Chii chinonzi Peginesatide: Zvayakashandiswa, Madosi, Migumisiro Yakaipa uye Zvimwe

Peginesatide yaive mushonga wekugadzirwa wakagadzirirwa kurapa anemia muvanhu vane chirwere cheitsvo chisingaperi vari pa dialysis. Inoshanda nekukurudzira mupengo wako kuti ugadzire maseru matsvuku eropa akawanda, zvakafanana nemabasa eiyo hormone yako yechisikigo erythropoietin. Zvisinei, mushonga uyu wakabviswa mumusika muna 2013 nekuda kwekunetseka kwakakomba kwekuchengeteka, kusanganisira maitiro akakomba ekugumbuka ayo akatungamira kukuvadzwa muzvipatara uye kufa.

Chii chinonzi Peginesatide?

Peginesatide yaive mushonga weprotein wakagadzirwa nemunhu uyo wakatevedzera chiito che erythropoietin mumuviri wako. Erythropoietin i hormone itsvo dzako dzinogadzira zvakasikwa kuti dziratidze mupengo wako kuti ugadzire maseru matsvuku eropa. Kana itsvo dzako dzakakuvadzwa kubva kuchirwere chisingaperi, hadzigoni kugadzira zvakakwana zve hormone iyi, zvichitungamira ku anemia.

Mushonga uyu wakagadzirwa zvakananga kune vanhu vane chirwere cheitsvo chisingaperi vaive vachigamuchira kurapwa kwe dialysis. Yakapiwa sejojo kamwe chete pamwedzi, iyo yaive nyore kupfuura mamwe mishonga yakafanana yaida dosing kakawanda. Nehurombo, peginesatide haichawanikwi kushandiswa nekuda kwenyaya dzekuchengeteka dzakabuda mushure mekubvumidzwa kwayo.

Chii chaishandiswa Peginesatide?

Peginesatide yaishandiswa kurapa anemia muvanhu vakuru vane chirwere cheitsvo chisingaperi vaive pa dialysis. Anemia inoitika kana usina maseru matsvuku eropa akakwana kutakura okisijeni mumuviri wako wese, zvichikusiya uchinzwa kuneta, kusimba, uye kufema zvishoma.

Vanhu vane chirwere cheitsvo vanowanzoita anemia nekuti itsvo dzavo dzakakuvadzwa hadzigoni kugadzira erythropoietin yakakwana. Izvi zvinogadzira kutenderera uko muviri wako unonetseka kugadzira maseru matsvuku eropa aanoda. Peginesatide yakagadzirirwa kupinda uye kupa chiratidzo ichocho chisipo kumupengo wako.

Mushonga uyu wakabvumirwa chete kurapwa kwevarwere vaitambira kurapwa kwe dialysis. Haina kuitirwa vanhu vane chirwere cheitsvo chinyoro kana avo vasati vaita dialysis. Chiremba wako angadai akafunga nezve sarudzo iyi kana mamwe marapirwo aisashanda zvakanaka zvakakwana kudzora zviratidzo zve anemia yako.

Peginesatide yaishanda sei?

Peginesatide yaishanda nekubatanidza kune zvakafanana zvinogamuchira mumupengo wako wemapfupa ayo anopindura kune erythropoietin yechisikigo. Funga nezvazvo sekushandisa kiyi inokodzera kukiya kumwe chete kwainoshandisa mahomoni ako echisikigo. Kana yabatanidzwa, yakaita kuti mupengo wako wemapfupa utange kugadzira masero matsvuku eropa akawanda.

Mushonga uyu waionekwa semushonga wakasimba nekuti waigona kuwedzera zvakanyanya kugadzirwa kwemasero matsvuku eropa. Zvisinei, simba iri rairevawo kuti raida kutarisa zvakanyanya kudzivirira mazinga ako emasero matsvuku eropa kubva pakukwira nekukurumidza kana kukwira zvakanyanya, izvo zvaigona kukonzera matambudziko ane njodzi.

Muviri wako unowanzo kutanga kupindura kune peginesatide mukati memavhiki mashoma, kunyangwe zvaigona kutora kusvika kumwedzi mitatu kuti uone mhedzisiro yakazara. Mushonga uyu wakagara uchishanda mumuviri wako kwemwedzi mumwe chete, ndosaka waifanira kupiwa kamwe chete pamwedzi.

Peginesatide yaifanira kutorwa sei?

Peginesatide yaipiwa sejojo kana mutsinga (intravenously) kana pasi peganda (subcutaneously) kamwe chete pamwedzi. Mupi wako wehutano angadai akapa mushonga uyu panguva yako ye dialysis kana panzvimbo yekurapa. Haisiri chinhu chaunogona kutora kumba wega.

