekufamba kwenguva.

• Progressive multifocal leukoencephalopathy (PML) - hutachiona hwehuropi husingawanzoitiki
• Matambudziko akakomba echiropa
• Kusagadzikana kwemoyo
• Tumor lysis syndrome - kana maseru ekenza achiputsika nekukurumidza
• Kuverenga ropa kwakaderera kwakanyanya kunogara vhiki dzakawanda
• Kuvandudzwa kwehutachiona hwehepatitis B muvanhu vakambove nazvo

Chikwata chako chekurapa chichakutarisa zvakanyanya kuti uone matambudziko aya asingawanzoitiki kuburikidza nekuongororwa kweropa nguva dzose uye kuongororwa.

Ndiani Asingafaniri Kutora Obinutuzumab?

Obinutuzumab haikodzerani nemunhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yezvokurapa asati akurudzira kurapwa uku. Kuva akatendeseka nezve hutano hwako kunobatsira kuona kuti mushonga uyu wakachengeteka kwauri.

Vanhu vane zvirwere zvakakomba, zvinoshanda vanowanzo fanira kumirira kusvikira chirwere chacho chapera vasati vatanga kurapwa. Immune system yako inofanira kuva yakasimba zvakakwana kuti ibate mushonga zvakachengeteka.

Kana uine nhoroondo ye hepatitis B, kunyangwe yakanga isiri kushanda kwemakore, unozoda kuongororwa kwakakosha. Mushonga dzimwe nguva unogona kumutsazve hutachiona uhu, asi timu yako yezvokurapa inoziva maitiro ekuona uye kudzivirira dambudziko iri.

Vakadzi vane pamuviri havafaniri kugamuchira obinutuzumab, sezvo ichigona kukuvadza mwana ari kukura. Kana uri kuronga kuva nepamuviri, chiremba wako achakurukura dzimwe nzira dzekurapa kana nguva dzakakodzera newe.

Mazita eObinutuzumab Brand

Obinutuzumab inotengeswa pasi pezita rekuti Gazyva muUnited States nenyika dzakawanda. Unogonawo kuiona ichinzi Gazyvaro mune dzimwe nyika dzeEurope.

Mushonga uyu wakafanana zvisinei nezita remhando. Pharmacy yako kana nzvimbo yekurapa ichaona kuti unogamuchira fomu rakarairwa nachiremba wako weoncologist.

Zvimwe Zvinhu Zvokutsiva Obinutuzumab

Mishonga yakati wandei inoshanda zvakafanana ne obinutuzumab yekurapa kenza yeropa. Chiremba wako angangofunga nezvezvimwe zvinhu zvakatsiva izvi zvichienderana nemamiriro ako chaiwo, kurapwa kwakapfuura, kana inishuwarenzi.

Rituximab ndiyo imwe monoclonal antibody inotarisa iyo imwechete CD20 protein. Yave ichishandiswa kwenguva refu kupfuura obinutuzumab uye ine yakagadzwa zvakanaka kuchengeteka profile, kunyangwe zvidzidzo zvichiratidza kuti obinutuzumab inogona kushanda zvakanyanya kune mamwe mamiriro.

Dzimwe nzira dzinosanganisira ofatumumab, imwe antibody inorwisa CD20, kana mhando dzakasiyana dzekurapa kwakanangana senge BTK inhibitors. Chiremba wako weoncologist achatsanangura kuti sei vachitenda kuti obinutuzumab ndiyo sarudzo yakanakisa yerudzi rwako rwekenza uye mamiriro ako.

Ko Obinutuzumab Ari Nani Kudarika Rituximab?

Zvidzidzo zvakaratidza kuti obinutuzumab inogona kushanda zvakanyanya kudarika rituximab kune mamwe marudzi ekenza yeropa, kunyanya chronic lymphocytic leukemia. Zvisinei, "zviri nani" zvinoenderana nemamiriro ako ega uye nhoroondo yezvokurapa.

Obinutuzumab yakagadzirirwa zvakananga kuti ive nesimba kudarika rituximab mukuparadza maseru ekenza. Miedzo yekiriniki yakaratidza kuti vanhu vane mamwe makemikari vanowanzo rarama kwenguva refu vasina chirwere chavo chichifambira mberi kana vachirapwa neobinutuzumab vachienzaniswa ne rituximab.

Zvisinei, rituximab yakashandiswa zvinobudirira kwemakore mazhinji uye ine rekodhi yakareba yezvinhu zvakachengeteka. Chiremba wako achafunga nezvezvinhu zvakaita se zera rako, hutano hwako hwese, kurapwa kwakapfuura, uye hunhu chaihwo hwekenza paachifunga kuti ndechipi mushonga unokupa mukana wakanakisa wekubudirira.

Mibvunzo Inowanzo Bvunzwa Nezve Obinutuzumab

Mubvunzo 1. Ko Obinutuzumab Akachengeteka Kune Vanhu Vane Matambudziko Emoyo?

