Chii chinonzi Pafolacianine: Zvinoshandiswa, Mishonga, Migumisiro Yemativi uye Zvimwe

Pafolacianine imishonga inoratidza mifananidzo inobatsira vanachiremba kuvona masero ekenza zvakajeka panguva yekuvhiya. Mushonga uyu wakakosha unoshanda semucherechedzi wemaviri ekenza, uchiita kuti upenye pasi pechiedza chakakosha che infrared kuitira kuti vanachiremba vagone kuziva nekubvisa tuma tumor vachichengetedza tishu ine hutano.

Mishonga iyi inomiririra kufambira mberi kukuru mukuvhiya kwakaringana, kunyanya nzira dzekenza yeovari. Inopiwa kuburikidza ne IV isati yavhiyiwa uye inoungana mumaseru ekenza, ichibatsira vanachiremba kufamba mumabasa akaoma nekuvimba kukuru uye kururama.

Pafolacianine Inoshandiswa Kunei?

Pafolacianine inonyanya kushandiswa kubatsira vanachiremba kuziva tishu yekenza yeovari panguva yekuvhiya. Mushonga uyu unoshanda segwara rekuona, uchiratidza masero ekenza ayo angave akaoma kusiyanisa kubva kune tishu ine hutano nemaziso akashama.

Mumiririri uyu wekuona anobvumidzwa zvakanyanya kuvakadzi vakuru vari kuvhiyiwa nekuda kwefungidziro kana kusimbiswa kwekenza yeovari. Inobatsira vanachiremba kuita zvisarudzo zvine ruzivo rwakawanda pamusoro petishu yekubvisa uye iyo yekuchengetedza, zvichikwanisa kuvandudza mhedzisiro yekuvhiya.

Mishonga iyi iri kudzidzwawo kune mamwe marudzi ekenza kuvhiya, kunyangwe kenza yeovari ichiramba iri yayo yekutanga yakabvumidzwa kushandiswa. Chikwata chako chekuvhiya chichasarudza kana mumiririri uyu wekuona akakodzera mamiriro ako chaiwo.

Pafolacianine Inoshanda Sei?

Pafolacianine inoshanda nekunangana nefolate receptors, ayo ari mapuroteni anowanikwa mumakoncentiresheni akakwirira pamaseru mazhinji ekenza. Funga nezve receptors izvi sezviteshi zvekuisa zvinoshandiswa nemaseru ekenza kuti aunganidze zvinovaka muviri zvaanoda kuti akure uye ararame.

Kana yaiswa mumutsipa wako weropa, mushonga unofamba mumuviri wako wese uye unonamatira kune aya ma folate receptors. Masero ekenza anowanzo kuva nemareceptors akawanda kupfuura masero ane hutano, saka mushonga unoungana zvakanyanya munyama ine kenza.

Panguva yekuvhiya, chiremba wako anovhiya anoshandisa kamera yakakosha ye infrared kuti aone kwakaunganidzwa mushonga. Nyama yekenza inoita seinojeka kana kuita fluorescence pasi pechiedza ichi chakakosha, ichigadzira musiyano wakajeka wekuona pakati penzvimbo dzine hutano nedzine kenza.

Izvi zvinoonekwa seane simba repakati pekuongorora rinopa ruzivo rwakakosha pasina kuchinja zvakanyanya mabasa ako akajairika emuviri. Mushonga haurape kenza pachayo asi unoshanda sechishandiso chekuvhiya.

Ndingatora sei Pafolacianine?

Pafolacianine inopiwa chete nenyanzvi dzehutano kuburikidza nemutsipa we intravenous (IV) muchipatara kana nzvimbo yekuvhiya. Hauzotore mushonga uyu kumba kana nemuromo.

Mushonga unowanzoitwa maawa 1 kusvika ku9 isati yatanga kuvhiya kwako. Chikwata chako chekurapa chichasarudza nguva chaiyo zvichienderana nemaitiro ako chaiwo uye zvaunoda zvekurapa.

