Chii chinonzi Safinamide: Zvinoshandiswa, Mishonga, Migumisiro Yakaipa uye Zvimwe

Safinamide mushonga unopiwa nachiremba unobatsira kudzora zviratidzo zvechirwere cheParkinson kana uchishandiswa pamwe chete nemamwe marapirwo. Iyo ndeyeboka remishonga inonzi MAO-B inhibitors, iyo inoshanda nekudzivisa enzyme inoputsa dopamine muuropi hwako. Izvi zvinobatsira kuchengetedza mazinga akanaka e dopamine, ayo anogona kuvandudza matambudziko ekufamba uye kuderedza nguva dzekuti "off" apo mushonga wako mukuru weParkinson haushande zvakanaka.

Chii chinonzi Safinamide?

Safinamide mushonga mutsva wakagadzirirwa kubatsira vanhu vane chirwere cheParkinson. Inoshanda sekuwedzera kurapwa, zvinoreva kuti iwe unozotora pamwe chete nemishonga yako iripo yeParkinson pane kuvatsiva. Mushonga uyu une chiito chakasiyana-siyana - haingodzivisi enzyme yeMAO-B chete asiwo inokanganisa glutamate activity muuropi hwako, iyo inogona kupa mamwe mabhenefiti ekudzora kufamba.

Mushonga uyu unoonekwa semushonga wepakati-pakati musimbi yeParkinson. Haisi simba se levodopa, asi inogona kupa kuvandudzwa kunoreva mukushanda kwemazuva ese uye mhando yehupenyu. Vanachiremba vazhinji vanoiraira kana varwere vakatanga kusangana nenguva dzakawanda dze "off" kana mishonga yavo iripo ichida kusimudzwa.

Chii chinoshandiswa Safinamide?

Safinamide inonyanya kushandiswa kurapa chirwere cheParkinson sekuwedzera kurapwa kune levodopa/carbidopa. Chiremba wako angakuraira kana uri kusangana nekuchinja kwemotokari, ayo ari nguva apo mushonga wako mukuru unopera uye zviratidzo zvako zvinodzoka. Izvi zviitiko zve "off" zvinogona kuva zvinoodza mwoyo uye zvinokanganisa mabasa ako ezuva nezuva zvakanyanya.

Mishonga iyi inobatsira zvikuru vanhu vari muzvikamu zvepakati nepashure zvechirwere cheParkinson. Inogona kubatsira kupfavisa zvinhu zvose zvakanaka nezvakaipa zvekudzora zviratidzo zuva rese. Vamwe varwere vanoonawo ichibatsira kuderedza dyskinesia, izvo zviri kufamba kusingadiwi kunogona kuitika semhedzisiro yekushandiswa kwenguva refu kwelevodopa.

Safinamide Inoshanda Sei?

Safinamide inoshanda nekudzivisa enzyme inonzi MAO-B, iyo inowanzoita kuti dopamine mumucheche wako iparadzwe. Nekudzivisa enzyme iyi, dopamine yakawanda inoramba iripo kuti masero ako ehuropi ashandise. Izvi zvinonyanya kukosha muParkinson's disease, uko masero anogadzira dopamine anorasika zvishoma nezvishoma nekufamba kwenguva.

Chinoita kuti safinamide ive yakasarudzika ndiyo nzira yayo yechipiri yekuita. Inovharisawo sodium channels uye inoderedza glutamate release, iyo inogona kubatsira kuchengetedza masero ehuropi uye kuvandudza kutonga kwekufamba. Iyi dual action inogona kutsanangura nei vamwe varwere vachiona mabhenefiti kupfuura izvo zvavanowana kubva kune mamwe MAO-B inhibitors.

Mishonga iyi inoonekwa seyepakati nepakati yakasimba ichienzaniswa nemamwe marapirwo eParkinson. Haina simba selevodopa, asi inogona kupa kuvandudzwa kukuru kana ichishandiswa nemazvo. Varwere vazhinji vanoona kuvandudzwa zvishoma nezvishoma kwemavhiki akati wandei pane shanduko dzakakurumidza dzinoshamisa.

Ndingatora Sei Safinamide?

Tora safinamide sezvinorayirwa nachiremba wako, kazhinji kamwe pazuva uine kana usina chikafu. Mishonga iyi inouya muchimiro chepiritsi uye inofanira kumedzwa yose nemvura. Haufaniri kuitora nemukaka kana chero chikafu chakati, izvo zvinoita kuti zvive nyore kukodzera muhurongwa hwako hwezuva nezuva.

Vazhinji vanachiremba vanotanga varwere padosi yakaderera uye zvishoma nezvishoma vanoiwedzera zvichienderana nekuti unopindura sei uye unotsungirira sei mishonga. Tora panguva imwechete zuva rega rega kuti uchengetedze mazinga akagadzikana muhurongwa hwako. Kana ukaitora mangwanani, namatira kumadosi emangwanani mukati mekurapwa kwako.

