Chii chinonzi Ocrelizumab: Zvazvinoshandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe Zvinhu

Ocrelizumab mushonga unopiwa nachiremba unobatsira kunonotsa multiple sclerosis (MS) nekunangana nemaseru chaiwo emuviri anorwisa zvirwere. Inopiwa kuburikidza neIV infusion muhofisi yachiremba wako kana nzvimbo yeinfusion, kazhinji mwedzi mitanhatu yega yega mushure memadosi ako ekutanga.

Mushonga uyu unomiririra kufambira mberi kukuru mukurapa MS, uchipa tariro kune vanhu vane zvese zvinodzoka uye fomu re primary progressive rechirwere. Kunzwisisa mashandiro ainoita uye zvekutarisira zvinogona kukubatsira kuti unzwe wakavimbika nezvekufamba kwako kurapwa.

Chii chinonzi Ocrelizumab?

Ocrelizumab imonoclonal antibody inonyanya kunangana neB maseru mumuviri wako unodzivirira zvirwere. Aya maB maseru anotamba basa rakakosha mukuita autoimmune iyo inokuvadza tsinga dzemitsipa mu multiple sclerosis.

Funga nezvazvo semushonga chaiwo unovanda, uchishanda semutinhimira unotungamirirwa, uchitsvaga uye uchisunga kune mapuroteni chaiwo anonzi CD20 paB maseru. Kana yangobatana, inobatsira kuderedza huwandu hwemaseru aya anogona kukonzera kuzvimba mumutsipa wako.

Mushonga uyu ndewechikamu chinonzi disease-modifying therapies (DMTs), zvinoreva kuti haingorapi zviratidzo chete asi inoshanda kunonotsa kufambira mberi kweMS pachayo. Izvi zvinoita kuti zvive zvakasiyana nemishonga inongobatsira chete nezviratidzo zvakaita semaspasm emhasuru kana kuneta.

Chii chinonzi Ocrelizumab chinoshandiswa?

Ocrelizumab inobvumidzwa neFDA yekurapa mhando mbiri huru dze multiple sclerosis. Ndiyo yekutanga uye chete mushonga wakabvumidzwa we primary progressive MS, izvo zvinoita kuti zvive zvakakosha kune vanhu vane iyi fomu yechirwere.

Kune mafomu eMS anodzokorora, izvi zvinosanganisira relapsing-remitting MS uye active secondary progressive MS. Aya ndiwo marudzi ayo vanhu vanowana kurwisa kwakajeka kana kudzoka vachiteverwa nenguva yekupora kana kugadzikana.

Chiremba wako angakurudzira ocrelizumab kana usina kupindura zvakanaka kune mamwe marapirwo eMS, kana uine primary progressive MS uko dzimwe sarudzo dzakaganhurirwa. Dzimwe nguva inosarudzwa semushonga wekutanga wevanhu vane highly active relapsing MS.

Ocrelizumab Inoshanda Sei?

Ocrelizumab inoshanda nekuderedza B cells, ayo ari maseru ekudzivirira anobatsira mukuvhiringidzika muMS. Iyi inoonekwa se nzira yakasimba zvishoma kumushonga weMS, yakanyanya kupfuura mamwe mishonga yemuromo asi isina kukwana kupfuura mamwe marapirwo ekupinza.

Mishonga inosungirwa kuCD20 mapuroteni pamusoro peB cells, ichivaisa kuti aparadzwe ne immune system yako. Iyi nzira inoderedza zvakanyanya huwandu hweB cells inotenderera mumuviri wako kwemwedzi yakati wandei.

Chinoita kuti nzira iyi ive inoshanda zvakanyanya ndechekuti inotarisa maseru chaiwo ekudzivirira anonyanya kubatanidzwa mukuenderera mberi kweMS ichisiya mamwe mativi e immune system yako akati wandei. Kuderedzwa kweB cell kunowanzoitika kwemwedzi yakati wandei, ndosaka mushonga uchiitwa mwedzi mitanhatu yega yega.

Mukati memavhiki mashoma ekurapa, iwe uchava neB cells shoma zvakanyanya muhurongwa hwako. Nekufamba kwenguva, maseru aya anodzoka zvishoma nezvishoma, asi mhedzisiro yemishonga yekumisa kufambira mberi kweMS inogona kuramba ichienderera mberi kunyangwe huwandu hweB cell huchipora.

Ndingatora Sei Ocrelizumab?

Ocrelizumab inopiwa chete kuburikidza neIV infusion panzvimbo yekurapa, kwete kumba. Dose yako yekutanga inowanzoitwa kuita infusions mbiri dzakapiwa mavhiki maviri akaparadzana, ne infusion imwe neimwe ichitora anenge 2.5 kusvika 3.5 maawa.

