Chii chinonzi Panitumumab: Zvazvinoshandiswa, Mishonga, Migumisiro Yakaipa nezvimwe

Panitumumab mushonga wekenza unovavarira kubatsira kurwisa kenza yeguru nekudzivisa mapuroteni chaiwo anobatsira masero ekenza kukura. Inopiwa kuburikidza neIV infusion kuchipatara kana nzvimbo yekurapa kenza, uko timu yako yezvokurapa inogona kukutarisa zvakanyanya panguva yese yacho.

Mishonga iyi ndeyeboka rinonzi monoclonal antibodies, iro rinoshanda semabhomba anotungamirirwa anovavarira masero ekenza vachisiya masero mazhinji ane hutano ega. Chiremba wako anowanzo kuraira panitumumab kana dzimwe nzira dzekurapa dzisina kushanda sezvaitarisirwa, kana pamwe chete nemimwe mishonga yekenza kuti kurapa kuve kunobudirira.

Chii chinonzi Panitumumab?

Panitumumab ndeye antibody yakagadzirwa murabhoritari iyo inotevedzera mapuroteni emuviri wako echisikigo ekudzivirira. Inonyanya kuvavarira uye inovharisa puroteni inonzi EGFR (epidermal growth factor receptor) iyo inogara pamusoro pemasero ekenza uye inovabatsira kuwanda nekupararira.

Funga nezve EGFR sechivharo pamasero ekenza, uye panitumumab sechinhu chinokodzera muchivharo ichocho uye chinomisa kushanda kwayo. Kana puroteni iyi ikavharwa, masero ekenza haagone kugamuchira zviratidzo zvavanoda kuti vakure nekukurumidza.

Mishonga iyi yakagadzirwa zvachose, zvinoreva kuti inogadzirwa murabhoritari panzvimbo yekutorwa kubva kuvanhu kana mhuka. Maitiro ekugadzira anovimbisa kuenderana uye kuchengeteka mune yega yega dose yaunogamuchira.

Chii chinonzi Panitumumab chinoshandiswa?

Panitumumab inorapa kenza yeguru inopararira, zvinoreva kenza yakatanga muguru rako kana rectum uye yakapararira kune dzimwe nhengo dzemuviri wako. Chiremba wako anongoraira mushonga uyu chete kana masero ako ekenza aine genetic makeup chaiyo inoita kuti vave nemukana wekupindura zvakanaka.

Usati watanga kurapwa, unozoda bvunzo chaiyo yegeni inonzi KRAS kuti uone kana maseru ako ekenza aine shanduko dzakasiyana. Bvunzo iyi yakakosha nekuti panitumumab inoshanda zvakanaka chete muvanhu vane maseru ekenza asina shanduko idzi dzeKRAS.

Oncologist wako angakurudzira panitumumab seimwe chete yekurapa kana kuibatanidza nemamwe madhiragi echemotherapy akadai seFOLFOX kana FOLFIRI. Nzira yekubatanidza inowanzo kubatsira kuvandudza mhedzisiro yekurapa nekutambudza maseru ekenza nenzira dzakawanda panguva imwe chete.

Dzimwe nguva vanachiremba vanonyora panitumumab kana mamwe marapirwo amira kushanda zvakanaka, vachikupa imwe sarudzo yekurwisa kenza. Inoshandiswawo seyekutanga-mutsetse kurapwa mune dzimwe nguva apo bvunzo dzegeni dzinoratidza kuti kenza yako inogona kupindura zvakanaka.

Panitumumab Inoshanda Sei?

Panitumumab inoshanda nekuzvibatanidza kune mapuroteni eEGFR pamusoro pemaseru ekenza, zvichivharira zviratidzo zvinoudza maseru ekenza kukura nekukwidziridzwa. Iyi nzira yakatarwa inoita kuti ive kurapwa kwakanyatsojeka zvichienzaniswa nechemotherapy yechinyakare iyo inokanganisa maseru ane hutano uye ane kenza.

