Chii chinonzi Remdesivir: Kushandiswa, Madosi, Migumisiro uye Zvimwe

Remdesivir mushonga unopesana nemavhairasi unobatsira muviri wako kurwisa zvirwere zvakawanda zvevairasi nekumisa mavhairasi kubva pakuzviparadzanisa. Ungazviziva zvakanaka seimwe yemishonga inoshandiswa yeCOVID-19, kunyangwe yakatanga kugadzirwa kurapa zvimwe zvirwere zvakakomba zvevairasi. Mushonga uyu unoshanda nekukanganisa maitiro anoita mavhairasi kuzvinyora mukati memaseru ako, zvichipa immune system yako mukana uri nani wekubvisa hutachiona.

Chii chinonzi Remdesivir?

Remdesivir mushonga unopiwa nemurapi unopesana nemavhairasi uyo ari muboka remishonga inonzi nucleoside analogs. Funga nezvayo sechinhu chinonyengera chemolekular chinonyengedza mavhairasi kuti aishandise panzvimbo yezvivakwa zvaanoda kuti azviparadzire. Kana mavhairasi aedza kushandisa remdesivir kuti azvigadzire, maitiro acho anokanganiswa uye anomira kushanda nemazvo.

Mushonga uyu wakatanga kugadzirwa neGilead Sciences kurapa chirwere cheEbola virus. Zvisinei, vatsvakurudzi vakawana kuti inogona kushandawo kune mamwe mavhairasi, kusanganisira coronavirus inokonzera COVID-19. Mushonga uyu wakagamuchira mvumo yekushandiswa nekukurumidza kubva kuFDA muna 2020 uye mvumo yakazara muna 2021 yekurapa COVID-19 muvarwere vari muchipatara.

Remdesivir inoonekwa semushonga unopesana nemavhairasi wakasimba zvishoma. Kunyange isingashande zvakanyanya semamwe maantivirals anoshandiswa kune mamwe mamiriro, yakaratidza mabhenefiti anokosha mukuderedza nguva yekupora uye pamwe kudzivirira matambudziko akakomba mune vamwe varwere vane COVID-19.

Chii chinonzi Remdesivir chinoshandiswa?

Remdesivir inonyanya kushandiswa kurapa COVID-19 muvanhu vakuru nevarwere vevana vari muchipatara kana vari panjodzi huru yechirwere chakakomba. Mushonga uyu wakaratidza kushanda zvakanyanya kana wakatanga kutanga muchikamu chekutanga chechirwere, zvakanakira mukati memazuva mashoma ekutanga ekutanga kwezviratidzo.

Vapi vanopa hutano vanowanzo nyora remdesivir kuvashandi vane zviratidzo zveCOVID-19 zvine mwero kusvika zvakanyanya uye vanoda okisijeni yekuwedzera kana imwe rutsigiro. Inoshandiswawo kune vamwe varwere vane njodzi yakakwirira vanobva kunze kwechipatara vane COVID-19 yakapfava kusvika pakati nepakati asi vanogona kuenda kuzvirwere zvakanyanya zvichibva munhoroondo yavo yekurapa uye njodzi.

Kunze kweCOVID-19, remdesivir yakadzidzwa kune dzimwe hutachiona hwehutachiona, kunyangwe izvi zvinoshandiswa zvisingawanzoitiki. Vamwe vanachiremba vakashandisa kunze kwemavara ekuita severe respiratory syncytial virus (RSV) infections kana dzimwe hurwere hwakakomba hwehutachiona, kunyanya muvarwere vane immune system isina simba vangasaite zvakanaka kumishonga yakajairika.

Remdesivir Inoshanda Sei?

Remdesivir inoshanda nekutevedzera imwe yezvivakwa zvakasikwa zvinodiwa nemavhairasi kuti abudise zvinhu zvavo zvegeneti. Kana vhairasi ichiedza kuzvinyora, inokanganisa inobatanidza remdesivir muchikamu chayo chegeneti panzvimbo pechikamu chakarurama.