Jojo harina kuda chero kugadzirira kwakakosha maererano nechikafu kana chinwiwa. Waigona kudya zvakajairika usati watora mushonga uye mushure mekuutora. Chiremba wako angadai akasarudza chiyero chakakodzera zvichienderana nehuremu hwako, mazinga ako emaseru matsvuku eropa, uye kuti waipindura sei kurapwa.

Mberi kwejekiseni rega rega, timu yako yehutano yaizenge yaongorora ropa rako uye yatarisa mhedzisiro yako yelabhureti ichangoburwa. Vaizokutarisawo zvakanyatsonaka kune chero zviratidzo zvekuita allergic, kunyanya panguva yekutanga kwako madosi mashoma apo kuita kwaiita kuti kuitike.

Peginesatide yaifanira kutora nguva yakareba sei?

Kureba kwekurapa kwe peginesatide kwaizenge kwakasiyana zvichienderana nemhinduro yako yega yega uye kushivirira kumushonga. Vanhu vazhinji vaizenge vaenderera mberi nekurapa chero bedzi anemia yavo yaivepo uye mushonga waibatsira pasina kukonzera mhedzisiro yakakosha.

Chiremba wako aizenge achitarisa mazinga ako eropa tsvuku zvakanyatsonaka, kazhinji achiaongorora mumasvondo mashoma ekutanga, wobva wamwedzi mumwe kana mazinga ako agadziriswa. Kana anemia yako yakavandudzika zvakanyanya kana ukasangana nemhedzisiro inonetsa, chiremba wako angadai akachinja chiyero kana kufunga nezve kuchinja kune imwe kurapwa.

Sezvo peginesatide yakabviswa mumusika, chero munhu aitora aizenge achichinjirwa kune dzimwe nzira dzekurapa anemia. Timu yako yehutano yaizenge ichishanda newe kuti uwane kurapa kwakanakisa kwemamiriro ako chaiwo.

Ndezvipi zvaive zvinokonzeresa zvePeginesatide?

Peginesatide yaive nemhedzisiro yakati wandei, kubva pakureruka kusvika kune inotyisa-hupenyu. Kunetseka kwakanyanya kwaive kuita kwakanyanya allergic, izvo zvakatungamira kumushonga uchibviswa mumusika. Izvi zviito zvaigona kuve zvakananga uye zvine njodzi, zvichida kurapwa kwechimbichimbi.

Mhedzisiro yakajairika iyo vanhu vakasangana nayo yaisanganisira:

• Muscle spasms uye kurwadziwa
• Kurwadziwa kwemumashure
• Kukosora
• High blood pressure
• Diarhea
• Nausea
• Kuzvimba mumaoko kana makumbo

Izvi zvinokonzeresa zvezuva nezuva zvaive zvichigoneka uye kazhinji zvakavandudzika sezvo muviri wako wakajairana nemushonga. Zvisinei, vaifanira kuziviswa kutimu yako yehutano.

Mhedzisiro yakakomba iyo yakazopedzisira yatungamira kubviswa kwe peginesatide yaive mhinduro dzakakomba dzekurwara dzainzi anaphylaxis. Mhinduro idzi dzaigona kukonzera matambudziko ekufema, kudonha kwakanyanya kweropa, kuzvimba kwechiso nehuro, uye dzaigona kuuraya kana dzisingarapwa nekukasira. Vamwe vanhu vakasanganawo nematambudziko akakomba emoyo, kusanganisira kurwisa kwemoyo uye sitiroko.

Mavhiri eropa aive imwe nyaya yakakosha, kunyanya munzvimbo dzekuwana dzinoshandiswa kudialysis. Mushonga uyu waigonawo kukonzera kuti mazinga ako emaseru matsvuku eropa akwire nekukurumidza, zvichitungamira kune ropa repamusoro rinotyisa uye mamwe matambudziko.

Ndiani asina fanira kutora Peginesatide?

Mapoka akati wandei evanhu aisafanira kutora peginesatide, kunyangwe yaivapo. Chero ani zvake ane allergy inozivikanwa ku peginesatide kana chero chimwe chezvikamu zvayo anofanira kunge akadzivisa mushonga uyu zvachose. Vanhu vane ropa repamusoro risingadzorwe vaisavawo vakakodzera kurapwa.

Vakadzi vane pamuviri uye vanoyamwisa vakakurudzirwa kusashandisa peginesatide nekuda kwemashoko asina kukwana ekuchengeteka. Mhedzisiro yemushonga pavacheche vari kukura haina kunzwisiswa zvizere, zvichiita kuti zvive zvine njodzi zvakanyanya kushandiswa panguva yekuzvitakura kana uchiyamwisa.

