Chii chinonzi Pegaspargase: Zvinoshandiswa, Mishonga, Mativi eMuviri uye Zvimwe

Pegaspargase mushonga wakanangana nekenza unoshandiswa kurapa marudzi akati wandei e leukemia uye lymphoma. Inoshanda nekuparadza amino acid inonzi asparagine iyo masero ekenza anoda kuti ararame, zvichinyanya kuita kuti masero aya anokuvadza anzwe nzara uku achisiya masero mazhinji ane hutano asina kukanganiswa. Iyi nzira yakatarwa inoita kuti ive chishandiso chinokosha mukurwisa kenza yeropa, kunyanya muvana nevechidiki.

Chii chinonzi Pegaspargase?

Pegaspargase imhando yakagadziridzwa ye enzyme asparaginase yakagadzirirwa kuti igare kwenguva refu mumuviri wako. Funga nezvayo sechombo chebhayoloji chakagadzirirwa zvakananga kutarisa masero ekenza nekubvisa chimwe chinhu chavanonyanya kuda kuti vakure uye vazhinjise.

Chikamu che

Chiremba wako angakurudzira pegaspargase kana wakaongororwa uine marudzi aya chaiwo ekenza yeropa uye masero ako ekenza haakwanise kugadzira asparagine yawo. Muedzo wega wega unogona kuona kana masero ako ekenza aine kusagadzikana uku, zvichiita kuti pegaspargase ive sarudzo yekurapa inoshanda kwauri.

Pegaspargase Inoshanda Sei?

Pegaspargase inoshanda nekunangana nekukanganisa kwakakosha mumasero ekenza. Masero akajairika ane hutano anogona kugadzira asparagine yawo, amino acid yavanoda kuvaka mapuroteni uye kurarama. Zvisinei, mamwe masero ekenza akarasikirwa nekugona uku uye anofanira kuwana asparagine kubva mumutsipa wako weropa.

Kana pegaspargase yapinda mumuviri wako, inoputsa asparagine yese muropa rako. Masero ako ane hutano anongogadzira imwe asparagine yavo, asi masero ekenza haagone kuita izvi uye anotanga kufa nenzara.

Mishonga iyi inoonekwa seyepakati nepakati yakasimba munyika yekurapa kenza. Haina kuoma semamwe madhiragi echemotherapy, asi ichiri simba rakakwana kukonzera migumisiro yakakosha. Mashoko akanaka ndewekuti nzira yayo yakatarwa zvinoreva kuti kazhinji iri nyore pamuviri wako kupfuura dzimwe nzira dzakawanda dzekurapa kenza.

Ndingatora Sei Pegaspargase?

Haugone kutora pegaspargase kumba semushonga wenguva dzose. Panzvimbo pezvo, chikwata chako chekuchengetedza hutano chichakupa iwe sekudzivirira mumhasuru yako (intramuscular) kana kuburikidza neIV mutsinga yako (intravenous) panzvimbo yekurapa.

Usati wagamuchira pegaspargase, haufaniri kutevera chero zvirambidzo zvakakosha zvekudya kana kuitora nezvokudya zvakakosha. Zvisinei, chikwata chako chekurapa chingakupa mishonga pamberi kuti ibatsire kudzivirira maitiro ekuita allergic, akadai seantihistamines kana steroids.

Maitiro ejekiseni pachayo anotora maminitsi mashoma chete kana akapihwa intramuscularly, kana anenge maminitsi makumi matatu kusvika kumaawa maviri kana akapihwa intravenously. Chikwata chako chekuchengetedza hutano chichakutarisa zvakanyanya panguva uye mushure mejekiseni kuti utarise chero maitiro ekukasira.

Unofanira kugara panzvimbo yekurapwa kuti uongororwe mushure mekuwana pegaspargase. Iyi nguva yekutarisa inowanzoita awa 1-2 kuti uve nechokwadi chekuti hauzove nekupindura kweallergy kana mamwe matambudziko ekukurumidza.

Ndingatora Pegaspargase Kwenguva Yakareba Sei?

Kureba kwekurapa ne pegaspargase kunoenderana nerudzi rwekenza yako, chirongwa chekurapa, uye kuti unopindura sei kurapa. Vanhu vazhinji vanoiwana sechikamu chechirongwa chekurapa chakarongeka chinogona kutora mwedzi yakati wandei kusvika gore rimwe.

