Chii chinonzi Ocriplasmin: Kushandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Ocriplasmin jekiseni remaziso rakakosha rinobatsira kurapa mamiriro chaiwo anonzi vitreomacular adhesion. Mushonga uyu unoshanda nekunyungudutsa kubatana kusinganzwisisike pakati pezvikamu zviviri zve ziso rako - vitreous gel uye macula (chikamu che retina yako chine basa rekuona kwakapinza, kwepakati).

Kana chiremba wako akakurudzira ocriplasmin, unogona kunge uri kubata nekuchinja kwekuona kunokanganisa mabasa ako ezuva nezuva. Kurapa uku kunomiririra kufambira mberi kukuru mukutarisirwa kwemaziso, kuchipa imwe nzira isingapindi kune kuvhiyiwa kwemaziso echinyakare kune vamwe varwere.

Chii chinonzi Ocriplasmin?

Ocriplasmin mushonga wakavakirwa pa enzyme unojekeswa zvakananga muziso rako kurapa vitreomacular adhesion. Iprotein yakacheneswa inoshanda semagetsi emamorekuru, ichinyatso kuputsa mapuroteni anogadzira hukama husina kufanira muziso rako.

Mushonga uyu unobva ku enzyme hombe inonzi plasmin, iyo muviri wako unogadzira zvakasikwa. Vechiremba vakagadzirisa enzyme iyi kuti iite yakatarwa uye inoshanda pakurapa mamiriro emaziso chaiwo. Funga nezvayo sechishandiso chechokwadi chakagadzirirwa zvakananga nyama yakaoma yeziso.

Kurapa uku kutsva zvishoma munyika yekutarisirwa kwemaziso, mushure mekubvumidzwa neFDA muna 2012. Inotengeswa pasi pezita rekuti Jetrea uye inomiririra kubudirira kukuru kune vanhu vakambove vaine sarudzo shoma dzekurapa.

Chii chinonzi Ocriplasmin chinoshandiswa?

Ocriplasmin inorapa vitreomacular adhesion, mamiriro apo chinhu chakaita se gel muziso rako (vitreous) chinonamatira zvisina kujairika kune macula yako. Kubatana uku kusingadiwi kunogona kukonzera matambudziko ekuona, kusanganisira kuona kwakajeka kana kwakatsveyama kwepakati.

Chiremba wako angakurudzira kurapwa uku kana uri kusangana nezviratidzo zvakaita semitsara yakatwasuka ichioneka yakakombama, kuoma kuverenga, kana matambudziko nemabasa akadzama. Mamiriro acho anowanzoita vanhu vane makore anopfuura 65, kunyangwe achigona kuitika pazera ripi zvaro.

Mune dzimwe nguva, ocriplasmin inogona kubatsirawo nemakomba madiki e macular - misodzi midiki mumacula inogona kukanganisa zvakanyanya maonero ako epakati. Zvisinei, inonyanya kushanda pamakomba madiki kudarika 400 micrometers muhupamhi.

Ocriplasmin Inoshanda Sei?

Ocriplasmin inoshanda nekuparadza mapuroteni akasiyana anobata gel ye vitreous kumacula yako. Inotarisa mapuroteni anonzi fibronectin uye laminin, ayo ari makurukota makuru anogadzira kunamatira uku kusina kujairika.

Kana yajowa muziso rako, mushonga unotanga kushanda mukati meawa kusvika kumazuva. Inonyanya kunyungudutsa molecular "glue" iri kukonzera dambudziko, ichibvumira vitreous yako kuparadzanisa zvakasikwa kubva kumacula. Iyi nzira inonzi vitreous detachment.

Mishonga inoonekwa seyepakati pesimba rekutarisira maziso. Iine simba rakakwana kugadzira kuparadzanisa kunodiwa asi yakapfava zvakakwana kudzivirira kukuvadza tishu yakatenderedza ine hutano. Vazhinji varwere vanoona kuvandudzwa mukati memavhiki mashoma, kunyangwe vamwe vachigona kuona shanduko nekukurumidza.