Unogona kutora safinamide uine kana usina chikafu, asi edza kuenderana nesarudzo yako. Vamwe vanhu vanowana kutora nacho chikafu kunobatsira kudzivirira dumbu kusagadzikana, nepo vamwe vachida kutora mudumbu risina chinhu. Hakuna zvirambidzo zvakajeka zvekudya, asi kuchengetedza kudya kwakaringana kunogona kutsigira chirongwa chako chekurapa.

Ndingatora Safinamide Kwenguva Yakareba Sei?

Safinamide inowanzoita kurapwa kwenguva refu kwaunoenderera mberi chero ichipa mabhenefiti uye uchichigamuchira zvakanaka. Vanhu vazhinji vane chirwere cheParkinson vanoda kutora mishonga yavo kwenguva isingagumi, sezvo mamiriro acho achienderera mberi uye asingaperi. Chiremba wako achatarisa mhinduro yako uye achigadzirisa chirongwa chako chekurapa sezvinodiwa nekufamba kwenguva.

Mabhenefiti akazara e safinamide anogona kutora mavhiki akati wandei kuti aonekwe. Vamwe varwere vanoona kuvandudzwa mukati memwedzi wekutanga, nepo vamwe vachigona kuda kusvika kumwedzi mitatu kuti vawane mhedzisiro yakazara. Kutanga uku zvishoma nezvishoma kwakajairika uye hakureve kuti mushonga haushandi.

Chiremba wako achagara achiongorora kana safinamide ichienderera mberi ichibatsira kune mamiriro ako chaiwo. Kana zviratidzo zvako zveParkinson zvichichinja kana kana iwe ukawana matambudziko emhedzisiro, vanogona kugadzirisa muyero wako kana kufunga nezveimwe mishonga. Usambomira kutora safinamide kamwe kamwe usina kubvunza mupi wako wehutano, sezvo izvi zvinogona kuwedzera zviratidzo zvako.

Ndezvipi Zvakaipa ZveSafinamide?

Semishonga yese, safinamide inogona kukonzera mhedzisiro, kunyangwe vanhu vazhinji vachigamuchira zvakanaka. Mhedzisiro yakajairika inowanzoita nyoro uye inowanzoita nani sezvo muviri wako uchigadzirisa kumushonga. Kunzwisisa zvekutarisira kunogona kukubatsira kuti unzwe wakagadzirira uye wakavimbika nezvekurapa kwako.

Heano mhedzisiro inonyanya kuziviswa iyo varwere vanowana:

• Kutadza kufara uye dumbu kusagadzikana
• Kutenderera musoro kana kunzwa kusimba
• Kurwadziwa nemusoro
• Kutadza kurara kana kurota zvakajeka
• Kuwedzera kufamba kusingadiwi (dyskinesia)
• Kuneta kana kunzwa kuneta
• Kuvharika mudumbu
• Muromo wakaoma

Izvi zvinowanzoitika zvinowanzoitika uye zvinogona kudzikira nekufamba kwenguva. Kutora mushonga uyu pamwe chete nechikafu kunogona kubatsira kuderedza kutadza kufara, uye kugara uine mvura yakawanda kunogona kubatsira nemuromo wakaoma uye kuvharika mudumbu.

Zvisingawanzoitiki asi zvakanyanya kukomba zvinoda kutariswa kwechiremba nekukurumidza. Kunyange izvi zvichiitika muzvikamu zvishoma zvevarwere, zvakakosha kuziva nezvazvo:

• Kukwira kweropa kwakanyanya, kunyanya kana iwe uchidya chikafu chine tyramine yakawanda
• Zviitiko zvekukurumidza kurara panguva yezviitiko zvemazuva ese
• Kurota kana kuvhiringidzika
• Kuchinja kwemanzwiro akanyanya kana kuora mwoyo
• Kurwadziwa muchipfuva kana matambudziko emoyo
• Kuita ganda kwakanyanya kana rash
• Zviratidzo zvematambudziko echiropa sekusviba kweganda kana maziso

Bata chiremba wako nekukurumidza kana uine chero ipi zvayo yezvinhu izvi zvakakomba. Vanogona kubatsira kuona kana mushonga uchida kugadziriswa kana kumiswa.

Ndiani Asingafaniri Kutora Safinamide?

Safinamide haina kuchengeteka kune vese, uye chiremba wako achanyatsoongorora nhoroondo yako yekurapa usati wamupa. Mamwe mamiriro ekurapa nemishonga zvinogona kuita zvine njodzi ne safinamide, saka zvakakosha kupa ruzivo rwakakwana nezve hutano hwako.

