Chii chinonzi Rasagiline: Zvayakashandiswa, Mushonga, Migumisiro Yakaipa nezvimwe

Rasagiline mushonga unopiwa nachiremba unobatsira kudzora zviratidzo zvechirwere cheParkinson nekudzivisa enzyme inoputsa dopamine muuropi hwako. Mushonga uyu unononoka asi unoshanda unovanda kumashure kuti ubatsire kuchengetedza dopamine inodiwa neuropi hwako kuti kufamba kwako kuve kwakatsetseka uye kuwirirana.

Kana iwe kana mumwe munhu waunoda akanyorerwa rasagiline, ungangove uri kutsvaga ruzivo rwakajeka, rwechokwadi nezve zvaunofanira kutarisira. Ngatitarisei zvese zvaunoda kuziva nezve mushonga uyu nenzira inoita seinodzoreka uye inovimbisa.

Chii chinonzi Rasagiline?

Rasagiline ndeyeboka remishonga inonzi MAO-B inhibitors, zvinoreva kuti inovharira enzyme chaiyo muuropi hwako inonzi monoamine oxidase type B. Iyi enzyme inowanzo putsa dopamine, mutumwa wemakemikari unobatsira kudzora kufamba uye kuwirirana.

Nekudzivisa zvinyoro-nyoro iyi enzyme, rasagiline inobatsira kuchengeta dopamine yakawanda muuropi hwako. Funga nezvazvo sekubatsira uropi hwako kubata dopamine ichiri kugadzira, pane kuimanikidza kuti ibudise zvakawanda.

Mushonga uyu unoonekwa semushonga wepakati nepakati. Haina simba selevodopa, asi inopa rutsigiro rwakagadzikana, rwakatsiga urwo vanhu vazhinji vanowana vachibatsira pakudzora zviratidzo zvavo.

Rasagiline Inoshandiswa Kunei?

Rasagiline inonyanya kunyorerwa kurapa chirwere cheParkinson, zvese semushonga wega muzvikamu zvekutanga uye sekuwedzera-pane-therapy kana ichishandiswa nemimwe mishonga. Chiremba wako angakurudzira kana uri kusangana nematambudziko ekufamba, kuoma, kana kuzununguka zvine chekuita nechirwere cheParkinson.

Muchikamu chekutanga chechirwere cheParkinson, rasagiline inogona kubatsira kunonotsa kudiwa kwemishonga yakasimba ichipa zororo rezviratidzo. Kana Parkinson ichifambira mberi, inowanzo sanganiswa nelevodopa kubatsira kupfavisa kumusoro nekudzika kunogona kuitika nemushonga iwoyo.

Vamwe vanachiremba vanogonawo kupa rasagiline kunze kwemavara ekurapa mamwe mamiriro ane dopamine, kunyangwe izvi zvisingawanzoitika. Mukoti wako wehutano achasarudza kana mushonga uyu wakakodzera mamiriro ako chaiwo.

Rasagiline Inoshanda Sei?

Rasagiline inoshanda nekudzivirira zvakasarudzika enzyme yeMAO-B muuropi hwako, iyo ine basa rekuparadza dopamine. Kana enzyme iyi yakavharwa, mazinga e dopamine anoramba akagadzikana zuva rese.

Iyi nzira inoitika zvishoma nezvishoma uye zvinyoro nyoro. Hauzonzwe kukurumidza kana shanduko huru sezvaungaita nemamwe mishonga. Pane kudaro, rasagiline inopa rutsigiro rwakagadzikana rwemashure runovaka nekufamba kwenguva.

Mushonga uyu unogonawo kuve nemamwe maitiro ekudzivirira maseru etsinga, kunyangwe vatsvakurudzi vachiri kudzidza kubatsirwa uku. Zvatinoziva nechokwadi ndechekuti inobatsira kuchengetedza mazinga e dopamine nenzira inotsigira kufamba kuri nani uye kubatana.

Ndinofanira Kutora Sei Rasagiline?

Rasagiline inowanzo torwa kamwe chete pazuva, kazhinji mangwanani aine kana pasina chikafu. Iyo yakajairika yekutanga dose inowanzoita 0.5 mg, iyo chiremba wako anogona kuwedzera kusvika 1 mg zuva nezuva zvichienderana nemhinduro yako nezvido.

Unogona kutora mushonga uyu nemvura, uye hazvina basa kana wanga wadyisa nguva pfupi yadarika. Zvisinei, vamwe vanhu vanozviwana zviri nyore kuyeuka kana vachizvitora nekudya kwemangwanani kana imwe tsika yenguva dzose yemangwanani.

