Chii chinonzi Raltegravir: Zvazvinoshandiswa, Dosage, Side Effects uye Zvimwe

Raltegravir mushonga weHIV unobatsira kuchengeta hutachiona huchidzorwa mumuviri wako. Iwo wekirasi yemishonga inonzi integrase inhibitors, iyo inoshanda nekudzivirira HIV kubva pakuzvinyora uye kupararira kumasero ane hutano.

Mushonga uyu wakava chikamu chakakosha chemishonga yemazuva ano yeHIV nekuti inowanzoshivirirwa zvakanaka uye inoshanda. Iwe unowanzoitora sechikamu chekurapa kwakabatanidzwa nemimwe mishonga yeHIV, iyo inobatsira kugadzira dziviriro yakasimba kubva kuhutachiona.

Chii chinonzi Raltegravir?

Raltegravir mushonga weantiviral wakanyorwa zvakananga kurapa HIV-1 infection. Inoshanda nekunangana neimwe enzyme iyo HIV inoda kuzvinyora mumuviri wako.

Mishonga iyi yakatanga kubvumidzwa neFDA muna 2007 uye kubvira ipapo yakabatsira mamiriyoni evanhu kudzora HIV yavo nemazvo. Inoonekwa seimwe sarudzo yekutanga yekurapa, zvinoreva kuti vanachiremba vanowanzoikurudzira semumwe wemishonga yekutanga yevanhu vachangobva kuongororwa.

Unogona kunzwa murapi wako achitaura nezvayo nezita rayo remhando, Isentress, kana kungoti integrase inhibitor. Mushonga uyu unouya muchimiro chepiritsi uye wakagadzirirwa kutorwa nemuromo uine kana pasina chikafu.

Chii chinonzi Raltegravir chinoshandiswa?

Raltegravir inonyanya kushandiswa kurapa HIV-1 infection muvanhu vakuru nevana vanorema angangoita 4.4 pounds (2 kilograms). Inogara ichishandiswa pamwe chete nemimwe mishonga yeHIV, kwete yega.

Chiremba wako angakunyore raltegravir kana uchangobva kuongororwa neHIV kana kana uchida kuchinja kubva kune imwe mishonga yeHIV. Zvinonyanya kubatsira vanhu vakagadzira kuramba kune dzimwe mishonga yeHIV kana avo vanowana matambudziko emigumisiro kubva kumishonga yakasiyana.

Mushonga uyu unoshandiswawo muvarwere vakambotambura nekurapwa avo HIV yavo yakava nemishonga yakasiyana. Muzviitiko izvi, raltegravir inogona kupa nzira itsva yekudzora hutachiona kana dzimwe nzira dzisina kushanda zvakanaka.

Raltegravir Inoshanda Sei?

Raltegravir inoshanda nekudzivisa enzyme inonzi integrase iyo HIV inoda kuti iise zvinhu zvayo zve genetic muzvinhu zvako zvine hutano. Funga nezve integrase sechinhu chinokosha icho HIV inoshandisa kuvhura uye kupinda mumasero ako.

Kana HIV ikapinda muchitokisi, inoda kubatanidza kodhi yayo yegene muzvinhu zveDNA zvechitokisi kuti ibereke. Raltegravir inonyanya kuvharisa maitiro aya, ichidzivirira hutachiona kubva pakugadzira nzvimbo yechigarire mumasero ako.

Mushonga uyu unoonekwa seune simba zvine mwero uye unoshanda zvakanyanya kana uchishandiswa sechikamu chekurapa kwakasiyana. Hauperekedzi HIV, asi unogona kuderedza huwandu hwehutachiona muropa rako kusvika pamatanho asinganzwisisike, izvo zvinobatsira kuchengetedza immune system yako uye kudzivirira kupararira kune vamwe.

Ndingatora Sei Raltegravir?

Unofanira kutora raltegravir sezvakanyorwa nachiremba wako, kazhinji kaviri pazuva uine kana usina chikafu. Madosi akajairika evakuru anowanzoita 400 mg kaviri pazuva, asi chiremba wako achasarudza huwandu hwakakodzera kune mamiriro ako chaiwo.