Kana remdesivir yaiswa muchinhu chegeneti chevairasi, inoshanda semugwagwa unodzivisa vhairasi kubva kupedzisa maitiro ayo ekubereka. Izvi zvinonyatso kumisa vhairasi kubva pakuita makopi matsva ayo, izvo zvinopa immune system yako nguva yekugadzira mhinduro yakasimba uye kubvisa hutachiona.

Mishonga inonyanya kutarisana ne enzyme inonzi RNA polymerase, iyo yakakosha kumavhairasi mazhinji kuti abereke. Nekuvharisa enzyme iyi, remdesivir inogona kuderedza kana kumisa kubereka kwevairasi pamhando dzakasiyana dzemavhairasi, kunyangwe ichishanda zvakanyanya pamavhairasi eRNA akaita se coronaviruses.

Ndinofanira Kutora Sei Remdesivir?

Remdesivir inowanikwa chete semushonga weintravenous (IV), zvinoreva kuti inofanira kupihwa zvakananga muropa rako kuburikidza nemutsipa. Hauzokwanisi kutora mushonga uyu nemuromo, uye unofanirwa kupihwa munzvimbo yekutarisira hutano senge chipatara, nzvimbo yekupinza, kana kiriniki yekunze.

Mushonga uyu unowanzo kupiwa semushonga unoyerera zvishoma nezvishoma muIV kwemaminitsi 30 kusvika ku120, zvichienderana nemwero wemushonga uye mamiriro ako. Chikwata chako chehutano chichakutarisa zvakanyanya panguva uye mushure mekuiswa kwemushonga wega wega kuti chitarise chero mhedzisiro isingadiwi kana mativi emishonga.

Haufaniri kudya kana kunwa chero chinhu chakakosha usati wapiwa remdesivir, kunyangwe kugara uine mvura yakakwana nguva dzose kunobatsira paunenge uchirwisa hutachiona. Chikwata chako chekurapa chichapa mirairo chaiyo yekudya nekunwa zvichienderana nemamiriro ako ese uye mamwe marapirwo aunogona kuwana.

Maitiro ekuisa mushonga pachayo anowanzo kuva akareruka. Uchagara zvakanaka kana kurara pamubhedha apo mushonga unodonha zvishoma nezvishoma mumutsipa wako weIV. Varwere vazhinji vanoshandisa nguva iyi kuzorora, kuverenga, kana kuona zvekuzvivaraidza pamidziyo yavo.

Ndingatora Remdesivir Kwenguva Yakareba Sei?

Nzira yakajairika yekurapa remdesivir inotora mazuva matatu kusvika ku5, kunyangwe izvi zvichigona kusiyana zvichienderana nemamiriro ako chaiwo uye maitiro ako kumushonga. Chiremba wako achasarudza nguva chaiyo yekurapa zvichienderana nezvinhu zvakaita sekukomba kwechirwere chako, hutano hwako hwese, uye nekukurumidza kwaunopora.

Kune varwere vakavharirwa muchipatara vane COVID-19, nzira yakajairika yekurapa inowanzoita mazuva mashanu. Zvisinei, kana uri kuratidza kuvandudzwa kukuru, chiremba wako angasarudza kupedzisa kurapwa mushure memazuva matatu chete. Mune dzimwe nguva apo kupora kunonoka kana matambudziko akamuka, kurapwa kungawedzera kupfuura mazuva mashanu.

Varwere vekunze vanogamuchira remdesivir vanowanzoita mazuva matatu ekurapa. Iyi nguva pfupi inowanzoita yakakwana kune vanhu vanorapwa pakutanga kwechirwere chavo uye vasina zviratidzo zvakakomba.

Vashandi venyu vezvehutano vachaongorora kufambira mberi kwenyu zuva nezuva uye vanogona kuchinja chirongwa chekurapa sezvinodiwa. Vachafunga nezvezvinhu zvakaita semazinga ako eokisijeni, kuvandudzwa kwezviratidzo, uye mamiriro ako ese ekiriniki pavanenge vachisarudza kana vachienderera mberi kana kupedzisa nzira ye remdesivir.