Vanhu vane mamiriro aya vanofanirwa kudzivisa safinamide kana kuishandisa nekuchenjerera kukuru:

• Chirwere chechiropa chakakomba kana kutadza kwechiropa
• Nhoroondo yematambudziko e retina kana macular degeneration
• Chirwere cheitsvo chakakomba
• Nhoroondo ye psychosis kana mamiriro akakomba ehutano hwepfungwa
• Kukwira kweropa kusingadzoreki
• Nhoroondo ye sitiroko kana chirwere chakakosha chemwoyo

Chiremba wako achadawo kuziva nezve mishonga yese yaunotora, sezvo safinamide inogona kushamwaridzana nemapoka akati wandei emishonga. Izvi zvinosanganisira mishonga inopiwa nachiremba, mishonga inotengwa pasina chiremba, uye zvinowedzera zvemishonga yemakwenzi.

Kuzvitakura nekuyamwisa zvinoda kufunga kwakakosha. Kunyange zvazvo paine mashoko mashoma pamusoro pekushandiswa kwe safinamide panguva yekuzvitakura, chiremba wako achayerera zvakanakira zvinogona kuitika pamusoro pemigumisiro inogona kuitika. Kana uri kuronga kuva nepamuviri kana kuti uri kuyamwisa, kurukura izvi nemupi wako wehutano usati watanga kurapwa.

Mazita eSafinamide Brand

Safinamide inowanika pasi pezita rekuti Xadago muUnited States nenyika dzakawanda. Iyi ndiyo fomu inonyanya kupihwa iyo iwe ungangosangana nayo pakemisi yako. Mushonga uyu unogadzirwa nemakambani akati wandei emishonga pasi pemvumo yekupa rezinesi.

Mune dzimwe nzvimbo, safinamide inogona kuwanika pasi pemazita akasiyana ebrand kana semashanduro ejeneric. Kemisiti yako inogona kukubatsira kuziva fomu chaiyo yaunogamuchira uye kuona kuti uri kuwana mushonga wakarurama. Nguva dzose tarisa nemupi wako wehutano kana ukaona chero shanduko mumaitiro emushonga wako kana kurongedza.

Zvimwe Zvinhu Zviri Kutsiva Safinamide

Kana safinamide isingakukodzere kana isingapi zvakakwana, mishonga yakati wandei inogona kubatsira kubata zviratidzo zvechirwere cheParkinson. Chiremba wako angangofunga mamwe maMAO-B inhibitors, dopamine agonists, kana COMT inhibitors zvichienderana nezvaunoda uye nhoroondo yako yekurapa.

Mamwe maMAO-B inhibitors anosanganisira selegiline uye rasagiline, ayo anoshanda zvakafanana ne safinamide asi ane akasiyana side effect profiles. Dopamine agonists senge pramipexole uye ropinirole inokurudzira zvakananga dopamine receptors uye inogona kushanda sekuwedzera kurapwa. COMT inhibitors senge entacapone inobatsira kuwedzera mhedzisiro yelevodopa nekudzivirira kuparara kwayo.

Sarudzo yezvimwe zvinovimba nezviratidzo zvako, mamwe mishonga yaunotora, uye kugona kwako kutakura mhedzisiro yakasiyana. Chiremba wako achashanda newe kuti awane musanganiswa unonyanya kushanda wekurapa mamiriro ako chaiwo.

Ko Safinamide Zviri Nani Pane Rasagiline?

Vose safinamide ne rasagiline vanodzivirira MAO-B vanoshandiswa kurapa chirwere cheParkinson, asi vane misiyano yakakosha. Safinamide itsva uye ine nzira mbiri yekushanda, ichivharira MAO-B uye ichikanganisa nzira dze glutamate. Rasagiline inoshanda zvakanyanya kuburikidza ne MAO-B inhibition uye yakashandiswa kwenguva refu, ichipa vanachiremba ruzivo rwakawanda nemhedzisiro yayo.

Zvidzidzo zvinoratidza kuti safinamide inogona kunge iri nyore mukuderedza nguva ye "off" uye kuvandudza zviratidzo zvemotokari mune vamwe varwere. Zvisinei, rasagiline ine rekodhi refu uye inogona kutakurwa zviri nani nevamwe vanhu. Sarudzo pakati pavo inowanzoenderana nezviratidzo zvako, mamwe mishonga, uye kuti unopindura sei kumushonga wega wega.

Hapana mushonga uri wese "zviri nani" pane mumwe. Chiremba wako achafunga nezvezvinhu zvakaita sematanho ako echirwere cheParkinson, zviratidzo zvazvino, mamwe mamiriro ehutano, uye zvinangwa zvekurapa paanokurudzira sarudzo yakakodzera kwauri.

Mibvunzo Inowanzo Bvunzwa Nezve Safinamide

Ko Safinamide Yakachengeteka Kune Vanhu vane Chirwere chemoyo?