Hauwanzo kuwana pegaspargase zuva rega rega kana kunyange vhiki rega rega. Nekuti inoramba ichishanda mumuviri wako kwemavhiki 2-3, unogona kuwana majekiseni mwedzi miviri kana mina, zvichienderana nechirongwa chako chekurapa.

Chiremba wako achasarudza nguva chaiyo zvichienderana nechirongwa chako chekurapa. Vamwe vanhu vanogona kuwana 6-8 doses dzese, nepo vamwe vachigona kuda zvakawanda kana zvishoma zvichienderana nemamiriro avo chaiwo uye kuti kenza yavo inopindura sei.

Ndezvipi Zvipingamupinyi zvePegaspargase?

Kufanana nemishonga yese yekenza, pegaspargase inogona kukonzera matambudziko, kunyangwe kwete munhu wese anoawana. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye uzive kuti ungabatana riini nechikwata chako chehutano.

Matambudziko anowanzoitika aunogona kusangana nawo anosanganisira kusvotwa, kurutsa, uye kuneta. Izvi zvinowanzoitika mukati memazuva mashoma ekutanga mushure mekuwana jekiseni uye kazhinji anovandudza sezvo muviri wako uchigadzirisa kumushonga.

Heano matambudziko anowanzoitika ayo vanhu vazhinji vanosangana nawo:

• Kusvotwa uye kurutsa
• Kunetwa uye kusava nesimba
• Kurasikirwa nechido
• Kurwadziwa mudumbu
• Kutemwa nemusoro
• Fivha
• Kurwadziwa mumajoini kana mumasuru
• Meno paganda kana maitiro ekujekiseni

Izvi zvinowanzoitika zvinowanzoitika zvinowanzoitika nekuchengetwa kunotsigira uye mishonga iyo chikwata chako chehutano chinogona kupa.

Vamwe vanhu vanogona kusangana nemigumisiro yakakomba inoda kutariswa kwechimbichimbi kwekurapa. Kunyange izvi zvisingawanzoitiki, zvakakosha kuziva nezvazvo kuitira kuti iwe ugone kutsvaga rubatsiro nekukurumidza kana zvikaitika.

Migumisiro yakakomba inoda kutarisirwa kwechimbichimbi kwekurapa inosanganisira:

• Kupindura kwakanyanya kweallergy nekufema kwakaoma, kuzvimba, kana rash yakakomba
• Zviratidzo zvematambudziko echiropa senge ganda reyellowing kana maziso, weti yakasviba, kana kurwadziwa kwakanyanya mudumbu
• Kubuda ropa kusinganzwisisike kana kupwanya
• Zviratidzo zvemaropa senge kurwadziwa muchipfuva, kufema kwemhepo, kana kuzvimba kwemakumbo
• Kuvhiringidzika kwakanyanya kana shanduko mumamiriro epfungwa
• Fivha yepamusoro inoramba iripo kana zviratidzo zveutachiona

Chikwata chako chehutano chichakutarisa zvakanyanya kuti uone izvi zvinokanganisa zvakanyanya kuburikidza nekuongororwa kweropa nguva dzose uye kuongororwa.

Kune zvakare mamwe matambudziko asingawanzoitiki asi anogona kuve akakomba ayo timu yako yekurapa ichatarisa zvakanyanya. Izvi zvinosanganisira pancreatitis (kuzvimba kwepancreas), iyo inogona kukonzera kurwadziwa kwakanyanya mudumbu, uye shanduko mumazinga eshuga yeropa. Vamwe vanhu vanogona kukudziridza matambudziko ekuumbwa kweropa, kana kuumbwa kwakanyanya kana kugona kushoma.

Ndiani Asingafaniri Kutora Pegaspargase?

Pegaspargase haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuvimbisa. Vanhu vane mamiriro akati wandei vangangotadza kugamuchira mushonga uyu zvakachengeteka.

Haufanire kugamuchira pegaspargase kana wakambove neallergy yakanyanya ku asparaginase kana pegaspargase munguva yakapfuura. Izvi zvinosanganisira maitiro senge rash yakakomba, kufema kwakaoma, kana kuzvimba kwechiso, miromo, rurimi, kana huro.