Ndezvipi Zvakaipa ZveRemdesivir?

Vanhu vazhinji vanotsungirira remdesivir zvakanaka, asi semishonga yese, inogona kukonzera mhedzisiro kune vamwe vanhu. Mashoko akanaka ndewekuti mhedzisiro yakakomba haisi yakajairika, uye vashandi venyu vezvehutano vachakutarisa zvakanyanya panguva yekurapa.

Heano mhedzisiro yakajairika yaungasangana nayo, uye kunzwisisa izvi kunogona kukubatsira kuti unzwe wakagadzirira uye usina hanya nezvekurapa kwako:

• Nausea: Iyi ndiyo mhedzisiro inonyanya kuziviswa, ichikanganisa vanenge 1 kubva pa10 varwere. Kazhinji inenge iri nyoro uye inogona kugadziriswa nemishonga inorwisa nausea kana zvichidikanwa.
• Kuwedzera kwezvinhu zvechiropa: Miedzo yeropa inogona kuratidza kuwedzera kwenguva pfupi mumakona ekuita kwechiropa, ayo anowanzo dzokera kune zvakajairika mushure mekunge kurapwa kwapera.
• Infusion site reactions: Vamwe vanhu vanowana kurwadziwa kudiki, kuzvimba, kana kutsvuka kutenderedza saiti yeIV.
• Kutemwa nemusoro: Izvi zvinoitika muzvikamu zvidiki zvevarwere uye zvinowanzoita nyoro kusvika pakati nepakati.
• Kuneta: Unogona kunzwa wakaneta kupfuura zvakajairika, kunyangwe izvi zvingave zvakabatana nekurwara kwako kuri pasi.

Izvi zvinowanzoitika zvinowanzoitika zvinowanzoitika uye zvinowanzoita kuti zvigadziriswe zvega. Vashandi venyu vezvehutano vane ruzivo rwekubatsira varwere kuburikidza nekusagadzikana kwenguva pfupi uku.

Kune zvakare mamwe mashoma asi akakomba mhedzisiro iyo timu yako yezvokurapa ichatarisa zvakanyanya. Kunyangwe izvi zvisingawanzoitiki, zvakakosha kuziva nezvazvo:

• Kusangana nemishonga: Kusangana nemishonga kwakanyanya hakuzivikanwe asi kunogona kusanganisa kuoma kufema, kuzvimba kwechiso kana pahuro, kana rash yakapararira.
• Matambudziko eitsvo: Mune zviitiko zvisingawanzoitiki, remdesivir inogona kukanganisa kushanda kweitsvo, ndosaka vanachiremba vako vachatarisa kushanda kweitsvo yako nemiedzo yeropa.
• Kukuvadzwa kwechiropa: Nepo kusimudzwa kwemajini echiropa zvishoma zvakajairika, matambudziko echiropa akakomba haawanzoitiki asi anogoneka.
• Kusangana nekupinza: Vamwe varwere vanogona kusangana nezviratidzo zvakaita sefivha, kutonhora, kana shanduko yeropa panguva yekupinza.

Chikwata chako chehutano chakadzidziswa zvakanaka kuziva nekugadzirisa matambudziko aya asingawanzoitiki kana akaitika. Vachange vachitarisa zviratidzo zvako zvakakosha uye mhedzisiro yelabhu mukati mekurapa kwako kuti vabatwe chero matambudziko ekutanga.

Ndiani Asingafaniri Kutora Remdesivir?

Remdesivir haina kukodzera munhu wese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wairaira. Kune mamwe mamiriro ezvinhu apo njodzi dzinogona kukunda mabhenefiti, uye mamwe marapirwo angave akakodzera.

Haufanire kugamuchira remdesivir kana iwe uchiziva kusangana nemishonga kumushonga kana chero zvikamu zvawo. Kana wakambove nekusangana nemishonga ku remdesivir munguva yakapfuura, ita shuwa kuti unozivisa chikwata chako chehutano nekukasira.