Pamberi pe infusion yega yega, iwe uchagamuchira pre-medications kubatsira kudzivirira infusion reactions. Izvi zvinowanzo sanganisira antihistamine senge diphenhydramine, corticosteroid senge methylprednisolone, uye dzimwe nguva acetaminophen. Mishonga iyi inobatsira muviri wako kuti utore infusion zviri nani.

Haufaniri kudya ocrelizumab pamwe chete nechikafu sezvo ichipihwa zvakananga muropa rako. Zvisinei, kudya chikafu chakareruka usati waenda kunosangana kwako kwejekiseni kunogona kukubatsira kuti unzwe wakasununguka panguva yekuita kwenguva refu.

Panguva yejekiseni, vashandi vezvokurapa vachakutarisa zvakanyanya kuti vaone kana paine zvinoitika. Mushonga unopihwa zvishoma nezvishoma pakutanga, ipapo mwero unogona kuwedzerwa kana uchizvitsungirira zvakanaka. Vanhu vazhinji vanogona kuverenga, kushandisa foni yavo, kana kutokora hope panguva yejekiseni.

Ndingatora Ocrelizumab Kwenguva Yakareba Sei?

Ocrelizumab inowanzoita kurapwa kwenguva refu kwaunozoramba uchitora chero bedzi ichibatsira MS yako uye uchizvitsungirira zvakanaka. Vanhu vazhinji vanoramba vachishandisa mushonga uyu kwemakore, vachitariswa nguva dzose kuti vaone kuti unoramba wakachengeteka uye uchishanda.

Chiremba wako achaongorora mhinduro yako kumushonga mwedzi mitanhatu yega yega, kazhinji panguva yejekiseni rako rinotevera. Vachatarisa zvinhu zvakaita sekudzokorora kutsva, shanduko dzeMRI, kufambira mberi kwekuremara, uye chero mhedzisiro yaunowana.

Vamwe vanhu vangada kumira ocrelizumab kana vakawana zvirwere zvakakomba, mamwe marudzi ekenza, kana maitiro akakomba ejekiseni. Chiremba wako achakurukura njodzi idzi newe uye achatarisa chero zviratidzo zvekuti mushonga unofanirwa kumiswa.

Sarudzo yekuramba kana kumisa ocrelizumab inofanira kugara ichiitwa pamwe chete nenyanzvi yako yeMS, ichiyera mabhenefiti aunowana pamusoro penjodzi kana mhedzisiro yaunowana.

Ndezvipi Zvakaipa zveOcrelizumab?

Semishonga yese, ocrelizumab inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachizvitsungirira zvakanaka. Mhedzisiro inowanzoitika inosanganisirwa nejekiseni uye kuwedzera kutapukirwa nezvirwere.

Heano mhedzisiro inonyanya kuziviswa yaungangowana:

• Kushatirwa kwemuviri kunge kutsvuka kweganda, kukwenya, kana fivha diki panguva kana nguva pfupi mushure mekurapa
• Zvirwere zvemudzivo wekumusoro kufema zvakadai se zvirwere zvefuru kana zvirwere zve sinus
• Zvirwere zvepaganda kana kuputika kweherpes mumuromo
• Kuneta kunogona kugara mazuva mashoma mushure mekuiswa
• Kutemwa nemusoro kana kurwadziwa kwemuviri kudiki
• Muvengu kana kusagadzikana mudumbu

Izvi zvinowanzoitika zvinogona kutarisirwa uye zvinowanzoita nani sezvo muviri wako uchigadzirisa mushonga.

Zvimwe zvinokuvadza zvakanyanya asi zvisingawanzoitiki zvinoda kutariswa kwekurapa nekukasira zvinosanganisira:

• Kushatirwa kwakanyanya kwemuviri nekutadza kufema, kuzvimba kwakanyanya, kana kurwadziwa muchipfuva
• Zviratidzo zvezvirwere zvakakomba zvakaita sefivha inoramba iripo, kuneta kwakanyanya, kana zviratidzo zvisingawanzoitiki
• Progressive multifocal leukoencephalopathy (PML), chirwere chehuropi chisingawanzoitiki
• Hepatitis B reactivation muvanhu vakambobatwa nayo
• Mhando dzekenza, kunyanya kenza yemazamu

Vashandi vehutano vachakutarisa zvakanyanya kuti vaone matambudziko aya asingawanzoitiki asi akakomba kuburikidza nekuongororwa kweropa nguva dzose uye kuongororwa.

Ndiani Asingafaniri Kutora Ocrelizumab?