Chiremba wako achavawo akanyatso chenjerera nezvekupa pegaspargase kana uine mamiriro akati wandei ekurapa anogona kuita kuti kurapwa kuve kwakanyanya njodzi:

• Pancreatitis inoshanda kana ichangobva kuitika
• Chirwere chechiropa chakakomba
• Nhoroondo yezvirwere zvinobuda ropa zvakanyanya
• Matambudziko aripo ekuumbwa kweropa
• Chirwere cheitsvo chakakomba
• Zvirwere zvakakomba zviri kushanda

Kuzvitakura nekuyamwisa zvinoda kufunga kwakakosha, sezvo pegaspargase inogona kukuvadza mwana asati aberekwa kana mucheche anoyamwisa. Chikwata chako chekuchengetwa kwehutano chichakurukura njodzi idzi newe kana wakazvitakura, uchironga kuzvitakura, kana kuyamwisa.

Zera rinogonawo kuva chinhu, sezvo vanhu vakuru vangave vachinyanya kunzwa kune migumisiro yepegaspargase. Zvisinei, izvi hazvikubvise pakurapa - chiremba wako achayerera mabhenefiti achipesana nenjodzi dzemamiriro ako chaiwo.

Mazita ePegaspargase Brand

Pegaspargase inowanikwa pasi pezita remhando Oncaspar, iyo ndiyo fomu inonyanya kunyorerwa yemushonga uyu. Oncaspar inogadzirwa neServier Pharmaceuticals uye ndiyo vhezheni inonyanya kushandiswa nezvipatara zvakawanda nemazvipatara ekenza.

Kune zvakare fomu itsva inonzi Asparlas, iyo ishanduro yakasiyana zvishoma yepegaspargase inogona kushandiswa mune mamwe mamiriro. Mishonga yese iri miviri inoshanda zvakafanana, asi chiremba wako achasarudza iyo yakanyanya kukodzera chirongwa chako chekurapa.

Paunogamuchira mushonga wako, pharmacy kana chipatara zvinowanzo shandisa zita remhando panzvimbo yezita re generic pegaspargase. Izvi zvinobatsira kuona kuti unogamuchira fomu uye chiyero chakarurama.

Zvimwe Zvingashandiswa Pane Pegaspargase

Kana pegaspargase isiri yakakunakira, kune mamwe mishonga yeasparaginase inogona kushanda panzvimbo payo. Imwe nzira yakajairika ndeye native E. coli asparaginase, iyo inoshanda nenzira imwechete asi haigari kwenguva refu mumuviri wako.

Imwe nzira ndeye Erwinia asparaginase, iyo inobva kune imwe bhakitiriya sosi uye inogona kushandiswa kana wakaita allergic reaction kune zvigadzirwa zvinobva kuE. coli. Imwe nzira iyi inonyanya kubatsira vanhu vasingakwanise kutora pegaspargase.

Chiremba wako angangofungawo nezve mamwe marudzi akasiyana emishonga yekenza kana kurapwa kunobva paasparaginase kusiri kushanda kana kukonzera matambudziko mazhinji. Izvi zvinogona kusanganisira mamwe mishonga yekemotheraphy, targeted therapies, kana immunotherapy medications, zvichienderana nerudzi rwako rwekenza.

Sarudzo yeimwe nzira inoenderana nezvinhu zvakawanda, kusanganisira rudzi rwako rwekenza, kurapwa kwakapfuura, hutano hwako hwese, uye kuti muviri wako wakapindura sei kune mamwe mishonga.

Ko Pegaspargase Zviri Nani Pane Asparaginase Yenguva Dzose?

Pegaspargase inopa zvakanakira zvakawanda pamusoro peasparaginase yenguva dzose, ndosaka vanachiremba vazhinji vachiiisa pamberi pevarwere vese. Chinhu chikuru ndechekuti pegaspargase inoramba ichishanda mumuviri wako kwenguva refu, kazhinji 2-3 mavhiki zvichienzaniswa nemazuva mashoma chete e asparaginase yenguva dzose.

Uku kureba kwenguva kunoreva kuti unoda majekiseni mashoma ese, izvo zvinogona kuita kuti kurapwa kuve kuri nyore uye kunogona kuve kunoshanda zvakanyanya. Majekiseni mashoma zvinorevawo mikana mishoma yematambudziko ane chekuita nejekiseni pachayo.

Zvisinei,

Pegaspargase inogona kukanganisa mazinga eshuga yeropa, saka vanhu vane chirwere cheshuga vanoda kuongororwa zvakanyanya panguva yekurapa. Mushonga uyu unogona kukonzera zvese zviri zviviri zviitiko zvepamusoro uye zvepasi shuga yeropa, izvo zvinoreva kuti chirongwa chako chekugadzirisa chirwere cheshuga chingangoda kugadziriswa.