Vanhu vane chirwere cheitsvo chakakomba vanoda kufunga kwakakosha, sezvo remdesivir ichigadziriswa kuburikidza neitsvo. Kana kushanda kweitsvo yako kwakakanganiswa zvakanyanya, chiremba wako angasarudza imwe nzira yekurapa kana kugadzirisa muyero nekuchenjerera nekutarisa pedyo.

Mamwe mamiriro ezvinhu anoda kungwarira kwakawedzerwa, uye chiremba wako achayerera njodzi nemabhenefiti nekuchenjerera kana uine chero mamiriro aya:

• Chirwere chakakomba chechiropa: Sezvo remdesivir inogona kukanganisa kushanda kwechiropa, vanhu vane matambudziko echiropa vanoda kunyatsoongororwa.
• Kuzvitakura: Kunyange remdesivir ichigona kushandiswa panguva yekuzvitakura kana mabhenefiti achipfuura njodzi, sarudzo iyi inoda kufungwa zvakanyanya.
• Kuyamwisa: Kuchengeteka kwe remdesivir panguva yekuyamwisa hakuna kunyatsojekeswa, saka chiremba wako achakubatsira kuyera sarudzo.
• Kurwara kwakanyanya: Mune dzimwe nguva apo murwere ari kurwara zvakanyanya, mabhenefiti anogona kunge akaganhurirwa.

Chikwata chako chehutano chichaongorora zvese izvi zvinhu uye kukurukura nzira yakanakisa yekurapa yemamiriro ako chaiwo. Vane ruzivo rwekuita sarudzo idzi uye vachakutungamira kuburikidza nemaitiro acho.

Mazita eBrand eRemdesivir

Remdesivir inotengeswa pasi pezita rebrand Veklury naGilead Sciences. Iri ndiro chete zita rebrand rinowanikwa parizvino munyika zhinji, kusanganisira United States.

Unogona zvakare kunzwa vapi vanopa hutano vachitaura nezvazvo se "remdesivir" kana nezita rayo rekare rekuyedza "GS-5734," kunyangwe iyi yekupedzisira designation isingawanzo shandiswa mukiriniki. Paunogamuchira mushonga uyu, chinyorwa chinowanzo ratidza "Veklury" sezita rebrand.

Mhando dzakajairika dze remdesivir dziri kuwanikwa mune dzimwe nyika, asi muUnited States, Veklury inoramba iri iyo yekutanga formulation inoshandiswa muzvipatara uye nzvimbo dzehutano.

Zvimwe zvingashandiswa panzvimbo peRemdesivir

Mamwe marapirwo akati wandei anowanikwa eCOVID-19 uye mamwe hutachiona, uye chiremba wako achasarudza sarudzo yakanakisa zvichienderana nemamiriro ako chaiwo. Sarudzo yekurapa inoenderana nezvinhu zvakaita sekuti urwere hwako hwakatanga riini, njodzi dzako, uye zviratidzo zvako zviripo.

Pamusoro pekurapa COVID-19, dzimwe nzira dzinosanganisira Paxlovid (nirmatrelvir-ritonavir), iyo mushonga unotorwa nemuromo unogona kutorwa kumba kune zviitiko zvakapfava kusvika pakati nepakati. Kune zvakare molnupiravir (Lagevrio), imwe antiviral yemumuromo inogona kufungwa mune dzimwe nguva.

Kurapa kwemuviri wemonoclonal antibody kwaimboshandiswa kuCOVID-19, kunyangwe vazhinji vasingashande zvakanaka pamhando dzazvino dzemavhairasi. Chiremba wako achaziva kuti ndedzipi kurapwa zvazvino zvichikurudzirwa zvichibva pamirairo yazvino uye mhando dzemavhairasi ari kutenderera.

Kune dzimwe hutachiona hwemavhairasi, dzimwe nzira dzinogona kusanganisira mishonga yakasiyana yeantiviral yakatarwa kune vhairasi inokonzera kurwara kwako. Chikwata chako chekuchengetedza hutano chichakurukura zvese zvingasarudzwa zviripo uye kukubatsira kunzwisisa kuti nei vachikurudzira nzira yekurapa yakatarwa.