Unogona kutora mushonga uyu nezvokudya, zvekudya zviduku, kana mudumbu risina chinhu - chero zvichishanda zvakanaka kune yako tsika. Vamwe vanhu vanoona zviri nyore kuyeuka madosi avo kana vachivatora nekudya kwemangwanani uye kudya kwemanheru.

Edza kutora madosi ako panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana emushonga mumuviri wako. Kugadzira zviyeuchidzo zvefoni kana kushandisa chirongwa chemapiritsi kunogona kukubatsira kuti urambe uchienderana nehurongwa hwako hwekurapa.

Medza mahwendefa ese nemvura kana chimwe chinwiwa. Usapwanya, kutsenga, kana kuputsa mahwendefa, sezvo izvi zvinogona kukanganisa nzira iyo mushonga unotorwa mumuviri wako.

Ndingatora Raltegravir Kwenguva Yakareba Sei?

Zvichida uchada kutora raltegravir kweupenyu hwako hwese sechikamu chekurapa kwako HIV. Kurapa HIV ibasa renguva refu, uye kumisa mishonga kunogona kubvumira hutachiona kuti huwedzere uye hugone kuita kuramba.

Chiremba wako achatarisa kufambira mberi kwako kuburikidza nemiedzo yeropa yenguva dzose inoyera mutoro wako wehutachiona uye huwandu hweCD4 cell. Miedzo iyi inobatsira kuona kuti mushonga uri kushanda sei uye kana kuchidikanwa kuchinja chirongwa chako chekurapa.

Vamwe vanhu vanonetseka nezvekutora mushonga zvachose, asi yeuka kuti kurapa nguva dzose kunokubatsira kuchengetedza hutano hwako uye kunodzivirira HIV kubva pakuenderera mberi kuAIDS. Vanhu vazhinji vari pakurapa HIV kunoshanda vanorarama hupenyu hurefu, hune hutano hune zvishoma zvekukanganisa pamabasa avo ezuva nezuva.

Ndezvipi Zvinhu Zvinokonzerwa neRaltegravir?

Vanhu vazhinji vanotsungirira raltegravir zvakanaka, asi semishonga yese, inogona kukonzera mhedzisiro. Mashoko akanaka ndeokuti mhedzisiro yakakomba haisi yakajairika, uye vanhu vazhinji vanowana matambudziko mashoma kana asina.

Heano mhedzisiro yakajairika yaungasangana nayo, uchifunga kuti vanhu vazhinji vane zviratidzo zvishoma zvinovandudzika nekufamba kwenguva:

• Kurwadziwa nemusoro
• Nausea
• Diarhea
• Kuneta kana kunzwa kuneta
• Dizziness
• Matambudziko ekurara
• Kurwadziwa mudumbu
• Kurwadziwa kwemhasuru

Izvi zvinowanzoitika zvinokonzerwa zvinowanzoita zvishoma sezvo muviri wako uchigadzirisa kumushonga mumavhiki mashoma ekutanga ekurapa.

Nepo zvisingawanzoitiki, pane zvimwe zvinokonzeresa zvakanyanya zvinoda kutariswa kwekurapa nekukasira. Izvi zvisingawanzoitiki asi zvakakosha zvinosanganisira:

• Zvikuru zveganda kana rash
• Zviratidzo zvematambudziko echiropa (kushanduka kweganda kana maziso, weti yakasviba, kurwadziwa mudumbu kwakanyanya)
• Kurwadziwa kwemhasuru kwakanyanya kana kusimba
• Kuchinja kwehutano hwepfungwa senge kuora mwoyo kana pfungwa dzekuzviuraya
• Zvikuru zvinokonzeresa allergic

Kana uine zviratidzo zvakanyanya, taura nachiremba wako nekukasira. Rangarira kuti mabhenefiti ekurapa HIV anowanzo kunda njodzi dzemigumisiro.

Ndiani Asingafaniri Kutora Raltegravir?

Raltegravir haikodzeri munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuraira. Haufaniri kutora mushonga uyu kana uine allergic ku raltegravir kana chero zvinhu zvawo.