Edza kutora rasagiline panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana muhurongwa hwako. Kana uri kuitora nemamwe mishonga yeParkinson, chiremba wako achapa mirairo chaiyo yenguva yekuvandudza mashandiro avanoita pamwe chete.

Gara uchimedza piritsi rose pane kuripwanya kana kuritsenga. Izvi zvinovimbisa kuti mushonga unoburitswa nemazvo muhurongwa hwako.

Ndinofanira Kutora Rasagiline Kwenguva Yakareba Sei?

Rasagiline inowanzoita mushonga wenguva refu waunozoramba uchitora chero uchiri kubatsira zviratidzo zvako. Vanhu vazhinji vane chirwere cheParkinson vanochitora kwemwedzi kana makore, sezvo chakagadzirirwa kupa rutsigiro rwekuenderera mberi panzvimbo yekugadzirisa nekukurumidza.

Chiremba wako achatarisa kuti mushonga uri kushanda sei kwauri panguva yekutarisa nguva dzose. Vachatarisa kuti zviratidzo zvako zviri kupindura sei uye kana uri kusangana nemamwe matambudziko anopfuura mabhenefiti.

Vamwe vanhu vanotora rasagiline kwemakore mazhinji vaine mhedzisiro yakanaka, nepo vamwe vachida kugadzirisa kuronga kwavo kurapwa sezvo mamiriro avo achichinja. Chinhu chakakosha kuchengetedza kutaurirana kwakavhurika nechikwata chako chehutano nezvekuti unonzwa sei.

Ndezvipi Zvakaipa zveRasagiline?

Semishonga yese, rasagiline inogona kukonzera matambudziko, kunyangwe vanhu vazhinji vachigamuchira zvakanaka. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye wakavimbika nezvekurapa kwako.

Matambudziko anowanzoitika anowanzoita akapfava uye anowanzoita nani sezvo muviri wako uchigadzirisa kumushonga:

• Kutemwa nemusoro
• Kurwadziwa kwemajoini kana kuoma
• Kusagaya kana dumbu rinogumbuka
• Zviratidzo zvakaita sefuru
• Kushungurudzika kana shanduko dzemafungiro
• Dizziness
• Muromo wakaoma

Aya matambudziko ezuva nezuva haawanzoita kuti umise mushonga, asi unofanirwa kuakurukura nachiremba wako kana akava anoshungurudza kana kuenderera mberi.

Zvisingawanzoitiki asi zvakanyanya matambudziko anogona kuitika, kunyangwe achikanganisa vanhu vashoma:

• Zviitiko zvekukasira zvekurara panguva yezviitiko zvemazuva ese
• Hallucinations kana kuvhiringidzika
• Ganda rakakomba kana rash
• Zvisingawanzoitika zvekuda kana maitiro (kutamba, kutenga, kudya)
• Shanduko dzakakosha dzeropa
• Kurwadziwa muchipfuwa kana kurova kwemoyo kusingaite

Kana uine zvimwe zvezvinhu izvi zvakanyanya, taura nachiremba wako nekukurumidza. Vanogona kubatsira kuona kana mushonga uchida kuchinjwa kana kumiswa.

Kazhinji, rasagiline inogona kuita pamwe chete nezvimwe zvekudya zvine tyramine yakawanda (senge chizi yakakura kana nyama yakaporeswa) kana mamwe mishonga kukonzera kukwira kweropa kunotyisa. Chiremba wako achapa gwara rekudya kana zvichidikanwa.

Ndiani Asingafaniri Kutora Rasagiline?

Rasagiline haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa asati akuraira. Zvimwe zvirwere nemishonga zvinogona kuita kuti rasagiline isachengeteke kana kushanda zvishoma.

Haufaniri kutora rasagiline kana uchishandisa mamwe maantidepressants, kunyanya MAOIs, SSRIs, kana SNRIs. Musanganiswa unogona kukonzera kusangana kunotyisa kunokanganisa ropa rako uye makemikari ehuropi.

Vanhu vane chirwere chechiropa chakanyanya vanofanira kudzivisa rasagiline nekuti chiropa chinogadzirisa mushonga uyu. Chiremba wako anogona kuraira bvunzo dzechiropa asati atanga kurapwa kuti ave nechokwadi chekuti zvakachengeteka kwauri.

