Chii chinonzi Pralatrexate: Zvazvinoshandiswa, Madosi, Mativi eMuviri, nezvimwe

Pralatrexate mushonga wemakemikari wakakosha unopiwa kuburikidza neIV kurapa marudzi akati wandei ekenza yeropa. Yakagadzirirwa kunangana nekumisa masero ekenza akave asingashandi kune mamwe marapirwo, ichipa tariro kana dzimwe sarudzo dzisingashande zvakanaka.

Mushonga uyu ndewechikamu chinonzi antifolate drugs, chinoshanda nekukanganisa maitiro anoshandisa masero ekenza folate (rudzi rweB vhitamini) kukura nekukwidziridza. Funga nezvazvo sekukanganisa kugona kwemasero ekenza kugadzira zvivakwa zvavanoda kuti vararame nekupararira.

Chii chinonzi Pralatrexate?

Pralatrexate mushonga wemakemikari unonangana nawo unodzivirira masero ekenza kushandisa folate, chikafu chakakosha chavanoda kuti vakure. Yakagadzirirwa zvakananga kushanda kurwisa mamwe marudzi ekenza yeropa akagadzira kusashanda kune mamwe mishonga inovharisa folate.

Mushonga uyu unopiwa chete munzvimbo dzehutano kuburikidza neIV infusion, iyo inobvumira vanachiremba kukutarisa zvakanyanya panguva yekurapa. Iyi nzira yekuchenjerera inobatsira kuona kuti unogamuchira madosi akakodzera uchibata chero mativi emuviri anogona kuitika.

Pralatrexate Inoshandiswa Kunei?

Pralatrexate inonyanya kushandiswa kurapa peripheral T-cell lymphoma (PTCL), rudzi rusingawanzoitiki rwekenza yeropa inokanganisa immune system yako. Inowanzocherechedzwa kana mamwe marapirwo asina kushanda zvakanaka kana kana kenza yakadzoka mushure mekurapa kwapfuura.

Chiremba wako angakurudzira mushonga uyu kana uine relapsed kana refractory PTCL, zvinoreva kuti kenza yako yakadzoka mushure mekurapa kana isina kupindura zvakanaka kune yekutanga therapies. Kunyangwe izvi zvichigona kunzwa zvakanyanya, pralatrexate inopa imwe sarudzo yekurapa yakagadzirirwa zvakananga mamiriro aya akaoma.

Pralatrexate Inoshanda Sei?

Pralatrexate inoshanda nekudzivisa enzyme inonzi dihydrofolate reductase, iyo maseru ekenza anoda kugadzirisa folate uye kugadzira DNA. Pasina maitiro aya achishanda nemazvo, maseru ekenza haakwanise kubereka uye pakupedzisira anofa.

Mishonga iyi inoonekwa seyakasimba, inotarisa kurapa iyo ine simba kupfuura mamwe madhiragi ekare anovharisa folate. Yakagadzirirwa zvakanyanya kuti ipinde mukati memasero ekenza zvinobudirira, ndosaka ichikwanisa kushanda kunyangwe mamwe mishonga yakafanana isina kubudirira.

Mishonga inofamba kuburikidza neropa rako uye inonyanya kutarisisa maseru anokurumidza kukamuka, ayo anosanganisira maseru ekenza. Kunyange zvazvo ichigona kukanganisa mamwe maseru ane hutano zvakare, chinangwa ndechekurwisa maseru ekenza zvakanyanya kupfuura matishu ako akajairika, ane hutano.

Ndingatora sei Pralatrexate?

Pralatrexate inogara ichipiwa nenyanzvi dzehutano kuburikidza neIV line muchipatara kana nzvimbo yekupinza. Iwe uchaiwana se infusion kwemaminitsi anenge 3-5, kazhinji kamwe pavhiki kwemavhiki matanhatu, ichiteverwa nekuzorora kwevhiki imwe.