Mupi wako wehutano achada kuziva nezve mamwe mamiriro uye mishonga inogona kushamwaridzana ne raltegravir. Ita shuwa kuti unovaudza kana uine:

• Chirwere chechiropa kana hepatitis
• Matambudziko eitsvo
• Mamiriro ehutano hwepfungwa, kunyanya kuora mwoyo
• Matambudziko emhasuru
• Nhoroondo yechero maitiro akakomba eganda kumishonga

Vakadzi vane pamuviri uye vanoyamwisa vanogona kutora raltegravir, asi izvi zvinoda kunyatsoongororwa nemupi wehutano ane ruzivo mukurapa HIV. Mushonga uyu unogona kuva chikamu chakakosha chekudzivirira kutapurirana kweHIV kubva kumai kuenda kumwana.

Chiremba wako achatarisawo mishonga yako yese iripo, kusanganisira mishonga yakanyorwa, mishonga isingatengwi, uye zvinowedzera, kuti aone kana paine kushamwaridzana kunogona kuitika.

Mazita eBrand eRaltegravir

Raltegravir inonyanya kuzivikanwa nezita rayo rebrand Isentress, iro rinogadzirwa neMerck & Co. Iyi ndiyo yekutanga formulation iyo vanhu vazhinji vanogamuchira kana vakanyorerwa raltegravir.

Kune zvakare Isentress HD, iyo iri formulation yepamusoro-dose iyo inobvumira vamwe vanhu kutora mushonga kamwe chete pazuva panzvimbo pezvakapetwa kaviri pazuva. Chiremba wako achasarudza kuti ndeipi formulation yakanakira mamiriro ako chaiwo.

Mhando dzemajenari dze raltegravir dzinogonawo kuwanikwa, izvo zvinogona kubatsira kuderedza mari yekurapa. Aya majenari emishonga ane chinhu chimwe chete chinoshanda uye anoshanda zvakanyanya semhando dzemazita emhando.

Zvimwe Zvingashandiswa Panzvimbo peRaltegravir

Kana raltegravir isingashande zvakanaka kwauri kana kukonzera matambudziko, pane mamwe mishonga yeHIV chiremba wako angangofunga. Zvimwe zvinodzivirira integrase zvinosanganisira dolutegravir (Tivicay) uye bictegravir (Biktarvy).

Mupi wako wehutano angangakurudzirawo mishonga kubva kumapoka akasiyana emishonga, senge non-nucleoside reverse transcriptase inhibitors (NNRTIs) kana protease inhibitors, zvichienderana nemamiriro ako chaiwo uye chero maitiro ekuramba mishonga.

Sarudzo yemishonga imwe inotsamira pazvinhu zvakaita seviral load yako, CD4 count, chero kurapwa kweHIV kwawakambotora, uye hutano hwako hwese. Chiremba wako achashanda newe kuti awane musanganiswa unoshanda zvakanyanya uye unogona kushivirirwa.

Rangarira kuti kuchinja mishonga yeHIV kunofanirwa kuitwa nguva dzose pasi pekutariswa kwechiremba. Chiremba wako achanyatso kuronga chero shanduko kuti ave nechokwadi chekuenderera mberi kweviral suppression panguva yekuchinja.

Raltegravir Zviri Nani Kudarika Dolutegravir Here?

Zvese raltegravir uye dolutegravir zvinoshanda integrase inhibitors, asi vane misiyano inogona kuita kuti imwe ikukodzere kupfuura imwe. Dolutegravir inowanzo torwa kamwe pazuva, nepo raltegravir inowanzo torwa kaviri pazuva.

Zvidzidzo zvinoratidza kuti dolutegravir inogona kuve neyakakwira chipingamupinyi chekuramba, zvinoreva kuti zvakaoma kuti HIV ivake kuramba kwayo. Zvisinei, raltegravir yanga iripo kwenguva refu uye ine rekodhi yakakura yekuchengeteka uye kushanda.

Dolutegravir inogona kukonzera kuwedzera uremu uye kusagadzikana kwekurara kune vamwe vanhu, nepo raltegravir inowanzo shivirirwa zviri nani maererano nemhedzisiro iyi. Sarudzo pakati pavo inowanzoenderana nemamiriro ako ega uye zvaunofarira.

Chiremba wako achafunga nezvezvinhu zvakaita sehupenyu hwako, mamwe mishonga yaunotora, uye chero nhoroondo yekurapa yapfuura paanokurudzira kuti ndeupi integrase inhibitor angashanda zvakanyanya kwauri.

