Chii chinonzi Pasireotide: Zvazvinoshandiswa, Madosi, Mativi eMuviri uye Zvimwe

Pasireotide mushonga we synthetic hormone unotevedzera hormone yechisikigo inonzi somatostatin mumuviri wako. Yakagadzirirwa kubatsira kudzora mazinga emahormone muvanhu vane mamiriro akati wandei e endocrine, kunyanya ayo anokanganisa pituitary gland uye adrenal glands.

Mishonga iyi inoshanda nekubatanidza kune mamwe ma receptors mumuviri wako kuti ideredze kugadzirwa kwemahormone akawandisa. Funga nezvayo sechinhu chinodzora chinobatsira kuunza maseru anogadzira mahormone akawandisa kudzoka kuenzaniso kana masisitimu ako echisikigo ekudzora asiri kushanda nemazvo.

Chii chinonzi Pasireotide chinoshandiswa?

Pasireotide inonyanya kunyorerwa chirwere cheCushing, mamiriro asingawanzoitiki apo pituitary gland yako inogadzira hormone yakawanda inonzi ACTH. Izvi zvinotungamira kumaglands ako e adrenal achigadzira huwandu hwakawandisa hwe cortisol, iyo inogona kukonzera matambudziko makuru ehutano mumuviri wako wese.

Chiremba wako angangokunyorerawo pasireotide ye acromegaly, imwe mamiriro asingawanzoitiki apo pituitary gland yako inogadzira hormone yakawanda yekukura. Izvi zvinowanzoitika muvanhu vakuru uye zvinogona kukonzera shanduko dzakasiyana-siyana dzemuviri uye matambudziko ehutano kana akasiyiwa asina kurapwa.

Mune zvimwe zviitiko, vanopa hutano vanoshandisa pasireotide kurapa mamwe marudzi e neuroendocrine tumors. Aya matumors asingawanzoitiki anogona kugadzira mahormone akawandisa uye kukonzera zviratidzo zvisingafadzi zvakaita se flushing, manyoka, kana kurwadziwa mudumbu.

Pasireotide inoshanda sei?

Pasireotide inoonekwa semushonga une simba unoshanda nekutevedzera hormone yako yechisikigo somatostatin. Inonamatira kune mamwe ma receptors pamaseru anogadzira mahormone, zvichivaudza kuti videredze basa ravo.

Kana uine zvirwere zvakaita seCushing's disease kana acromegaly, maseru akati wandei mugland yako ye pituitary anova akanyanya kushanda uye anoburitsa mahomoni akawandisa. Pasireotide inoshanda semabhureki, ichibatsira kuderedza kuburitswa kwemahomoni akawandisa uye kuunza mazinga pedyo neakajairika.

Mushonga uyu unoshanda zvakanyanya nekuti unotarisa mhando dzakawanda dze somatostatin receptors. Iyi nzira yakakura inobatsira kuti ishande pamhando dzakasiyana dzemasero anoburitsa mahomoni, zvichiita kuti ibatsire kune mamiriro akasiyana e endocrine.

Ndingatora sei Pasireotide?

Pasireotide inouya nenzira mbiri: majekiseni e subcutaneous aunozvipa iwe pasi peganda, uye majekiseni e intramuscular anopiwa zvakadzama mumusuru wenyama nemupi wehutano. Fomu rauchashandisa rinotsamira pamamiriro ako chaiwo uye kurudziro yachiremba wako.

Kune majekiseni e subcutaneous, iwe unowanzo jekisisa mushonga kaviri pazuva munzvimbo dzakaita sedhiza rako, dumbu, kana ruoko rwepamusoro. Chikwata chako chehutano chichakudzidzisa nzira yekujekisisa yakakodzera uye kukubatsira kutenderedza nzvimbo dzekujekisisa kudzivirira kutsamwa kweganda.

Kana iwe uchigamuchira majekiseni e intramuscular, aya anowanzo piwa kamwe chete pamwedzi muhofisi yachiremba wako kana kiriniki. Mushonga unojekeswa zvakadzama mumusuru wako webuttock nehunyanzvi hwehutano hwakadzidziswa.

Unogona kutora pasireotide uine kana pasina chikafu, asi edza kuchengetedza kuenderana nekuita kwako. Vamwe vanhu vanozviwana zvichibatsira kuzvitora panguva imwe chete zuva rega rega kuchengetedza mazinga emahormone akagadzikana mumuviri wavo.

Ndingatora Pasireotide Kwenguva Yakareba Sei?

Kureba kwekurapa kwe pasireotide kunosiyana zvakanyanya zvichienderana nemamiriro ako chaiwo uye kuti unopindura sei kumushonga. Kune vanhu vazhinji vane Cushing's disease kana acromegaly, izvi zvinova kurapwa kwenguva refu kunogona kuramba kwemakore.

Chiremba wako achagara achiongorora mazinga ako emahormone kuburikidza nemiedzo yeropa kuti aone kuti mushonga uri kushanda sei. Kuongororwa uku kunowanzoitika mwedzi mishoma yega yega pakutanga, zvino zvinogona kuve zvishoma kana mazinga ako agadzika.