Usati wapiwa infusion yega yega, unozofanira kutora folic acid uye vitamin B12 zvinowedzera kubatsira kuchengetedza maseru ako ane hutano kubva kumigumisiro yemishonga. Chikwata chako chehutano chichakupa mirairo chaiyo yekuti ungatora riini uye sei zvinowedzera izvi - iyi chikamu chakakosha chechirongwa chako chekurapa.

Haufaniri kutsanya usati wapiwa infusion yako, asi kudya chikafu chakareruka pamberi zvinogona kukubatsira kuti unzwe wakasununguka panguva yekurapa. Vamwe vanhu vanoona zvichibatsira kuunza zvekudya zviduku nemvura kuti vagare vakanyoroveswa panguva yekushanya kwavo.

Ndingatora Pralatrexate kwenguva yakareba sei?

Kureba kwekurapa kwako kwepralatrexate kunoenderana nekuti kenza yako inopindura sei uye kuti uri kushivirira sei mishonga. Vanhu vazhinji vanoenderera mberi nekurapa chero bedzi ichishanda uye migumisiro yacho ichiramba ichidzoreka.

Chiremba wako achagara achiongorora kufambira mberi kwako kuburikidza nemiedzo yeropa, scans, uye bvunzo dzemuviri kuti aone kana kurapwa kuchibatsira. Vamwe vanhu vanogona kugamuchira matenderedzwa akati wandei ekurapa, nepo vamwe vangada kugadzirisa chirongwa chavo zvichienderana nekuti vari kupindura sei.

Sarudzo yekuramba kana kumisa kurapwa inogara ichiitwa pamwe chete nechikwata chako chehutano, ichifunga zvese zvakanakira zvauri kuona uye chero mhedzisiro yaunowana.

Ndezvipi Zvipingamupinyi zvePralatrexate?

Kufanana nemishonga yakawanda yekemotherapy, pralatrexate inogona kukonzera mhedzisiro, kunyangwe ruzivo rwemunhu wese rwakasiyana. Mhedzisiro yakajairika inowanzo manejwa nerutsigiro rwakakodzera rwekurapa uye kuongorora.

Heano mhedzisiro yaungasangana nayo, uye zvakakosha kuyeuka kuti chikwata chako chehutano chakagadzirira kukubatsira manejimendi chero ipi zvayo:

• Kuderera kwemasero eropa: Izvi zvinogona kukuitisa kuti utapukirwe zvakanyanya, kuputika, kana kunzwa kuneta
• Maronda emuromo: Izvi zvinogona kusagadzikana asi zvinowanzo pora pakati pematenderedzwa ekurapa
• Nausea uye kurutsa: Mishonga inorwisa nausea inogona kubatsira zvakanyanya nezviratidzo izvi
• Kuneta: Izvi zvakajairika uye zvinowanzoita nani pakati pematenderedzwa ekurapa
• Ganda reactions: Unogona kuona rashes kana shanduko mumavara eganda
• Kurasikirwa nechido: Kushanda nemunyanzvi wezvekudya kunogona kubatsira kuchengetedza chikafu chakakodzera

Zvisingawanzoitiki asi zvakanyanya mhedzisiro inogona kusanganisira hutachiona hwakakomba nekuda kwehuwandu hwehuwandu hwemasero machena eropa, kana matambudziko echiropa anoratidzwa mumiedzo yeropa. Chikwata chako chekurapa chinotarisa izvi zvakanyanya kuburikidza nebasa renguva dzose relab.

Zvimwe zvisingawanzoitiki asi zvakakomba zvinosanganisira matambudziko akakomba eganda, matambudziko emapapu, kana matambudziko eitsvo. Kunyange izvi zvisingawanzoitiki, zvakakosha kuti utaure nechikwata chako chehutano nekukasira kana ukaona fivha, kuoma kufema, kana chero zviratidzo zvinokunetsa pakati pekurapwa.