Vanhu vane mamiriro emoyo vanogona kugamuchira obinutuzumab, asi vanoda kutarisa zvakanyanya panguva yekurapa. Chiremba wako wecardiologist uye oncologist vachashanda pamwe chete kuti vave nechokwadi chekuti moyo wako unogona kubata mushonga zvakachengeteka.

Maitiro ekuisa anogona kuchinjwa kune vanhu vane matambudziko emoyo, vane kumhanya kwekutungamira kwakaderera uye kuongorora kakawanda. Chikwata chako chekurapa chinogonawo kugadzirisa pre-medications yaunogamuchira kuti ideredze chero kushushikana pamoyo wako.

Kana uine nhoroondo yechirwere chemoyo, ita shuwa kuti unokurukura izvi zvakadzama nachiremba wako weoncologist. Vanogona kutsanangura njodzi dzakakosha uye mabhenefiti mumamiriro ako uye kuti chii chichatariswa.

Q2. Ndingaita Sei Kana Ndikagamuchira Obinutuzumab Yakawandisa Netsaona?

Sezvo obinutuzumab ichipiwa nenyanzvi dzehutano munzvimbo yekurapa, kuwandisa netsaona hakusi kwakajairika. Mushonga unoverengwa zvakanyatsonaka zvichienderana nehuremu hwemuviri wako uye unopiwa nevashandi vekurapa vakadzidziswa.

Kana iwe ukafungidzira kuti kukanganisa kwakaitika panguva yekurapa kwako, taura nekukurumidza. Chikwata chako chekurapa chinotora izvi zvakakomba uye chichaongorora chero nyaya dzinogona kuitika nekukurumidza.

Muchiitiko chisingaite chekuwandisa, iwe unozotariswa zvakanyanya kuti uone kuwedzera kwemigumisiro, uye chikwata chako chekurapa chichapa rutsigiro rwekukubatsira muviri wako kugadzirisa mushonga wakawandisa zvakachengeteka.

Q3. Ndingaita Sei Kana Ndikakanganwa Dose yeObinutuzumab?

Kana iwe ukakanganwa infusion yeobinutuzumab yakarongwa, taura nechikwata chako cheoncology nekukurumidza sezvinobvira kuti urongezve. Vachasarudza nguva yakanakisa yekurapa kwako kunotevera zvichienderana nechirongwa chako chekurapa uye nguva yakapfuura.

Kazhinji, zvakakosha kuti urambe uri pedyo nechirongwa chako chekurapa chakarongeka sezvinobvira kuti uwane mhedzisiro yakanaka. Zvisinei, chikwata chako chekurapa chinonzwisisa kuti dzimwe nguva kurwara, emergencies, kana dzimwe mamiriro anogona kukanganisa misangano yako.

Usaedze kugadzirisa madhizi akarasika nekugadzirisa kurapwa pedyo. Oncologist wako achagadzirisa chirongwa chako chekurapa zvakachengeteka kuti ave nechokwadi chekuti uchiri kugamuchira zvizere zvemushonga.

Q4. Ndingamira Rini Kutora Obinutuzumab?

Haufaniri kumisa kurapwa kweobinutuzumab usati wataurirana neoncologist wako kutanga. Sarudzo yekumisa kurapwa inoenderana nekuti kenza yako iri kupindura sei uye kana uri kusangana nemigumisiro inogoneka.

Chiremba wako achagara achiongorora kufambira mberi kwako kuburikidza nemiedzo yeropa, zvidzidzo zve imaging, uye kuongororwa kwemuviri. Kana kenza yako ichipindura zvakanaka uye wapedza matenderedzwa ako ekurapa akarongwa, vachakurukura kuti zvakakodzera kurega rini.

Vamwe vanhu vangangoda kumisa kurapwa nekukurumidza nekuda kwemigumisiro yakakomba, nepo vamwe vangabatsirwa nemamwe matenderedzwa. Chikwata chako chekurapa chichaita zvisarudzo izvi zvichibva mukupindura kwako kwega uye hutano hwese.

Mubvunzo 5. Ndingawana Majekiseni Ndiri Kutora Obinutuzumab Here?

Majekiseni mhenyu anofanira kudziviswa paunenge uchigamuchira obinutuzumab uye kwemwedzi yakati wandei mushure mekunge kurapwa kwapera. Zvisinei, mamwe majekiseni asiri mhenyu angakurudzirwa kukudzivirira kubva kuzvirwere.

Chikwata chako chehutano chichapa gwara rakatarwa pamusoro pemajekiseni api akachengeteka uye anobatsira panguva yekurapa kwako. Vangakurudzira majekiseni eflu kana mamwe majekiseni kuti akubatsire kukudzivirira kana immune system yako ichishanda nesimba kurwisa kenza.

Nguva dzose tarisa nachiremba wako weoncologist usati watora chero majekiseni, kunyangwe ayo enguva dzose. Vachabatana nachiremba wako wekutanga kuti vave nechokwadi chekuti unogamuchira majekiseni akakodzera zvakachengeteka.