Vamwe vanhu vanogona kuda kutora pasireotide nekusingaperi kuti vachengetedze mazinga avo emahormone achidzorwa. Vamwe vangashandise sekurapa kwebhiriji vachigadzirira kuvhiyiwa kana mamwe maitiro. Chikwata chako chekuchengetwa kwehutano chichashanda newe kuti chizive nzira yakanakisa yemamiriro ako ezvinhu.

Ndezvipi Zvakaipa zvePasireotide?

Kufanana nemishonga yese, pasireotide inogona kukonzera mhedzisiro, kunyangwe kwete munhu wese anoiziva. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye uzive kuti ungataurirana riini nemupi wako wehutano.

Mhedzisiro yakajairika inowanzo kuve inodzoreka uye inowanzo kuvandudza sezvo muviri wako uchigadzirisa kumushonga:

• Mazinga epamusoro eshuga yeropa (hyperglycemia) - iyi ndiyo mhedzisiro inowanzoitika
• Kusvotwa uye kusagadzikana mudumbu
• Dhayareya kana zvigaro zvakasununguka
• Maitiro ekudzivirira jekiseni senge kutsvuka kana kuzvimba
• Kutemwa nemusoro
• Kuneta kana kunzwa kuneta kupfuura zvakajairika
• Dizziness
• Kurwadziwa mudumbu

Mhedzisiro iyi yakajairika inowanzoita kuti isanyanye kunetsa nekufamba kwenguva sezvo muviri wako uchigadzirisa kurapwa.

Vamwe vanhu vanogona kusangana nemhedzisiro yakakosha iyo inoda kuongororwa pedyo:

• Chirwere cheshuga kana kuwedzera kwechirwere chiripo cheshuga
• Matambudziko e gallbladder kana gallstones
• Kuchinja kwemoyo
• Kuchinja kwechiropa
• Kuderera kweropa
• Kuchinja kwekidney

Chiremba wako achakutarisa nguva dzose kuti uone mhedzisiro iyi yakakomba kuburikidza nemiedzo yeropa uye mamwe maekisami.

Zvisingawanzoitiki asi zvakakomba zvinogona kusanganisira mhinduro dzakanyanya dzekurwara, matambudziko makuru emoyo, kana matambudziko akakomba echiropa. Kunyange izvi zvisingawanzoitiki, zvakakosha kuziva zviratidzo zvekuyambira uye kutsvaga rubatsiro rwekurapa nekukurumidza kana zvikaonekwa.

Ndiani Asingafaniri Kutora Pasireotide?

Pasireotide haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora kana yakakukodzera. Vanhu vane mamwe mamiriro emoyo, kunyanya avo vane matambudziko emoyo, vangave vasiri vakakodzera mushonga uyu.

Kana uine chirwere chechiropa chakakomba, chiremba wako anogona kudzivisa kupa pasireotide kana kuishandisa nekuchenjerera kukuru. Mushonga unogona kukanganisa basa rechiropa, saka matambudziko aripo echiropa anogona kuwedzera.

Vanhu vane chirwere cheshuga chisingadzorwi vanofanira kuve nehuwandu hweshuga yeropa hwakanyatso manejwa vasati vatanga pasireotide. Sezvo mushonga unogona kukwidza mazinga eshuga yeropa, kutanga nechirwere cheshuga chisingadzorwi kunogona kutungamira kumatambudziko akakomba.

Vakadzi vane pamuviri havafaniri kutora pasireotide kunze kwekunge mabhenefiti achipfuura njodzi. Kana uri kuronga kuva nepamuviri kana kuti uri kuyamwisa, kurukura izvi zvakadzama nemupi wako wehutano.

Mazita ePasireotide Brand

Pasireotide inowanikwa pasi pezita rekuti Signifor kune ese ari maviri subcutaneous uye intramuscular formulations. Iyo subcutaneous vhezheni inowanzozivikanwa seSignifor, nepo iyo yakareba-inoita intramuscular vhezheni inozivikanwa seSignifor LAR.

Mavhezheni ese ane chinhu chimwe chete chinoshanda asi akagadzirirwa zvakasiyana dosing schedules. Chiremba wako achasarudza fomu rakakodzera zvichienderana nezvido zvako uye kufunga kwehupenyu.

Zvimwe Zvinhu Zvinotsiva Pasireotide

Kana pasireotide isingakukodzere kana isingape kutonga kwakakwana kwehutano hwako, dzimwe nzira dzinogona kufungwa. Octreotide imwe somatostatin analog iyo inoshanda zvakafanana asi inogona kuve nemamwe maitiro ekushanda.

Pamusoro pechirwere cheCushing zvakananga, mishonga yakaita seketoconazole, metyrapone, kana mifepristone inogona kuva sarudzo. Izvi zvinoshanda kuburikidza nemaitiro akasiyana ekudzora mazinga e cortisol.

Sarudzo dzekuvhiya, dzakadai sekuvhiya pituitary yeCushing's chirwere kana acromegaly, dzinogona kufungwa seimwe nzira kumishonga kana pamwe chete nekurapa nemishonga. Endocrinologist wako achabatsira kuona nzira yakanakisisa yemamiriro ako chaiwo.