Haufaniri kutora mushonga uyu nechikafu kana mukaka sezvo uchipiwa zvakananga mumutsipa wako weropa. Zvisinei, chikwata chako chekuvhiya chingakupa mirairo chaiyo yekudya kana kunwa usati waita maitiro ako, ayo aunofanira kutevera nekuchenjerera.

Maitiro ekugadzirira akareruka. Mukoti wako achatanga mutsipa we IV uye zvishoma nezvishoma achinjisa mushonga kwemaminitsi akati wandei. Wobva wamirira nguva yakakodzera isati yatanga kuvhiya kwako.

Ndingatora Pafolacianine kwenguva yakareba sei?

Pafolacianine inopiwa sedosi imwe chete isati yavhiyiwa, kwete sekurapa kuri kuenderera mberi. Uchapihwa mushonga kamwe chete, uye uchashanda mukati memaitiro ako ekuvhiya.

Mushonga uyu unogara uchishanda mumuviri mako kwemaawa akati wandei, izvo zvakakwana kuita nzira dzakawanda dzekuvhiya. Muviri wako uchabvisa mushonga uyu zvakasikwa mumazuva anotevera pasina chero imwe kurapwa kunodiwa.

Kusiyana nemishonga yakawanda inoda madosi ezuva nezuva kana nzira dzakawedzerwa dzekurapa, pafolacianine yakagadzirirwa kushandiswa kamwe chete. Hapana chikonzero chekunetseka nezvekuyeuka kutora madosi kana kutarisira chirongwa chemishonga chakaoma.

Ndezvipi Zvipingamupinyi zvePafolacianine?

Vanhu vazhinji vanotsungirira pafolacianine zvakanaka, nemigumisiro inowanzoita nyoro uye yenguva pfupi. Maitiro anowanzoitika munguva pfupi mushure mekuwana jekiseni uye anowanzoenda nekukurumidza.

Heano migumisiro yaungasangana nayo, uchifunga kuti vanhu vazhinji havana chero maitiro anozivikanwa:

Migumisiro yakajairika inosanganisira:

• Kusvotwa kana dumbu rinotsamwisa
• Kushanduka kwenguva pfupi kwemumvuri weweti (inogona kuoneka yero kana girini)
• Maitiro eganda akapfava panzvimbo yekujekiseni
• Dizziness pfupi kana lightheadedness
• Kushanduka kwenguva pfupi mukuti zvinhu zvinonaka sei

Migumisiro isingawanzoitiki asi yakakomba inogona kusanganisira:

• Maitiro ekuita allergic ane zviratidzo zvakaita serash, itching, kana kuoma kufema
• Kushanduka kukuru muropa
• Kusvotwa kwakanyanya kana kurutsa
• Kurwadziwa muchipfuva kana shanduko yerhythm yemoyo
• Maitiro akakomba panzvimbo yekujekiseni

Chikwata chako chekurapa chichakutarisa zvakanyanya mushure mekuwana mushonga uye mukati mekuvhiya kwako. Kana iwe ukasangana nechero zviratidzo zvinonetsa, vakagadzirira zvakanaka kuzvigadzirisa nekukurumidza.

Ndiani Asingafaniri Kutora Pafolacianine?

Pafolacianine haina kukodzera munhu wese, uye chikwata chako chekurapa chichanyatsoongorora nhoroondo yako yehutano usati waona kana yakakukodzera. Mushonga uyu une zvinopesana zvinoita kuti usakodzere vanhu vakati wandei.

Hamufaniri kugamuchira pafolacianine kana muchiziva kuti mune allergy kumushonga uyu kana chimwe chezvinhu zvaunoshandisa. Chiremba wenyu achakurukura nezve chero allergic reactions dzamakambove nadzo kumishonga kana imaging agents.