Ndingatora Sei Ocriplasmin?

Ocriplasmin inopiwa sejojo rimwechete zvakananga muziso rako nenyanzvi yeziso (ophthalmologist kana retinal specialist). Iyi nzira inonzi intravitreal injection uye inoitika muhofisi yachiremba wako kana nzvimbo yekuvhiyiwa yekunze.

Pamberi pejekiseni, chiremba wako achachenesa nzvimbo yakatenderedza ziso rako uye achashandisa madonhwe ekunyaradza kuti aderedze kusagadzikana. Vanogonawo kukupa madonhwe eantibiotic kudzivirira hutachiona. Jekiseni chairo rinotora masekondi mashoma, kunyangwe musangano wese unogona kutora maminitsi makumi matatu kusvika makumi matanhatu.

Haufaniri kutsanya usati waita maitiro acho, uye unogona kudya zvakajairika usati waita. Zvisinei, unofanira kuronga kuti mumwe munhu akutyairire kumba, sezvo maonero ako anogona kuva asina kujeka kana kusagadzikana kwenguva pfupi mushure mejekiseni.

Mushure mejekiseni, chiremba wako anogona kunyora madonhwe emaziso eantibiotic ekushandisa kwemazuva akati wandei. Vachaitawo nguva yekutevera-up yekutarisa kufambira mberi kwako uye kuona kuti kurapwa kuri kushanda nemazvo.

Ndingatora Ocriplasmin Kwenguva Yakareba Sei?

Ocriplasmin inowanzoitwa sejekiseni rimwe chete, uye vazhinji varwere havadi kurapwa kudzokorora. Mushonga unopfuurira kushanda muziso rako kwemavhiki akati wandei mushure mejekiseni, zvishoma nezvishoma uchinyungudutsa kunamatira kusingajairiki.

Chiremba wako achatarisa kufambira mberi kwako kuburikidza nekuongorora ziso nguva dzose mumwedzi inotevera. Mazuva ano anowanzoitika pavhiki rimwe, mwedzi mumwe, uye mwedzi mitatu mushure mejekiseni. Vamwe varwere vanogona kuda kutevera-ups zvichienderana nemhinduro yavo kurapwa.

Kana jekiseni rekutanga risingawani mhedzisiro yaunoda mushure memwedzi mitatu, chiremba wako angakurukura dzimwe nzira dzekurapa. Zvisinei, kudzokorora majekiseni eocriplasmin hazviwanzowanikwi, sezvo mushonga unokwanisa kushanda mumwedzi mishoma yekutanga kana nzira dzimwe dzichifungwa.

Ndezvipi Zvakaipa zveOcriplasmin?

Vanhu vazhinji vanowana zvimwe zvinokonzeresa mushure mejekiseni reocriplasmin, izvo zvakajairika sezvo ziso rako richigadzirisa kurapwa. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye usina hanya nezve maitiro acho.

Zvimwe zvinowanzoitika zvaungawana zvinosanganisira:

• Kurwadziwa kweziso kwenguva pfupi kana kusagadzikana (kazhinji nyoro uye kunopera mukati memazuva mashoma)
• Kuona madiki anoyangarara kana "floaters" mumuviri wako
• Maonero asina kujeka kwenguva pfupi kana kusagadzikana
• Kutsvedza kweziso kana kutsamwa
• Kunzwa chiedza kwemazuva mashoma
• Kunzwa sekunge chimwe chinhu chiri muziso rako

Mhedzisiro iyi inowanzoita nani mukati mevhiki uye zviratidzo zvekuti ziso rako riri kupindura kurapwa. Chiremba wako achapa mirairo chaiyo yekugadzirisa chero kusagadzikana.