Ocrelizumab haina kukodzera munhu wese ane MS. Chiremba wako achanyatsoongorora nhoroondo yako yekurapa kuti aone kana mushonga uyu wakachengeteka kwauri.

Haufaniri kutora ocrelizumab kana uine chirwere chehepatitis B, sezvo mushonga uyu unogona kukonzera kuti hutachiona uhu huve hunoshanda zvakare. Unozoda kuongororwa kweropa kuti uone hepatitis B usati watanga kurapwa.

Vanhu vane zvirwere zvakakomba, zvinofanirwa kumirira kusvikira izvi zvapera zvakakwana vasati vatanga ocrelizumab. Izvi zvinosanganisira hutachiona hwebhakitiriya, hutachiona hwehutachiona, kana hutachiona hwefungal hunogona kuipa kana immune system yako yakadzvanyirirwa.

Kana wakambove nemaitiro akakomba ekurwara ne ocrelizumab kana mishonga yakafanana munguva yakapfuura, kurapwa uku hakukurudzirwi. Chiremba wako achakurukura dzimwe nzira dzingave dzakachengeteka kwauri.

Vakadzi vane pamuviri havafaniri kupiwa ocrelizumab, sezvo inogona kukuvadza mwana ari kukura. Kana uri kuronga kuva nepamuviri, kurukura izvi nachiremba wako nguva isati yakwana, sezvo mushonga uyu unogona kukanganisa immune system yako kwemwedzi yakawanda mushure memushonga wako wekupedzisira.

Mazita eBrand eOcrelizumab

Ocrelizumab inotengeswa pasi pezita rebrand rekuti Ocrevus muUnited States nenyika zhinji. Iri ndiro zita rebrand chete riripo parizvino, sezvo pasina mhando dzegeneric dzemushonga uyu.

Ocrevus inogadzirwa neGenentech muUS uye neRoche mune dzimwe nyika. Makambani ese ari chikamu cheboka rimwe chete remishonga, saka mushonga uyu unenge wakafanana zvisinei nekwaunogadzirwa.

Paunenge uchikurukura kurapwa kwako nevapi vehutano kana makambani einishuwarenzi, unogona kunzwa mazita ese achishandiswa zvakachinjana. Vamwe vashandi vehutano vanosarudza kushandisa zita re generic (ocrelizumab) nepo vamwe vachishandisa zita rebrand (Ocrevus).

Zvimwe Zvingashandiswa Panzvimbo peOcrelizumab

Mishonga yakati wandei inogona kurapa MS, kunyangwe sarudzo yakanakisa inoenderana nerudzi rwako rweMS uye mamiriro ako ega. Chiremba wako achakubatsira kuyera zvakanakira nezvakaipira sarudzo imwe neimwe.

Ye relapsing MS, dzimwe nzira dzinosanganisira mishonga yemuromo senge fingolimod (Gilenya), dimethyl fumarate (Tecfidera), kana teriflunomide (Aubagio). Izvi zvinowanzo kuve nyore kutora asi zvinogona kunge zvisina kubudirira kune chirwere chine simba.

Mamwe marapirwo e infusion anosanganisira natalizumab (Tysabri) uye alemtuzumab (Lemtrada), ese ari maviri anoshanda zvakasiyana ne ocrelizumab. Natalizumab inopiwa mwedzi wega wega, nepo alemtuzumab ichibatanidza nzira mbiri dzekurapa gore rimwe nerimwe.

Pamusoro peMS inofambira mberi yekutanga, ocrelizumab ndiyo chete mushonga wakabvumirwa neFDA parizvino, zvichiita kuti ive yegoridhe standard yechimiro ichi chechirwere. Zvisinei, vamwe vanachiremba vanogona kufunga kushandisa mamwe mishonga kunze kwemavara mumamiriro ezvinhu akasiyana.

Ko Ocrelizumab Ari Nani Pane Rituximab?

Ocrelizumab uye rituximab mishonga yakafanana inotarisana neB masero, asi ocrelizumab yakagadzirirwa zvakanyanya uye yakabvumirwa kurapa MS. Rituximab inonyanya kushandiswa kune mamwe marudzi ekenza uye zvirwere zve autoimmune, kunyangwe vamwe vanachiremba vakashandisa kunze kwemavara eMS.

Ocrelizumab inoonekwa seyakanyatsogadzirwa kupfuura rituximab, ine shanduko dzinoita kuti ive yakachengeteka uye inoshanda zvakanyanya yeMS. Yakagadzirirwa kuti ive isinganyanyi immunogenic, zvinoreva kuti muviri wako haunganyanyi kugadzira ma antibodies pairi.