Vanhu vane chirwere chakakomba cheitsvo vangave vasina kukodzera mushonga uyu, sezvo muviri uchivimba nebasa reitsvo kuti ubvise mushonga. Chiremba wenyu achaongorora bvunzo dzebasa reitsvo renyu musati maenderera mberi nekusarudza izvi.

Kana muri nepamuviri kana muchiyamwisa, kuchengeteka kwepafolacianine hakuna kumiswa zvizere. Chikwata chenyu chekurapa chichayerera zvakanakira nenjodzi zvakanyatso chenjerera mumamiriro ezvinhu aya.

Mamwe mamiriro emoyo kana matambudziko eropa anogonawo kuita kuti mushonga uyu usakodzere. Chiremba wenyu wekuvhiya uye anesthesiologist vachaongorora nhoroondo yenyu yekurapa kuti vave nechokwadi chekuchengeteka kwenyu.

Mazita ePafolacianine Brand

Pafolacianine inotengeswa pasi pezita rekuti Cytalux muUnited States. Iri ndiro zita rekutanga rekutengesa iro muchangosangana naro kana muchikurukura mushonga uyu nechikwata chenyu chehutano.

Mushonga uyu unogona kutaurwa nezita rawo generic (pafolacianine) kana zita remhando (Cytalux) zvakatsinhaniswa munzvimbo dzekurapa. Mazita ese ari maviri anoreva mushonga mumwe chete une zvinhu zvakafanana uye mhedzisiro.

Paunenge uchironga kuvhiyiwa kwako kana kuongorora chirongwa chako chekurapa, unogona kuona rimwe zita rinoshandiswa mumarekodhi ako ekurapa kana mirairo yekubuda. Usanetseka kana ukaona mazita ese ari maviri - imishonga imwe chete.

Zvimwe Zvinhu zvePafolacianine

Parizvino, pane zvishoma zvakananga zvinotsiva pafolacianine yekuvhiya kunotungamirwa nefluorescence muovarian cancer. Nzira dzekuvhiya dzechinyakare dzinovimba nekuongorora kwekuona kwechiremba uye ruzivo pasina gwara refluorescent.

Dzimwe nzira dzekuongorora dzinoshandiswa panguva yekuvhiyiwa dzinosanganisira intraoperative ultrasound, iyo inoshandisa masaisai eruzha kugadzira mifananidzo yechokwadi yezvinhu zvemukati. Zvisinei, izvi zvinopa ruzivo rwakasiyana pane fluorescent imaging.

Mamwe masangano ekurapa anoshandisa mamwe ma fluorescent agents emhando dzakasiyana dzekuvhiyiwa kwekenza, asi izvi hazviwanzo kuchinjana ne pafolacianine yezvirongwa zvekenza yeovari.

Chiremba wako achakurukura nzira yakanakisa yemamiriro ako chaiwo, iyo inogona kusanganisira kushandisa pafolacianine, nzira dzekuvhiya dzechinyakare, kana musanganiswa wenzira kuti uwane mhedzisiro yakanakisa.

Ko Pafolacianine Zviri Nani Pane Dzimwe Nzira Dzekuongorora Here?

Pafolacianine inopa zvakanakira zvakasiyana pane nzira dzechinyakare dzekuongorora kuvhiya, kunyanya mukukwanisa kwayo kuratidza tishu rekenza munguva chaiyo panguva yekuvhiyiwa. Izvi zvinogona kubatsira zvakanyanya mumamiriro akaoma apo tishu rekenza rinogona kuoma kusiyanisa kubva kune tishu ine hutano.

Nzira dzechinyakare dzekuvhiya dzinovimba zvakanyanya nekuongorora kwechiremba, kuongorora tactile, uye ruzivo. Kunyange zvazvo nzira idzi dzichibudirira, hadzisi kupa rumwe ruzivo rwekuona runopiwa ne fluorescent imaging.

Kana ichienzaniswa nedzimwe nzira dzekuongorora dzakadai seCT scans kana MRI, pafolacianine inopa ruzivo panguva yekuvhiyiwa chaiko panzvimbo pekutanga. Iyi gwara renguva chaiyo rinogona kubatsira machiremba kuita sarudzo dzine ruzivo rwakawanda nezvekubviswa kwetishu.