Safinamide inoda kufungwa zvakanyanya muvanhu vane chirwere chemoyo, kunyanya avo vane high blood pressure isingadzorwi kana matambudziko emoyo achangobva kuitika. Mushonga unogona kukanganisa blood pressure uye rhythm yemoyo, kunyanya kana yakasanganiswa nezvimwe zvekudya kana mamwe mishonga. Cardiologist yako uye neurologist vanofanira kushanda pamwechete kuti vaone kana safinamide yakakodzera mamiriro ako chaiwo emoyo.

Kana uine chirwere chemoyo chiri nyore, chinodzorwa zvakanaka, safinamide inogona kuva imwe sarudzo nekuchenjerera. Chiremba wako anogona kuda kutarisa ropa rako nguva dzose uye anogona kukurudzira kudzivisa chikafu chine tyramine yakawanda, iyo inogona kukonzera kuwedzera kweropa kunotyisa kana yakasanganiswa neMAO-B inhibitors.

Ndingaita Sei Kana Ndakashandisa Safinamide Yakawanda Netsaona?

Kana ukatora safinamide yakawanda netsaona kupfuura yakarairwa, taura nachiremba wako kana nzvimbo yekudzora muchetura nekukasira, kunyangwe ukanzwa zvakanaka. Kutora safinamide yakawanda kunogona kukonzera mhedzisiro yakakomba kusanganisira kuwedzera kweropa kunotyisa, kusvotwa kwakanyanya, kuvhiringidzika, uye matambudziko emoyo.

Usamirira kuti uone kana zviratidzo zvichikura - kupindira kwekutanga kwakakosha nekupfuurisa mishonga. Chengeta bhodhoro remushonga newe paunotsvaga rubatsiro kuitira kuti vanopa hutano vazive chaizvo zvawakatora uye yakawanda sei. Kana uri kusangana nezviratidzo zvakakomba zvakaita sekurwadziwa muchipfuva, kuoma kufema, kana kuvhiringidzika, fonera masevhisi ekukurumidzira nekukasira.

Ndingaita Sei Kana Ndikakanganwa Dose yeSafinamide?

Kana ukakanganwa dose ye safinamide, itore paunorangarira, kunze kwekunge yava nguva yekuita dose yako inotevera. Muchiitiko ichocho, skip dose yakakanganwa uye uenderere mberi nehurongwa hwako hwekuita dose. Usambofa wakatora madosi maviri panguva imwe chete kuti ugadzirise dose yakakanganwa, sezvo izvi zvinogona kuwedzera njodzi yako yemhedzisiro.

Edza kutora safinamide panguva imwe chete zuva rega rega kuti uchengetedze mazinga akagadzikana muhurongwa hwako. Kugadzira alarm yezuva nezuva kana kushandisa chirongwa chemapiritsi kunogona kukubatsira kuyeuka madosi ako. Kana iwe uchikanganwa madosi kazhinji, taura nachiremba wako nezve nzira dzekuvandudza kutevedzera mishonga.

Ndingamira Rini Kutora Safinamide?

Unofanira kungomira kutora safinamide pasi pekutungamirirwa nachiremba wako. Kumira kamwe kamwe kunogona kukonzera zviratidzo zveParkinson zvako kuwedzera nekukurumidza, izvo zvinogona kuva nengozi uye zvinokanganisa zvakanyanya hupenyu hwako. Chiremba wako anowanzo kurudzira kuderedzwa zvishoma nezvishoma kwemushonga pane kumisa kamwe kamwe.

Pane zvikonzero zvakawanda nei chiremba wako angarudzira kumisa safinamide, kusanganisira mhedzisiro yakakomba, kushaya kushanda, kana kudiwa kwekutamira kumushonga wakasiyana. Vachashanda newe kuti vagadzire chirongwa chakachengeteka chekubvisa mushonga vachichengetedza kutonga kwakakwana kwezviratidzo nekumwe kurapwa.

Ndinganwa Doro Ndiri Kutora Safinamide Here?

Doro rinogona kushamwaridzana ne safinamide uye rinogona kuwedzera mamwe mhedzisiro senge dzungu, kurara, uye kuvhiringidzika. Nepo huwandu hudiki hwedoro huchigona kugamuchirwa kune vamwe vanhu, zvakakosha kukurukura kunwa doro nachiremba wako usati wamwa uchitora safinamide.

Doro rinogonawo kukanganisa zviratidzo zvako zveParkinson uye rinogona kukanganisa kushanda kwemishonga yako. Vamwe vanhu vanowana kuti doro rinoita kuti kuzununguka kwavo kuwedzere kana kukanganisa chiyero chavo nekubatana. Chiremba wako anogona kukubatsira kunzwisisa kuti doro ringakanganisa sei chirongwa chako chekurapa uye hutano hwako hwese.