Chii chinonzi Panobinostat: Zvazvinoshandiswa, Mishonga, Migumisiro Yakaipa uye Zvimwe

Panobinostat mushonga wekenza unovavarira unoshanda nekudzivisa mapuroteni akati wandei anobatsira masero ekenza kukura nekurarama. Iwo wekirasi yemishonga inonzi histone deacetylase inhibitors, iyo inobatsira miviri yako yechisikigo yekurwisa tumor nzira dzekushanda zvakanyanya. Mushonga uyu unonyanya kushandiswa kurapa mamwe marudzi ekenza yeropa, kunyanya multiple myeloma kana dzimwe nzira dzekurapa dzisina kushanda sezvaitarisirwa.

Chii chinonzi Panobinostat?

Panobinostat mushonga wekenza wemuromo unovavarira masero ekenza padanho remolekyu. Inoshanda nekukanganisa ma enzymes anonzi histone deacetylases, ayo masero ekenza anoda kukura nekuzviparadzanisa.

Funga nezvazvo semushonga unobatsira kudzorera kugona kwemuviri wako kwechisikigo kudzora kukura kwemasero asina kujairika. Kusiyana nechemotherapy iyo inokanganisa masero ese anokurumidza kupatsanurwa, panobinostat inosarudza zvakanyanya maitiro ayo anovavarira masero ekenza. Iyi nzira yakatarwa inogona kuiita inoshanda uku ichikonzera mashoma mashoma emigumisiro yakaipa kupfuura chemotherapy yechinyakare.

Mushonga uyu unouya muchimiro chekapsule uye unotorwa nemuromo, zvichiita kuti zvive nyore kupfuura kurapwa kunoda kushanya kuchipatara kuti vapiwe. Chiremba wako achakupa mushonga uyu sechikamu chechirongwa chakazara chekenza chakagadzirirwa zvakananga mamiriro ako.

Chii chinonzi Panobinostat chinoshandiswa?

Panobinostat inobvumidzwa zvakananga kurapa multiple myeloma, rudzi rwekenza yeropa inokanganisa masero eplasma mumapfupa ako. Inowanzo kupihwa kana iwe wakatotora nzira mbiri dzekurapa, kusanganisira immunomodulatory agent uye proteasome inhibitor.

Multiple myeloma inogona kuve yakaoma kurapa nekuti masero ekenza anowanzo kukudziridza kuramba mishonga nekufamba kwenguva. Panobinostat inopa nzira yakasiyana yekuita, zvinoreva kuti inogona kubatsira kana dzimwe nzira dzekurapa dzamira kushanda zvakanaka.

Chiremba wako wezve oncology angakurudzira panobinostat sechikamu chekurapa kwakabatana, kazhinji ichibatanidzwa nemimwe mishonga yakaita sebortezomib uye dexamethasone. Iyi nzira yekubatanidza inobatsira kurwisa kenza kubva kumativi akawanda, zvichigona kuvandudza mhedzisiro yekurapa.

Panobinostat Inoshanda Sei?

Panobinostat inoshanda nekudzivisa ma enzymes anonzi histone deacetylases (HDACs) ayo masero ekenza anoda kudzora gene expression. Kana ma enzymes aya akavharwa, masero ekenza haakwanise kudzora kukura kwavo uye nzira dzekurarama.

Mishonga iyi inoonekwa seyakati simba rekurapa kenza ine chinangwa chekuita. Yakagadzirirwa kuve nesimba rakakwana rekukanganisa masero ekenza uku ichisarudza kupfuura mishonga yechinyakare yechemotherapy.

Mishonga iyi inobatsira kudzorera maitiro e cellular akajairika ayo masero ekenza akavhiringidza. Nekupindira munzira idzi dzakatarwa, panobinostat inogona kukonzera masero ekenza kurega kukura kana kutofa, uku ichiita zvishoma pamaseru ane hutano mumuviri wako wese.

Ndingatora Sei Panobinostat?

Tora panobinostat sezvakanyorwa nachiremba wako, kazhinji katatu pavhiki pamazuva akatarwa. Iyo yakajairika purogiramu ndeyeMuvhuro, Chitatu, uye Chishanu yevhiki 1 ne2 yega yega 21-zuva rekutenderera kwekurapa.