Kana maseru ekenza asingakwanise kugamuchira zviratidzo zvekukura kuburikidza neEGFR, anova asina hukasha uye anogona kutotanga kufa zvakasikwa. Iyi nzira haizoitiki husiku humwe, ndosaka uchizoda kurapwa kwakawanda kwemwedzi yakati wandei kuti uone mabhenefiti akazara.

Mishonga inoonekwa seyakasimba zvine mwero kurapwa kwekenza, yakatarwa zvakanyanya pane chemotherapy yechinyakare asi ichiri ine simba rakakwana rekukonzera mhedzisiro yakakosha. Muviri wako wekudzivirira chirwere unogonawo kutanga kuziva nekutambudza maseru ekenza zvakanyanya kana panitumumab ikavhiringidza maitiro avo ekukura.

Kusiyana nemishonga yechemotherapy inoshanda mumuviri wako wese, panitumumab inonyanya kukanganisa masero ane mazinga epamusoro eEGFR mapuroteni. Iyi nzira yekusarudza inobatsira kutsanangura nei ichigona kushanda pamarudzi akati wandei ekenza ichikonzera mashoma mativi emuviri.

Ndingatora Sei Panitumumab?

Panitumumab inogara ichipiwa seIV infusion kuchipatara, nzvimbo yekenza, kana kiriniki yakakosha uko vashandi vehutano vakadzidziswa vanogona kukutarisa zvakanyanya. Hauzogone kutora mushonga uyu kumba kana semupiritsi, sezvo uchida kupiwa zvakananga muropa rako.

Vashandi vehutano vako vachaisa tsono diki mutsinga muruoko rwako, kana kuti unogona kuva nemutsara wepakati kana chiteshi kana uri kuwana kurapwa kwakawanda kwekenza. Iyo infusion inowanzo tora maminitsi angangoita 60 kusvika 90, panguva iyo uchagara zvakanaka muchigaro chinotsamira.

Pamberi peimwe neimwe infusion, iwe unowanzo gamuchira premedication kubatsira kudzivirira maitiro ekuita allergic. Izvi zvinogona kusanganisira antihistamines, steroids, kana mamwe mishonga inobatsira muviri wako kutsungirira kurapwa zviri nani.

Haufaniri kudzivisa chikafu usati warapwa, asi kudya chikafu chakareruka pamberi kunogona kubatsira kudzivirira kusvotwa. Kugara uine mvura yakawanda nekunwa mvura yakawanda mumazuva anotungamira ku infusion yako kunobatsirawo muviri wako kugadzirisa mushonga zvakanyanya.

Ronga kupedza maawa anenge 3 kusvika 4 panzvimbo yekurapa pakuenda kumwe nekumwe, kusanganisira nguva yekugadzirira, iyo infusion chaiyo, uye nguva shoma yekutarisa mushure. Kuunza bhuku, piritsi, kana kuva nemumwe wemhuri anokuperekedza kunogona kubatsira kuita kuti nguva ipfuure zviri nyore.

Ndingatora Kwenguva Yakareba Sei Panitumumab?

Kureba kwekurapwa kwe panitumumab kunosiyana zvakanyanya zvichienderana nekuti kenza yako inopindura sei uye kuti muviri wako unotsungirira sei mushonga. Vanhu vazhinji vanogamuchira infusions mumasvondo maviri ega ega, asi chirongwa chako chaiwo chichavimba nechirongwa chako chekurapa.

Chiremba wako wezve oncology achaenderera mberi nekurapa chero bedzi kenza yako ichipindura zvakanaka uye iwe usiri kusangana nemigumisiro yakakomba inodarika mabhenefiti. Vamwe vanhu vanogamuchira panitumumab kwemwedzi yakati wandei, nepo vamwe vachigona kuida kwegore kana kupfuura.