Ndiani Asingafaniri Kutora Pralatrexate?

Pralatrexate haikodzeri munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yezvokurapa asati akurudzira kurapwa uku. Vanhu vane mamiriro akati wandei vangangoda dzimwe nzira dzekurapa kana kuongororwa kwakakosha.

Unofanira kukurukura dzimwe nzira nachiremba wako kana uine chero mamiriro aya:

• Matambudziko akakomba eitsvo: Mushonga unogadziriswa kuburikidza neitsvo dzako
• Zvirwere zvakakomba zviri kushanda: Mushonga uyu unogona kuderedza kugona kwemuviri wako kurwisa zvirwere
• Chirwere chakakomba chechiropa: Izvi zvinogona kukanganisa nzira iyo muviri wako unogadzirisa mushonga
• Kuzvitakura kana kuyamwisa: Mushonga uyu unogona kukuvadza vana vari kukura
• Matambudziko akakomba emoyo: Vamwe vanhu vangangoda kuongororwa kwemoyo panguva yekurapwa

Chikwata chako chehutano chichafungawo nezve hutano hwako hwese, mamwe mishonga yaunotora, uye zviitiko zvakapfuura kune kurapwa kwakafanana pakuona kana pralatrexate yakakukodzera.

Zita reBrand rePralatrexate

Pralatrexate inotengeswa pasi pezita rebrand Folotyn muUnited States. Iri ndiro zita rebrand chete riripo parizvino remushonga uyu.

Sezvo uyu uri mushonga wekenza wakakosha, unowanikwa chete kuburikidza nenzvimbo dzehutano dzakakosha uye makambani emishonga akakosha anoshanda nekurapwa kweoncology. Nzvimbo yako yekenza icharonga kuwana mushonga uyu wekurapwa kwako.

Dzimwe Nzira dzePralatrexate

Kana pralatrexate isina kukodzera kwauri kana ikamira kushanda zvakanaka, dzimwe nzira dzekurapa dziripo dze peripheral T-cell lymphoma. Sarudzo inoenderana nemamiriro ako chaiwo uye nhoroondo yako yekurapa.

Kurapa kwakasiyana kungasanganisira mamwe makemikari ekurapa, mishonga inotarwa se romidepsin kana belinostat, kana nzira dzekurapa dzemuviri. Vamwe vanhu vangavewo vakakodzera kutamiswa kwemasero emuti kana vakave neutano hwakanaka.

Oncologist wako achakurukura izvi newe zvichibva pamaitiro ekenza yako, kurapwa kwako kwakapfuura, uye hutano hwako hwese. Sarudzo imwe neimwe ine zvainobatsira nezvinhu zvekufunga.

Ko Pralatrexate Zviri Nani Pane Methotrexate?

Pralatrexate uye methotrexate zvese mishonga inovharisa folate, asi anoshanda zvakasiyana uye anoshandiswa kune mamiriro akasiyana. Pralatrexate yakagadzirirwa zvakananga kenza yeropa iyo yakave isingashandi kune dzimwe nzira dzekurapa, kusanganisira methotrexate.

Ye peripheral T-cell lymphoma, pralatrexate inowanzo shanda zvakanyanya nekuti yakagadzirwa kuti ipinde mumasero ekenza zviri nyore kupfuura methotrexate. Izvi zvinoita kuti zvibatsire zvakanyanya kana dzimwe mishonga inovharisa folate isina kushanda zvakanaka.

Zvisinei, methotrexate inoshandiswa kune mamiriro akawanda akasiyana uye inowanzoonekwa seyekutanga kurapa kenza dzakasiyana uye zvirwere zve autoimmune. Sarudzo pakati pavo inoenderana zvachose nekuongororwa kwako kwakakosha uye nhoroondo yekurapa.