Unofanira kutora makapisi nemvura, uye unogona kuatora uine kana pasina chikafu. Zvisinei, kuatora nechikafu kungabatsira kuderedza dumbu kana ukaona kusvotwa. Usapwanye, kutsenga, kana kuvhura makapisi - amedze ese kuti uve nechokwadi chekunyudzwa kwakakodzera.

Zvakakosha kutora zviyero zvako panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana emishonga mumuviri wako. Kana ukarutsa mukati meawa imwe chete yekutora chiyero, usatore imwe chiyero zuva iroro - mirira kusvika chiyero chako chinotevera chakatarwa.

Usati watanga kurapwa, chiremba wako anogona kukurudzira kudya chikafu chakareruka kana snack maminitsi angangoita 30 usati watora mushonga. Izvi zvinogona kubatsira kuderedza mhedzisiro yegastrointestinal iyo vamwe vanhu vanowana.

Ndingatora Panobinostat Kwenguva Yakareba Sei?

Kureba kwekushandisa panobinostat kunosiyana zvakanyanya kubva kumunhu nemunhu uye kunoenderana nekuti mushonga unoshanda sei kune mamiriro ako chaiwo. Vanhu vazhinji vanoenderera mberi nekurapwa chero bedzi zvichibatsira kudzora kenza yavo uye mhedzisiro yacho ichiramba ichidzoreka.

Chiremba wako achatarisa mhinduro yako kumishonga kuburikidza nekuongororwa kweropa nguva dzose, zvidzidzo zvekufungidzira, uye kuongororwa kwemuviri. Ongororo idzi dzinobatsira kuona kana mushonga uchishanda nemazvo uye kana zvakachengeteka kuti uenderere mberi.

Vamwe vanhu vanogona kutora panobinostat kwemwedzi yakati wandei, nepo vamwe vachigona kuenderera mberi kwegore kana kupfuura. Chinhu chakakosha ndechokuwana chiyero chakakodzera pakati pekutonga kenza uye hupenyu hwemhando yepamusoro. Chikwata chako chekuchengetedza hutano chichashanda newe kuti uite shanduko sezvinodiwa mukati merwendo rwako rwekurapa.

Ndezvipi Zvipingamupinyi zvePanobinostat?

Kufanana nemishonga yese yekenza, panobinostat inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anozviwana. Mhedzisiro yakajairika inowanzo dzoreka nerutsigiro rwakakodzera rwekurapa uye kutariswa.

Heano mhedzisiro yakajairika yaungasangana nayo:

• Kuneta uye kusimba
• Nausea uye kurutsa
• Dhayareya
• Kuderera kwechido
• Kuderera kwemasero eropa
• Kuzvimba mumaoko, tsoka, kana makumbo
• Kurwadziwa kwemhasuru kana majoini

Mhedzisiro iyi inowanzoita nyoro kusvika pakati nepakati uye inowanzoita nani muviri wako uchigadzirisa kumishonga. Chikwata chako chekuchengetedza hutano chinogona kupa nzira nemishonga yekubatsira kudzora zviratidzo izvi nemazvo.

Mhedzisiro yakakomba asi isingawanzoitiki inogona kusanganisira zvirwere zvakakomba nekuda kwehuwandu hushoma hwemasero machena eropa, matambudziko emoyo, kana manyoka akakomba anotungamira mukushaya mvura mumuviri. Kunyange zvazvo izvi zvisingawanzoitiki, zvakakosha kuti uzivise chero zviratidzo zvinonetesa kuna chiremba wako nekukasika.

Vamwe vanhu vanogona kusangana nemagwamba eropa, kuneta kwakanyanya, kana matambudziko echiropa. Chiremba wako achakutarisa zvakanyanya nemiedzo yeropa yenguva dzose kuti abate chero matambudziko angangogona kutanga uye kugadzirisa kurapwa kwako kana zvichidikanwa.

Ndiani Asingafaniri Kutora Panobinostat?

Panobinostat haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana yakakukodzera. Vanhu vane mamiriro emoyo akati wandei, kunyanya avo vane nhoroondo yekurova kwemoyo kusingaite kana matambudziko emoyo, vangave vasiri vakakodzera mushonga uyu.