Iyo clinical trial data ye ocrelizumab muMS yakakura kwazvo kupfuura ye rituximab, ichipa vanachiremba ruzivo rwakawanda nezve kushanda kwayo uye kuchengeteka. Izvi zvinoita kuti ocrelizumab ive sarudzo inofarirwa kune vazhinji nyanzvi dzeMS.

Zvisinei, rituximab dzimwe nguva inogona kushandiswa kana ocrelizumab isingawanikwi kana isingavharirwi neinishuwarenzi, sezvo mishonga miviri ichishanda nenzira dzakafanana. Chiremba wako anogona kukubatsira kunzwisisa kuti ndeipi sarudzo ingave yakanakira mamiriro ako chaiwo.

Mibvunzo Inowanzo Bvunzwa Nezve Ocrelizumab

Ko Ocrelizumab Akachengeteka Kune Vanhu vane Chirwere Chemoyo?

Ocrelizumab inogona kushandiswa zvakachengeteka muvanhu vane chirwere chemoyo, asi cardiologist yako uye neurologist vachada kuronga kutarisirwa kwako. Kunetseka kukuru nderekuti infusion reactions dzinogona kukonzera kushushikana mumoyo wako.

Usati watanga kurapwa, chiremba wako achaongorora mamiriro ako emoyo uye anogona kukurudzira imwe monitoring panguva ye infusions. Vamwe vanhu vane matambudziko emoyo akakomba vangangoda kuti infusions yavo ipiwe zvishoma nezvishoma kana munzvimbo yechipatara panzvimbo pekunze infusion center.

Ndingaita Sei Kana Ndakakanganwa Kudya Mushonga weOcrelizumab?

Taura nehofisi yachiremba wako paunenge waziva kuti wakanganwa kugadzwa kwako kwejekiseni. Vachakubatsira kuronga zvakare nekukurumidza sezvinobvira, zvakanaka mukati memavhiki mashoma kubva pazuva raunenge wakanganwa.

Kukanganwa kudya mushonga kunogona kuderedza kushanda kwemushonga uye pamwe kunobvumira chiitiko cheMS kudzoka. Zvisinei, usavhunduka kana ukakanganwa kugadzwa nekuda kwekurwara kana zvimwe zviitiko. Chikwata chako chekurapa chichashanda newe kuti udzokere munzira zvakachengeteka.

Ndingaita Sei Kana Ndikava Nekuita Kwakanyanya Panguva yejekiseni?

Udza mukoti wako wejekiseni nekukasira kana ukaona chero zviratidzo zvinokunetsa panguva yekurapa. Zviratidzo zvakajairika zvekuita kwejekiseni zvinosanganisira ganda rinotsvuka, kuita ganda, kuoma kufema, kuoma pachipfuva, kana kunzwa kufenda.

Vashandi vezvokurapa vakadzidziswa kubata nemamiriro ezvinhu aya uye vanogona kunonotsa kana kumisa jekiseni, kukupa mishonga yekuwedzera, uye kukutarisa zvakanyanya. Mazhinji ekuita kwejekiseni anogoneka uye haakudzivise kupedzisa kurapwa, kunyangwe zvingatora nguva yakareba.

Ndingamira Rini Kutora Ocrelizumab?

Sarudzo yekumisa ocrelizumab inofanira kugara ichiitwa nenyanzvi yako yeMS, kwete wega. Hapana nguva yakatarwa yekurapa, sezvo vanhu vazhinji vachibatsirwa nekugara pamushonga kwenguva refu.

Chiremba wako angakurudzira kumisa kana ukava nemigumisiro yakakomba, kana MS yako ikava isina basa kwenguva yakareba, kana kana uchida kutanga mhuri. Vachakubatsira kuyera njodzi nemabhenefiti ekuenderera mberi vachipesana nekumisa kurapwa.

Ndingawana Majekiseni Ndingati Ndichiri Kutora Ocrelizumab?

Unogona kuwana majekiseni mazhinji uchiri pa ocrelizumab, asi anogona kushanda zvishoma nekuti immune system yako yakadzvanyirirwa. Chiremba wako achakurudzira kupedzisa chero majekiseni anodiwa usati watanga kurapwa pazvinobvira.

Mishonga inodzivirira miviri inorarama inofanira kudziviswa paunenge uchitora ocrelizumab, nekuti inogona kukonzera zvirwere. Izvi zvinosanganisira majekiseni akaita sejekiseni re furu rinorarama, MMR, uye jekiseni re varicella (chickenpox). Zvisinei, majekiseni asina simba akaita sejekiseni re furu renguva dzose anowanzova akachengeteka uye anokurudzirwa.