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Samarium Sm 153 lexidronam mushonga une radioactive unoshandiswa kurapa kurwadziwa kwemapfupa kunokonzerwa nekenza yakapararira kumapfupa. Kurapa uku kwakakosha kunobatanidza chinhu chine radioactive (samarium-153) nechinhu chinotsvaga mapfupa chinopa radiation yakanangana zvakananga kunzvimbo dzemapfupa anorwadza. Inowanzo shandiswa kana mamwe mishonga yekurwadziwa asina kupa rubatsiro rwakakwana kuvanhu vane kenza yakafambira mberi.
Samarium Sm 153 lexidronam mushonga we radiopharmaceutical unonangana nenyama yemumafupa inobatwa nekenza. Mushonga unoshanda sembombe inotungamirirwa, ichitsvaga nzvimbo dzakapararira kenza kumapfupa ako uye ichipa kurapwa kwakatarisana ne radiation. Iyi nzira inobvumira vanachiremba kurapa nzvimbo dzakawanda dzemapfupa anorwadza mumuviri wako wese nejojo rimwe chete.
Mishonga iyi ndeyeboka remishonga inonzi bone-seeking radiopharmaceuticals. Mishonga iyi yakagadzirirwa kuunganidza munzvimbo dzemabasa emapfupa akawedzera, ndiko chaizvo uko masero ekenza anowanzo kukura paanopararira kumapfupa. Iyo radioactive samarium-153 ine hafu-hupenyu hupfupi, zvinoreva kuti inoparara zvakasikwa uye inobuda mumuviri wako nekufamba kwenguva.
Mushonga uyu unonyanya kushandiswa kubatsira kurwadziwa kwemapfupa kuvanhu vane kenza yakapararira kunzvimbo dzakawanda dzemapfupa. Inobatsira zvikuru kuvashandi vane prostate, mazamu, mapapu, kana kenza yetsvo yakapararira kumapfupa. Chiremba wako angakurudzira kurapwa uku kana uri kutambura nekurwadziwa kwemapfupa kwakapararira uko mamwe mishonga asina kudzora zvakakwana.
Kurapa uku kunokosha zvikuru nokuti kunogona kubata marwadzo mumapfupa ako ose mumusangano mumwe chete. Pane kurapa nzvimbo imwe neimwe ine marwadzo emapfupa zvakasiyana, mushonga uyu unogona kubata nzvimbo dzakawanda panguva imwe chete. Izvi zvinoita kuti ive sarudzo inoshanda kune vanhu vari kutarisana nemarwadzo ekenza munzvimbo dzakawanda dzemapfupa.
Vamwe vanachiremba vanoshandisawo mushonga uyu sechikamu chechirongwa chakakura chekudzora marwadzo. Inogona kusanganiswa nemamwe marapirwo akadai sekurapa nekunze, mishonga yekurapa marwadzo, kana kurapa mahomoni kuti ipe hanya yakazara yemarwadzo ekenza ane hukama nemapfupa.
Mishonga iyi inoshanda nekutumira radiation yakatarwa zvakananga kunzvimbo dzakakanganiswa nemapfupa ako nekenza. Kana yajekeswa muropa rako, musanganiswa unotsvaga mapfupa unotakura radioactive samarium-153 kunzvimbo dzemabasa emapfupa akawedzera. Masero ekenza mumapfupa anogadzira kutendeuka kwemapfupa kupfuura tishu ine hutano, izvo zvinoita kuti zvive zvakajairika zvekuti kurapwa uku.
Iyo radioactive samarium-153 inoburitsa beta particles dzinofamba chinhambwe chipfupi chete mumuviri wako. Izvi zvinoreva kuti radiation inokanganisa nzvimbo iri pedyo nemasero ekenza, ichideredza kukuvadzwa kumatishu ane hutano ari pedyo. Iyo radiation yakatarwa inobatsira kuderedza marwadzo nekunangana nemasero ekenza uye maitiro ekuzvimba avanogadzira mumapfupa ako.
Izvi zvinoonekwa seimwe sarudzo yekurapa yakasimba. Kunyange isinganyanyi kushinga semamwe marapirwo e radiation, inotarwa zvakanyanya kupfuura systemic chemotherapy. Iyo radiation dose inoverengwa zvakanyatsonaka zvichienderana nemamiriro ako chaiwo uye hutano hwese.
Mushonga uyu unopiwa sejojo rimwe chete mutsinga, kazhinji muchipatara kana nzvimbo yekurapa yakakosha. Haufaniri kutsanya usati wajojewa, asi chiremba wako anogona kukurudzira kunwa mvura yakawanda usati wapa mushonga uye mushure mekurapa kuti ubatsire itsvo dzako kugadzirisa mushonga. Jojo racho pacharo rinowanzo tora maminitsi mashoma.
Usati wapiwa jojo, unofanira kubvisa weti yako zvachose. Izvi zvinobatsira kuderedza kuratidzwa kwemwaranzi kuweti yako nenhengo dzakapoteredza. Chikwata chako chehutano chichakupawo mirairo chaiyo pamusoro pezvinhu zvekuchengetedza radiation zvekutevera mushure mekurapa.