Kana uine matambudziko akakomba echiropa kana zvirwere zvinoshanda, zvisingadzoreki, chiremba wako anogona kukurudzira kumirira kusvikira mamiriro aya achidzorwa zviri nani usati watanga panobinostat. Mushonga uyu unogona kukanganisa immune system yako, zvichiita kuti zvirwere zvive zvakakomba.

Vakadzi vane pamuviri kana vanoyamwisa havafaniri kutora panobinostat, sezvo inogona kukuvadza vana vari kukura. Kana uri pazera rekubereka, uchada kushandisa nzira yekudzivirira kubata pamuviri panguva yekurapa uye kwemwedzi yakati wandei mushure mekumisa mushonga.

Vanhu vane matambudziko akakomba eitsvo kana avo vari kutora mishonga yakati wandei inokanganisa rhythm yemoyo vanogonawo kuda dzimwe nzira dzekurapa. Chiremba wako achatarisa mishonga yako yese yazvino uye mamiriro ehutano kuti ave nechokwadi chekuti panobinostat yakachengeteka kwauri.

Mazita ePanobinostat Brand

Panobinostat inowanikwa pasi pezita rekuti Farydak munyika zhinji, kusanganisira United States. Iri ndiro zita rekutanga rauchaona pabhodhoro rako remishonga uye kurongedza mishonga.

Parizvino, Farydak ndiyo mhando huru iripo, sezvo panobinostat iri mushonga mutsva uyo uchiri pasi pekudzivirirwa kwepatent. Mhando dzisina zita dzisipo zvakanyanya, kunyangwe izvi zvingachinja mune ramangwana sezvo mapatent apera.

Paunenge uchikurukura kurapwa kwako nevashandi vehutano kana vanachiremba vemaparmazi, unogona kutaura nezvemushonga nezita ripi zvaro - panobinostat kana Farydak - uye vachaziva chaizvo zvauri kutaura nezvazvo.

Zvimwe Zvinhu Zvokutsiva Panobinostat

Kana panobinostat isina kukodzera iwe kana ikamira kushanda zvakanaka, kurapwa kwakawanda kwakasiyana kunowanikwa kune multiple myeloma. Chiremba wako angangofunga nezvemamwe ma histone deacetylase inhibitors kana mishonga ine nzira dzakasiyana dzekuita.

Zvimwe zvinhu zvinotsiva zvinosanganisira mamwe marapirwo akatarwa se carfilzomib, pomalidomide, kana daratumumab. Mishonga iyi inoshanda nenzira dzakasiyana dzekurwisa maseru ekenza, ichipa sarudzo kana panobinostat isiri iyo yakakodzera mamiriro ako.

Nzira itsva dzekurapa immunotherapy, kusanganisira CAR-T cell therapy, dzinogona zvakare kuve sarudzo zvichienderana nemamiriro ako chaiwo. Miedzo yekiriniki ichiongorora kurapwa kwekuongorora inogona kupa mamwe mikana yevanhu vakaedza akawanda marapirwo akajairika.

Zvakanyanya kunaka zvinoenderana nekurapwa kwako kwekare, hutano hwese, uye hunhu chaihwo hwekenza yako. Oncologist wako achashanda newe kuti aone matanho anotevera akakodzera kana panobinostat isiri kushanda kana kukonzera mhedzisiro isingagamuchirwe.

Panobinostat Zviri Nani Kudarika Bortezomib Here?

Panobinostat uye bortezomib zvinoshanda nenzira dzakasiyana, saka kuenzanisa hazvina kunanga. Bortezomib is proteasome inhibitor iyo inowanzo shandiswa pakutanga mukurapa multiple myeloma, nepo panobinostat inowanzo chengeterwa mitsara yekupedzisira yekurapa.

Mukutsvagurudza kwekurapa, panobinostat inowanzo shandiswa pamwe chete nebortezomib panzvimbo yekutsiva nayo. Nzira iyi yekubatanidza yakaratidza mhedzisiro iri nani pane mushonga mumwe chete muvanhu vane multiple myeloma yakadzoka.