Ma scans enguva dzose uye bvunzo dzeropa dzichabatsira timu yako yezvokurapa kuti izive kana kurapwa kuri kushanda zvakanaka. Kana ma scans achiratidza kuti tumor iri kudzikira kana kuramba yakagadzikana, iwe ungangodaro uchaenderera mberi nechirongwa chazvino.

Kurapa kunogona kumiswa kana kumiswa kana iwe ukaita migumisiro yakakomba isingavandudzi nekutarisirwa kunotsigira, kana kana ma scans achiratidza kuti kenza iri kukura pasinei nekurapa. Chiremba wako achakurukura izvi zvinogoneka newe uye achakubatsira kunzwisisa zvekutarisira.

Ndezvipi Zvipingamupinyi zvePanitumumab?

Panitumumab inogona kukonzera migumisiro yakasiyana-siyana, nematambudziko ane chekuita neganda achiita seanowanzoitika uye kazhinji anonyanya kuoneka. Kunzwisisa zvekutarisira kunogona kukubatsira kuti utarise izvi zvinokonzeresa uye kutaurirana zvinobudirira nechikwata chako chehutano.

Migumisiro inowanzoitika yaungasangana nayo inosanganisira maitiro eganda anogona kunge asina kugadzikana asi anowanzo manejwa nekutarisirwa kwakakodzera:

• Meno-akaita serashi pachiso chako, chipfuva, uye kumashure zvinogona kuoneka mukati memavhiki mashoma ekurapa
• Ganda rakaoma, rakatsemuka rinogona kuva rinorwadza kana kuva nehutachiona kana risina kunyoroveswa zvakanaka
• Kuchinja mukuumbwa kwebvudzi rako, richiita kuti riome, riome, kana kukombama
• Kuchinja kwembambo kusanganisira kurwadziwa, kuzvimba, kana hutachiona kutenderedza zvigunwe zvako nezvigunwe
• Kuwedzera kunzwisiswa kwechiedza chezuva, zvichiita kuti upise nyore
• Kuneta kunogona kuita kuti mabasa ezuva nezuva ave nematambudziko
• Dhiria inogona kubva pakati nepakati kusvika kune yakakomba
• Nausea uye dzimwe nguva kurutsa

Mhedzisiro iyi inowanzoita nani muviri wako paunojaira kurapwa, uye timu yako yehutano inogona kupa mishonga uye nzira dzekubatsira kuzvidzora nemazvo.

Vamwe vanhu vanowana mhedzisiro yakakomba inoda kutariswa kwekurapa nekukurumidza, kunyangwe izvi zvisingawanzoitiki:

• Kusagadzikana kwakanyanya kwemuviri panguva kana nguva pfupi mushure mekuiswa, kusanganisira kuoma kufema, kuoma pachipfuva, kana kuzvimba
• Zvirwere zvakakomba zvepaganda zvinobva pakukwenya kana kutarisirwa kusina kukwana kwemakwapa
• Kushaya mvura kwakanyanya kubva kurutsvo rusingaperi kana kurutsa
• Matambudziko emaziso anosanganisira kuoma kwakanyanya, kurwadziwa, kana shanduko dzekuona
• Kusagadzikana kweelectrolyte kunogona kukonzera kushaya simba, kuvhiringidzika, kana matambudziko emoyo
• Matambudziko emapapu anosanganisira kufema nekukurumidza kana kukosora kusingaperi

Timu yako yezvokurapa ichakutarisa zvakanyanya kuti uone mhedzisiro iyi yakakomba uye ichapa kurapwa nekukurumidza kana ikaitika. Mhedzisiro yakawanda inogoneka nerutsigiro rwakakodzera rwekurapa uye haidi kumisa kurapwa zvachose.

Ndiani Asingafaniri Kutora Panitumumab?

Panitumumab haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana iri sarudzo chaiyo yemamiriro ako chaiwo. Mamiriro akati wandei uye mamiriro anoita kuti kurapwa uku kusakodzera kana kungave kwengozi.