Mhedzisiro yakakomba inowanzoitika asi inoda kutariswa kwechiremba nekukasira. Matambudziko aya asingawanzoitika anogona kusanganisira:

• Kurwadziwa kwakanyanya kweziso kusingavandudzi nemishonga yekurwadziwa inowanikwa pasina chiremba
• Kurasikirwa kwechiratidzo kamwe kamwe, kwakakura
• Mwenje unopenya kana kuwedzera kamwe kamwe kwezvinhu zvinoyangarara
• Zviratidzo zvehutachiona zvakaita sekutsvedza kwakawedzera, kubuda, kana fivha
• Kuparadzana kwemagadzirirwo eziso (kunokanganisa vanhu vashoma pane 1%)
• Kuwedzera kukuru kwekumanikidzwa kweziso

Kunyange zvazvo matambudziko akakomba aya asingawanzoitiki, zvakakosha kuti utaure nachiremba wako nekukasira kana ukaona chero zviratidzo izvi. Kurapwa nekukurumidza kunogona kudzivirira matambudziko echiratidzo asingagadzirisike.

Ndiani Asingafaniri Kutora Ocriplasmin?

Ocriplasmin haina kukodzera munhu wese ane vitreomacular adhesion. Chiremba wako achanyatsoongorora mamiriro ako chaiwo kuti aone kana uri munhu akakodzera kurapwa uku.

Haufaniri kugamuchira ocriplasmin kana uine:

• Hutachiona hweziso hunoshanda kana kuzvimba
• Makomba makuru emacular (akakura kupfuura 400 micrometers)
• High myopia (kuona pedyo kwakanyanya) nekuchinja kwemagadzirirwo eziso kwakabatana
• Kuvhiyiwa kweziso kana trauma ichangobva kuitika
• Zvimwe zvirwere zvemagadzirirwo eziso zvinokanganisa macula
• Proliferative diabetic retinopathy ine kukura kwemidziyo yeropa inoshanda

Chiremba wako achafungawo nezvehutano hwako hwese nemimwe mishonga yaunotora. Kunyange zvazvo ocriplasmin ichijowainwa zvakananga muziso, zvakakosha kuti ukurukure nhoroondo yako yezvokurapa kuti uve nechokwadi chekuti kurapwa kwakachengeteka kwauri.

Vakadzi vane pamuviri uye vanoyamwisa vanofanira kukurukura njodzi nemabhenefiti nachiremba wavo, sezvo paine ruzivo rushoma pamusoro pemigumisiro yeocriplasmin panguva yekuzvitakura nekuyamwisa.

Zita reBrand reOcriplasmin

Ocriplasmin inotengeswa pasi pezita rebrand rekuti Jetrea muUnited States nemamwe mazhinji nyika. Iri ndiro rimwechete fomu reocriplasmin rinowanikwa rekutengeswa rekubata vitreomacular adhesion.

Jetrea inogadzirwa neOxurion (aimbova ThromboGenics), kambani yeBelgian pharmaceutical inonyanya kugadzira mishonga yeziso. Mushonga uyu unouya mune vial imwe chete ine 0.1 mL yemhinduro.

Chiremba wako anogona kureva mushonga uyu nezita rimwe chete - ocriplasmin kana Jetrea - asi imishonga imwe chete. Zita rebrand rinowanzo shandiswa munzvimbo dzekurapa uye magwaro einishuwarenzi.

Zvimwe Zvinhu Zviri Kutsiva Ocriplasmin

Kana ocriplasmin isina kukodzera mamiriro ako kana isingape mhedzisiro yaunoda, pane dzimwe nzira dzekurapa dziripo. Chiremba wako achakubatsira kunzwisisa kuti ndeipi sarudzo ingashanda zvakanyanya kumamiriro ako chaiwo.

Imwe nzira huru ndeye vitrectomy, maitiro ekuvhiya uko chiremba wako anobvisa vitreous gel kubva muziso rako uye anotsiva nemhinduro yesaline. Kuvhiya uku kunopinda zvakanyanya kupfuura jekiseni reocriplasmin asi rine chiyero chekubudirira chakakwira chekurapa vitreomacular adhesion.