Sarudzo pakati pemishonga iyi inoenderana nenhoroondo yako yekurapa, maitiro akaita kenza yako kumishonga yapfuura, uye hutano hwako hwese. Chiremba wako achafunga nezvezvinhu zvakaita semhedzisiro yakamboitika, zviratidzo zviripo, uye hunhu chaihwo hwekenza yako pavanenge vachipa mazano ekurapa.

Mibvunzo Inowanzo Bvunzwa Nezve Panobinostat

Panobinostat Yakachengeteka Here Kune Vanhu Vane Matambudziko Emoyo?

Panobinostat inoda kunyatso tariswa muvanhu vane matambudziko emoyo nekuti inogona kukanganisa rhythm yemoyo. Chiremba wako achaita electrocardiogram (ECG) vasati vatanga kurapwa uye nguva dzose panguva yekurapa kuti vatarise mabasa emagetsi emoyo wako.

Kana uine nhoroondo yematambudziko e rhythm yemoyo, kukundikana kwemoyo, kana mamwe matambudziko makuru emoyo, chiremba wako angakurudzira mamwe marapirwo kana kutora matanho ekuwedzera kana panobinostat iri sarudzo yako yakanakisa. Vachashanda pedyo nachiremba wemoyo kuti vave nechokwadi chekuti hutano hwemoyo wako hunodzivirirwa panguva yekurapa.

Ndoitei Kana Ndikatora Panobinostat Yakawandisa Netsaona?

Kana netsaona ukatora panobinostat yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasika. Usamirira kuti uone kana zviratidzo zvichikura - zviri nani kutsvaga mazano ekurapa nekukasika.

Kutora panobinostat yakawanda kunogona kuwedzera njodzi yemhedzisiro yakakomba, kunyanya matambudziko e rhythm yemoyo uye kudonha kwakanyanya kwemaseru eropa. Chikwata chako chehutano chingada kukutarisa zvakanyanya uye pamwe kugadzirisa zvikamu zvako zvinotevera kuti uve nechokwadi chekuchengeteka kwako.

Ndoitei Kana Ndikakanganwa Dose yePanobinostat?

Kana ukakundikana kutora mushonga we panobinostat, usautore kana zvapfuura maawa gumi nemaviri kubva panguva yako yakatarwa. Panzvimbo pezvo, siya mushonga wakakundikana wotora mushonga wako unotevera panguva yakatarwa.

Usambofa wakatora mishonga miviri panguva imwe chete kuti ugadzirise mushonga wakakundikana, nekuti izvi zvinogona kuwedzera njodzi yemigumisiro yakakomba. Kana uchikundikana kutora mishonga kazhinji, taura nechikwata chako chehutano nezve nzira dzekukubatsira kuyeuka, sekugadzira maalarm efoni kana kushandisa chirongwa chemishonga.

Ndingamira Rini Kutora Panobinostat?

Unofanira kungomira kutora panobinostat pasi pekutungamirirwa nachiremba wako. Sarudzo yekumisa kurapwa inoenderana nekuti mushonga uri kushanda sei, migumisiro yaunowana, uye hutano hwako hwese.

Vamwe vanhu vangangoda kumira kwenguva pfupi kana vaine migumisiro yakakomba, nepo vamwe vachigona kumisa zvachose kana kenza ichifambira mberi kana migumisiro yacho ikava isingadzoreki. Chiremba wako achakubatsira kuyera mabhenefiti nenjodzi kuti uite sarudzo yakanakisa yemamiriro ako chaiwo.

Ndingatora Mimwe Mishonga Ndiri paPanobinostat?

Mishonga yakawanda inogona kuita interaction ne panobinostat, saka zvakakosha kuti uudze chiremba wako nezve mishonga yese yakanyorwa, mishonga isingatengwe, uye zvinowedzerwa zvauri kutora. Dzimwe mishonga dzinogona kuwedzera mazinga e panobinostat muropa rako, zvichikonzera migumisiro yakawanda.

Chiremba wako achaongorora mishonga yako yese uye anogona kuda kugadzirisa zviyero kana kukurudzira dzimwe nzira dzemishonga yakati. Usatanga mishonga mitsva kana zvinowedzerwa usina kuzvikurukura nechikwata chako chehutano kutanga, nekuti kunyangwe zvigadzirwa zvinoita sezvisina njodzi dzimwe nguva zvinogona kuita interaction nekurapa kenza.