Ko Pasireotide Zviri Nani Pane Octreotide?

Pasireotide uye octreotide zvose zvakafanana zve somatostatin, asi zvinoshanda zvishoma zvakasiyana mumuviri wako. Pasireotide inosunga kune mamwe marudzi e somatostatin receptors, izvo zvinogona kuita kuti zvive zvinobudirira kune mamwe mamiriro.

Pachirwere cheCushing, pasireotide inowanzo farirwa nekuti ine basa riri nani pamareceptors chaiwo anowanikwa mumaviri e pituitary anokonzera iyi mamiriro. Octreotide kazhinji haina kubudirira seyeCushing's chirwere.

Zvisinei, yeacromegaly uye neuroendocrine tumors, mishonga yose inogona kubudirira. Sarudzo inowanzoenderana nezvinhu zvakaita sekushivirira mhedzisiro, nyore yekushandisa, uye kupindura kwemunhu kumishonga.

Chiremba wako achafunga nezve mamiriro ako chaiwo, nhoroondo yekurapa, uye zvinangwa zvekurapa paunenge uchisarudza pakati pemishonga iyi. Dzimwe nguva, vanhu vasingapinduri zvakanaka kumishonga imwe vanogona kuita zviri nani neimwe.

Mibvunzo Inowanzo Bvunzwa Nezve Pasireotide

Ko Pasireotide Yakachengeteka Kune Vanhu vane Chirwere cheShuga?

Pasireotide inogona kushandiswa muvanhu vane chirwere cheshuga, asi inoda kunyatso tarisa uye kazhinji kugadzirisa kumishonga yechirwere cheshuga. Mishonga inowanzo wedzera mazinga eshuga yeropa, saka chirongwa chako chekudzora chirwere cheshuga chinogona kuda kugadziriswa.

Chiremba wako achashanda pedyo newe kuti atarise mazinga eshuga yeropa yako kakawanda paunotanga pasireotide. Unogona kuda shanduko kudya kwako, tsika yekurovedza muviri, kana mishonga yechirwere cheshuga kuti uchengetedze kutonga kwakanaka kweshuga yeropa.

Ndingaita Sei Kana Ndikashandisa Pasireotide Yakawandisa Netsaona?

Kana ukabaya pasireotide yakawandisa netsaona, taura nachiremba wako nekukasika kana kutsvaga rubatsiro rwekurapa rwekukurumidza. Kudhakwa kunogona kukonzera kudonha kwakanyanya kweshuga yeropa, kudzvinyirirwa kweropa, uye kurova kwemoyo.

Panguva yekumirira rubatsiro rwekurapa, zviise pasi pecherechedzo yezviratidzo zvakaita sedzungu rakanyanya, kufenda, kusvotwa, kana kunzwa usina kunaka zvakanyanya. Usaedze kuzvirapa iwe pachako - kuongororwa kwekurapa kwenyanzvi kwakakosha.

Ndingaita Sei Kana Ndikakanganwa Dose yePasireotide?

Kana ukakanganwa jekiseni repasi peganda, ritora nekukasika sezvaunorangarira, kunze kwekunge yava nguva ye dose yako inotevera. Muchiitiko ichocho, skip the missed dose uye uenderere mberi nechirongwa chako chetsika. Usambofa wakatora dose kaviri kuti ugadzirise imwe yakakanganwa.

Kune jekiseni remhasuru rinotora nguva refu, taura nachiremba wako kana ukakanganwa musangano. Vachakubatsira kuronga zvakare uye vanogona kuda kugadzirisa chirongwa chako chekurapa kwenguva pfupi.

Ndingamira Rini Kutora Pasireotide?

Usambofa wakamira kutora pasireotide kamwe kamwe usina kubvunza chiremba wako. Kumira kamwe kamwe kunogona kukonzera kuti mazinga ako emahormone akwirezve, zvichikonzera kudzoka kwezviratidzo kana matambudziko.

Chiremba wako achakutungamira kuburikidza nechero shanduko kuchirongwa chako chekurapa. Kana uchida kumisa pasireotide, zvinowanzoitwa zvishoma nezvishoma uchicherechedza mazinga ako emahormone zvakanyanya kuti uve nechokwadi chekuti mamiriro ako anoramba achidzora.

Ndingafamba Here Ndichitora Pasireotide?

Hongu, unogona kufamba uchitora pasireotide, asi zvinoda kuronga. Kana uchishandisa majekiseni epasi peganda, uchafanirwa kutakura mushonga wako newe, pamwe chete nezvinhu zvakakodzera zvekuchengetera kuti uuchengete pakupisa kwakakodzera.

Nguva dzose takura tsamba kubva kuna chiremba wako ichitsanangura mamiriro ako ezvinhu ekurapa uye kudiwa kwemishonga inobaiwa. Izvi zvinobatsira nekuchengetedzwa kwendege netsika. Kune rwendo rurefu, bata neanokupa hutano nezvekuwedzera mishonga uye chero kugadzirisa nzvimbo yenguva inodiwa kune chirongwa chako chekushandisa mishonga.