Sarudzo pakati pe pafolacianine nedzimwe nzira dzinoenderana nemamiriro ako chaiwo, kuoma kwekuvhiyiwa kwako, uye hunyanzvi hwechiremba wako. Machiremba mazhinji anoshandisa nzira dzakawanda pamwechete kuti vawane mhedzisiro yakanakisa.

Mibvunzo Inowanzo Bvunzwa Nezve Pafolacianine

Ko Pafolacianine Yakachengeteka Kuvanhu Vane Chirwere Cheitsvo Here?

Pafolacianine ingangove isina kukodzera vanhu vane chirwere chakakomba cheitsvo sezvo itsvo dzichitamba basa rakakosha mukubvisa mushonga mumuviri wako. Chiremba wako achatarisa bvunzo dzemabasa eitsvo yako asati asarudza kana mushonga uyu wakakodzera iwe.

Kana uine matambudziko eitsvo akapfava kusvika pakati nepakati, timu yako yezvokurapa ingangofunga kushandisa pafolacianine asi ichakutarisa zvakanyanya. Vanogonawo kugadzirisa zvimwe zvikamu zvekutarisirwa kwako kuti vatarise kubviswa kwemishonga kunonoka.

Ndingaita Sei Kana Ndikawana Maitiro eAllergic kuPafolacianine?

Sezvo pafolacianine ichipiwa munzvimbo yechipatara nevashandi vezvokurapa varipo, chero maitiro eallergic achazivikanwa nekukurumidza uye kurapwa nechikwata chako chehutano. Haufaniri kuita chero chiito chaicho iwe pachako.

Zviratidzo zveallergic reaction zvinosanganisira rash, itching, matambudziko ekufema, kana kuzvimba. Chikwata chako chezvokurapa chakadzidziswa kubata izvi zviitiko uye chine mishonga yekukurumidzira inowanikwa kana zvichidikanwa.

Ndingaita Sei Kana Ndine Zvinetso Pamusoro peMishonga?

Kusiyana nemishonga yaunotora kumba, pafolacianine inotungamirirwa nenyanzvi dzehutano dzichakutarisa iwe mukati mekuita. Kana uine chero zvinetso usati watora mushonga, taura navo nechikwata chako chekuvhiya.

Vapi vako vehutano varipo kuti vataure chero mibvunzo kana kunetseka kwaungave uine pamusoro pemushonga kana kuvhiyiwa kwako. Usazeze kutaura kana chimwe chinhu chisinganzwe zvakanaka.

Mishonga Ichasiya Rinhi System Yangu?

Pafolacianine inowanzo kubviswa mumuviri wako mukati memazuva mashoma mushure mekuvhiyiwa kwako. Itswo dzako dzinobvisa mushonga zvakasikwa, uye uchauisa kuburikidza neweti yako.

Unogona kuona imwe ruvara rwenguva pfupi rwevheti yako kwezuva rimwe kana maviri mushure mekutora mushonga. Izvi zvakajairika uye zvinoratidza kuti muviri wako uri kugadzirisa uye kubvisa mushonga sezvaitarisirwa.

Ndingatyaira Mota Mushure meKugamuchira Pafolacianine?

Sezvo pafolacianine ichipiwa pamberi pekuvhiyiwa, hauzotyairi mota pakarepo mushure mekuigamuchira. Mushonga wacho pachake hauwanzokanganisa kugona kwako kutyaira, asi uchavhiyiwa uye pamwe uchagamuchira anesthesia.

Chikwata chako chekuvhiya chichapa mirairo chaiyo yekuti unogona kutangazve kutyaira rini zvichibva pane maitiro ako nekupora. Sarudzo iyi ichatsamira zvakanyanya pakuva kwako uye anesthesia pane pafolacianine pachayo.