Ko Remdesivir Zviri Nani Pane Paxlovid?

Remdesivir naPaxlovid vese vanoshanda kurapa COVID-19, asi vanoshandiswa mumamiriro akasiyana pane kuve vakwikwidzi vakananga. Sarudzo yakanaka zvachose inoenderana nemamiriro ako chaiwo, nguva yekurwara, uye zvinhu zvehutano hwemunhu.

Paxlovid ane zvimwe zvakanakira kune vamwe varwere nekuti inotorwa nemuromo kumba, zvichiita kuti zvive nyore kune vanhu vasingade kupinda muchipatara. Inoshanda zvakanyanya kana yatanga mukati memazuva mashanu ekutanga kwezviratidzo uye yakaratidza mhedzisiro yakasimba mukudzivirira kurwara kwakanyanya muvarwere vane njodzi yepamusoro.

Remdesivir, kune rumwe rutivi, inowanzo chengeterwa varwere vari muchipatara kana vari panjodzi yakanyanya yekurwara kwakanyanya. Inogona kushandiswa gare gare mukufamba kwekurwara kupfuura Paxlovid uye ine rekodhi refu rekushandiswa muvarwere vari muchipatara.

Chiremba wako achafunga zvinhu zvakati wandei pakusarudza pakati pemishonga iyi. Izvi zvinosanganisira kuti wagara uine zviratidzo kwenguva yakareba sei, kana uri muchipatara, mamwe mamiriro ako ekurapa, uye mimwe mishonga yaunotora inogona kukanganisa kurapwa.

Mishonga yese miviri ine mabhenefiti akaratidzwa, uye sarudzo pakati payo inofanira kugara ichiitwa mukubvunzana nemupi wezvehutano wako anogona kuongorora mamiriro ako ega.

Mibvunzo Inowanzo Bvunzwa Pamusoro peRemdesivir

Q1. Remdesivir Yakachengeteka Kune Vanhu vane Chirwere cheShuga here?

Hongu, remdesivir inowanzova yakachengeteka kune vanhu vane chirwere cheshuga, uye kuva nechirwere cheshuga hakukudzivisi kuwana mushonga uyu. Muchokwadi, vanhu vane chirwere cheshuga vanowanzoita njodzi huru yeCOVID-19 yakakomba, saka mabhenefiti ekurapa antiviral senge remdesivir anogona kukosha zvakanyanya.

Chikwata chako chehutano chichatarisa mazinga eshuga yeropa rako zvakanyanya panguva yekurapa, sezvo kurwara uye mimwe mishonga inogona kukanganisa kudzora glucose yeropa. Vachashanda newe kuti utarise mishonga yako yechirwere cheshuga uye insulin sezvinodiwa paunenge uchigamuchira remdesivir.

Ita shuwa yekuzivisa timu yako yezvokurapa nezvemishonga yako yechirwere cheshuga uye kudzora shuga yeropa ichangoburwa kuti vakwanise kupa kutarisirwa kwakanakisa panguva yekurapa kwako.

Q2. Ndoitei kana ndikawana Remdesivir yakawandisa netsaona?

Sezvo remdesivir ichipiwa nenyanzvi dzehutano munzvimbo yekurapa inodzorwa, overdoses netsaona hazviwanzoitika. Mushonga unoyereswa zvakanyatso uye unopiwa kuburikidza neIV infusion pombi dzinodzora chiyero uye huwandu hwese hwaunowana.

Kana uine hanya nedosi yako kana ukaona chero zviratidzo zvisingawanzoitiki panguva kana mushure mekuiswa kwako, udza timu yako yehutano nekukasira. Vanogona kutarisa marekodhi ako emishonga uye kukutarisa chero zviratidzo zvemigumisiro isingadiwi.

Chikwata chako chekurapa chinotevera mitemo yakasimba yekuchengetedza mishonga, kusanganisira kutarisa kaviri madosi uye kushandisa masisitimu emagetsi kudzivirira zvikanganiso. Vakadzidziswa kuziva uye kubata chero matambudziko ane chekuita nemishonga anogona kuitika.