Haufanire kugamuchira panitumumab kana uine gomarara remukati rakashandurwa neKRAS, sezvo bvunzo dzemajini dzakaratidza kuti mushonga uyu haushande mumamiriro ezvinhu aya. Chiremba wako anogara achiraira bvunzo iyi yemajini asati arayira kurapwa.

Vanhu vane matambudziko akakomba emoyo, mapapu, kana chiropa vangave vasiri vakakodzera panitumumab, sezvo mamiriro aya anogona kuita kuti muviri wako utarisane nemushonga zvakachengeteka. Timu yako yezvokurapa ichaongorora nhoroondo yako yezvokurapa yakazara usati waita sarudzo dzekurapa.

Kana wakambove nemaitiro akakomba ekurwara nemamwe ma monoclonal antibodies kana mishonga yakafanana, panitumumab ingasava yakakunakira. Chiremba wako achakurukura nhoroondo yako yekurwara zvakadzama kuti aongorore njodzi.

Vakadzi vane pamuviri havafaniri kupiwa panitumumab, nekuti inogona kukuvadza mwana ari kukura. Kana uri pazera rekubereka vana, unozofanira kushandisa nzira dzinoshanda dzekudzivirira pamuviri panguva yekurapwa uye kwemwedzi yakati wandei mushure meizvozvo.

Vanhu vane zvirwere zvakakomba, zvinoshanda vangangoda kumirira kusvikira izvi zvapera zvakakwana vasati vatanga panitumumab, nekuti mushonga unogona kukanganisa kugona kwemuviri wako kurwisa zvirwere.

Mazita eBrand ePanitumumab

Panitumumab inotengeswa pasi pezita rebrand Vectibix muUnited States nemamwe mazhinji nyika. Iri ndiro chete fomu rinowanikwa rekutengeserana remushonga uyu, rinogadzirwa neAmgen.

Kusiyana nemimwe mishonga ine mazita akawanda ebrand kana mavhezheni e generic, panitumumab inongowanikwa seVectibix. Izvi zvinovimbisa kuenderana mukuyera uye mhando, sezvo varwere vese vachigamuchira fomu rimwe chete pasinei nekuti vanogamuchira kurapwa kupi.

Kambani yako yeinishuwarenzi nevapi vehutano vachashandisa zita rimwe chete remushonga uyu - panitumumab kana Vectibix - uye zvinoreva chinhu chimwe chete. Vamwe vashandi vezvokurapa vanosarudza kushandisa zita re generic, asi vamwe vanoshandisa zita rebrand kazhinji.

Zvimwe zvinogona kushandiswa panzvimbo pePanitumumab

Mishonga yakati wandei inoshanda zvakafanana nepanitumumab yekurapa kenza yemukati, kunyangwe imwe neimwe iine mashandisiro ayo chaiwo uye maitiro ekukanganisa. Oncologist wako achasarudza sarudzo yakanakisa zvichienderana nemaitiro ekenza yako uye hutano hwako hwese.

Cetuximab (Erbitux) ndiyo imwe nzira yakafanana, sezvo ichinangisawo mapuroteni eEGFR pamasero ekenza. Kufanana nepanitumumab, inoshanda chete muvanhu vane masero ekenza asina KRAS mutations, asi inopiwa vhiki nevhiki panzvimbo pemavhiki maviri ega ega.

Bevacizumab (Avastin) inoshanda nemumwe mutoo nekudzivisa kukura kwemidzi yeropa inodyisa tuma. Mushonga uyu unogona kushandiswa zvisinei nekuti KRAS mutation status yakaita sei, zvichiita kuti ive sarudzo yevanhu vasingakwanise kugamuchira panitumumab.