Unogona kudya zvakajairika usati wapiwa jojo uye mushure mekuvhiwa. Vamwe vanachiremba vanokurudzira kugara uine mvura yakawanda nekunwa mvura yakawanda mumazuva anotevera kurapwa. Izvi zvinobatsira muviri wako kubvisa zvinhu zvinobuda mumwaranzi zvakanyanya kuburikidza neweti yako.
Kurapa kunowanzoitwa panze, zvinoreva kuti unogona kuenda kumba zuva rimwe chete. Zvisinei, unofanira kutevera matanho ekuchengetedza akasiyana kuti udzivirire nhengo dzemhuri nevamwe kubva mukuratidzwa kwemwaranzi, kunyanya mumazuva mashoma ekutanga mushure mekurapa.
Vanhu vazhinji vanogamuchira kurapwa uku sejojo rimwe chete, kunyangwe vamwe vachigona kuda dose yechipiri mushure memwedzi yakati wandei. Iyo radioactive samarium-153 inoenderera mberi ichishanda mumuviri wako kwemavhiki akati wandei mushure mekuvhiwa, ichideredza zvishoma nezvishoma sezvo zvinhu zvinobuda mumwaranzi zvichiwora zvakasikwa.
Chiremba wako achatarisa mhinduro yako kumushonga uye kuverenga ropa mumavhiki nemwedzi anotevera. Kana jojo rekutanga ripa rubatsiro rwakakwana rwekurwadziwa, unogona kusada mamwe marapirwo. Zvisinei, kana kurwadziwa kukadzoka kana kusina kudzora zvakakwana, chiremba wako anogona kukurudzira jojo rinodzokororwa mushure mekunge kuverenga ropa rako kwadzoka.
Nguva pakati pekurapa, kana zvichidikanwa, inowanzoita mwedzi miviri kana mitatu. Izvi zvinobvumira muviri wako kuti upore kubva mumhedzisiro yeradiation uye kuverengwa kwemasero eropa ako kuti adzoke kumazinga akachengeteka. Chiremba wako achashandisa bvunzo dzeropa uye mazinga ako ekurwadziwa kuti aone kana uye rini kurapwa kwakawedzerwa kungave kubatsira.
Kunzwisisa zvakashata zvinogona kukubatsira kugadzirira kurapwa uye kuziva zvekutarisira. Zvakawanda zvezvakaipa zvinogoneka uye zvenguva pfupi, kunyangwe zvimwe zvichida kutariswa zvakanyanya nechikwata chako chehutano.
Zvakashata zvakajairika zvinosanganisira kuwedzera kwenguva pfupi kwekurwadziwa kwemapfupa, kuneta, uye kusvotwa. Izvi zvinowanzoitika mukati memazuva mashoma ekutanga mushure mekurapwa uye zvinowanzoita nani zvega. Chiremba wako anogona kunyora mishonga yekubatsira kudzora zviratidzo izvi kana zvikava zvisina kunaka.
Zvakashata zvine chekuita neropa zvakare zvakajairika uye zvinoda kutarisa:
Chiremba wako achatarisa kuverengwa kweropa rako nguva dzose kuti ave nechokwadi chekuti anoramba ari mukati mehuwandu hwakachengeteka uye kupora zvakanaka nekufamba kwenguva.
Zvisingawanzoitiki asi zvakanyanya zvakashata zvinogona kusanganisira kudonha kwakanyanya muhuwandu hwemasero eropa, zvirwere zvakakomba, kana kubuda ropa kwakanyanya. Izvi hazviwanzowanikwi asi zvinoda kutariswa kwekurapa nekukasira kana zvikaitika. Chikwata chako chehutano chichatsanangura zviratidzo zvekuyambira zvekutarisa uye kana kuvabata.
Vamwe vanhu vanonzwa kuwedzera kwenguva pfupi kwekurwadziwa kwemapfupa mumazuva mashoma ekutanga mushure mekurapwa, kazhinji kunonzi
Kurapa uku hakukodzeri munhu wese, uye chiremba wako achanyatsoongorora kana zvakachengeteka kuti zvive zvakanakira mamiriro ako chaiwo. Mamwe mamiriro ezvinhu ezvokurapa uye mamiriro anoita kuti mushonga uyu usakodzere kana kuti ungave nengozi.
Vanhu vane nhamba dzeropa dzakaderera zvakanyanya havafaniri kupiwa kurapwa uku. Mushonga uyu unogona kuwedzera kuderedza nhamba dzeropa, izvo zvinogona kukonzera matambudziko akakomba sehutachiona hwakakomba kana kubuda ropa kunotyisa. Chiremba wako achatarisa nhamba dzeropa rako usati wapiwa kurapwa kuti ave nechokwadi chekuti dzakakwana.
Mushonga uyu haukurudzirwi kune vanhu vane:
Chiremba wako achafungawo nezvehutano hwako hwese, mamwe mishonga yaunotora, uye mamiriro ako chaiwo ekenza paunenge uchiziva kana kurapwa uku kwakakodzera kwauri.