Mibvunzo Inowanzo Bvunzwa Nezve Pralatrexate

Q1. Ko Pralatrexate Yakachengeteka Kune Vanhu vane Chirwere cheItsvo?

Pralatrexate inoda kufunga zvakanyanya kana uine matambudziko eitsvo nekuti itsvo dzako dzinobatsira kugadzirisa mushonga uyu. Vanhu vane matambudziko eitsvo akapfava vanogona kuramba vachigamuchira kurapwa, asi vanogona kuda kugadzirisa dosi uye kuongorora zvakanyanya.

Kana uine chirwere cheitsvo chakati wandei kana chakanyanya, chiremba wako angakurudzira mamwe marapirwo kana kuda mamwe maedzo ekuona kuti mushonga wacho wakachengeteka kwauri. Sarudzo iyi ichaenderana nekushanda kweitsvo dzako uye hutano hwako hwese.

Mubvunzo 2. Ndingaita Sei Kana Ndikawana Pralatrexate Yakawandisa Netsaona?

Sezvo pralatrexate ichipiwa nenyanzvi dzehutano munzvimbo dzakadzorwa, kuwandisa netsaona hakusi kwakajairika. Zvisinei, kana uine mhedzisiro yakakomba mushure mekurapwa, taura nechikwata chako cheoncology nekukasira.

Chikwata chako chekurapa chinotarisa chiyero chako zvakanyatso uye chine mitemo yekudzivirira kukanganisa kwechiyero. Kana kuwandisa kukaitika, vaizopa rutsigiro rwekutarisira uye kukutarisa zvakanyanya kune chero matambudziko.

Mubvunzo 3. Ndingaita Sei Kana Ndikarasikirwa neDose yePralatrexate?

Kana ukakanganwa infusion ye pralatrexate yakarongwa, taura nechikwata chako cheoncology nekukasira kuti urongezve. Vachasarudza nzira yakanakisa zvichienderana nekuti yakapfuura nguva yakawanda sei uye chirongwa chako chekurapa.

Usaedze kugadzirisa madhizi akarasika nekugadzirisa mamwe marapirwo. Chikwata chako chehutano chichagadzirisa chirongwa chako chekurapa zvakakodzera kuti uchengetedze nzira inoshanda uye yakachengeteka yemamiriro ako ezvinhu.

Mubvunzo 4. Ndingamira Rini Kutora Pralatrexate?

Sarudzo yekumisa kurapwa kwe pralatrexate inogara ichiitwa pamwe chete nechikwata chako cheoncology zvichibva pakuti kurapwa kuri kushanda sei uye kuti uri kuzvigamuchira sei. Izvi zvinogona kuitika kana kenza yako ikaenda mukuregererwa, kana mhedzisiro ikava yakaoma kudzora, kana kurapwa kukamira kushanda.

Chiremba wako achashandisa ma scans enguva dzose, bvunzo dzeropa, uye bvunzo dzemuviri kuti atarise kufambira mberi kwako uye atarise nguva yakakodzera yekuti uenderere mberi, kugadzirisa, kana kumisa kurapwa. Usambomira kurapwa wega usina kukurukura nechikwata chako chehutano kutanga.

Mubvunzo 5. Ndingatora Mamwe Mishonga Nguva yePralatrexate?

Mishonga mimwe inogona kukanganisa pralatrexate, saka zvakakosha kuti uudze timu yako ye oncology nezve mishonga yese, zvinowedzerwa, uye mishonga isingatengeswe. Izvi zvinosanganisira mavitamini, zvinowedzerwa zvechirimwa, uye zvinobvisa marwadzo.

Mishonga yakati, kunyanya iyo inokanganisa itsvo dzako kana immune system, inogona kuda kugadziriswa kana kudziviswa panguva yekurapa. Chikwata chako chehutano chichaongorora runyorwa rwako rwemishonga rwese uye chigadzirise chero shanduko dzinodiwa kuti uchengetedzwe panguva yekurapa.