Mishonga mitsva yakaita se regorafenib (Stivarga) uye TAS-102 (Lonsurf) isarudzo dzemuromo dzinogona kufungwa kana kurapwa kweIV senge panitumumab kusingachashandi. Izvi zvinoshanda nemimwe migwagwa uye zvinowanzo shandiswa gare gare mukurapa.

Mishonga yeImmunotherapy yakaita se pembrolizumab (Keytruda) inogona kuva sarudzo yevanhu vane gomarara remukati remukati rine hunhu hwemajini hunonzi microsatellite instability. Chiremba wako achayedza hunhu uhwu kuti aone kana immunotherapy yakakodzera.

Ko Panitumumab Ari Nani Kudarika Cetuximab?

Panitumumab na cetuximab vese vanorapa gomarara remukati remukati, uye tsvagiridzo inoratidza kuti vanoshanda zvakafanana mune akawanda mamiriro. Sarudzo pakati pavo inowanzoenderana nezvinhu zvinoshanda senge dosing schedule uye kusiyana kwemigumisiro panzvimbo yekuti imwe iri nani zvachose.

Panitumumab ine mukana mudiki wekuti inopiwa mazuva gumi nemana ega ega panzvimbo yevhiki nevhiki, izvo zvinoreva kushanya kushoma kunzvimbo yekurapa. Izvi zvinogona kubatsira kunyanya kana uchigara kure nenzvimbo yako yegomarara kana uine matambudziko ekufambisa.

Zvimwe zvidzidzo zvinoratidza kuti panitumumab inogona kukonzera kushoma kwakanyanya kwemagumirwo ekugadzirisa muviri kana ichienzaniswa ne cetuximab, kunyangwe mishonga yese iri miviri inogona kukonzera matambudziko akakosha eganda. Kushanda kwese mukudzikisa tuma uye kuwedzera kupona kunoita sekunge kwakafanana kwazvo pakati pemishonga miviri.

Oncologist wako achafunga nezvezvinhu zvakaita semimwe mishonga yako, zvaunofarira kurapwa, uye inishuwarenzi paunenge uchisarudza pakati pesarudzo idzi. Ose ari maviri anoonekwa sekurapa kwakanaka kana achishandiswa muvarwere vakakodzera.

Mibvunzo Inowanzo Bvunzwa Nezve Panitumumab

Ko Panitumumab Yakachengeteka Here Kune Vanhu vane Chirwere chemoyo?

Panitumumab inogona kushandiswa kune vanhu vane chirwere chemoyo, asi inoda kunyatso tariswa uye pamwe kugadzirisa dosi. Chiremba wako wemoyo uye oncologist vachashanda pamwechete kuti vave nechokwadi chekuti mamiriro ako emoyo anoramba akagadzikana panguva yekurapa.

Mishonga dzimwe nguva inogona kukonzera shanduko mumazinga e-electrolyte, kunyanya magnesium uye potassium, izvo zvinogona kukanganisa rhythm yemoyo. Chikwata chako chekurapa chichatarisa mazinga aya nguva dzose uye chichapa zvinowedzerwa kana zvichidikanwa kuti mwoyo wako urambe uchishanda zvakanaka.

Kana uine kukundikana kwemoyo kwakanyanya kana kurwisa kwemoyo kwemazuva ano, vanachiremba vako vanogona kukurudzira mamwe marapirwo kana kunonotsa panitumumab kusvikira mamiriro ako emoyo agadzikana. Mamiriro ega ega anoongororwa ega ega kuti aenzanise mabhenefiti ekurapa kenza nenjodzi dzehutano hwemoyo.

Ndingaita Sei Kana Ndikakanganwa Dosi yePanitumumab?

Kana iwe ukakanganwa infusion yakarongwa ye panitumumab, taura nechikwata chako cheoncology nekukurumidza kuti urongezve nekukurumidza sezvinobvira. Usamirira kusvika kumusangano wako unotevera wakarongeka, sezvo kuchengetedza nguva yekurapa nguva dzose kwakakosha pakuita zvakanaka.