Mibvunzo Inowanzo Bvunzwa Nezve Raltegravir

Raltegravir Yakachengeteka Here Kune Vanhu vane Chirwere chechiropa?

Raltegravir inogona kushandiswa zvakachengeteka muvanhu vane chirwere chechiropa, asi inoda kunyatso tariswa. Chiremba wako achada kutarisa kushanda kwechiropa chako nguva dzose kuburikidza nemiedzo yeropa kuti ave nechokwadi chekuti mushonga hausi kukonzera matambudziko.

Vanhu vane hepatitis B kana C co-infection vanogona kutora raltegravir, asi vangada kuongororwa kakawanda. Mushonga uyu unowanzoonekwa sewakachengeteka kune chiropa kupfuura mamwe mamwe maHIV drugs, ndosaka vanachiremba dzimwe nguva vachisarudza iyo kune varwere vane matambudziko echiropa.

Ndoita Sei Kana Ndikatora Raltegravir Yakawandisa Netsaona?

Kana netsaona ukatora raltegravir yakawanda kupfuura yakarairwa, taura nechiremba wako kana nzvimbo yekudzora muchetura nekukasira. Kunyangwe overdoses isingawanzoitika, zvakakosha kuwana zano rekurapa nezvekuti chii chekuita chinotevera.

Usaedze kutsiva chiyero chakawedzerwa nekusvetuka chiyero chako chinotevera chakatarwa. Pane kudaro, tevera mirairo yachiremba wako nezvekuti ungadzokera riini kuchirongwa chako chekushandisa. Chengeta nguva yaakatora chiyero chakawedzerwa kuti ubatsire vanachiremba kuongorora mamiriro acho ezvinhu.

Ndoita Sei Kana Ndikakanganwa Kutora Raltegravir?

Kana ukakanganwa kutora raltegravir, itore paunorangarira, kunze kwekunge yava nguva yechiyero chako chinotevera chakatarwa. Muchiitiko ichocho, svetuka chiyero chakarasika uye uenderere mberi nechirongwa chako chetsika.

Usambofa wakatora zviyero zviviri panguva imwe chete kuti utsigire chiyero chakarasika. Kana iwe uchikanganwa zviyero kazhinji, taura nechiremba wako nezve nzira dzekukubatsira kurangarira, senge kumisa maalarm efoni kana kushandisa murongi wepiritsi.

Kukanganwa zviyero dzimwe nguva kazhinji hakuna njodzi, asi kugara uchikanganwa zviyero kunogona kubvumira HIV kuti ivake kuramba mushonga, zvichiita kuti isashande nekufamba kwenguva.

Ndingamira Rini Kutora Raltegravir?

Haufaniri kumbomira kutora raltegravir usati watanga kukurukura nachiremba wako. Kurapa HIV kunowanzoitwa kwenguva refu, uye kumisa mishonga kunogona kubvumira hutachiona kuti huwedzere nekukurumidza uye hugone kuita kuramba.

Chiremba wako angangofunga kuchinja mushonga wako weHIV kana uri kusangana nemigumisiro yakakura kana kana mushonga usingashande zvakanaka. Zvisinei, chero shanduko kuronga kwako kurapwa kunofanira kurongwa zvakanaka uye kutarisirwa.

Kana uine hanya nemushonga wako kana uchifunga kumisa kurapwa, ita hurukuro yakavhurika nachiremba wako nezvekuzvidya mwoyo kwako uye mhinduro dzinogoneka.

Ndinganwa Doro Ndiri Kutora Raltegravir Here?

Kunwa doro zvine mwero kazhinji kwakanaka uchitora raltegravir, asi zviri nani kukurukura tsika dzako dzekunwa nachiremba wako. Doro harina hukama zvakananga ne raltegravir, asi rinogona kukanganisa chiropa chako uye immune system.

Kana uine chirwere chechiropa kana mamwe mamiriro ehutano, chiremba wako angangokurudzira kuderedza kana kudzivisa doro zvachose. Yeuka kuti doro rinogonawo kuita kuti zviome kuyeuka kutora mishonga yako nguva dzose.

Iva akatendeseka nachiremba wako nezvekunwa kwako doro kuti vakwanise kukupa zano rakanakisa remamiriro ako chaiwo uye kutarisisa hutano hwako zvakakodzera.