Vanhu vane mamwe marudzi ekenza, kunyanya ayo anokanganisa ropa kana mupengo wemuzongoza, havafanira kunge vakashandisa peginesatide. Mushonga uyu unogona kukurudzira kukura kweseru rekenza muzviitiko izvi. Uye zvakare, chero ani zvake aine nhoroondo yemhinduro dzakakomba dzekurwara kumishonga yakafanana angadai aive panjodzi huru.

Avo vane zvirwere zvinoshanda kana mamiriro ekuzvimba vangangoda kumirira kusvikira nyaya idzi dzagadziriswa vasati vatanga kurapwa. Mhinduro yako yekudzivirira chirwere ku peginesatide inogona kusafanotaurwa kana uchibata nezvimwe zvehutano panguva imwe chete.

Zita rechiratidzo re Peginesatide

Peginesatide yaishambadzwa pasi pezita rekuti Omontys muUnited States. Iri ndiro raive zita rimwe chete iro mushonga uyu waishambadzwa usati wabviswa mumusika muna 2013.

Mishonga iyi yakagadzirwa neAffymax uye yakashambadzwa pamwe chete neTakeda Pharmaceuticals. Yakagamuchira mvumo yeFDA muna Kurume 2012 asi yakazvidzwa nevagadziri muna Kukadzi 2013 nekuda kwekunetseka kwakakomba kwekuchengeteka.

Zvimwe zvinotsiva Peginesatide

Zvimwe zvinotsiva peginesatide zviripo zvekutarisira anemia muvanhu vane chirwere cheitsvo chisingaperi. Mishonga iyi inoshanda zvakafanana nekukurudzira kugadzirwa kwemasero matsvuku eropa, asi vane nzira dzakasiyana dzekuchengeteka uye zvirongwa zvekushandisa.

Zvimwe zvinotsiva zvinosanganisira:

• Epoetin alfa (Epogen, Procrit) - inopiwa 1-3 nguva pavhiki
• Darbepoetin alfa (Aranesp) - inopiwa vhiki nevhiki kana imwe vhiki
• Methoxy polyethylene glycol-epoetin beta (Mircera) - inopiwa mwedzi woga woga

Mishonga iyi yakashandiswa kwenguva refu kupfuura peginesatide uye ine marekodhi akasimbiswa ekuchengeteka. Chiremba wako achasarudza sarudzo yakanakisa zvichienderana nezvido zvako, kuti unogona kuuya kangani kuzotora majekiseni, uye kuti unotsungirira sei mushonga wega wega.

Zvimwe zvinowedzerwa simbi zvinowanzo shandiswa pamwe chete nemishonga iyi kuti uve nechokwadi chekuti muviri wako une simbi yakakwana yekugadzira masero matsvuku eropa ane hutano. Vamwe vanhu vanogona zvakare kubatsirwa nekutapurirwa ropa mune dzimwe nguva, kunyangwe izvi zvakachengeterwa zviitiko zvakakomba.

Peginesatide yaive nani pane Epoetin alfa here?

Peginesatide uye epoetin alfa zvose zvaibatsira pakurapa anemia muvanhu vane chirwere cheitsvo chisingaperi, asi vaive nezvakanakira nezvakaipira zvakasiyana. Chinhu chikuru chaibatsira peginesatide yaive chirongwa chayo chekushandisa kamwe chete pamwedzi, ichienzaniswa nekuda kweepoetin alfa kwemajekiseni 1-3 pavhiki.

Panyaya yekushanda, zvidzidzo zvakaratidza kuti peginesatide yaikwanisa kuchengetedza mazinga ehemoglobin zvakafanana neepoetin alfa. Mishonga yese miviri yaigona kubudirira kurapa anemia uye kuderedza kudiwa kwekuwedzerwa kweropa muvarwere vazhinji.

Zvisinei, chimiro chekuchengeteka chepeginesatide chakaratidza kuipa zvakanyanya pane cheepoetin alfa. Maitiro akakomba ekurwara neallergies akatungamira mukubviswa kwepeginesatide haana kuwanikwa kazhinji neepoetin alfa, iyo yakashandiswa zvakachengeteka kwemakore mazhinji. Izvi zvinoita kuti epoetin alfa ive sarudzo iri nani pakazara, kunyangwe ichida majekiseni anowanzoitika.

Nhasi, epoetin alfa inoramba iri sarudzo yekurapa yakajairika ine rekodhi yekuchengetedza yakanyatsojeka. Kunyange zvazvo nyore yekushandisa kamwe chete pamwedzi yaive inokwezva, njodzi dzakakomba dzakabatana nepeginesatide dzakazopedzisira dzaita kuti isakodzere kuenderera mberi nekushandisa.