Mamwe mishonga asingashande zvakanaka ne rasagiline anosanganisira:

• Meperidine (pethidine) nemamwe mishonga yekurwadziwa yeopioid
• Dextromethorphan (inowanikwa mumishonga yekukosora)
• St. John's wort
• Tramadol
• Mamwe maantibayoti senge linezolid

Nguva dzose udza chiremba wako nezve mishonga yese, zvinowedzera, uye zvigadzirwa zvechirimwa zvauri kutora. Izvi zvinosanganisira mishonga inotengeswa pasina mvumo inogona kuita seinoshaya njodzi asi inogona kuita pamwe chete ne rasagiline.

Rasagiline Mazita eBrand

Rasagiline inowanikwa pasi pezita rebrand Azilect, iyo ndiyo vhezheni inonyanya kurairwa. Mhando dzakajairika dze rasagiline dziripo zvakare uye dzinogadzirisa zvakafanana nemushonga wezita rebrand.

Kambani yako yemishonga inogona kuva nemhando yezita kana vhezheni yechinyakare, zvichienderana nekavharo yako yeinishuwarenzi nezvaunofarira. Zvose zvine chinhu chimwe chete chinoshanda uye zvakanyatso shanda.

Kana uri kuchinja pakati pemhando yezita uye vhezheni yechinyakare, kana pakati pevagadziri vakasiyana vechinyakare, zivisa chiremba wako. Kunyange zvichishamisa, vamwe vanhu vanoona misiyano midiki mukuita kwavanonzwa, uye chiremba wako anogona kubatsira kuongorora mhinduro yako.

Zvimwe Zvingashandiswa Panzvimbo yeRasagiline

Mishonga yakati wandei inogona kurapa chirwere cheParkinson kana rasagiline isiri yakanaka kwauri kana ikamira kushanda zvakanaka. Chiremba wako angangofunga nezvezvimwe zvingashandiswa panzvimbo zvichienderana nezviratidzo zvako zvakajeka uye nhoroondo yako yekurapa.

Zvimwe zvinodzivirira MAO-B zvinosanganisira selegiline, iyo inoshanda zvakafanana ne rasagiline asi inotorwa kaviri pazuva. Vamwe vanhu vanoita zviri nani neimwe pane imwe, kazhinji nekuda kwemaitiro emigumisiro kana zvaunofarira nguva.

Dopamine agonists senge pramipexole, ropinirole, kana rotigotine (inowanikwa sechigamba) inoshanda zvakasiyana nekukurudzira zvakananga dopamine receptors. Izvi zvinogona kuva zvimwe zvingashandiswa zvakanaka, kunyanya mukutanga chirwere cheParkinson.

Kune zviratidzo zvakanyanya, levodopa inoramba iri kurapwa kwegoridhe. Inowanzo sanganiswa ne carbidopa kuderedza migumisiro uye kuvandudza kushanda. Chiremba wako angangakurudzira izvi kana rasagiline yega isingapi kutonga kwakakwana kwezviratidzo.

Ko Rasagiline Ari Nani Pane Selegiline Here?

Zvese rasagiline ne selegiline zvinodzivirira MAO-B zvinoshanda zvakafanana, asi zvine misiyano yakakosha inogona kuita kuti imwe ive yakakodzera kwauri pane imwe.

Rasagiline inotorwa kamwe chete pazuva, nepo selegiline inowanzo torwa kaviri pazuva. Izvi zvinogona kuita kuti rasagiline ive nyore kune vanhu vazhinji, kunyanya avo vakatove vachibata mishonga yakawanda.

Zvimwe zvidzidzo zvinoratidza kuti rasagiline ingave isina kuwanda kwekuwirirana nezvikafu zvine tyramine, kunyangwe mishonga yese iri miviri inowanzo kuda kuziva kudya. Rasagiline zvakare inowanzoita kuti ive nemhedzisiro inofungidzirwa muvanhu vazhinji.

Selegiline yanga iripo kwenguva refu uye ine data yakawanda yekuchengetedza kwenguva refu, iyo vamwe vanachiremba vanosarudza. Zvisinei, rasagiline inowanzoita kuti ive nekukanganiswa kushoma kwekurara sezvo isingaputswe mumakomponi akafanana neamphetamine.

Chiremba wako achafunga nezve maitiro ako ezuva nezuva, mamwe mishonga, uye zvaunofarira pachako paunenge uchisarudza pakati pezvisarudzo izvi. Hapana imwe iri nani zvachose - zvinoenderana nezvinoshanda zvakanaka kune yako yega mamiriro.

Mibvunzo Inowanzo Bvunzwa Nezve Rasagiline

Rasagiline Yakachengeteka Kune Vanhu vane Chirwere Chemoyo Here?