Kune vamwe varwere, kuchenjerera kungave kwakakodzera, kunyanya kana zviratidzo zviri nyoro. Zvizhinji zvezviitiko zvevitreomacular adhesion zvinogadzirisa zvega nekufamba kwenguva pasina kurapwa.

Mishonga mimwe iri kutsvagiswa yemamiriro akafanana, asi ocriplasmin inoramba iri iyo chete FDA-yakabvumidzwa kurapwa kwemishonga ye vitreomacular adhesion. Nyanzvi yako yeziso inogona kukurukura kuti ndeipi nzira inoita zvakanyanya kunzwisisa kune yako chaiyo kesi.

Ko Ocriplasmin Zviri Nani Kupfuura Kuvhiya kweVitrectomy?

Ocriplasmin uye kuvhiya kwevitrectomy imwe neimwe ine zvakanakira zvakasiyana, uye sarudzo yakanakisa inoenderana nemamiriro ako chaiwo uye zvaunofarira. Hapana kurapwa kwakanyanya - vanoshumira varwere vakasiyana uye mamiriro.

Ocriplasmin inopa mabhenefiti akati wandei seimwe nzira isingapindi zvakanyanya. Maitiro ejekiseni anotora maminitsi mashoma chete, haadi anesthesia yakajairika, uye ane nguva pfupi yekupora. Unogona kazhinji kudzokera kumabasa ako akajairika mukati memazuva mashoma, uye hapana njodzi yekugadzirwa kwecataract, iyo inogona kuitika mushure mevitrectomy.

Zvisinei, kuvhiyiwa kwevitrectomy kune chiyero chekubudirira chakakwirira, ichishanda mune angangoita 90-95% yezviitiko zvichienzaniswa ne25-40% yekubudirira kweocriplasmin. Kuvhiyiwa kunobvumira chiremba wako kuti agadzirise mamwe matambudziko emaziso panguva imwe chete uye inopa mhedzisiro inotungamira.

Chiremba wako achafunga nezvezvinhu zvakaita sehukuru hwegomba re macular, simba re vitreomacular adhesion, zera rako, uye hutano hwako hwese paanokurudzira kurapwa. Madhokotera mazhinji anoedza ocriplasmin kutanga kana zvakakodzera, sezvo isingapindi zvakanyanya uye inogona kudzivirira kudiwa kwekuvhiyiwa.

Mibvunzo Inowanzo Bvunzwa Nezve Ocriplasmin

Ocriplasmin Yakachengeteka Here Kune Vanhu vane Chirwere cheShuga?

Ocriplasmin inogona kuva yakachengeteka kune vanhu vane chirwere cheshuga, asi chiremba wako achada kuongorora zvakanyatsonaka mamiriro ako emaziso ekutanga. Kana uine diabetic retinopathy, kunyanya mhando inobereka ine kukura kwemidzi yeropa itsva, ocriplasmin inogona kusakurudzirwa.

Chirwere cheshuga chinogona kukanganisa retina yako nenzira dzinoita kuti ocriplasmin isashande zvakanaka kana kuva nenjodzi. Chiremba wako achaita kuongororwa kwemaziso kwakadzama uye anogona kuraira bvunzo dzakakosha dzekufungidzira kuti aongorore kana ocriplasmin yakakodzera kwauri.

Kana uine chirwere cheshuga chinodzorwa zvakanaka pasina shanduko huru dzeretinal, ocriplasmin inogona kuva imwe sarudzo. Chinhu chakakosha ndechokuva nekukurukurirana kwechokwadi nenyanzvi yako yeretinal pamusoro pekutarisirwa kwako chirwere cheshuga uye hutano hwemaziso ako hwese.

Ndingaita Sei Kana Ndikawana Kurwadziwa Kwakanyanya Mushure meOcriplasmin Injection?

Taura nachiremba wako nekukasira kana uine kurwadziwa kwakanyanya kwemaziso kusingavanduki nemishonga yekurwadziwa inowanikwa pasina mushonga kana kuwedzera kuipa nekufamba kwenguva. Kunyange kusagadzikana kudiki kwakajairika mushure mejekiseni, kurwadziwa kwakanyanya kunogona kuratidza matambudziko anoda kurapwa nekukasira.