Mibvunzo inowanzo bvunzwa nezve Peginesatide

Q1. Peginesatide yakachengeteka here kuvanhu vane chirwere cheshuga?

Panguva iyo peginesatide yaivapo, vanhu vane chirwere cheshuga avo vaivewo nechirwere cheitsvo chisingaperi vaigona kushandisa mushonga uyu, asi zvaida kungwarira kwakawanda. Chirwere cheshuga chinowanzo kukonzera chirwere cheitsvo, uye vanhu vazhinji vane zvese zvirwere vanokudziridza anemia inoda kurapwa.

Zvisinei, vanhu vane chirwere cheshuga vanowanzoita njodzi huru yematambudziko emoyo, ayo aigona kuwedzerwa nemigumisiro yepeginesatide. Maitiro emushonga ekukwidza ropa uye kuwedzera njodzi yekuvhara ropa zvaiita kuti zvive zvinonetesa kune varwere vane chirwere cheshuga. Chiremba wako angadai akaongorora njodzi idzi zvakanyatsonaka asati arayira peginesatide kumunhu ane chirwere cheshuga.

Q2. Ndoita sei kana ndikashandisa peginesatide yakawandisa netsaona?

Kupfuura muyero wepeginesatide kwaizove dambudziko rakakomba rekurapa rinoda kutarisirwa kuchipatara nekukasira. Kuwanda kwemushonga uyu kwaigona kukonzera kuti mazinga ako emaseru matsvuku eropa akwire zvakanyanya, zvichikonzera high blood pressure yakakomba, ropa rinovhara, matambudziko emoyo, uye sitiroko.

Sezvo peginesatide yaipiwa chete nevapi vezvehutano munzvimbo dzekurapa, kuwandisa kwemishonga netsaona kwaizova kushoma. Zvisinei, kana kuwandisa kwemishonga kwakaitika, kurapwa kwaizotarisa pakugadzirisa matambudziko, sekudzora ropa uye kudzivirira ropa. Pakanga pasina mushonga chaiwo wekuwandisa peginesatide.

Q3. Ndingaita sei kana ndikakanganwa dose yePeginesatide?

Kana wakakanganwa jekiseni re peginesatide rakarongwa, waizofanira kubata chiremba wako nekukasira kuti urongezve. Kukanganwa madosi kunogona kukonzera kuti anemia yako iwedzere, zvichikonzera kuneta, kushaya simba, uye zvimwe zviratidzo zvichidzoka.

Chiremba wako aizogadzirisa nguva yakanakisa ye dose yako yekugadzirisa zvichienderana nekuti wakakanganwa jekiseni racho riini uye mazinga ako emazuva ano e red blood cell. Vangangodaro vakagadzirisa madosi ako mashoma anotevera kuti udzokere panzira nehurongwa hwako hwekurapa. Zvaive zvakakosha kuti usaedze kugadzirisa madosi akakanganwa wega.

Q4. Ndingamira rini kutora Peginesatide?

Sarudzo yekumisa peginesatide yaizogadzirwa nachiremba wako zvichienderana nezvinhu zvakati wandei. Kana basa reitsvo yako rakavandudzika zvakanyanya, muviri wako ungadai wakatanga kugadzira erythropoietin yechisikigo zvakare, zvichiita kuti mushonga usadiwe.

Ungamirawo kutora peginesatide kana ukasangana nemigumisiro yakakomba kana maitiro ekuita allergic. Muzviitiko zvakawanda, zvisinei, vanhu vane chronic kidney disease pa dialysis vaizofanira kuenderera mberi neimwe mhando yekurapa anemia kwenguva refu. Kana peginesatide yakabviswa, varwere vakachinjirwa kumimwe mishonga panzvimbo yekumisa kurapwa kwe anemia zvachose.

Q5. Nei Peginesatide yakabviswa mumusika?

Peginesatide yakabviswa mumusika muna Kukadzi 2013 nekuda kwemishumo yezvinetso zvakakomba uye dzimwe nguva zvinouraya zve allergic reactions. Mushure mekunge mushonga uyu wabvumirwa uye uchishandiswa zvakanyanya, vanopa hutano vakatanga kutaura nezve zviitiko zve severe anaphylaxis izvo zvaitoda kurapwa nekukurumidza.

FDA nevagadziri vakasarudza kuti njodzi yezviitiko izvi zvinotyisa upenyu yaive yakanyanya kukwirisa kuti vaenderere mberi nekutengesa mushonga. Sarudzo yakaitwa yekuzvidira kuyeuka zvese zvigadzirwa zve peginesatide uye kumisa kushandiswa kwayo. Varwere vaive vachitora peginesatide vakachinjirwa kune dzimwe nzira dzakachengeteka dzekurapa anemia yavo.