Q3. Ndoitei kana ndikarasikirwa nedosi yeRemdesivir?

Kusavhiringika mushonga we remdesivir hakuiti sezvo unopiwa munzvimbo yekuchengetera hutano uko timu yako yezvokurapa inotungamira chirongwa chako chekurapa. Zvisinei, kana mushonga wakanonoka nekuda kwenyaya dzekuronga kana zvikonzero zvekurapa, timu yako yezvokurapa ichasarudza nzira yakanakisisa yekuenderera mberi nayo.

Vanogona kugadzirisa chirongwa chako chekurapa kuti vave nechokwadi chekuti unogamuchira mushonga wakazara, kana kuti vanogona kuchinja nguva zvichienderana nemamiriro ako ekiriniki uye mhinduro kumushonga. Chinhu chakakosha ndechokuti zvisarudzo pamusoro pemishonga yakarasika kana yakazengurwa zvinogadzirwa nevapi vako vehutano.

Kana uine zvinokunetsa nezve chirongwa chako chekurapa kana kana uchida kubva panzvimbo yacho nechikonzero chipi zvacho panguva yekurapa kwako, kurukura izvi netimu yako yezvokurapa kuti vakwanise kuronga zvinoenderana.

Q4. Ndingamira Rini Kutora Remdesivir?

Sarudzo yekumisa kurapwa kwe remdesivir inofanira kugara ichigadzirwa netimu yako yezvokurapa zvichibva pamamiriro ako ekiriniki uye mhinduro kumushonga. Varwere vazhinji vanopedzisa nzira yakatarwa yemazuva matatu kusvika mashanu, asi izvi zvinogona kusiyana zvichienderana nemamiriro emunhu.

Chiremba wako achafunga nezvezvinhu zvakaita sekugadzirisa zviratidzo zvako, mazinga eokisijeni, mhedzisiro yelabhu, uye mamiriro ako ese ekiriniki paachisarudza kana kuenderera mberi kana kupedzisa kurapwa. Vanogona kumisa kurapwa kare kana uri kupora zvakanaka, kana kuwedzera kana uchida rubatsiro rwekuwedzera.

Usanetseka nezvekuita sarudzo iyi iwe pachako - timu yako yezvokurapa ichakutungamira kuburikidza nemaitiro uye kutsanangura zvikonzero zvavo zvekuchinja chero chirongwa chako chekurapa. Vane ruzivo rwekutarisira mishonga iyi uye vachave nechokwadi chekuti unogamuchira huwandu hwakakodzera hwekurapa mumamiriro ako ezvinhu.

Q5. Ndingatyaira Mushure meKugamuchira Remdesivir Here?

Remdesivir pachayo kazhinji haina kukanganisa kugona kwako kutyaira, asi chirwere chako chepakutanga nezvimwe zvinhu zvine chekuita nekurapwa kwako zvinogona kukanganisa kuchengeteka kwako kumashure kwesirivha. Chinhu chakakosha kufunga ndechokuti wakanaka zvakakwana kutyaira zvakachengeteka, kwete kunyanya mushonga wacho pachayo.

Kana uri kugamuchira remdesivir semurwere wekunze, unogona kunzwa wakaneta kana kusanzwa zvakanaka kubva kuchirwere chako chevhairasi, izvo zvinogona kukanganisa nguva yako yekupindura nekutonga. Vamwe vanhu vanewo mativi madiki akadai sekuoma musoro kana kusvotwa izvo zvingaita kuti kutyaira kusakodzere.

Vashandi vako vezvehutano vachapa gwara rekutangazve mabasa akajairika zvichienderana nemamiriro ako ese uye kufambira mberi kwekupora. Vachafunga nezvezvinhu zvakaita sesimba rako, kugadzirisa zviratidzo, uye chero mamwe mishonga yaunotora inogona kukanganisa kugona kwako kutyaira zvakachengeteka.