Chikwata chako chekuchengetedza hutano chinowanzoedza kukugadzirisa mukati memazuva mashoma emusangano wako wakarasika. Vanogona zvakare kugadzirisa hurongwa hwako hwemunguva yemberi zvishoma kuti udzokere panzira nechirongwa chako chekurapa.

Kukanganwa dosi imwe chete dzimwe nguva hakuzokanganisi kurapwa kwako, asi edza kuchengeta misangano yakarasika shoma. Chikwata chako chekurapa chinonzwisisa kuti emergency dzinoitika uye chichashanda newe kuti uchengetedze chirongwa chekurapa chakanakisa.

Ndingaita Sei Kana Ndikava neMhinduro Yakakomba Panguva yeInfusion?

Kana iwe ukaona zviratidzo zvakaita sekufema kwakaoma, kurwadziwa muchipfuva, maitiro akakomba eganda, kana dzungu panguva ye panitumumab infusion yako, zivisa mukoti wako nekukurumidza. Nzvimbo dzekurapa dzakashongedzerwa zvakanaka kubata mamiriro aya uye dzichamisa infusion ipapo ipapo.

Chikwata chako chekurapa chingangokupa mishonga yakaita se antihistamines, steroids, kana epinephrine kudzivisa maitiro acho. Mazhinji emaitiro ekuisa mukati anogona kubatwa zvakanaka kana akabatwa nekukurumidza uye akarapwa nekukurumidza.

Mushure mekuita, chiremba wako anogona kukurudzira premedications pamberi pekuisa mukati kwemunguva yemberi kana angaderedza mwero wekuisa mukati kuti ubatsire muviri wako kutsungirira kurapwa zviri nani. Vamwe vanhu vanogona kuramba vachirapwa zvakabudirira mushure mekuita shanduko yemaitiro.

Ndingamira Rini Kutora Panitumumab?

Unogona kumira panitumumab kana chiremba wako akasarudza kuti mabhenefiti haachapfuuri njodzi, kana kana scans dzichiratidza kuti kenza yako haichapinduri kurapwa. Sarudzo iyi inogara ichiitwa pamwe chete pakati pako nechikwata chako cheoncology.

Vamwe vanhu vanosarudza kumisa kurapwa kana mhedzisiro yacho yava kuoma zvikuru kubata, kunyange kana kenza ichiri kupindura. Hunhu hwehupenyu hwako chinhu chakakosha mukufunga uku, uye chikwata chako chekurapa chichatsigira chero sarudzo yaunoita.

Usambomira panitumumab wega usina kuzvikurukura ne oncologist wako kutanga. Vanogona kukubatsira kunzwisisa zvazvinoreva uye kuona kuti une dzimwe sarudzo dzekurapa kana zvichidikanwa.

Ndingatora Dzimwe Mishonga Ndiri paPanitumumab?

Mishonga yakawanda inogona kutorwa zvakachengeteka ne panitumumab, asi unofanira kugara uchizivisa oncologist wako nezve chero mapepa matsva, zvinodhaka zvisingatengeswe, kana zvinowedzera zvaunoda kutanga. Dzimwe mishonga inogona kuita interaction kana kuda kugadziridzwa kwemadosi.

Zvinoderedza ropa, mishonga yemoyo, uye zvinodhaka zvinokanganisa immune system yako zvinogona kuda kuongororwa kwakakosha kana zvichibatanidzwa ne panitumumab. Chikwata chako chekurapa chichabatana nevamwe vanachiremba vako kuti vaone kuti mishonga yako yose inoshanda zvakanaka pamwe chete.

Nguva dzose uuye ne runyora rwakakwana rwemishonga yose nemamwe mashandisirwo ayo kumusangano wese, kusanganisira madosi nenguva yekutora. Izvi zvinobatsira chikwata chako chehutano kupa kurapwa kwakachengeteka uye kunobatsira sezvinobvira.