Zera rega rega harikwanisi munhu kubva mukurapwa, asi vanhu vakuru vangada kunyatsotariswa nekuda kwekugona kunonoka kupora kwenhamba dzeropa. Chikwata chako chehutano chichayera mabhenefiti anogona kuwanikwa pamwe nenjodzi dzemamiriro ako ega ega.
Mushonga uyu unozivikanwa zvakanyanya nezita rayo rekuti Quadramet. Zita re generic, samarium Sm 153 lexidronam, rakareba uye rine hunyanzvi, saka vanopa hutano nevarwere vanowanzo shandisa zita rayo rebrand kuti zvive nyore.
Quadramet inogadzirwa nemakambani akasiyana-siyana emishonga uye angasavapo pazvipatara zvese zvekutarisirwa. Chiremba wako achakubatsira kuwana nzvimbo inogona kupa kurapwa uku kana zvichikurudzirwa kuti zvikubatsire.
Mamwe marapirwo anogona kubatsira kudzora kurwadziwa kwemapfupa kubva kune gomarara, kunyangwe imwe neimwe iine zvainobatsira uye zvainofanira kufungwa nezvazvo. Chiremba wako achakubatsira kunzwisisa kuti ndeapi maoption angashanda zvakanyanya kune yako chaiyo mamiriro.
Mamwe ma radiopharmaceuticals anosanganisira radium-223 (Xofigo), iyo inonyanya kubvumidzwa kune gomarara re prostate rakapararira kumapfupa. Strontium-89 (Metastron) imwezve kurapwa kunotsvaga mapfupa ane radioactive, kunyangwe ichishandiswa kazhinji kashoma pane samarium-153.
Zvimwe zvisiri zve radioactive zvinosanganisira:
Chiremba wako achafunga nezvezvinhu zvakaita sehutano hwako hwese, rudzi rwegomarara, huwandu hwekukanganiswa kwemapfupa, uye kurapwa kwakapfuura paanokurudzira nzira yakanakisa yekudzora kurwadziwa kwemapfupa ako.
Mishonga yese miviri inoshanda pakurapa kurwadziwa kwemapfupa kubva kune gomarara, asi inoshanda zvishoma zvakasiyana uye inobvumidzwa kune mamiriro akasiyana. Sarudzo pakati pavo inoenderana nerudzi rwako rwegomarara uye mamiriro ako ega.
Radium-223 (Xofigo) inobvumidzwa zvakananga kenza yegurokuro yakapararira kumapfupa uye inogona kubatsira vanhu kurarama kwenguva refu. Inopiwa semajekiseni akawanda kwemwedzi yakati wandei. Samarium-153, kune rimwe divi, inobvumidzwa kune marudzi akasiyana ekenza akapararira kumapfupa uye anowanzo piwa sejojo rimwe chete.
Chiremba wako achafunga zvinhu zvakaita serudzi rwekenza yako, hutano hwako hwese, kurapwa kwakapfuura, uye zvinangwa zvekurapa paachasarudza kuti mushonga upi ungave wakakodzera. Zvese zvinogona kushanda, asi sarudzo yakanakisa inosiyana kubva kumunhu nemunhu.
Vanhu vane chirwere cheitsvo chakakomba havafanirwe kugamuchira kurapwa uku nekuti itsvo dzavo dzinogona kusakwanisa kubvisa zvinhu zvinobudisa mheni nemazvo. Izvi zvinogona kutungamira kune kuratidzwa kwenguva refu kwemwaranzi uye kuwedzera njodzi yemigumisiro.
Kana uine matambudziko eitsvo akapfava kusvika pakati nepakati, chiremba wako angangofunga kurapwa uku asi achakutarisa zvakanyanya. Vanogona kugadzirisa muyero kana kutora matanho ekuwedzera kuti vaone kuti mushonga unogadziriswa zvakachengeteka nemuviri wako.
Sezvo mushonga uyu uchipiwa nenyanzvi dzehutano munzvimbo inodzorwa, overdose netsaona haisi kuzoitika. Muyero unoverengwa zvakanyatsoenderana nehuremu hwemuviri wako uye mamiriro ezvinhu, uye jekiseni rinogadzirirwa uye rinopiwa nenyanzvi dzakadzidziswa.
Kana uine hanya nemuyero wawakagamuchira, taura nemupi wako wehutano nekukasira. Vanogona kuongorora marekodhi ako ekurapa uye kugadzirisa chero zvaunonetseka nezvehuwandu hwemushonga wawakagamuchira.
Mamiriro ezvinhu aya haanyanyi kushanda nekuti mushonga uyu unowanzo kupiwa sejekiseni rimwe chete muchipatara. Kana makakanganwa kugadzwa kwemusi wekurapwa, fonerai hofisi yachiremba wenyu nekukurumidza sezvinobvira kuti mugadzirise zvakare.
Kana maifanira kuwana jekiseni rekutevera uye makakanganwa kugadzwa, chiremba wenyu achada kuongorora mamiriro enyu azvino uye kuverengwa kweropa musati maona nguva yakanakisa yekurapa.
Sezvo ichi chiri kurapwa kamwe chete, hamu