Chiremba wako anogona kuda kuongorora ziso rako kuti aone zviratidzo zveutachiona, kuwedzera kumanikidzwa kwemaziso, kana zvimwe zvikonzero. Vanogona kunyora mishonga yekurwadziwa yakasimba kana mamwe marapirwo zvichienderana nezvavanowana.

Usamirira kuti uone kana kurwadziwa kwakanyanya kuchivanduka pachako. Kupindira nekukasira kunogona kudzivirira matambudziko akakomba uye kubatsira kuchengetedza chiono chako. Mazhinji emakiriniki emaziso ane nhamba dzekubata dzekunze kwemaawa dzekunetseka nekukasira.

Ndichaziva rini kana Ocriplasmin iri kushanda?

Unogona kutanga kuona kuvandudzwa muchiono chako mukati memavhiki mashoma ekutanga mushure mejekiseni, kunyange vamwe varwere vachiona shanduko nekukurumidza. Mushonga uyu unoenderera mberi uchishanda kwemavhiki akati wandei, saka usanetseka kana usingaone mhedzisiro nekukasira.

Chiremba wako achatarisa kufambira mberi kwako kuburikidza nekugadzwa kwekutevera nguva dzose, kazhinji kwakarongwa pavhiki rimwe, mwedzi mumwe, uye mwedzi mitatu mushure mejekiseni. Vachashandisa bvunzo dzakakosha dzekufananidza kuti vaone kana vitreomacular adhesion iri kusununguka.

Panguva yemwedzi mitatu, chiremba wako anogona kazhinji kuona kana kurapwa kwakabudirira. Kana ocriplasmin isina kuwana mhedzisiro yaunoda panguva iyoyo, vanozokurukura dzimwe nzira dzekurapa newe.

Ndingatyaira here mushure mekuwana Ocriplasmin?

Haufanire kutyaira nekukasira mushure mekuwana jekiseni reocriplasmin, sezvo chiono chako chingave chisina kujeka kana kusagadzikana kwenguva pfupi. Ronga kuti mumwe munhu akutyairire kumba kubva kumusangano.

Varwere vazhinji vanogona kutangazve kutyaira mukati mezuva rimwe kana maviri, kana chiono chavo chajeka uye chero kusagadzikana kwapera. Zvisinei, unofanira kumirira kusvikira wanzwa kuti chiono chako chakachengeteka kutyaira uye unogona kuverenga zviratidzo zvemigwagwa zvakajeka.

Chiremba wako achapa gwara rakajeka rekuti unogona kudzokera kupururira rini zvichienderana nekuti ziso rako rinopindura sei kurapwa. Kana uine zvinokunetsa nezvekuona kwako mushure mejekiseni, usazeze kubata hofisi yachiremba wako.

Kune Zvipi Zvipingamupinyi Zvenguva Refu zve Ocriplasmin?

Vazhinji varwere havawanzove nemigumisiro yenguva refu kubva kurapwa kwe ocriplasmin. Mushonga wakagadzirirwa kushanda kwenguva pfupi wobva wabviswa muziso rako zvakasikwa nekufamba kwenguva.

Vamwe varwere vanogona kuona shanduko dzechigarire muma floaters avo kana mhando yekuona yakasiyana zvishoma, asi izvi zvinowanzoenderana nechinhu chiri pasi pezvirwere panzvimbo yemushonga wacho pachayo. Chinangwa ndechekuvandudza kuona kwako kwese uye mhando yehupenyu.

Chiremba wako achaenderera mberi nekutarisa hutano hweziso rako panguva yekutevera-kumusoro kusangana kuti ave nechokwadi chekuti hapana migumisiro isingatarisirwi yenguva refu. Kana ukaona chero shanduko dzinonetsa mukuona kwako mwedzi kana makore mushure mekurapwa, bata mupi weziso rako kuti aongorore.