Rasagiline inogona kushandiswa zvakachengeteka muvanhu vazhinji vane mamiriro emoyo, asi inoda kutarisa zvakanyanya. Mushonga unogona dzimwe nguva kukanganisa ropa uye rhythm yemoyo, saka chiremba wako achada kuongorora nhoroondo yako yemoyo zvakadzama.

Kana uine chirwere chemoyo chinodzorwa zvakanaka, rasagiline inogona kunge ichiri sarudzo ine kutarisirwa kwakakodzera kwekurapa. Chiremba wako angakurudzira kuongororwa kakawanda kana kuwedzera kuongororwa kwemoyo paunotanga mushonga.

Vanhu vane ropa rakakwira risingadzorwe kana kurwisa kwemoyo kwemazuva ano vangangoda kudzivisa rasagiline kana kuishandisa nekuchenjerera kwakanyanya. Nguva dzose kurukura nhoroondo yako yakazara yemoyo nemupi wako wehutano usati watanga chero mushonga mutsva.

Ndoita Sei Kana Ndikatora Rasagiline Yakawandisa Netsaona?

Kana netsaona ukatora rasagiline yakawanda kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira. Kutora zvakanyanya kunogona kukonzera shanduko dzengozi yeropa, kurwadziwa kwemusoro kwakanyanya, kana zvimwe zviratidzo zvakakomba.

Usamirira kuti uone kana zviratidzo zvichioneka – tsvaga mazano ekurapa nekukasira. Kuva nebhodhoro remushonga newe kunogona kubatsira vanopa hutano kuti vazive chaizvo kuti wakatora zvakawanda sei uye kupa kurapwa kwakakodzera.

Kudzivirira kuwandisa kwemishonga netsaona, funga kushandisa chirongwa chemishonga kana kumisa zviyeuchidzo zvefoni. Kana uri kutarisira mumwe munhu ane matambudziko ekuyeuka, vabatsire kumisa tsika yakachengeteka yemishonga.

Ndingaita Sei Kana Ndakakanganwa Dose yeRasagiline?

Kana ukakanganwa dose ye rasagiline, itore paunenge uchiziva, kunze kwekunge yava nguva yechikamu chako chinotevera. Muchiitiko ichocho, rega dose yakakanganwa uye uenderere mberi nechirongwa chako chemazuva ese.

Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa. Izvi zvinogona kuwedzera njodzi yako yezvinetso zvisingadiwi pasina kupa rubatsiro rwakawedzerwa.

Kana iwe uchikanganwa madosi kazhinji, edza kubatanidza mushonga wako netsika yezuva nezuva senge kukwesha mazino ako kana kudya kwemangwanani. Kuenderana kunobatsira kuchengetedza mazinga akagadzikana emushonga mumuviri wako.

Ndingamira Rini Kutora Rasagiline?

Unofanira kungomira kutora rasagiline pasi pekutungamirirwa nachiremba wako. Kumira kamwe kamwe hakuzokonzeri zviratidzo zvinotyisa zvekubviswa, asi zviratidzo zvako zveParkinson zvinogona kudzoka kana kuipa pasina rubatsiro rwemushonga.

Chiremba wako angakurudzira kumira rasagiline kana uri kusangana nezvinetso zvakakosha zvisingadiwi, kana isingachabatsiri zviratidzo zvako, kana uri kuchinja kune imwe nzira yekurapa.

Vamwe vanhu vanogona zvishoma nezvishoma kuderedza dose yavo vasati vamira zvachose, nepo vamwe vachigona kumira nekukasira zvichienderana nekukurudzirwa nachiremba wavo. Chinhu chakakosha kuva nechirongwa chakagadzirirwa kutarisira zviratidzo zvako panguva yekuchinja.

Ndinganwa Doro Ndiri Kutora Rasagiline?

Kunwa doro zvine mwero kunogamuchirika kazhinji uchitora rasagiline, asi unofanira kukurukura izvi nachiremba wako kutanga. Doro rinogona kuita pamwe chete nemishonga uye zviratidzo zvechirwere cheParkinson nenzira dzinosiyana-siyana kubva kumunhu nemunhu.

Vamwe vanhu vanoona kuti doro rinowedzera zviratidzo zvavo zvemaitiro kana kuwedzera dzungu kana richibatanidzwa ne rasagiline. Vamwe vangacherechedza kuti kugona kwavo doro kwakachinja kubva pavakatanga mushonga.

Kana chiremba wako achibvumira kushandiswa kwedoro dzimwe nguva, tanga nezvinhu zvishoma kuti uone kuti muviri wako unoita sei. Nguva dzose isa pamberi kuchengeteka kwako uye dzivisa doro kana ukaona chero kusangana kunonetesa kana kuwedzera zviratidzo.