Chikwata chako chehutano chichaongorora shuga yako yeropa kakawanda iwe uchigamuchira pegaspargase. Vangangoda kugadzirisa mishonga yako yechirwere cheshuga kana madosi e insulin kuti uchengetedze shuga yako yeropa iri munzvimbo yakachengeteka.

Kuva nechirwere cheshuga hakuzokudzivisi otomatiki kugamuchira pegaspargase, asi zvinoda kuongororwa zvakanyanya uye kubatana pakati pechikwata chako chekurapa kenza nevapi vako vekutarisira chirwere cheshuga.

Ndoita Sei Kana Ndikashandisa Pegaspargase Yakawandisa Netsaona?

Sezvo pegaspargase ichingopiwa nevashandi vehutano muzvivakwa zvekurapa, overdose netsaona haina kumbowanikwa. Zvisinei, kana iwe uchinetseka kuti wakagamuchira mushonga wakawandisa, taura nechikwata chako chehutano nekukasira.

Zviratidzo zve pegaspargase yakawandisa zvinogona kusanganisira kusvotwa kwakanyanya, kurutsa, kuvhiringika, kana kusimba kusinganzwisisike. Chikwata chako chekurapa chichakutarisa zvakanyanya uye chichapa rutsigiro rwekuchengetedza zviratidzo zvipi zvazvo.

Chinhu chakakosha ndechokutaurirana chero zvinonetsa kuchikwata chako chehutano nekukasira. Vane ruzivo rwekugadzirisa mamiriro aya uye vanogona kupa kutarisirwa kwakakodzera kana zvichidikanwa.

Ndoita Sei Kana Ndikakanganwa Dosi yePegaspargase?

Kana iwe ukakanganwa kugadzwa kwe pegaspargase, taura nechikwata chako chehutano nekukasira kuti uise zvakare. Usamirira kusvika kushanya kwako kunotevera kwakarongwa, sezvo nguva inogona kukosha pakuchengetedza kushanda kwekurapa kwako kenza.

Chikwata chako chekurapa chichashanda newe kuti uwane nguva yekugadzwa itsva inoenderana nechirongwa chako chekurapa chose. Vangangoda kugadzirisa nguva yemimwe mishonga kana kurapwa kuti vagadzirise shanduko.

Kusavhiringa mushonga kamwe chete kazhinji hakuine ngozi, asi zvakakosha kudzokera pachirongwa nekukurumidza sezvinobvira kuti uve nechokwadi chekuti kurapwa kwako kenza kunoramba kuchishanda.

Ndingamira Rini Kutora Pegaspargase?

Unofanira kungomira kutora pegaspargase kana timu yako yehutano yakuudza kuti zvakachengeteka kuita kudaro. Sarudzo iyi yakavakirwa pamhinduro yako kumishonga, hutano hwako hwese, uye chirongwa chako chaicho chekurapa kenza.

Vamwe vanhu vanopedzisa nzira yavo yakarongwa ye pegaspargase vozopfuurira kune dzimwe mishonga kana kupinda muchikamu chekutarisa. Vamwe vangangoda kumira kare kana vakawana matambudziko akakomba anovaita kuti mishonga irambe isina kuchengeteka.

Usambomira mishonga wega, kunyangwe uchinzwa zviri nani kana uchiona matambudziko. Nguva dzose kurukura chero zvinokunetsa netimu yako yehutano kutanga, sezvo vachigona kubatsira kubata matambudziko kana kugadzirisa chirongwa chako chemishonga kana zvichidikanwa.

Ndingawana Majekiseni Ndiri Kutora Pegaspargase?

Majekiseni mhenyu anofanira kudziviswa paunenge uchigamuchira pegaspargase, sezvo immune system yako ingasapindura zvakajairika kwavari. Izvi zvinosanganisira majekiseni akadai se measles-mumps-rubella (MMR) vaccine, varicella (chickenpox) vaccine, uye live flu vaccines.

Majekiseni asina basa, akadai se flu shot kana pneumonia vaccine, anowanzo chengeteka asi achiri kufanira kurukurwa netimu yako yehutano. Vanogona kukurudzira nguva yakanaka yemajekiseni aya kutenderedza mishonga yako ye pegaspargase.

Timu yako yezvokurapa ichapa gwara rakajeka pamusoro pemajekiseni api akachengeteka kwauri uye nguva yekuvaona. Vachabatanawo nachiremba wako wekutanga kuti uve nechokwadi chekuti unogamuchira kutarisirwa kunodzivirira kwakakodzera panguva yekurapa kwako kenza.